FI112486B - Pyrroloisokinoliini- ja bensodipyrrolidionioksiimijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö - Google Patents

Pyrroloisokinoliini- ja bensodipyrrolidionioksiimijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö Download PDF

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Publication number: FI112486B
Authority: FI; Finland
Prior art keywords: phenyl; methyl; tetrahydro; dione; pyrrolo
Prior art date: 1994-09-14

Application number

FI970785A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI970785A7 (fi

FI970785A0 (fi

Inventor

Frank Waetjen

Peter Moldt

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-14

Filing date

1997-02-25

Publication date

2003-12-15

1997-02-25 Application filed by Neurosearch As filed Critical Neurosearch As

1997-02-25 Publication of FI970785A0 publication Critical patent/FI970785A0/fi

1997-03-13 Publication of FI970785A7 publication Critical patent/FI970785A7/fi

2003-12-15 Application granted granted Critical

2003-12-15 Publication of FI112486B publication Critical patent/FI112486B/fi

Links

238000002360 preparation method Methods 0.000 title claims description 17
238000000034 method Methods 0.000 title claims description 16
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150000001875 compounds Chemical class 0.000 claims abstract description 63
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JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

FI970785A 1994-09-14 1997-02-25 Pyrroloisokinoliini- ja bensodipyrrolidionioksiimijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö FI112486B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DK105494		1994-09-14
DK105494		1994-09-14
EP9503594		1995-09-12
PCT/EP1995/003594 WO1996008495A1 (en)	1994-09-14	1995-09-12	Fused indole and quinoxaline derivatives, their preparation and use

Publications (3)

Publication Number	Publication Date
FI970785A0 FI970785A0 (fi)	1997-02-25
FI970785A7 FI970785A7 (fi)	1997-03-13
FI112486B true FI112486B (fi)	2003-12-15

Family

ID=8100467

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI970785A FI112486B (fi)	1994-09-14	1997-02-25	Pyrroloisokinoliini- ja bensodipyrrolidionioksiimijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö

Country Status (12)

Country	Link
US (1)	US5801174A (de)
EP (1)	EP0781285B1 (de)
JP (1)	JP3164372B2 (de)
AT (1)	ATE188701T1 (de)
AU (1)	AU686888B2 (de)
CA (1)	CA2199614C (de)
DE (1)	DE69514533T2 (de)
EE (1)	EE03772B1 (de)
FI (1)	FI112486B (de)
NO (1)	NO308851B1 (de)
NZ (1)	NZ293266A (de)
WO (1)	WO1996008495A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA54403C2 (uk)	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2781482B1 (fr) *	1998-07-27	2001-08-31	Adir	Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK1183025T3 (da)	1999-05-19	2009-05-04	Painceptor Pharma Corp	Hæmmere af proton-styrede kationskanaler og deres anvendelse til behandling af iskæmiske lidelser
EP1255734B1 (de) *	2000-01-24	2006-06-21	NeuroSearch A/S	Isatinderivate mit neurotropen aktivität
WO2007059608A1 (en)	2005-11-23	2007-05-31	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
US7825122B2 (en)	2005-12-14	2010-11-02	Amgen Inc.	Diaza heterocyclic sulfonamide derivatives and their uses
CA2652307A1 (en) *	2006-04-10	2007-10-18	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
US20090246134A1 (en) *	2007-05-30	2009-10-01	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
CA2868238A1 (en)	2012-04-18	2013-10-24	Ramot At Tel Aviv University Ltd.	Lipidated glycosaminoglycan particles for the delivery of nucleic acids
WO2016114655A1 (en) *	2015-01-12	2016-07-21	Ry Pharma B.V.	Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation
WO2017065602A1 (en) *	2015-10-13	2017-04-20	Ry Pharma B.V.	Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX9204914A (es) *	1991-08-28	1993-07-01	Frank Watjen	Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
ATE157977T1 (de) *	1992-10-13	1997-09-15	Warner Lambert Co	Chinoxalinderivate als eaa antagonisten

1995
- 1995-09-12 EE EE9700051A patent/EE03772B1/xx not_active IP Right Cessation
- 1995-09-12 AT AT95932730T patent/ATE188701T1/de not_active IP Right Cessation
- 1995-09-12 AU AU35665/95A patent/AU686888B2/en not_active Ceased
- 1995-09-12 JP JP50990896A patent/JP3164372B2/ja not_active Expired - Fee Related
- 1995-09-12 DE DE69514533T patent/DE69514533T2/de not_active Expired - Lifetime
- 1995-09-12 NZ NZ293266A patent/NZ293266A/en unknown
- 1995-09-12 US US08/809,086 patent/US5801174A/en not_active Expired - Lifetime
- 1995-09-12 CA CA002199614A patent/CA2199614C/en not_active Expired - Fee Related
- 1995-09-12 WO PCT/EP1995/003594 patent/WO1996008495A1/en not_active Ceased
- 1995-09-12 EP EP95932730A patent/EP0781285B1/de not_active Expired - Lifetime
1997
- 1997-02-25 FI FI970785A patent/FI112486B/fi active
- 1997-02-27 NO NO970903A patent/NO308851B1/no unknown

Also Published As

Publication number	Publication date
NZ293266A (en)	1998-01-26
EE03772B1 (et)	2002-06-17
ATE188701T1 (de)	2000-01-15
EP0781285A1 (de)	1997-07-02
NO970903D0 (no)	1997-02-27
US5801174A (en)	1998-09-01
EE9700051A (et)	1997-08-15
DE69514533T2 (de)	2000-07-06
NO970903L (no)	1997-05-07
CA2199614A1 (en)	1996-03-21
JPH09511525A (ja)	1997-11-18
AU3566595A (en)	1996-03-29
FI970785A7 (fi)	1997-03-13
DE69514533D1 (de)	2000-02-17
JP3164372B2 (ja)	2001-05-08
FI970785A0 (fi)	1997-02-25
EP0781285B1 (de)	2000-01-12
CA2199614C (en)	2000-02-22
AU686888B2 (en)	1998-02-12
NO308851B1 (no)	2000-11-06
WO1996008495A1 (en)	1996-03-21

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EP0781284B1 (de)	2000-01-12	Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung
US6239128B1 (en)	2001-05-29	Indole-2,3-dione-3-oxime derivatives for therapeutic use
US7282511B2 (en)	2007-10-16	Isatine derivatives with neurotrophic activity
ES2371928T3 (es)	2012-01-11	Nuevos aza-heterociclos que actúan como inhibidores de la quinasa.
MXPA98004365A (en)	1999-01-11	Novel indole-2,3-dione-3-oxime derivatives