FI108113B - Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi - Google Patents

Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi Download PDF

Info

Publication number: FI108113B
Authority: FI; Finland
Prior art keywords: ahpba; boc; same manner; give; title compound
Prior art date: 1990-12-11

Application number

FI915819A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI915819A0 (fi

FI915819L (fi

Inventor

Yoshiaki Kiso

Tsutomu Mimoto

Naoko Hattori

Makoto Shintani

Yuuichi Nagano

Original Assignee

Japan Energy Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-11

Filing date

1991-12-11

Publication date

2001-11-30

1991-12-11 Application filed by Japan Energy Corp filed Critical Japan Energy Corp

1991-12-11 Publication of FI915819A0 publication Critical patent/FI915819A0/fi

1992-06-12 Publication of FI915819L publication Critical patent/FI915819L/fi

2001-11-30 Application granted granted Critical

2001-11-30 Publication of FI108113B publication Critical patent/FI108113B/fi

Links

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HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical group CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
239000003826 tablet Substances 0.000 description 1
125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
CVQYDTMTWJMFIX-JTQLQIEISA-N tert-butyl (2s)-2-(tert-butylcarbamoyl)pyrrolidine-1-carboxylate Chemical compound CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C CVQYDTMTWJMFIX-JTQLQIEISA-N 0.000 description 1
JMAXTWCTIHZZLL-ZJUUUORDSA-N tert-butyl (2s,4r)-2-(tert-butylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate Chemical compound CC(C)(C)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C JMAXTWCTIHZZLL-ZJUUUORDSA-N 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
BOUJRTUVSGNZPU-UHFFFAOYSA-N tert-butyl n-(1-amino-1-oxobutan-2-yl)carbamate Chemical compound CCC(C(N)=O)NC(=O)OC(C)(C)C BOUJRTUVSGNZPU-UHFFFAOYSA-N 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
ORQXBVXKBGUSBA-QMMMGPOBSA-N β-cyclohexyl-alanine Chemical compound OC(=O)[C@@H](N)CC1CCCCC1 ORQXBVXKBGUSBA-QMMMGPOBSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Crystallography & Structural Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Quinoline Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

FI915819A 1990-12-11 1991-12-11 Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi FI108113B (fi)

Applications Claiming Priority (10)

Application Number	Priority Date	Filing Date	Title
JP40967390		1990-12-11
JP40967390		1990-12-11
JP2575591		1991-01-25
JP2575591		1991-01-25
JP8997691		1991-03-28
JP8997691		1991-03-28
JP16917491		1991-06-14
JP16917491		1991-06-14
JP30404391		1991-10-23
JP30404391		1991-10-23

Publications (3)

Publication Number	Publication Date
FI915819A0 FI915819A0 (fi)	1991-12-11
FI915819L FI915819L (fi)	1992-06-12
FI108113B true FI108113B (fi)	2001-11-30

Family

ID=27520768

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI915819A FI108113B (fi)	1990-12-11	1991-12-11	Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi

Country Status (10)

Country	Link
EP (1)	EP0490667B1 (fr)
JP (1)	JP2700511B2 (fr)
AT (1)	ATE181080T1 (fr)
AU (1)	AU653972B2 (fr)
CA (1)	CA2056911C (fr)
DE (1)	DE69131317T2 (fr)
DK (1)	DK0490667T3 (fr)
ES (1)	ES2134764T3 (fr)
FI (1)	FI108113B (fr)
GR (1)	GR3031004T3 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5976541A (en) *	1988-01-26	1999-11-02	The United States Of America As Represented By The Department Of Health And Human Services	Potent peptide for stimulation of cytotoxic T lymphocytes specific for the HIV-1 envelope
JP2500034B2 (ja) *	1991-02-08	1996-05-29	三共株式会社	β−アミノ−α−ヒドロキシカルボン酸誘導体
US5888992A (en) *	1992-03-11	1999-03-30	Narhex Limited	Polar substituted hydrocarbons
JPH07504654A (ja) *	1992-03-11	1995-05-25	ナルヘックス　リミテッド	オキソ及びヒドロキシ置換炭化水素のアミン誘導体
US6071895A (en) *	1992-03-11	2000-06-06	Narhex Limited	Polar-substituted hydrocarbons
MXPA93002392A (es)	1992-03-11	2005-02-04	Narhex Ltd	Derivados amino de hidrocarburos-oxo e hidroxi-substituidos.
US5644028A (en) *	1992-05-13	1997-07-01	Japan Energy Corporation	Process for producing peptide derivatives and salts therefor
US5559256A (en) *	1992-07-20	1996-09-24	E. R. Squibb & Sons, Inc.	Aminediol protease inhibitors
NZ248332A (en) *	1992-08-07	1995-01-27	Sankyo Co	Hiv protease inhibitor and its use
US5484926A (en) *	1993-10-07	1996-01-16	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
US5846993A (en) *	1992-12-22	1998-12-08	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
IL110898A0 (en) *	1993-09-10	1994-11-28	Narhex Australia Pty Ltd	Polar-substituted hydrocarbons
IL110752A (en) *	1993-09-13	2000-07-26	Abbott Lab	Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
US5559158A (en) *	1993-10-01	1996-09-24	Abbott Laboratories	Pharmaceutical composition
US5527829A (en) *	1994-05-23	1996-06-18	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
EP0706794B1 (fr) *	1994-10-14	2001-12-12	Japan Energy Corporation	Composition pharmaceutique anti-SIDA et procédé de préparation
AU4188096A (en) *	1994-12-14	1996-07-03	Sankyo Company Limited	Ahpba-containing tripeptide derivative
US6008228A (en) *	1995-06-06	1999-12-28	Hoffman-La Roche Inc.	Pharmaceutical compositions containing proteinase inhibitors
US6222043B1 (en)	1995-06-30	2001-04-24	Japan Energy Corporation	Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof
CA2179935C (fr) *	1995-06-30	2010-09-07	Ryohei Kato	Compose dipeptidique ou sel de ce dernier acceptable en pharmacie; utilisation en medecine
US5914332A (en)	1995-12-13	1999-06-22	Abbott Laboratories	Retroviral protease inhibiting compounds
US5925759A (en)	1996-09-05	1999-07-20	Agouron Pharmaceuticals, Inc.	Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
US5962725A (en)	1996-09-05	1999-10-05	Agouron Pharmaceuticals, Inc.	Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir
US5705647A (en) *	1996-09-05	1998-01-06	Agouron Pharmaceuticals, Inc.	Intermediates for making HIV-protease inhibitors
US6174905B1 (en)	1996-09-30	2001-01-16	Mitsui Chemicals, Inc.	Cell differentiation inducer
US6794392B1 (en)	1996-09-30	2004-09-21	Schering Aktiengesellschaft	Cell differentiation inducer
US6232333B1 (en)	1996-11-21	2001-05-15	Abbott Laboratories	Pharmaceutical composition
EP0900566A4 (fr) *	1996-12-27	2001-04-25	Japan Energy Corp	Nouveaux composes de tripeptides et medicaments anti-sida
US6001851A (en) *	1997-03-13	1999-12-14	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
US6084107A (en) *	1997-09-05	2000-07-04	Agouron Pharmaceuticals, Inc.	Intermediates for making HIV-protease inhibitors
TR201809435T4 (tr)	2000-01-19	2018-07-23	Abbvie Inc	Geliştirilmiş farmasötik formülasyonlar.
SE0000382D0 (sv)	2000-02-07	2000-02-07	Astrazeneca Ab	New process
US7169932B2 (en)	2001-06-11	2007-01-30	Pfizer Inc.	HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis
HN2002000136A (es) *	2001-06-11	2003-07-31	Basf Ag	Inhibidores de la proteasa del virus hiv, compuestos que contienen a los mismos, sus usos farmaceuticos y los materiales para su sintesis
US7094909B2 (en)	2001-06-11	2006-08-22	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
EP1463807A4 (fr)	2001-12-19	2006-04-12	Bristol Myers Squibb Co	Pichia pastoris formate deshydrogenase et ses utilisations
EP1604656A1 (fr)	2004-06-09	2005-12-14	Schwarz Pharma Ag	Utilisation nouvelle de peptides pour le traitement de la sclérose amytrophique latérale (ALS)
JP5260062B2 (ja)	2006-01-20	2013-08-14	株式会社カネカ	β−アミノ−α−ヒドロキシ酸アミド誘導体の製造法

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Publication number	Priority date	Publication date	Assignee	Title
US4656269A (en) *	1986-04-15	1987-04-07	Kissei Pharmaceutical Co., Ltd.	Histidine derivatives
GB8711747D0 (en) *	1986-06-05	1987-06-24	Ici America Inc	Difluoro peptide compounds
JPS6322081A (ja) *	1986-07-11	1988-01-29	Kissei Pharmaceut Co Ltd	新規なアミノ酸誘導体

1991
- 1991-12-04 CA CA002056911A patent/CA2056911C/fr not_active Expired - Fee Related
- 1991-12-05 JP JP3348705A patent/JP2700511B2/ja not_active Expired - Fee Related
- 1991-12-06 AU AU88900/91A patent/AU653972B2/en not_active Ceased
- 1991-12-11 FI FI915819A patent/FI108113B/fi active
- 1991-12-11 DK DK91311549T patent/DK0490667T3/da active
- 1991-12-11 AT AT91311549T patent/ATE181080T1/de not_active IP Right Cessation
- 1991-12-11 EP EP91311549A patent/EP0490667B1/fr not_active Expired - Lifetime
- 1991-12-11 ES ES91311549T patent/ES2134764T3/es not_active Expired - Lifetime
- 1991-12-11 DE DE69131317T patent/DE69131317T2/de not_active Expired - Fee Related
1999
- 1999-08-18 GR GR990402082T patent/GR3031004T3/el unknown

Also Published As

Publication number	Publication date
DE69131317D1 (de)	1999-07-15
EP0490667A3 (en)	1993-05-05
DK0490667T3 (da)	1999-12-13
GR3031004T3 (en)	1999-12-31
ES2134764T3 (es)	1999-10-16
JP2700511B2 (ja)	1998-01-21
EP0490667B1 (fr)	1999-06-09
FI915819A0 (fi)	1991-12-11
JPH05170722A (ja)	1993-07-09
EP0490667A2 (fr)	1992-06-17
FI915819L (fi)	1992-06-12
DE69131317T2 (de)	2000-01-13
AU653972B2 (en)	1994-10-20
ATE181080T1 (de)	1999-06-15
CA2056911A1 (fr)	1992-06-12
CA2056911C (fr)	1998-09-22
AU8890091A (en)	1992-06-18

Legal Events

Date	Code	Title	Description
1994-03-01	HC	Name/ company changed in application	Owner name: JAPAN ENERGY CORPORATION

Publication	Publication Date	Title
FI108113B (fi)	2001-11-30	Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi
US5114918A (en)	1992-05-19	Endothelin antagonistic cyclic pentapeptides
EP0007477B1 (fr)	1982-04-28	Dérivés d'acides aminés substitués par 1-(3-mercapto-2-méthyl-propanoyl)prolyle et leurs sels, procédés pour les préparer et compositions pharmaceutiques les contenant
US4692458A (en)	1987-09-08	Anti-hypertensive agents
US6858577B1 (en)	2005-02-22	Indole peptidomimetics as thrombin receptor antagonists
AU606312B2 (en)	1991-02-07	Peptide derivatives which inhibit renin and acid proteases
IE873383L (en)	1988-06-15	Phosphinic acid derivatives
IE902815A1 (en)	1991-02-27	Renin inhibitors, processes for their preparation and their¹use in medicaments
AU709330B2 (en)	1999-08-26	Serine protease inhibitors
EP0331921A1 (fr)	1989-09-13	Inhibiteurs de la rénine, contenant des alpha-hétéroatome-acides aminés
US4745124A (en)	1988-05-17	Orally effective anti-hypertensive agents
EP0362002A1 (fr)	1990-04-04	Inhibiteurs de protease HIV
EP0358660B1 (fr)	1994-05-25	Inhibiteurs synthetiques de collagenase mammifere
US6313094B1 (en)	2001-11-06	β-amino-α-hydroxycarboxylic acid derivatives and HIV protease inhibitors
EP0948523B1 (fr)	2004-03-17	Inhibiteurs peptidomimetiques de protease du cytomegalovirus humain
FI95272B (fi)	1995-09-29	Menetelmä terapeuttisesti käyttökelpoisen sykloheksyylidifluoroepeptidin valmistamiseksi
CN1137134C (zh)	2004-02-04	多氟烷基色氨酸三肽凝血酶抑制剂
Almquist et al.	1988	Synthesis and biological activity of ketomethylene-containing nonapeptide analogs of snake venom angiotensin converting enzyme inhibitors
HU185230B (en)	1984-12-28	Process for producing pharmacologically active encephaline analogous peptides
US4734420A (en)	1988-03-29	Anti-hypertensive agents
EP0036713A2 (fr)	1981-09-30	Inhibiteurs d'enzymes transformant de l'angiotensine
US4690936A (en)	1987-09-01	Anti-hypertensive agents
WO1997020856A1 (fr)	1997-06-12	DERIVES ENOL ACYLES DE α-CETOESTERS ET DE α-CETOAMIDES
EP0190597A2 (fr)	1986-08-13	Analogues rétro-inverso du peptide BPP5a renforçant la bradykinine
HK1015797B (en)	2004-10-29	Polydluoroalkyltryptophan tripeptide thrombin inhibitors