NO304407B1 - Tyggegummiblanding med akselerert, kontrollert frigivelse av aktive midler - Google Patents

Tyggegummiblanding med akselerert, kontrollert frigivelse av aktive midler Download PDF

Info

Publication number: NO304407B1
Authority: NO; Norway
Prior art keywords: chewing gum; esters; resin; mixture according; weight
Prior art date: 1989-07-24

Application number

NO920317A

Other languages

English (en)

Norwegian (no)

Other versions

NO920317L (no

NO920317D0 (no

Inventor

Carsten Andersen

Morten Pedersen

Original Assignee

Fertin Lab As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-24

Filing date

1992-01-23

Publication date

1998-12-14

1992-01-23 Application filed by Fertin Lab As filed Critical Fertin Lab As

1992-01-23 Publication of NO920317D0 publication Critical patent/NO920317D0/no

1992-03-23 Publication of NO920317L publication Critical patent/NO920317L/no

1998-12-14 Publication of NO304407B1 publication Critical patent/NO304407B1/no

Links

229940112822 chewing gum Drugs 0.000 title claims description 132
235000015218 chewing gum Nutrition 0.000 title claims description 132
239000000203 mixture Substances 0.000 title claims description 70
239000013543 active substance Substances 0.000 title claims description 63
238000013270 controlled release Methods 0.000 title claims description 7
239000011347 resin Substances 0.000 claims description 66
229920005989 resin Polymers 0.000 claims description 66
239000002904 solvent Substances 0.000 claims description 57
-1 fatty acid esters Chemical class 0.000 claims description 30
229920001971 elastomer Polymers 0.000 claims description 28
235000014113 dietary fatty acids Nutrition 0.000 claims description 24
239000000194 fatty acid Substances 0.000 claims description 24
229930195729 fatty acid Natural products 0.000 claims description 24
239000000796 flavoring agent Substances 0.000 claims description 22
239000005060 rubber Substances 0.000 claims description 22
235000003599 food sweetener Nutrition 0.000 claims description 18
239000003765 sweetening agent Substances 0.000 claims description 18
150000004665 fatty acids Chemical class 0.000 claims description 17
235000013355 food flavoring agent Nutrition 0.000 claims description 15
239000002023 wood Substances 0.000 claims description 15
239000003795 chemical substances by application Substances 0.000 claims description 12
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical class OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 11
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 10
150000002314 glycerols Chemical class 0.000 claims description 10
239000011118 polyvinyl acetate Substances 0.000 claims description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
229920002689 polyvinyl acetate Polymers 0.000 claims description 9
239000000654 additive Substances 0.000 claims description 8
239000003814 drug Substances 0.000 claims description 8
150000003505 terpenes Chemical class 0.000 claims description 8
235000007586 terpenes Nutrition 0.000 claims description 8
229920001214 Polysorbate 60 Polymers 0.000 claims description 7
150000002148 esters Chemical class 0.000 claims description 7
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
239000004480 active ingredient Substances 0.000 claims description 6
239000004359 castor oil Substances 0.000 claims description 6
235000019438 castor oil Nutrition 0.000 claims description 6
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 6
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 6
239000007962 solid dispersion Substances 0.000 claims description 6
108010011485 Aspartame Proteins 0.000 claims description 5
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 5
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 5
239000000605 aspartame Substances 0.000 claims description 5
235000010357 aspartame Nutrition 0.000 claims description 5
229960003438 aspartame Drugs 0.000 claims description 5
229920001223 polyethylene glycol Polymers 0.000 claims description 5
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 5
229940081974 saccharin Drugs 0.000 claims description 5
235000019204 saccharin Nutrition 0.000 claims description 5
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 5
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 4
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
229920005682 EO-PO block copolymer Polymers 0.000 claims description 4
239000001422 FEMA 4092 Substances 0.000 claims description 4
239000002202 Polyethylene glycol Substances 0.000 claims description 4
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
230000002738 anti-smoking effect Effects 0.000 claims description 4
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 4
ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 claims description 4
229920000223 polyglycerol Chemical class 0.000 claims description 4
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
235000019333 sodium laurylsulphate Nutrition 0.000 claims description 4
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical group CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 3
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 3
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
239000002253 acid Substances 0.000 claims description 3
230000002421 anti-septic effect Effects 0.000 claims description 3
229940064004 antiseptic throat preparations Drugs 0.000 claims description 3
WDRFFJWBUDTUCA-UHFFFAOYSA-N chlorhexidine acetate Chemical compound CC(O)=O.CC(O)=O.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WDRFFJWBUDTUCA-UHFFFAOYSA-N 0.000 claims description 3
229960001884 chlorhexidine diacetate Drugs 0.000 claims description 3
235000015872 dietary supplement Nutrition 0.000 claims description 3
150000002191 fatty alcohols Chemical class 0.000 claims description 3
229940041616 menthol Drugs 0.000 claims description 3
229960002715 nicotine Drugs 0.000 claims description 3
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 3
239000003002 pH adjusting agent Substances 0.000 claims description 3
239000011775 sodium fluoride Substances 0.000 claims description 3
235000013024 sodium fluoride Nutrition 0.000 claims description 3
229960000414 sodium fluoride Drugs 0.000 claims description 3
235000019155 vitamin A Nutrition 0.000 claims description 3
239000011719 vitamin A Substances 0.000 claims description 3
235000019166 vitamin D Nutrition 0.000 claims description 3
239000011710 vitamin D Substances 0.000 claims description 3
235000019165 vitamin E Nutrition 0.000 claims description 3
239000011709 vitamin E Substances 0.000 claims description 3
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 2
239000005973 Carvone Substances 0.000 claims description 2
235000011201 Ginkgo Nutrition 0.000 claims description 2
235000008100 Ginkgo biloba Nutrition 0.000 claims description 2
244000194101 Ginkgo biloba Species 0.000 claims description 2
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims description 2
235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 2
235000003140 Panax quinquefolius Nutrition 0.000 claims description 2
241000241413 Propolis Species 0.000 claims description 2
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 2
229930003316 Vitamin D Natural products 0.000 claims description 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 2
229930003427 Vitamin E Natural products 0.000 claims description 2
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 2
229960001948 caffeine Drugs 0.000 claims description 2
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims description 2
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
235000008434 ginseng Nutrition 0.000 claims description 2
239000001525 mentha piperita l. herb oil Substances 0.000 claims description 2
235000019477 peppermint oil Nutrition 0.000 claims description 2
229940069949 propolis Drugs 0.000 claims description 2
239000001959 sucrose esters of fatty acids Chemical class 0.000 claims description 2
235000010965 sucrose esters of fatty acids Nutrition 0.000 claims description 2
150000003710 vitamin D derivatives Chemical class 0.000 claims description 2
229940046009 vitamin E Drugs 0.000 claims description 2
229940045997 vitamin a Drugs 0.000 claims description 2
229940046008 vitamin d Drugs 0.000 claims description 2
WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims 2
229940080352 sodium stearoyl lactylate Drugs 0.000 claims 2
ODFAPIRLUPAQCQ-UHFFFAOYSA-M sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 claims 2
244000131316 Panax pseudoginseng Species 0.000 claims 1
229940112041 peripherally acting muscle relaxants other quaternary ammonium compound in atc Drugs 0.000 claims 1
239000000126 substance Substances 0.000 description 21
230000001055 chewing effect Effects 0.000 description 20
150000001875 compounds Chemical class 0.000 description 17
230000000694 effects Effects 0.000 description 15
238000000034 method Methods 0.000 description 15
210000000214 mouth Anatomy 0.000 description 13
239000004615 ingredient Substances 0.000 description 12
238000004519 manufacturing process Methods 0.000 description 12
238000001727 in vivo Methods 0.000 description 11
235000002639 sodium chloride Nutrition 0.000 description 11
239000003995 emulsifying agent Substances 0.000 description 10
150000003839 salts Chemical class 0.000 description 10
239000001993 wax Substances 0.000 description 9
239000000047 product Substances 0.000 description 8
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
239000011248 coating agent Substances 0.000 description 7
238000000576 coating method Methods 0.000 description 7
239000000470 constituent Substances 0.000 description 7
239000000463 material Substances 0.000 description 7
238000002156 mixing Methods 0.000 description 7
238000002360 preparation method Methods 0.000 description 7
239000004094 surface-active agent Substances 0.000 description 7
239000000806 elastomer Substances 0.000 description 6
238000009472 formulation Methods 0.000 description 6
239000000843 powder Substances 0.000 description 6
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 5
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
230000008901 benefit Effects 0.000 description 5
235000010445 lecithin Nutrition 0.000 description 5
239000000787 lecithin Substances 0.000 description 5
229940067606 lecithin Drugs 0.000 description 5
239000011734 sodium Substances 0.000 description 5
229910052708 sodium Inorganic materials 0.000 description 5
239000000600 sorbitol Substances 0.000 description 5
235000010356 sorbitol Nutrition 0.000 description 5
239000006188 syrup Substances 0.000 description 5
235000020357 syrup Nutrition 0.000 description 5
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
239000011575 calcium Substances 0.000 description 4
229910052791 calcium Inorganic materials 0.000 description 4
239000011162 core material Substances 0.000 description 4
229940079593 drug Drugs 0.000 description 4
239000003925 fat Substances 0.000 description 4
235000019197 fats Nutrition 0.000 description 4
235000019634 flavors Nutrition 0.000 description 4
239000007788 liquid Substances 0.000 description 4
239000011777 magnesium Substances 0.000 description 4
229910052749 magnesium Inorganic materials 0.000 description 4
238000002844 melting Methods 0.000 description 4
230000008018 melting Effects 0.000 description 4
230000008569 process Effects 0.000 description 4
238000012360 testing method Methods 0.000 description 4
230000001225 therapeutic effect Effects 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical class CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
235000013162 Cocos nucifera Nutrition 0.000 description 3
244000060011 Cocos nucifera Species 0.000 description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 3
RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 3
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 3
235000003084 food emulsifier Nutrition 0.000 description 3
150000002303 glucose derivatives Chemical class 0.000 description 3
235000011187 glycerol Nutrition 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
229920000136 polysorbate Polymers 0.000 description 3
239000011591 potassium Substances 0.000 description 3
229910052700 potassium Inorganic materials 0.000 description 3
235000000346 sugar Nutrition 0.000 description 3
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
QDHHCQZDFGDHMP-UHFFFAOYSA-N Chloramine Chemical compound ClN QDHHCQZDFGDHMP-UHFFFAOYSA-N 0.000 description 2
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 2
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
239000004378 Glycyrrhizin Substances 0.000 description 2
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
125000000129 anionic group Chemical group 0.000 description 2
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
239000004202 carbamide Substances 0.000 description 2
150000004649 carbonic acid derivatives Chemical class 0.000 description 2
238000001816 cooling Methods 0.000 description 2
229910052802 copper Inorganic materials 0.000 description 2
239000010949 copper Substances 0.000 description 2
229940109275 cyclamate Drugs 0.000 description 2
239000008121 dextrose Substances 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
239000007888 film coating Substances 0.000 description 2
238000009501 film coating Methods 0.000 description 2
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
235000013305 food Nutrition 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
239000008103 glucose Substances 0.000 description 2
125000005456 glyceride group Chemical group 0.000 description 2
LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
229960004949 glycyrrhizic acid Drugs 0.000 description 2
UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
235000019410 glycyrrhizin Nutrition 0.000 description 2
LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
238000010348 incorporation Methods 0.000 description 2
239000011256 inorganic filler Substances 0.000 description 2
229910003475 inorganic filler Inorganic materials 0.000 description 2
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
229910052742 iron Inorganic materials 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
229910052750 molybdenum Inorganic materials 0.000 description 2
239000011733 molybdenum Substances 0.000 description 2
239000002324 mouth wash Substances 0.000 description 2
229960003512 nicotinic acid Drugs 0.000 description 2
235000001968 nicotinic acid Nutrition 0.000 description 2
239000011664 nicotinic acid Substances 0.000 description 2
239000003921 oil Substances 0.000 description 2
235000019198 oils Nutrition 0.000 description 2
239000012188 paraffin wax Substances 0.000 description 2
235000021317 phosphate Nutrition 0.000 description 2
150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
239000004014 plasticizer Substances 0.000 description 2
229920001983 poloxamer Polymers 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
150000003856 quaternary ammonium compounds Chemical class 0.000 description 2
229960002477 riboflavin Drugs 0.000 description 2
239000011669 selenium Substances 0.000 description 2
229910052711 selenium Inorganic materials 0.000 description 2
SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
235000010413 sodium alginate Nutrition 0.000 description 2
239000000661 sodium alginate Substances 0.000 description 2
229940005550 sodium alginate Drugs 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
239000000892 thaumatin Substances 0.000 description 2
235000010436 thaumatin Nutrition 0.000 description 2
MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
229940034610 toothpaste Drugs 0.000 description 2
239000000606 toothpaste Substances 0.000 description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
239000000811 xylitol Substances 0.000 description 2
235000010447 xylitol Nutrition 0.000 description 2
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
229960002675 xylitol Drugs 0.000 description 2
239000011701 zinc Substances 0.000 description 2
229910052725 zinc Inorganic materials 0.000 description 2
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
DNISEZBAYYIQFB-PHDIDXHHSA-N (2r,3r)-2,3-diacetyloxybutanedioic acid Chemical compound CC(=O)O[C@@H](C(O)=O)[C@H](C(O)=O)OC(C)=O DNISEZBAYYIQFB-PHDIDXHHSA-N 0.000 description 1
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
FVJIUQSKXOYFKG-UHFFFAOYSA-N (3,4-dichlorophenyl)methanol Chemical compound OCC1=CC=C(Cl)C(Cl)=C1 FVJIUQSKXOYFKG-UHFFFAOYSA-N 0.000 description 1
ZXSQEZNORDWBGZ-UHFFFAOYSA-N 1,3-dihydropyrrolo[2,3-b]pyridin-2-one Chemical compound C1=CN=C2NC(=O)CC2=C1 ZXSQEZNORDWBGZ-UHFFFAOYSA-N 0.000 description 1
LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
WISVKXCNQOLCJL-UHFFFAOYSA-N 1-(4-chlorophenoxy)-3,3-dimethylbutan-2-one Chemical compound CC(C)(C)C(=O)COC1=CC=C(Cl)C=C1 WISVKXCNQOLCJL-UHFFFAOYSA-N 0.000 description 1
RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical class CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
ZILVNHNSYBNLSZ-UHFFFAOYSA-N 2-(diaminomethylideneamino)guanidine Chemical compound NC(N)=NNC(N)=N ZILVNHNSYBNLSZ-UHFFFAOYSA-N 0.000 description 1
QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 1
QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
XJBOZKOSICCONT-UHFFFAOYSA-N 4,6,6-trimethylbicyclo[3.1.1]hept-2-ene Chemical compound CC1C=CC2C(C)(C)C1C2 XJBOZKOSICCONT-UHFFFAOYSA-N 0.000 description 1
OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 description 1
WXNZTHHGJRFXKQ-UHFFFAOYSA-N 4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1 WXNZTHHGJRFXKQ-UHFFFAOYSA-N 0.000 description 1
PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 1
244000215068 Acacia senegal Species 0.000 description 1
WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
239000005995 Aluminium silicate Substances 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
244000099147 Ananas comosus Species 0.000 description 1
235000007119 Ananas comosus Nutrition 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
241000167854 Bourreria succulenta Species 0.000 description 1
239000004255 Butylated hydroxyanisole Substances 0.000 description 1
239000004322 Butylated hydroxytoluene Substances 0.000 description 1
VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
244000223760 Cinnamomum zeylanicum Species 0.000 description 1
240000000560 Citrus x paradisi Species 0.000 description 1
240000007154 Coffea arabica Species 0.000 description 1
229920000858 Cyclodextrin Polymers 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical class OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
244000004281 Eucalyptus maculata Species 0.000 description 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
235000016623 Fragaria vesca Nutrition 0.000 description 1
240000009088 Fragaria x ananassa Species 0.000 description 1
235000011363 Fragaria x ananassa Nutrition 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
206010017533 Fungal infection Diseases 0.000 description 1
240000001238 Gaultheria procumbens Species 0.000 description 1
235000007297 Gaultheria procumbens Nutrition 0.000 description 1
240000004670 Glycyrrhiza echinata Species 0.000 description 1
235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
229920002907 Guar gum Polymers 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
VHOQXEIFYTTXJU-UHFFFAOYSA-N Isobutylene-isoprene copolymer Chemical compound CC(C)=C.CC(=C)C=C VHOQXEIFYTTXJU-UHFFFAOYSA-N 0.000 description 1
LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
235000006679 Mentha X verticillata Nutrition 0.000 description 1
235000014749 Mentha crispa Nutrition 0.000 description 1
244000246386 Mentha pulegium Species 0.000 description 1
235000016257 Mentha pulegium Nutrition 0.000 description 1
244000078639 Mentha spicata Species 0.000 description 1
235000002899 Mentha suaveolens Nutrition 0.000 description 1
235000004357 Mentha x piperita Nutrition 0.000 description 1
235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
208000031888 Mycoses Diseases 0.000 description 1
240000009023 Myrrhis odorata Species 0.000 description 1
235000007265 Myrrhis odorata Nutrition 0.000 description 1
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
235000002637 Nicotiana tabacum Nutrition 0.000 description 1
244000061176 Nicotiana tabacum Species 0.000 description 1
240000004371 Panax ginseng Species 0.000 description 1
229930040373 Paraformaldehyde Natural products 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
235000012550 Pimpinella anisum Nutrition 0.000 description 1
229920002023 Pluronic® F 87 Polymers 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
229920002367 Polyisobutene Polymers 0.000 description 1
229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Chemical class OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
235000009827 Prunus armeniaca Nutrition 0.000 description 1
244000018633 Prunus armeniaca Species 0.000 description 1
240000007651 Rubus glaucus Species 0.000 description 1
235000011034 Rubus glaucus Nutrition 0.000 description 1
235000009122 Rubus idaeus Nutrition 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
229930182558 Sterol Natural products 0.000 description 1
UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Chemical class [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
244000299461 Theobroma cacao Species 0.000 description 1
239000005844 Thymol Substances 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
235000009499 Vanilla fragrans Nutrition 0.000 description 1
244000263375 Vanilla tahitensis Species 0.000 description 1
235000012036 Vanilla tahitensis Nutrition 0.000 description 1
229930003471 Vitamin B2 Natural products 0.000 description 1
WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
239000000619 acesulfame-K Substances 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
230000009471 action Effects 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
239000001361 adipic acid Substances 0.000 description 1
235000011037 adipic acid Nutrition 0.000 description 1
230000002411 adverse Effects 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
150000001299 aldehydes Chemical class 0.000 description 1
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
235000012211 aluminium silicate Nutrition 0.000 description 1
229940103272 aluminum potassium sulfate Drugs 0.000 description 1
235000001014 amino acid Nutrition 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Chemical class OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
230000003610 anti-gingivitis Effects 0.000 description 1
239000003429 antifungal agent Substances 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
235000006708 antioxidants Nutrition 0.000 description 1
229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
239000000305 astragalus gummifer gum Substances 0.000 description 1
229910052788 barium Inorganic materials 0.000 description 1
DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
235000013871 bee wax Nutrition 0.000 description 1
239000012166 beeswax Substances 0.000 description 1
239000003613 bile acid Substances 0.000 description 1
229960002685 biotin Drugs 0.000 description 1
235000020958 biotin Nutrition 0.000 description 1
239000011616 biotin Substances 0.000 description 1
229910052796 boron Inorganic materials 0.000 description 1
SNCZNSNPXMPCGN-UHFFFAOYSA-N butanediamide Chemical compound NC(=O)CCC(N)=O SNCZNSNPXMPCGN-UHFFFAOYSA-N 0.000 description 1
235000014121 butter Nutrition 0.000 description 1
229920005549 butyl rubber Polymers 0.000 description 1
235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
239000004204 candelilla wax Substances 0.000 description 1
235000013868 candelilla wax Nutrition 0.000 description 1
229940073532 candelilla wax Drugs 0.000 description 1
235000013736 caramel Nutrition 0.000 description 1
235000013877 carbamide Nutrition 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
239000004203 carnauba wax Substances 0.000 description 1
235000013869 carnauba wax Nutrition 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
239000000679 carrageenan Substances 0.000 description 1
229920001525 carrageenan Polymers 0.000 description 1
229940113118 carrageenan Drugs 0.000 description 1
239000000969 carrier Substances 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
229920003086 cellulose ether Polymers 0.000 description 1
230000008859 change Effects 0.000 description 1
235000019693 cherries Nutrition 0.000 description 1
229960005443 chloroxylenol Drugs 0.000 description 1
235000019219 chocolate Nutrition 0.000 description 1
229910052804 chromium Inorganic materials 0.000 description 1
239000011651 chromium Substances 0.000 description 1
235000017803 cinnamon Nutrition 0.000 description 1
239000010941 cobalt Substances 0.000 description 1
229910017052 cobalt Inorganic materials 0.000 description 1
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
235000016213 coffee Nutrition 0.000 description 1
235000013353 coffee beverage Nutrition 0.000 description 1
238000004040 coloring Methods 0.000 description 1
235000009508 confectionery Nutrition 0.000 description 1
229910000365 copper sulfate Inorganic materials 0.000 description 1
ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
229930003836 cresol Natural products 0.000 description 1
229940013361 cresol Drugs 0.000 description 1
239000013078 crystal Substances 0.000 description 1
229940097362 cyclodextrins Drugs 0.000 description 1
125000004855 decalinyl group Chemical class C1(CCCC2CCCCC12)* 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
208000002925 dental caries Diseases 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
235000013399 edible fruits Nutrition 0.000 description 1
230000001804 emulsifying effect Effects 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
210000003238 esophagus Anatomy 0.000 description 1
239000000686 essence Substances 0.000 description 1
150000002168 ethanoic acid esters Chemical class 0.000 description 1
239000000284 extract Substances 0.000 description 1
239000004744 fabric Substances 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
MDQRDWAGHRLBPA-UHFFFAOYSA-N fluoroamine Chemical class FN MDQRDWAGHRLBPA-UHFFFAOYSA-N 0.000 description 1
229960000304 folic acid Drugs 0.000 description 1
235000019152 folic acid Nutrition 0.000 description 1
239000011724 folic acid Substances 0.000 description 1
235000012041 food component Nutrition 0.000 description 1
239000005417 food ingredient Substances 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
235000011087 fumaric acid Nutrition 0.000 description 1
239000000499 gel Substances 0.000 description 1
238000007429 general method Methods 0.000 description 1
229960005150 glycerol Drugs 0.000 description 1
150000002315 glycerophosphates Chemical class 0.000 description 1
239000001087 glyceryl triacetate Substances 0.000 description 1
235000013773 glyceryl triacetate Nutrition 0.000 description 1
238000000227 grinding Methods 0.000 description 1
235000010417 guar gum Nutrition 0.000 description 1
239000000665 guar gum Substances 0.000 description 1
229960002154 guar gum Drugs 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
230000036541 health Effects 0.000 description 1
IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
229960004068 hexachlorophene Drugs 0.000 description 1
235000012907 honey Nutrition 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
239000008172 hydrogenated vegetable oil Substances 0.000 description 1
150000002433 hydrophilic molecules Chemical class 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
229940035535 iodophors Drugs 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
239000004310 lactic acid Chemical class 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
150000003903 lactic acid esters Chemical class 0.000 description 1
239000000832 lactitol Substances 0.000 description 1
235000010448 lactitol Nutrition 0.000 description 1
VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
229960003451 lactitol Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229940070765 laurate Drugs 0.000 description 1
239000011133 lead Substances 0.000 description 1
229940010454 licorice Drugs 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical class OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Chemical class 0.000 description 1
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
150000004702 methyl esters Chemical class 0.000 description 1
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
239000004200 microcrystalline wax Substances 0.000 description 1
235000019808 microcrystalline wax Nutrition 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
229940090668 parachlorophenol Drugs 0.000 description 1
229920002866 paraformaldehyde Polymers 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
230000008447 perception Effects 0.000 description 1
239000012169 petroleum derived wax Substances 0.000 description 1
235000019381 petroleum wax Nutrition 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
229960005323 phenoxyethanol Drugs 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
238000005498 polishing Methods 0.000 description 1
229960000502 poloxamer Drugs 0.000 description 1
239000008389 polyethoxylated castor oil Substances 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
239000003996 polyglycerol polyricinoleate Substances 0.000 description 1
235000010958 polyglycerol polyricinoleate Nutrition 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
235000011185 polyoxyethylene (40) stearate Nutrition 0.000 description 1
239000001194 polyoxyethylene (40) stearate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
230000008092 positive effect Effects 0.000 description 1
GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
239000000770 propane-1,2-diol alginate Substances 0.000 description 1
239000000473 propyl gallate Substances 0.000 description 1
235000010388 propyl gallate Nutrition 0.000 description 1
229940075579 propyl gallate Drugs 0.000 description 1
229960004063 propylene glycol Drugs 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
239000002994 raw material Substances 0.000 description 1
239000002151 riboflavin Substances 0.000 description 1
235000019192 riboflavin Nutrition 0.000 description 1
239000004170 rice bran wax Substances 0.000 description 1
235000019384 rice bran wax Nutrition 0.000 description 1
WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical class OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
238000012216 screening Methods 0.000 description 1
230000028327 secretion Effects 0.000 description 1
229910052814 silicon oxide Inorganic materials 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
150000003378 silver Chemical class 0.000 description 1
CQLFBEKRDQMJLZ-UHFFFAOYSA-M silver acetate Chemical compound [Ag+].CC([O-])=O CQLFBEKRDQMJLZ-UHFFFAOYSA-M 0.000 description 1
229940071536 silver acetate Drugs 0.000 description 1
LKZMBDSASOBTPN-UHFFFAOYSA-L silver carbonate Substances [Ag].[O-]C([O-])=O LKZMBDSASOBTPN-UHFFFAOYSA-L 0.000 description 1
229910001958 silver carbonate Inorganic materials 0.000 description 1
229910001961 silver nitrate Inorganic materials 0.000 description 1
230000000391 smoking effect Effects 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
229960004711 sodium monofluorophosphate Drugs 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
229960002799 stannous fluoride Drugs 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
229940013618 stevioside Drugs 0.000 description 1
OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
235000019202 steviosides Nutrition 0.000 description 1
229910052712 strontium Inorganic materials 0.000 description 1
CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
229920003048 styrene butadiene rubber Polymers 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
229920003051 synthetic elastomer Polymers 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000011975 tartaric acid Chemical class 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229960000790 thymol Drugs 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
235000019149 tocopherols Nutrition 0.000 description 1
229940024986 topical antifungal imidazole and triazole derivative Drugs 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229960003500 triclosan Drugs 0.000 description 1
231100000402 unacceptable toxicity Toxicity 0.000 description 1
229910052720 vanadium Inorganic materials 0.000 description 1
GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
235000019164 vitamin B2 Nutrition 0.000 description 1
239000011716 vitamin B2 Substances 0.000 description 1
235000019168 vitamin K Nutrition 0.000 description 1
239000011712 vitamin K Substances 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000004246 zinc acetate Substances 0.000 description 1
235000013904 zinc acetate Nutrition 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
239000011670 zinc gluconate Substances 0.000 description 1
235000011478 zinc gluconate Nutrition 0.000 description 1
229960000306 zinc gluconate Drugs 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/02—Apparatus specially adapted for manufacture or treatment of chewing gum
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/08—Chewing gum characterised by the composition containing organic or inorganic compounds of the chewing gum base
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Inorganic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Confectionery (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Circuits Of Receivers In General (AREA)
Telephonic Communication Services (AREA)
Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)

NO920317A 1989-07-24 1992-01-23 Tyggegummiblanding med akselerert, kontrollert frigivelse av aktive midler NO304407B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK365389A DK365389D0 (da)	1989-07-24	1989-07-24	Antifungalt tyggegummipraeparat
PCT/DK1990/000189 WO1991001132A1 (fr)	1989-07-24	1990-07-18	Composition de chewing-gum a liberation reglee et acceleree des agents actifs

Publications (3)

Publication Number	Publication Date
NO920317D0 NO920317D0 (no)	1992-01-23
NO920317L NO920317L (no)	1992-03-23
NO304407B1 true NO304407B1 (no)	1998-12-14

Family

ID=8125297

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO920317A NO304407B1 (no)	1989-07-24	1992-01-23	Tyggegummiblanding med akselerert, kontrollert frigivelse av aktive midler
NO983771A NO309672B1 (no)	1989-07-24	1998-08-18	Fremgangsmåte for fremstilling av tyggegummiblanding

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO983771A NO309672B1 (no)	1989-07-24	1998-08-18	Fremgangsmåte for fremstilling av tyggegummiblanding

Country Status (16)

Country	Link
US (1)	US5487902A (fr)
EP (1)	EP0486563B1 (fr)
KR (1)	KR0185574B1 (fr)
AT (1)	ATE94059T1 (fr)
AU (1)	AU637815B2 (fr)
CA (1)	CA2063819C (fr)
DE (1)	DE69003244T2 (fr)
DK (2)	DK365389D0 (fr)
ES (1)	ES2058929T3 (fr)
FI (2)	FI105068B (fr)
GR (1)	GR900100562A (fr)
IE (1)	IE64838B1 (fr)
NO (2)	NO304407B1 (fr)
PT (1)	PT94801B (fr)
WO (1)	WO1991001132A1 (fr)
ZA (1)	ZA905722B (fr)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5154938A (en) *	1990-12-20	1992-10-13	Wm. Wrigley Jr. Company	Gum composition having dispersed porous beads containing plasticizers
US5288508A (en) *	1992-03-20	1994-02-22	Fuisz Technologies, Ltd.	Delivery systems containing elastomer solvents subjected to flash flow
US5549906A (en) *	1993-07-26	1996-08-27	Pharmacia Ab	Nicotine lozenge and therapeutic method for smoking cessation
US5362496A (en) *	1993-08-04	1994-11-08	Pharmetrix Corporation	Method and therapeutic system for smoking cessation
MA23587A1 (fr) *	1994-06-23	1995-12-31	Procter & Gamble	Traitement du besoin en nicotine et/ou du syndrome de manque lie au tabagisme
GB9517031D0 (en) *	1995-08-19	1995-10-25	Procter & Gamble	Confection compositions
WO1998058637A1 (fr) *	1996-06-20	1998-12-30	Mcneil-Ppc	Analgesique a base d'acetaminophene et de diphenhydramine
ZA975444B (en) *	1996-06-20	1998-12-21	Mcneil Ppc Inc	Acetaminophen and meclizine hydrochloride analgesics
US5961958A (en) *	1996-07-16	1999-10-05	Four Star Partners	Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
MY117939A (en) *	1996-07-25	2004-08-30	Lg Chemical Ltd	Composition for enhancing oral hygiene
US6949264B1 (en)	1996-11-27	2005-09-27	Wm. Wrigley Jr. Company	Nutraceuticals or nutritional supplements and method of making
US6165516A (en) *	1996-11-27	2000-12-26	Wm. Wrigley Jr. Company	Method of controlling release of caffeine in chewing gum
US5792446A (en) *	1997-02-18	1998-08-11	Collagenex Pharmaceuticals, Inc.	Delivery system for administering dentin-hypersensitivity-ameliorating compositions
JP3202938B2 (ja) *	1997-03-18	2001-08-27	三井農林株式会社	チューインガム及びその製造法
US8765177B2 (en) *	1997-09-12	2014-07-01	Columbia Laboratories, Inc.	Bioadhesive progressive hydration tablets
US7153845B2 (en) *	1998-08-25	2006-12-26	Columbia Laboratories, Inc.	Bioadhesive progressive hydration tablets
US5922346A (en) *	1997-12-01	1999-07-13	Thione International, Inc.	Antioxidant preparation
RU2202220C2 (ru) *	1997-12-30	2003-04-20	Вм. Ригли Дж. Компани	Способ получения готовой жевательной резинки, содержащей антибактериальный агент с контролируемым высвобождением (варианты), и готовая жевательная резинка
US6592912B1 (en)	1997-12-30	2003-07-15	Wm. Wrigley Jr. Company	Method of controlling release of antimicrobial agents from chewing gum and gum produced thereby
AU2002318866B2 (en) *	1997-12-30	2005-12-22	Wm. Wrigley Jr. Company	Method of Controlling Release of Antimicrobial Agents in Chewing Gum and Gum Produced Thereby
GB9801141D0 (en) *	1998-01-21	1998-03-18	Porter William L	Bolus for ruminent animals
CA2478619A1 (fr) *	1998-03-04	1999-09-10	Dandy A/S	Chewing-gum enrobe contenant une substance active a activite systemique
US6024988A (en) *	1998-06-01	2000-02-15	Wm. Wrigley Jr. Company	Caffeine chewing gum
US6358060B2 (en) *	1998-09-03	2002-03-19	Jsr Llc	Two-stage transmucosal medicine delivery system for symptom relief
US6344222B1 (en)	1998-09-03	2002-02-05	Jsr Llc	Medicated chewing gum delivery system for nicotine
US20020098264A1 (en) *	1998-11-27	2002-07-25	Cherukuri Subraman R.	Medicated chewing gum delivery system for nicotine
US7163705B2 (en) *	1998-12-15	2007-01-16	Wm. Wrigley Jr. Company	Coated chewing gum product and method of making
US6531114B1 (en)	1999-04-06	2003-03-11	Wm. Wrigley Jr. Company	Sildenafil citrate chewing gum formulations and methods of using the same
CN1354624A (zh) *	1998-12-15	2002-06-19	Wm·雷格利Jr·公司	从口香糖中控制释放活性剂
US6586023B1 (en) *	1998-12-15	2003-07-01	Wm. Wrigley Jr. Company	Process for controlling release of active agents from a chewing gum coating and product thereof
US6627234B1 (en)	1998-12-15	2003-09-30	Wm. Wrigley Jr. Company	Method of producing active agent coated chewing gum products
CN1330516A (zh) *	1998-12-15	2002-01-09	Wm.雷格利Jr.公司	口香糖涂层中药物活性剂释放的改进
US6436369B2 (en) *	1998-12-17	2002-08-20	Wm. Wrigley Jr. Company	Anti-plaque emulsions and products containing same
DE29822862U1 (de)	1998-12-23	1999-03-18	Orantek, Katharina, 63165 Mühlheim	Kaugummi
US20020159956A1 (en) *	1999-04-06	2002-10-31	Ream Ronald L.	Over-coated chewing gum formulations
US6426090B1 (en) *	1999-04-06	2002-07-30	Wm. Wrigley Jr. Company	Over-coated product including tableted center and medicament
US6773716B2 (en)	1999-04-06	2004-08-10	Wm. Wrigley Jr. Company	Over-coated chewing gum formulations
US6322806B1 (en)	1999-04-06	2001-11-27	Wm. Wrigley Jr. Company	Over-coated chewing gum formulations including tableted center
US6355265B1 (en)	1999-04-06	2002-03-12	Wm. Wrigley Jr. Company	Over-coated chewing gum formulations
US7935362B2 (en) *	1999-04-06	2011-05-03	Wm. Wrigley Jr. Company	Over-coated product including consumable center and medicament
US6569472B1 (en)	2000-09-01	2003-05-27	Wm. Wrigley Jr. Company	Coated chewing gum products containing antacid and method of making
US6645535B2 (en)	1999-09-02	2003-11-11	Wm. Wrigley Jr. Company	Method of making coated chewing gum products containing various antacids
US6541048B2 (en)	1999-09-02	2003-04-01	Wm. Wrigley Jr. Company	Coated chewing gum products containing an acid blocker and process of preparing
US6663849B1 (en)	2000-09-01	2003-12-16	Wm. Wrigley Jr. Company	Antacid chewing gum products coated with high viscosity materials
US9253991B2 (en)	1999-09-20	2016-02-09	Jack Barreca	Chewing gum with B vitamins
WO2001021147A1 (fr) *	1999-09-20	2001-03-29	Mastercare	Gomme a macher et sucette de regime et de controle ponderal
US9387168B2 (en)	1999-09-20	2016-07-12	Jack Barreca	Chewing gum with tomatidine
KR100441271B1 (ko) *	1999-10-19	2004-07-23	주식회사 보락	다량의 충진제를 함유하는 츄잉껌
US7041277B2 (en) *	2000-03-10	2006-05-09	Cadbury Adams Usa Llc	Chewing gum and confectionery compositions with encapsulated stain removing agent compositions, and methods of making and using the same
WO2001089476A1 (fr) *	2000-05-19	2001-11-29	Npd Llc	Gommes a macher, pastilles, bonbons, tablettes, liquides et sprays destines a une administration efficace de medicaments et de supplements dietetiques
US6572900B1 (en)	2000-06-09	2003-06-03	Wm. Wrigley, Jr. Company	Method for making coated chewing gum products including a high-intensity sweetener
US7115288B2 (en) *	2000-06-09	2006-10-03	Wm. Wrigley Jr. Company	Method for making coated chewing gum products with a coating including an aldehyde flavor and a dipeptide sweetener
WO2002013781A1 (fr) *	2000-08-14	2002-02-21	Fertin Pharma A/S	Procede de preparation d'une gomme a macher ayant un gout agreable pour le consommateur
WO2002017730A1 (fr) *	2000-08-25	2002-03-07	Wm. Wrigley Jr. Company	Gommes a macher respectant l'environnement et contenant de la lecithine
US6444241B1 (en)	2000-08-30	2002-09-03	Wm. Wrigley Jr. Company	Caffeine coated chewing gum product and process of making
US6696043B2 (en) *	2000-09-20	2004-02-24	Scientific Pharmaceuticals, Inc.	Teeth whitening composition in the form of a chewing gum
US20050048007A1 (en) *	2000-11-02	2005-03-03	Inobys Ltd.	Plaque reducing composition
ES2178952B1 (es) *	2000-12-20	2003-09-16	Sl Para El Desarrollo Cientifi	Goma de mascar.
US6579545B2 (en)	2000-12-22	2003-06-17	Wm. Wrigley Jr. Company	Coated chewing gum products containing an antigas agent
KR20010069587A (ko) *	2001-04-18	2001-07-25	전창호	껌의 조성물
KR20010078976A (ko) *	2001-05-28	2001-08-22	전창호	껌의 조성물
AU2002323135A1 (en) *	2001-08-14	2003-03-03	Variant Holdings, Llc.	System for marketing goods and services utilizing computerized central and remote facilities
US20030087937A1 (en) *	2001-10-15	2003-05-08	Nils-Olof Lindberg	Nicotine and cocoa powder compositions
KR100352030B1 (en) *	2002-01-10	2002-09-11	Orion Corp	Gum composition for removing nicotine
NZ518044A (en) *	2002-04-26	2004-10-29	Phytomed Medicinal Herbs Ltd	A herbal composition and uses thereof
US20030232117A1 (en) *	2002-06-12	2003-12-18	Shaw Laurence J.	Confections that "swim" in a carbonated beverage
US7347985B2 (en) *	2002-06-25	2008-03-25	Wm. Wrigley Jr. Company	Breath freshening and oral cleansing product with magnolia bark extract
US7595065B2 (en) *	2002-06-25	2009-09-29	Wm. Wrigley Jr. Company	Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils
US7632525B2 (en) *	2002-06-25	2009-12-15	Wm. Wrigley Jr. Company	Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents
AU2003279301B2 (en) *	2002-06-25	2008-04-24	Wm. Wrigley Jr. Company	Breath freshening and oral cleansing product with Magnolia bark extract
KR20040016202A (ko) *	2002-08-16	2004-02-21	주식회사 제이알팜	쓴맛이 차폐된 히드로코르티손 경구용 약제 조성물 및 그제조방법
AU2003260091A1 (en) *	2002-08-27	2004-03-19	Wm. Wrigley Jr. Company	Breath freshening and oral cleansing product using carvacrol
DK1534252T3 (da) *	2002-08-27	2010-09-06	Wrigley W M Jun Co	Mundfriskende og oralt renseprodukt anvendende kardemommeolie
EP1545480A1 (fr) *	2002-08-27	2005-06-29	Wm. Wrigley Jr. Company	Produit rafraichisseur d'haleine et d'hygiene buccale
US7445769B2 (en) *	2002-10-31	2008-11-04	Cadbury Adams Usa Llc	Compositions for removing stains from dental surfaces and methods of making and using the same
PT1578422E (pt)	2002-12-20	2007-06-14	Niconovum Ab	Material particulado contendo nicotina fisicamente e quimicamente estável
BRPI0408099B1 (pt)	2003-03-05	2014-04-08	Byocoat Entpr Inc	Solução antimicrobiana e processo
DE10312173A1 (de) *	2003-03-19	2004-09-30	Ingo Hornung	Kaugummi mit beigemengten Mitteln
US7354569B2 (en) *	2003-07-11	2008-04-08	Colgate-Palmolive Company	Chewable antiplaque confectionery dental composition
US20050008747A1 (en) *	2003-07-11	2005-01-13	Barkalow David G.	Method of forming a sugarless coating on chewing gum
US6986907B2 (en) *	2003-07-28	2006-01-17	Wm. Wrigley Jr. Company	Chewing gum base and chewing gum compositions
US8627828B2 (en)	2003-11-07	2014-01-14	U.S. Smokeless Tobacco Company Llc	Tobacco compositions
CN104397869B (zh) *	2003-11-07	2016-06-08	美国无烟烟草有限责任公司	烟草组合物
US20060263474A1 (en) *	2005-05-23	2006-11-23	Cadbury Adams Usa Llc.	Enhanced flavor-release comestible compositions and methods for same
US8389032B2 (en) *	2005-05-23	2013-03-05	Kraft Foods Global Brands Llc	Delivery system for active components as part of an edible composition having selected particle size
US8591973B2 (en) *	2005-05-23	2013-11-26	Kraft Foods Global Brands Llc	Delivery system for active components and a material having preselected hydrophobicity as part of an edible composition
US8389031B2 (en) *	2005-05-23	2013-03-05	Kraft Foods Global Brands Llc	Coated delivery system for active components as part of an edible composition
US8597703B2 (en) *	2005-05-23	2013-12-03	Kraft Foods Global Brands Llc	Delivery system for active components as part of an edible composition including a ratio of encapsulating material and active component
US20050112236A1 (en) *	2003-11-21	2005-05-26	Navroz Boghani	Delivery system for active components as part of an edible composition having preselected tensile strength
US9271904B2 (en) *	2003-11-21	2016-03-01	Intercontinental Great Brands Llc	Controlled release oral delivery systems
US8591974B2 (en)	2003-11-21	2013-11-26	Kraft Foods Global Brands Llc	Delivery system for two or more active components as part of an edible composition
US20060263473A1 (en) *	2005-05-23	2006-11-23	Cadbury Adams Usa Llc	Compressed delivery system for active components as part of an edible composition
US8591968B2 (en)	2005-05-23	2013-11-26	Kraft Foods Global Brands Llc	Edible composition including a delivery system for active components
US8591972B2 (en) *	2005-05-23	2013-11-26	Kraft Foods Global Brands Llc	Delivery system for coated active components as part of an edible composition
WO2006000233A1 (fr) *	2004-06-29	2006-01-05	Fertin Pharma A/S	Gomme a macher contenant un alcaloide du tabac
US20090022846A1 (en) *	2004-06-30	2009-01-22	Helle Wittorff	Chewing Gum Comprising Flavor Emulsion
KR101168348B1 (ko) *	2004-07-06	2012-07-27	굼링크 에이/에스	압착된 츄잉 검 정제
US20060263476A1 (en) *	2004-08-25	2006-11-23	Cadbury Adams Usa, Llc.	Center-filled chewing gum with barrier layer
US7955630B2 (en) *	2004-09-30	2011-06-07	Kraft Foods Global Brands Llc	Thermally stable, high tensile strength encapsulated actives
US7727565B2 (en)	2004-08-25	2010-06-01	Cadbury Adams Usa Llc	Liquid-filled chewing gum composition
US20060068059A1 (en) *	2004-09-30	2006-03-30	Cadbury Adams Usa Llc	Encapsulated compositions and methods of preparation
US20060068058A1 (en) *	2004-09-30	2006-03-30	Cadbury Adams Usa Llc	Thermally stable, high tensile strength encapsulation compositions for actives
AU2004323874A1 (en) *	2004-10-08	2006-04-13	Gumlink A/S	Confectionery product
US9198448B2 (en) *	2005-02-07	2015-12-01	Intercontinental Great Brands Llc	Stable tooth whitening gum with reactive ingredients
CA2598102C (fr)	2005-03-03	2010-09-21	Wacker Polymer Systems Gmbh & Co. Kg	Uitlisation de composes de dioxyde de silicium en tant qu'auxiliaires d'ecoulement dans la fabrication de resines solides de polyvinylacetate
UY29445A1 (es) *	2005-03-30	2006-10-02	Generex Pharm Inc	Composiciones para la transmisión transmucosa oral de la metformina
US7851006B2 (en) *	2005-05-23	2010-12-14	Cadbury Adams Usa Llc	Taste potentiator compositions and beverages containing same
US7851005B2 (en) *	2005-05-23	2010-12-14	Cadbury Adams Usa Llc	Taste potentiator compositions and beverages containing same
EP1901622B1 (fr) *	2005-05-23	2014-07-16	Intercontinental Great Brands LLC	Preparations d' exhausteur de gout et boissons contenant ladite preparation
US20070178187A1 (en) *	2006-01-27	2007-08-02	Cadbury Adams Usa Llc	Chewing gum compositions including free neotame sweetener compositions
EP1996027B1 (fr) *	2006-02-20	2012-08-22	Gumlink A/S	Acide alimentaire encapsulé dans une résine
AU2007224584A1 (en)	2006-03-16	2007-09-20	Niconovum Ab	Improved snuff composition
US8642016B2 (en) *	2006-07-21	2014-02-04	Jsrnti, Llc	Medicinal delivery system, and related methods
CA2660992C (fr) *	2006-08-17	2014-10-14	Gumlink A/S	Edulcorant de grande intensite encapsule dans une resine
WO2008091588A1 (fr)	2007-01-22	2008-07-31	Targacept, Inc.	Administration intranasale, buccale ou sublinguale d'analogues de métanicotine
CA2686930A1 (fr) *	2007-05-14	2008-11-20	Cadbury Adams Usa Llc	Compositions d'exhausteur de gout dans des systemes d'administration orale
US20080300322A1 (en) *	2007-06-01	2008-12-04	Atlantic Pharmaceuticals, Inc.	Delivery vehicles containing rosin resins
US20090226549A1 (en) *	2008-03-06	2009-09-10	Kenneth John Hughes	Herbal extracts and flavor systems for oral products and methods of making the same
LT2280687T (lt)	2008-03-26	2019-08-26	Stichting Sanammad	Kramtomosios gumos kompozicijos, apimančios kanabinoidus
PL2712622T3 (pl)	2008-05-21	2017-01-31	Ferring B.V.	Ulegająca rozpadowi w ustach desmopresyna do zwiększania początkowego okresu snu niezakłócanego przez nokturię
US20100286045A1 (en)	2008-05-21	2010-11-11	Bjarke Mirner Klein	Methods comprising desmopressin
US11963995B2 (en)	2008-05-21	2024-04-23	Ferring B.V.	Methods comprising desmopressin
US8506936B2 (en) *	2008-11-25	2013-08-13	Watson Laboratories, Inc.	Stabilized nicotine chewing gum
EP2557947A1 (fr)	2010-04-14	2013-02-20	Altria Client Services Inc.	Produit de tabac sans fumée préformé
JP5856288B2 (ja)	2011-04-29	2016-02-09	インターコンチネンタルグレートブランズエルエルシー	封入酸、封入酸の調製方法、および封入酸を含むチューインガム
US10799548B2 (en)	2013-03-15	2020-10-13	Altria Client Services Llc	Modifying taste and sensory irritation of smokeless tobacco and non-tobacco products
JP2017520259A (ja)	2014-08-14	2017-07-27	インターコンチネンタルグレートブランズエルエルシー	改良されたチューインガム組成物及びその製造方法
WO2016136250A1 (fr) *	2015-02-27	2016-09-01	株式会社ロッテ	Chewing-gum
KR101976112B1 (ko) *	2017-06-30	2019-08-28	주식회사 삼양사	기능성 감미료를 포함하는 츄잉껌
US11672862B2 (en)	2019-12-09	2023-06-13	Nicoventures Trading Limited	Oral products with reduced irritation
USD1081739S1 (en)	2021-04-06	2025-07-01	Altria Client Services Llc	Die for gum forming
US12295412B2 (en)	2022-01-28	2025-05-13	Altria Client Services Llc	Oral pouch product
CN116711875A (zh) *	2023-06-15	2023-09-08	东莞市吉纯生物技术有限公司	一种防治龋齿的胶基型咀嚼物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4238475A (en) *	1979-08-01	1980-12-09	Life Savers Inc.	Chewing cum capable of releasing finely divided water-insoluble materials therefrom
US4387108A (en) *	1981-06-12	1983-06-07	Warner-Lambert Company	Non-stick chewing gum composition and method of preparation
US4379169A (en) *	1981-11-09	1983-04-05	Nabisco Brands, Inc.	New gum base and chewing gum containing same
US4518615A (en) *	1983-08-23	1985-05-21	Warner-Lambert Company	Non-adhesive chewing gum base composition
US4493849A (en) *	1983-10-21	1985-01-15	Warner-Lambert Company	Process for preparing a non-chalky, organoleptically pleasing chewing gum composition
US4597970A (en) *	1984-10-05	1986-07-01	Warner-Lambert Company	Chewing gum compositions containing novel sweetener delivery systems and method of preparation
US4675190A (en) *	1985-12-03	1987-06-23	Warner-Lambert Company	Dispensable chewing gum composition, and method of making same
US4983404A (en) *	1989-06-05	1991-01-08	Warner-Lambert Company	Controlled release flavor system and method of preparation

1989
- 1989-07-24 DK DK365389A patent/DK365389D0/da not_active Application Discontinuation
1990
- 1990-07-18 AT AT90912237T patent/ATE94059T1/de not_active IP Right Cessation
- 1990-07-18 AU AU61621/90A patent/AU637815B2/en not_active Ceased
- 1990-07-18 ES ES90912237T patent/ES2058929T3/es not_active Expired - Lifetime
- 1990-07-18 DE DE90912237T patent/DE69003244T2/de not_active Expired - Fee Related
- 1990-07-18 CA CA002063819A patent/CA2063819C/fr not_active Expired - Lifetime
- 1990-07-18 WO PCT/DK1990/000189 patent/WO1991001132A1/fr not_active Ceased
- 1990-07-18 EP EP90912237A patent/EP0486563B1/fr not_active Expired - Lifetime
- 1990-07-18 KR KR1019920700175A patent/KR0185574B1/ko not_active Expired - Fee Related
- 1990-07-18 DK DK90912237.6T patent/DK0486563T3/da active
- 1990-07-20 ZA ZA905722A patent/ZA905722B/xx unknown
- 1990-07-23 GR GR900100562A patent/GR900100562A/el not_active IP Right Cessation
- 1990-07-23 IE IE267290A patent/IE64838B1/en not_active IP Right Cessation
- 1990-07-24 PT PT94801A patent/PT94801B/pt not_active IP Right Cessation
1992
- 1992-01-23 NO NO920317A patent/NO304407B1/no not_active IP Right Cessation
- 1992-01-23 FI FI920300A patent/FI105068B/fi active
1994
- 1994-09-19 US US08/308,620 patent/US5487902A/en not_active Expired - Lifetime
1998
- 1998-08-18 NO NO983771A patent/NO309672B1/no not_active IP Right Cessation
1999
- 1999-02-09 FI FI990251A patent/FI105527B/fi active

Also Published As

Publication number	Publication date
ES2058929T3 (es)	1994-11-01
NO920317L (no)	1992-03-23
AU637815B2 (en)	1993-06-10
ATE94059T1 (de)	1993-09-15
FI105527B (fi)	2000-09-15
FI990251A0 (fi)	1999-02-09
FI990251L (fi)	1999-02-09
IE64838B1 (en)	1995-09-06
NO983771D0 (no)	1998-08-18
EP0486563A1 (fr)	1992-05-27
GR900100562A (el)	1991-12-10
KR0185574B1 (ko)	1999-03-20
DE69003244T2 (de)	1994-01-05
FI105068B (fi)	2000-06-15
DK0486563T3 (da)	1993-11-29
NO920317D0 (no)	1992-01-23
PT94801B (pt)	1997-03-31
NO309672B1 (no)	2001-03-12
DK365389D0 (da)	1989-07-24
CA2063819C (fr)	2000-02-22
CA2063819A1 (fr)	1991-01-25
WO1991001132A1 (fr)	1991-02-07
US5487902A (en)	1996-01-30
AU6162190A (en)	1991-02-22
EP0486563B1 (fr)	1993-09-08
PT94801A (pt)	1991-03-20
NO983771L (no)	1998-08-18
FI920300A0 (fi)	1992-01-23
DE69003244D1 (de)	1993-10-14
IE902672A1 (en)	1991-02-27
ZA905722B (en)	1991-04-24

Legal Events

Date	Code	Title	Description
2010-08-16	MK1K	Patent expired

Publication	Publication Date	Title
NO304407B1 (no)	1998-12-14	Tyggegummiblanding med akselerert, kontrollert frigivelse av aktive midler
JP5437574B2 (ja)	2014-03-12	タバコアルカロイド放出チューインガム
AU2019269881B2 (en)	2022-08-04	Disintegrating oral tablet suitable for active pharmaceutical ingredients
US6090401A (en)	2000-07-18	Stable foam composition
EP3793518B1 (fr)	2025-03-26	Comprimé pour administration orale pour masquer le goût de principes actifs, comprenant des particules d'alcool de sucre compressibles
EP3793534B1 (fr)	2023-04-05	Comprimé oral pour l'administration d'ingrédients actifs au tractus gastro-intestinal
EP3793533B1 (fr)	2023-07-05	Forme posologique de comprimé pour l'absorption buccale d'ingrédients actifs
EP3793532A1 (fr)	2021-03-24	Comprimé oral approprié pour une libération rapide d'ingrédients pharmaceutiques actifs
US20090087486A1 (en)	2009-04-02	Foam Wafer Containing a Polyvinyl Alcohol-Polyethyleneglycol-Graft Copolymer
CN113710235B (zh)	2024-03-29	经口大麻素片剂
EP1311240A1 (fr)	2003-05-21	Procede de preparation d'une gomme a macher ayant un gout agreable pour le consommateur
WO2000025598A1 (fr)	2000-05-11	Esters d'acide gras de saccharose prevus pour augmenter la liberation d'ingredients actifs
EP3793520B1 (fr)	2025-04-30	Comprimé oral pour l'administration d'ingrédients actifs à la gorge comprenant des particules d'alcool de sucre non directement compressibles