FI112866B - Menetelmä uusien, terapeuttisesti käyttökelpoisten, heksahydro-8-hydroksi-2,6-metano-2H-kinolitsiinien amidijohdannaisten valmistamiseksi sekä menetelmässä käytettävät välituotteet - Google Patents
Menetelmä uusien, terapeuttisesti käyttökelpoisten, heksahydro-8-hydroksi-2,6-metano-2H-kinolitsiinien amidijohdannaisten valmistamiseksi sekä menetelmässä käytettävät välituotteet Download PDFInfo
- Publication number
- FI112866B FI112866B FI922695A FI922695A FI112866B FI 112866 B FI112866 B FI 112866B FI 922695 A FI922695 A FI 922695A FI 922695 A FI922695 A FI 922695A FI 112866 B FI112866 B FI 112866B
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- Finland
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- formula
- methano
- trans
- octahydro
- quinolizin
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- 239000002674 ointment Substances 0.000 description 1
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- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- BSCHIACBONPEOB-UHFFFAOYSA-N oxolane;hydrate Chemical compound O.C1CCOC1 BSCHIACBONPEOB-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
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- 210000004303 peritoneum Anatomy 0.000 description 1
- 208000022821 personality disease Diseases 0.000 description 1
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- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
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- 210000001525 retina Anatomy 0.000 description 1
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- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
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- 239000000021 stimulant Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
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- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
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- XCTYLCDETUVOIP-UHFFFAOYSA-N thiethylperazine Chemical compound C12=CC(SCC)=CC=C2SC2=CC=CC=C2N1CCCN1CCN(C)CC1 XCTYLCDETUVOIP-UHFFFAOYSA-N 0.000 description 1
- 229960004869 thiethylperazine Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
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- 230000001052 transient effect Effects 0.000 description 1
- 210000003901 trigeminal nerve Anatomy 0.000 description 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 1
- CYHOMWAPJJPNMW-JIGDXULJSA-N tropine Chemical class C1[C@@H](O)C[C@H]2CC[C@@H]1N2C CYHOMWAPJJPNMW-JIGDXULJSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP91401550 | 1991-06-11 | ||
| EP91401550A EP0517984A1 (de) | 1991-06-11 | 1991-06-11 | Amidanaloge-Derivate von methanoverbrückten Chinolizinen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI922695A0 FI922695A0 (fi) | 1992-06-10 |
| FI922695L FI922695L (fi) | 1992-12-12 |
| FI112866B true FI112866B (fi) | 2004-01-30 |
Family
ID=8208580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI922695A FI112866B (fi) | 1991-06-11 | 1992-06-10 | Menetelmä uusien, terapeuttisesti käyttökelpoisten, heksahydro-8-hydroksi-2,6-metano-2H-kinolitsiinien amidijohdannaisten valmistamiseksi sekä menetelmässä käytettävät välituotteet |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP0517984A1 (de) |
| JP (1) | JP3377227B2 (de) |
| KR (1) | KR100234926B1 (de) |
| AT (1) | ATE214392T1 (de) |
| AU (1) | AU649836B2 (de) |
| CA (1) | CA2070573C (de) |
| DE (1) | DE69232473T2 (de) |
| DK (1) | DK0518767T3 (de) |
| ES (1) | ES2173863T3 (de) |
| FI (1) | FI112866B (de) |
| HU (1) | HU212735B (de) |
| IE (1) | IE921874A1 (de) |
| IL (1) | IL102132A (de) |
| NO (1) | NO305124B1 (de) |
| NZ (1) | NZ243031A (de) |
| PT (1) | PT518767E (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5508287A (en) * | 1992-02-24 | 1996-04-16 | Merrell Pharmaceuticals Inc. | 2,6-methano-2H-quinolizin derivative as 5-HT3 -receptor antagonist |
| EP0628043A1 (de) * | 1992-02-24 | 1994-12-14 | Merrell Pharmaceuticals Inc. | 216-methano-2h-quinolizine derivate als 5-ht3 rezeptor antagonist |
| GB9214184D0 (en) * | 1992-07-03 | 1992-08-12 | Smithkline Beecham Plc | Pharmaceuticals |
| GB9304500D0 (en) * | 1993-03-05 | 1993-04-21 | Glaxo Spa | Heterocyclic compounds |
| GB9406857D0 (en) * | 1994-04-07 | 1994-06-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| FR2765107B1 (fr) * | 1997-06-26 | 2000-03-24 | Sanofi Sa | Utilisation d'un antagoniste specifique des recepteurs 5ht2 pour la preparation de medicaments utiles dans le traitement du syndrome d'apnee du sommeil |
| DK1030667T3 (da) * | 1997-11-14 | 2005-06-20 | Akzo Nobel Nv | Anvendelse af mirtazapin til fremstilling af et lægemiddel til behandling af sövnapnö |
| US7160898B2 (en) | 2001-12-14 | 2007-01-09 | Board Of Trustees Of The University Of Illinois | Pharmacological treatment for sleep apnea |
| CA2321900C (en) | 1998-02-27 | 2011-07-19 | The Board Of Trustees Of The University Of Illinois | Agents with serotonin-related activity for the treatment for sleep apnea |
| US7666867B2 (en) | 2001-10-26 | 2010-02-23 | University Of Connecticut | Heteroindanes: a new class of potent cannabimimetic ligands |
| CA2590802A1 (en) | 2004-12-20 | 2006-06-29 | Collegium Pharmaceutical, Inc. | Pharmaceutical compositions for sleep disorders |
| WO2007081890A2 (en) | 2006-01-05 | 2007-07-19 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Production of dolasetron |
| CN101774971B (zh) * | 2010-02-10 | 2011-07-27 | 山东众诚药业股份有限公司 | 高纯度1-甲基吲唑-3-羧酸的生产方法 |
| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| WO2024052684A1 (en) | 2022-09-09 | 2024-03-14 | MyricX Pharma Limited | Antibody drug conjugate comprising nmt inhibitor and its use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB219363A (en) * | 1923-03-24 | 1924-07-24 | Abraham Preston | Improvements in or in connection with bed couches |
| DE3650772T2 (de) * | 1985-04-27 | 2003-04-03 | F. Hoffmann-La Roche Ag, Basel | Derivate von Indazole-3-carboxamide und -3-carboxylsäure |
| EP0330788A1 (de) * | 1988-03-01 | 1989-09-06 | Merrell Dow Pharmaceuticals Inc. | Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln zur Behandlung von Herz-Arrhythmie |
| GB8829079D0 (en) * | 1988-12-13 | 1989-01-25 | Beecham Group Plc | Novel compounds |
-
1991
- 1991-06-11 EP EP91401550A patent/EP0517984A1/de not_active Withdrawn
-
1992
- 1992-06-05 CA CA002070573A patent/CA2070573C/en not_active Expired - Lifetime
- 1992-06-05 NZ NZ243031A patent/NZ243031A/en not_active IP Right Cessation
- 1992-06-05 AU AU18037/92A patent/AU649836B2/en not_active Expired
- 1992-06-08 IL IL10213292A patent/IL102132A/en not_active IP Right Cessation
- 1992-06-10 FI FI922695A patent/FI112866B/fi not_active IP Right Cessation
- 1992-06-10 NO NO922270A patent/NO305124B1/no not_active IP Right Cessation
- 1992-06-10 KR KR1019920010016A patent/KR100234926B1/ko not_active Expired - Lifetime
- 1992-06-10 HU HU9201939A patent/HU212735B/hu unknown
- 1992-06-11 DK DK92401618T patent/DK0518767T3/da active
- 1992-06-11 ES ES92401618T patent/ES2173863T3/es not_active Expired - Lifetime
- 1992-06-11 PT PT92401618T patent/PT518767E/pt unknown
- 1992-06-11 JP JP17598392A patent/JP3377227B2/ja not_active Expired - Lifetime
- 1992-06-11 DE DE69232473T patent/DE69232473T2/de not_active Expired - Lifetime
- 1992-06-11 AT AT92401618T patent/ATE214392T1/de active
- 1992-06-11 EP EP92401618A patent/EP0518767B1/de not_active Expired - Lifetime
- 1992-07-01 IE IE187492A patent/IE921874A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP3377227B2 (ja) | 2003-02-17 |
| FI922695A0 (fi) | 1992-06-10 |
| EP0518767B1 (de) | 2002-03-13 |
| AU649836B2 (en) | 1994-06-02 |
| NO305124B1 (no) | 1999-04-06 |
| HU9201939D0 (en) | 1992-08-28 |
| KR930000518A (ko) | 1993-01-15 |
| HUT61549A (en) | 1993-01-28 |
| DE69232473T2 (de) | 2002-11-21 |
| NO922270D0 (no) | 1992-06-10 |
| PT518767E (pt) | 2002-09-30 |
| ES2173863T3 (es) | 2002-11-01 |
| KR100234926B1 (ko) | 1999-12-15 |
| CA2070573A1 (en) | 1992-12-12 |
| IL102132A0 (en) | 1993-01-14 |
| AU1803792A (en) | 1992-12-24 |
| EP0517984A1 (de) | 1992-12-16 |
| HU212735B (en) | 1996-10-28 |
| IL102132A (en) | 1996-10-31 |
| ATE214392T1 (de) | 2002-03-15 |
| DE69232473D1 (de) | 2002-04-18 |
| JPH05202044A (ja) | 1993-08-10 |
| FI922695L (fi) | 1992-12-12 |
| EP0518767A2 (de) | 1992-12-16 |
| NZ243031A (en) | 1994-02-25 |
| NO922270L (no) | 1992-12-14 |
| DK0518767T3 (da) | 2002-07-01 |
| CA2070573C (en) | 2003-04-15 |
| EP0518767A3 (en) | 1993-05-05 |
| IE921874A1 (en) | 1992-12-16 |
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