FI110609B - Menetelmä kasvuhormonikiteiden valmistamiseksi - Google Patents

Menetelmä kasvuhormonikiteiden valmistamiseksi Download PDF

Info

Publication number: FI110609B
Authority: FI; Finland
Prior art keywords: crystals; growth hormone; hgh; buffer; phenyl
Prior art date: 1992-10-28

Application number

FI952021A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI952021L (fi

FI952021A0 (fi

Inventor

Ronny Lundin

Ebba Florin-Robertsson

Sirkka Thome

Tomas Lundqvist

Elvy Hoekby

Gertrud Westin-Sjoedahl

Original Assignee

Pharmacia Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-28

Filing date

1995-04-27

Publication date

2003-02-28

1992-10-28 Priority claimed from SE9203175A external-priority patent/SE9203175D0/xx

1995-04-27 Application filed by Pharmacia Ab filed Critical Pharmacia Ab

1995-04-27 Publication of FI952021L publication Critical patent/FI952021L/fi

1995-04-27 Publication of FI952021A0 publication Critical patent/FI952021A0/fi

2003-02-28 Application granted granted Critical

2003-02-28 Publication of FI110609B publication Critical patent/FI110609B/fi

Links

239000013078 crystal Substances 0.000 title claims abstract description 94
102000018997 Growth Hormone Human genes 0.000 title claims abstract description 59
108010051696 Growth Hormone Proteins 0.000 title claims abstract description 59
239000000122 growth hormone Substances 0.000 title claims abstract description 59
238000000034 method Methods 0.000 title claims abstract description 32
238000002360 preparation method Methods 0.000 title description 12
239000000872 buffer Substances 0.000 claims abstract description 18
150000001875 compounds Chemical class 0.000 claims abstract description 11
125000001624 naphthyl group Chemical class 0.000 claims abstract description 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 6
125000000217 alkyl group Chemical group 0.000 claims abstract description 5
239000007864 aqueous solution Substances 0.000 claims abstract description 4
238000002156 mixing Methods 0.000 claims abstract description 3
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 36
235000019445 benzyl alcohol Nutrition 0.000 claims description 12
XPNGNIFUDRPBFJ-UHFFFAOYSA-N (2-methylphenyl)methanol Chemical compound CC1=CC=CC=C1CO XPNGNIFUDRPBFJ-UHFFFAOYSA-N 0.000 claims description 6
WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 claims description 6
VAJVDSVGBWFCLW-UHFFFAOYSA-N 3-Phenyl-1-propanol Chemical compound OCCCC1=CC=CC=C1 VAJVDSVGBWFCLW-UHFFFAOYSA-N 0.000 claims description 6
CDRQOYRPWJULJN-UHFFFAOYSA-N 1-naphthalen-1-ylethanol Chemical compound C1=CC=C2C(C(O)C)=CC=CC2=C1 CDRQOYRPWJULJN-UHFFFAOYSA-N 0.000 claims description 3
BDERNNFJNOPAEC-UHFFFAOYSA-N 1-propanol Substances CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 3
BDCFWIDZNLCTMF-UHFFFAOYSA-N 2-phenylpropan-2-ol Chemical compound CC(C)(O)C1=CC=CC=C1 BDCFWIDZNLCTMF-UHFFFAOYSA-N 0.000 claims description 3
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 2
101001075374 Homo sapiens Gamma-glutamyl hydrolase Proteins 0.000 claims 2
101000664737 Homo sapiens Somatotropin Proteins 0.000 claims 2
238000004519 manufacturing process Methods 0.000 abstract description 3
108010000521 Human Growth Hormone Proteins 0.000 description 38
102000002265 Human Growth Hormone Human genes 0.000 description 38
239000000854 Human Growth Hormone Substances 0.000 description 38
239000000203 mixture Substances 0.000 description 23
239000000243 solution Substances 0.000 description 17
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RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
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DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
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XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
239000008186 active pharmaceutical agent Substances 0.000 description 2
HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 2
230000004071 biological effect Effects 0.000 description 2
229960002685 biotin Drugs 0.000 description 2
239000011616 biotin Substances 0.000 description 2
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125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 2
238000000386 microscopy Methods 0.000 description 2
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
SQYNKIJPMDEDEG-UHFFFAOYSA-N paraldehyde Chemical compound CC1OC(C)OC(C)O1 SQYNKIJPMDEDEG-UHFFFAOYSA-N 0.000 description 2
229960003868 paraldehyde Drugs 0.000 description 2
239000012071 phase Substances 0.000 description 2
230000001817 pituitary effect Effects 0.000 description 2
210000003635 pituitary gland Anatomy 0.000 description 2
239000001509 sodium citrate Substances 0.000 description 2
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
239000002904 solvent Substances 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
238000005406 washing Methods 0.000 description 2
230000004584 weight gain Effects 0.000 description 2
235000019786 weight gain Nutrition 0.000 description 2
229910052725 zinc Inorganic materials 0.000 description 2
239000011701 zinc Substances 0.000 description 2
HQRWWHIETAKIMO-JTQLQIEISA-N (1s)-1-phenylbutan-1-ol Chemical compound CCC[C@H](O)C1=CC=CC=C1 HQRWWHIETAKIMO-JTQLQIEISA-N 0.000 description 1
BWRBVBFLFQKBPT-UHFFFAOYSA-N (2-nitrophenyl)methanol Chemical compound OCC1=CC=CC=C1[N+]([O-])=O BWRBVBFLFQKBPT-UHFFFAOYSA-N 0.000 description 1
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101100335894 Caenorhabditis elegans gly-8 gene Proteins 0.000 description 1
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101100285000 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) his-3 gene Proteins 0.000 description 1
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241000283973 Oryctolagus cuniculus Species 0.000 description 1
102000006877 Pituitary Hormones Human genes 0.000 description 1
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229920001213 Polysorbate 20 Polymers 0.000 description 1
229920005654 Sephadex Polymers 0.000 description 1
239000012507 Sephadex™ Substances 0.000 description 1
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
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101150006914 TRP1 gene Proteins 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
LVTKHGUGBGNBPL-UHFFFAOYSA-N Trp-P-1 Chemical compound N1C2=CC=CC=C2C2=C1C(C)=C(N)N=C2C LVTKHGUGBGNBPL-UHFFFAOYSA-N 0.000 description 1
208000026928 Turner syndrome Diseases 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
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239000000427 antigen Substances 0.000 description 1
102000036639 antigens Human genes 0.000 description 1
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238000013459 approach Methods 0.000 description 1
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125000003118 aryl group Chemical group 0.000 description 1
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235000020958 biotin Nutrition 0.000 description 1
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229940075397 calomel Drugs 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
235000013339 cereals Nutrition 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
150000001860 citric acid derivatives Chemical class 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000001514 detection method Methods 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 1
238000006471 dimerization reaction Methods 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
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238000001641 gel filtration chromatography Methods 0.000 description 1
239000005556 hormone Substances 0.000 description 1
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239000000960 hypophysis hormone Substances 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
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229910052500 inorganic mineral Inorganic materials 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
239000012931 lyophilized formulation Substances 0.000 description 1
239000011707 mineral Substances 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
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210000002826 placenta Anatomy 0.000 description 1
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239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
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239000012286 potassium permanganate Substances 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
238000000197 pyrolysis Methods 0.000 description 1
239000012925 reference material Substances 0.000 description 1
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LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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238000011179 visual inspection Methods 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

FI952021A 1992-10-28 1995-04-27 Menetelmä kasvuhormonikiteiden valmistamiseksi FI110609B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
SE9203175A SE9203175D0 (sv)	1992-10-28	1992-10-28	Growth hormone
SE9203175		1992-10-28
SE9302278		1993-07-02
SE19939302278A SE9302278D0 (sv)	1992-10-28	1993-07-02	Growth hormone
SE9300885		1993-10-27
PCT/SE1993/000885 WO1994010192A1 (en)	1992-10-28	1993-10-27	Process for manufacturing crystals of growth hormone and crystals thereby obtained

Publications (3)

Publication Number	Publication Date
FI952021L FI952021L (fi)	1995-04-27
FI952021A0 FI952021A0 (fi)	1995-04-27
FI110609B true FI110609B (fi)	2003-02-28

Family

ID=26661557

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI952021A FI110609B (fi)	1992-10-28	1995-04-27	Menetelmä kasvuhormonikiteiden valmistamiseksi

Country Status (13)

Country	Link
US (1)	US5734026A (da)
EP (1)	EP0669934B1 (da)
JP (1)	JP3470135B2 (da)
AT (1)	ATE174602T1 (da)
AU (1)	AU679012B2 (da)
CA (1)	CA2147482C (da)
DE (1)	DE69322654T2 (da)
DK (1)	DK0669934T3 (da)
ES (1)	ES2126660T3 (da)
FI (1)	FI110609B (da)
NO (1)	NO320171B1 (da)
SE (1)	SE9302278D0 (da)
WO (1)	WO1994010192A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9302278D0 (sv) *	1992-10-28	1993-07-02	Kabi Pharmacia Ab	Growth hormone
US6500933B1 (en)	1997-09-05	2002-12-31	Altus Biologics Inc.	Methods of preparing carbohydrate crosslinked glycoprotein crystals
WO1999012959A1 (en)	1997-09-05	1999-03-18	Altus Biologics Inc.	Carbohydrate crosslinked glycoprotein crystals
US6380357B2 (en) *	1997-12-16	2002-04-30	Eli Lilly And Company	Glucagon-like peptide-1 crystals
US6541606B2 (en) *	1997-12-31	2003-04-01	Altus Biologics Inc.	Stabilized protein crystals formulations containing them and methods of making them
CN1332711C (zh) *	2002-02-20	2007-08-22	埃米球科技有限公司	施用glp－1分子的方法
SE0202719D0 (sv) *	2002-09-13	2002-09-13	Pharmacia Ab	Process for mfg crystals of growth hormone
CA2512052C (en)	2002-12-31	2016-06-21	Altus Pharmaceuticals Inc.	Human growth hormone crystals and methods for preparing them
US20060286129A1 (en) *	2003-12-19	2006-12-21	Emisphere Technologies, Inc.	Oral GLP-1 formulations
US7444197B2 (en)	2004-05-06	2008-10-28	Smp Logic Systems Llc	Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes
US7799273B2 (en)	2004-05-06	2010-09-21	Smp Logic Systems Llc	Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes
WO2007076131A2 (en) *	2005-12-23	2007-07-05	Altus Pharmaceuticals Inc.	Compositions comprising polycation-complexed protein crystals and methods of treatment using them

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUT63185A (en) *	1990-06-04	1993-07-28	Schering Corp	Process for producing crystalline alpha-2-interferon
HU209313B (en) *	1990-06-15	1994-04-28	Schering Corp	Process for producing crystalline interleukin-4 and pharmaceutical compositions comprising same
DK168790D0 (da) *	1990-07-13	1990-07-13	Novo Nordisk As
US5015627A (en) *	1990-07-20	1991-05-14	Smithkline Beecham Corporation	Stabilized somatotropin for parenteral administration
SE9302278D0 (sv) *	1992-10-28	1993-07-02	Kabi Pharmacia Ab	Growth hormone

1993
- 1993-07-02 SE SE19939302278A patent/SE9302278D0/xx unknown
- 1993-10-27 AT AT93924266T patent/ATE174602T1/de not_active IP Right Cessation
- 1993-10-27 JP JP51096494A patent/JP3470135B2/ja not_active Expired - Fee Related
- 1993-10-27 WO PCT/SE1993/000885 patent/WO1994010192A1/en not_active Ceased
- 1993-10-27 EP EP93924266A patent/EP0669934B1/en not_active Expired - Lifetime
- 1993-10-27 DE DE69322654T patent/DE69322654T2/de not_active Expired - Fee Related
- 1993-10-27 CA CA002147482A patent/CA2147482C/en not_active Expired - Fee Related
- 1993-10-27 AU AU54011/94A patent/AU679012B2/en not_active Ceased
- 1993-10-27 DK DK93924266T patent/DK0669934T3/da active
- 1993-10-27 ES ES93924266T patent/ES2126660T3/es not_active Expired - Lifetime
- 1993-10-27 US US08/424,450 patent/US5734026A/en not_active Expired - Fee Related
1995
- 1995-04-24 NO NO19951547A patent/NO320171B1/no unknown
- 1995-04-27 FI FI952021A patent/FI110609B/fi active

Also Published As

Publication number	Publication date
FI952021L (fi)	1995-04-27
DE69322654D1 (de)	1999-01-28
HK1013299A1 (en)	1999-08-20
US5734026A (en)	1998-03-31
NO320171B1 (no)	2005-11-07
SE9302278D0 (sv)	1993-07-02
NO951547D0 (no)	1995-04-24
EP0669934B1 (en)	1998-12-16
WO1994010192A1 (en)	1994-05-11
JPH08505127A (ja)	1996-06-04
CA2147482C (en)	2003-09-23
AU5401194A (en)	1994-05-24
AU679012B2 (en)	1997-06-19
ATE174602T1 (de)	1999-01-15
FI952021A0 (fi)	1995-04-27
ES2126660T3 (es)	1999-04-01
JP3470135B2 (ja)	2003-11-25
DE69322654T2 (de)	1999-06-17
DK0669934T3 (da)	1999-08-23
EP0669934A1 (en)	1995-09-06
NO951547L (no)	1995-04-24
CA2147482A1 (en)	1994-05-11

Publication	Publication Date	Title
Lowry et al.	1973	Properties of a simplified bioassay for adrenocorticotrophic activity using the steroidogenic response of isolated adrenal cells
EP0367590B1 (en)	1995-03-08	Augmenting fetal hemoglobin by treatment with activin and/or inhibin
US5216004A (en)	1993-06-01	Method for preventing malaria
JP4482267B2 (ja)	2010-06-16	接合安定化されたポリペプチド組成物
US5919757A (en)	1999-07-06	Aqueous pharmaceutical preparations of G-CSF with a long shelf life
FI66751B (fi)	1984-08-31	Foerfarande foer framstaellning av ett stabilt insulinpreparatmed laongtidsverkan
EP0548276A1 (en)	1993-06-30	Method for increasing red blood cell production by treatment with activin or activin-related peptides
EP0669934B1 (en)	1998-12-16	Process for manufacturing crystals of growth hormone and crystals thereby obtained
AU638474B2 (en)	1993-07-01	Surfactant compositions and methods
KR20010041152A (ko)	2001-05-15	리포솜성 에리트로포이에틴 분산액
WO2024009205A1 (en)	2024-01-11	STABLE LIQUID FORMULATION OF AN ANTI-Α4ß7 ANTIBODY
US5898030A (en)	1999-04-27	hGH containing pharmaceutical compositions
CZ20031401A3 (cs)	2003-10-15	Repinotanová souprava
KR20040018458A (ko)	2004-03-03	Ｃｅｔｕｘｉｍａｂ 및 폴리옥시에틸렌 소르비탄 지방산에스테르를 포함하는 액형 제제
CA3234358A1 (en)	2023-05-04	Stable lyophilized formulation of an anti-.alpha.4.beta.7 antibody
CA2063273C (en)	2002-09-24	Surfactant compositions and methods
WO1996033216A1 (en)	1996-10-24	Truncated igf-i
CA1289071C (en)	1991-09-17	Pharmaceutical compositions for parenteral use containing a calcitonin as the active ingredient
KR100548107B1 (ko)	2006-02-02	뼈 유도 인자 인간 ｍｐ52 동결 건조 조성물
Oudejans et al.	1990	In vitro biosynthesis of locust adipokinetic hormones: isolation and identification of the bioactive peptides and their prohormones
HK1013299B (en)	2001-02-09	Process for manufacturing crystals of growth hormone and crystals thereby obtained
EP0397409B1 (en)	1993-07-21	The stabilization of organic compounds
JPH0249734A (ja)	1990-02-20	新規組成物