FI59023C - Foerfarande foer framstaellning av ett klarloesligt magsyraneutraliserande medel i flytande form - Google Patents

Foerfarande foer framstaellning av ett klarloesligt magsyraneutraliserande medel i flytande form Download PDF

Info

Publication number: FI59023C
Authority: FI; Finland
Prior art keywords: acid; polyethyleneimine; water; polyethylene; preparation
Prior art date: 1976-06-03

Application number

FI771660A

Other languages

English (en)

Finnish (fi)

Other versions

FI771660A7 (cs

FI59023B (fi

Inventor

Conny Boerje Bogentoft

Original Assignee

Haessle Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-06-03

Filing date

1977-05-24

Publication date

1981-06-10

1977-05-24 Application filed by Haessle Ab filed Critical Haessle Ab

1977-12-04 Publication of FI771660A7 publication Critical patent/FI771660A7/fi

1981-02-27 Application granted granted Critical

1981-02-27 Publication of FI59023B publication Critical patent/FI59023B/fi

1981-06-10 Publication of FI59023C publication Critical patent/FI59023C/fi

Links

229920002873 Polyethylenimine Polymers 0.000 description 92
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 40
239000002253 acid Substances 0.000 description 38
238000002360 preparation method Methods 0.000 description 35
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 34
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 27
-1 hydrogen ions Chemical class 0.000 description 25
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 21
239000004698 Polyethylene Substances 0.000 description 21
229920000573 polyethylene Polymers 0.000 description 21
239000000243 solution Substances 0.000 description 21
229940069428 antacid Drugs 0.000 description 20
239000003159 antacid agent Substances 0.000 description 20
239000000725 suspension Substances 0.000 description 19
241000700159 Rattus Species 0.000 description 17
239000000783 alginic acid Substances 0.000 description 17
235000010443 alginic acid Nutrition 0.000 description 17
229920000615 alginic acid Polymers 0.000 description 17
229960001126 alginic acid Drugs 0.000 description 17
150000004781 alginic acids Chemical class 0.000 description 17
230000001458 anti-acid effect Effects 0.000 description 17
238000001727 in vivo Methods 0.000 description 17
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 16
150000001875 compounds Chemical class 0.000 description 16
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 14
NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 12
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
239000000203 mixture Substances 0.000 description 12
239000000126 substance Substances 0.000 description 12
239000006188 syrup Substances 0.000 description 12
235000020357 syrup Nutrition 0.000 description 12
239000007864 aqueous solution Substances 0.000 description 11
238000006243 chemical reaction Methods 0.000 description 11
230000002496 gastric effect Effects 0.000 description 11
230000000694 effects Effects 0.000 description 10
KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 10
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 8
229920002230 Pectic acid Polymers 0.000 description 8
229910000147 aluminium phosphate Inorganic materials 0.000 description 8
210000004211 gastric acid Anatomy 0.000 description 8
238000000338 in vitro Methods 0.000 description 8
239000010318 polygalacturonic acid Substances 0.000 description 8
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 7
238000000034 method Methods 0.000 description 7
230000003472 neutralizing effect Effects 0.000 description 7
239000011574 phosphorus Substances 0.000 description 7
229910052698 phosphorus Inorganic materials 0.000 description 7
238000012360 testing method Methods 0.000 description 7
241001465754 Metazoa Species 0.000 description 6
239000000159 acid neutralizing agent Substances 0.000 description 6
235000005979 Citrus limon Nutrition 0.000 description 5
QXKAIJAYHKCRRA-JJYYJPOSSA-N D-arabinonic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(O)=O QXKAIJAYHKCRRA-JJYYJPOSSA-N 0.000 description 5
IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 5
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 5
IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 description 5
239000003814 drug Substances 0.000 description 5
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 5
239000001384 succinic acid Substances 0.000 description 5
239000011975 tartaric acid Substances 0.000 description 5
235000002906 tartaric acid Nutrition 0.000 description 5
PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 4
244000248349 Citrus limon Species 0.000 description 4
DSLZVSRJTYRBFB-UHFFFAOYSA-N Galactaric acid Natural products OC(=O)C(O)C(O)C(O)C(O)C(O)=O DSLZVSRJTYRBFB-UHFFFAOYSA-N 0.000 description 4
229920003091 Methocel™ Polymers 0.000 description 4
239000001530 fumaric acid Substances 0.000 description 4
DSLZVSRJTYRBFB-DUHBMQHGSA-N galactaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O DSLZVSRJTYRBFB-DUHBMQHGSA-N 0.000 description 4
239000000347 magnesium hydroxide Substances 0.000 description 4
229910001862 magnesium hydroxide Inorganic materials 0.000 description 4
229920000609 methyl cellulose Polymers 0.000 description 4
239000001923 methylcellulose Substances 0.000 description 4
230000007935 neutral effect Effects 0.000 description 4
238000006386 neutralization reaction Methods 0.000 description 4
239000001814 pectin Substances 0.000 description 4
229920001277 pectin Polymers 0.000 description 4
235000010987 pectin Nutrition 0.000 description 4
239000000523 sample Substances 0.000 description 4
210000002784 stomach Anatomy 0.000 description 4
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 3
206010002091 Anaesthesia Diseases 0.000 description 3
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 3
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 3
150000007513 acids Chemical class 0.000 description 3
230000037005 anaesthesia Effects 0.000 description 3
JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 3
235000014113 dietary fatty acids Nutrition 0.000 description 3
229940079593 drug Drugs 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
239000000194 fatty acid Substances 0.000 description 3
229930195729 fatty acid Natural products 0.000 description 3
150000004665 fatty acids Chemical class 0.000 description 3
238000009472 formulation Methods 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000002245 particle Substances 0.000 description 3
230000035484 reaction time Effects 0.000 description 3
230000009885 systemic effect Effects 0.000 description 3
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 2
229920000742 Cotton Polymers 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
239000001263 FEMA 3042 Substances 0.000 description 2
206010020601 Hyperchlorhydria Diseases 0.000 description 2
CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
239000004098 Tetracycline Substances 0.000 description 2
230000009471 action Effects 0.000 description 2
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
229910021502 aluminium hydroxide Inorganic materials 0.000 description 2
238000003556 assay Methods 0.000 description 2
230000037396 body weight Effects 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
229920003020 cross-linked polyethylene Polymers 0.000 description 2
239000004703 cross-linked polyethylene Substances 0.000 description 2
210000003736 gastrointestinal content Anatomy 0.000 description 2
210000001035 gastrointestinal tract Anatomy 0.000 description 2
230000036571 hydration Effects 0.000 description 2
238000006703 hydration reaction Methods 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
210000000936 intestine Anatomy 0.000 description 2
230000002475 laxative effect Effects 0.000 description 2
159000000003 magnesium salts Chemical class 0.000 description 2
239000001630 malic acid Substances 0.000 description 2
235000011090 malic acid Nutrition 0.000 description 2
LCLHHZYHLXDRQG-ZNKJPWOQSA-N pectic acid Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)O[C@H](C(O)=O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](OC2[C@@H]([C@@H](O)[C@@H](O)[C@H](O2)C(O)=O)O)[C@@H](C(O)=O)O1 LCLHHZYHLXDRQG-ZNKJPWOQSA-N 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
229920002635 polyurethane Polymers 0.000 description 2
239000004814 polyurethane Substances 0.000 description 2
210000001187 pylorus Anatomy 0.000 description 2
230000028327 secretion Effects 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000007790 solid phase Substances 0.000 description 2
LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 2
229940033123 tannic acid Drugs 0.000 description 2
235000015523 tannic acid Nutrition 0.000 description 2
229920002258 tannic acid Polymers 0.000 description 2
229920001864 tannin Polymers 0.000 description 2
239000001648 tannin Substances 0.000 description 2
235000018553 tannin Nutrition 0.000 description 2
235000019364 tetracycline Nutrition 0.000 description 2
150000003522 tetracyclines Chemical class 0.000 description 2
229940124597 therapeutic agent Drugs 0.000 description 2
238000004448 titration Methods 0.000 description 2
210000002700 urine Anatomy 0.000 description 2
238000005303 weighing Methods 0.000 description 2
241000345998 Calamus manan Species 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
244000131522 Citrus pyriformis Species 0.000 description 1
238000012404 In vitro experiment Methods 0.000 description 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
208000012868 Overgrowth Diseases 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
230000001078 anti-cholinergic effect Effects 0.000 description 1
229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
230000008901 benefit Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
150000004649 carbonic acid derivatives Chemical class 0.000 description 1
230000008859 change Effects 0.000 description 1
239000000812 cholinergic antagonist Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000013078 crystal Substances 0.000 description 1
239000002274 desiccant Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
230000029142 excretion Effects 0.000 description 1
210000003608 fece Anatomy 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
230000009969 flowable effect Effects 0.000 description 1
230000027119 gastric acid secretion Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
150000004679 hydroxides Chemical class 0.000 description 1
230000033444 hydroxylation Effects 0.000 description 1
238000005805 hydroxylation reaction Methods 0.000 description 1
150000002466 imines Chemical class 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000016507 interphase Effects 0.000 description 1
210000003041 ligament Anatomy 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
150000002681 magnesium compounds Chemical class 0.000 description 1
HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
239000000395 magnesium oxide Substances 0.000 description 1
239000000391 magnesium silicate Substances 0.000 description 1
229910052919 magnesium silicate Inorganic materials 0.000 description 1
235000019792 magnesium silicate Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
239000005416 organic matter Substances 0.000 description 1
210000002826 placenta Anatomy 0.000 description 1
231100000572 poisoning Toxicity 0.000 description 1
230000000607 poisoning effect Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
230000008569 process Effects 0.000 description 1
239000010453 quartz Substances 0.000 description 1
238000010791 quenching Methods 0.000 description 1
230000000171 quenching effect Effects 0.000 description 1
235000012950 rattan cane Nutrition 0.000 description 1
239000012429 reaction media Substances 0.000 description 1
238000007670 refining Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
239000002893 slag Substances 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
238000013223 sprague-dawley female rat Methods 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
229940040944 tetracyclines Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Inorganic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Control Of Combustion (AREA)
Manufacturing Of Printed Circuit Boards (AREA)

FI771660A 1976-06-03 1977-05-24 Foerfarande foer framstaellning av ett klarloesligt magsyraneutraliserande medel i flytande form FI59023C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE7606256A SE405445B (sv)	1976-06-03	1976-06-03	Forfarande for framstellning av ett magsyreneutraliserande antacidum i flytande form innehallande polyetylenimin
SE7606256		1976-06-03

Publications (3)

Publication Number	Publication Date
FI771660A7 FI771660A7 (cs)	1977-12-04
FI59023B FI59023B (fi)	1981-02-27
FI59023C true FI59023C (fi)	1981-06-10

Family

ID=20328121

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI771660A FI59023C (fi)	1976-06-03	1977-05-24	Foerfarande foer framstaellning av ett klarloesligt magsyraneutraliserande medel i flytande form

Country Status (21)

Country	Link
JP (1)	JPS52148630A (cs)
AT (1)	AT353406B (cs)
AU (1)	AU514929B2 (cs)
BE (1)	BE855349A (cs)
CA (1)	CA1087094A (cs)
CS (1)	CS207459B2 (cs)
DD (1)	DD131345A5 (cs)
DE (1)	DE2722486A1 (cs)
DK (1)	DK234077A (cs)
FI (1)	FI59023C (cs)
FR (1)	FR2353296A1 (cs)
GB (1)	GB1539162A (cs)
HU (1)	HU174584B (cs)
IE (1)	IE45208B1 (cs)
LU (1)	LU77480A1 (cs)
NL (1)	NL7706085A (cs)
NO (1)	NO771899L (cs)
NZ (1)	NZ184237A (cs)
SE (1)	SE405445B (cs)
SU (1)	SU812156A3 (cs)
ZA (1)	ZA772913B (cs)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5936192B2 (ja) *	2012-10-25	2016-06-15	学校法人神奈川大学	キラル超分子結晶及びそれからなる固体触媒、並びにキラル超分子結晶の製造方法

1976
- 1976-06-03 SE SE7606256A patent/SE405445B/xx unknown
1977
- 1977-05-16 ZA ZA00772913A patent/ZA772913B/xx unknown
- 1977-05-18 DE DE19772722486 patent/DE2722486A1/de not_active Withdrawn
- 1977-05-24 FI FI771660A patent/FI59023C/fi not_active IP Right Cessation
- 1977-05-27 DK DK234077A patent/DK234077A/da unknown
- 1977-05-30 NZ NZ184237A patent/NZ184237A/xx unknown
- 1977-05-30 AU AU25612/77A patent/AU514929B2/en not_active Expired
- 1977-05-31 NO NO771899A patent/NO771899L/no unknown
- 1977-05-31 IE IE1120/77A patent/IE45208B1/en unknown
- 1977-06-01 DD DD7700199241A patent/DD131345A5/xx unknown
- 1977-06-01 CS CS773612A patent/CS207459B2/cs unknown
- 1977-06-01 HU HU77HE737A patent/HU174584B/hu unknown
- 1977-06-02 SU SU772490602A patent/SU812156A3/ru active
- 1977-06-02 CA CA279,734A patent/CA1087094A/en not_active Expired
- 1977-06-02 FR FR7716916A patent/FR2353296A1/fr active Granted
- 1977-06-02 NL NL7706085A patent/NL7706085A/xx not_active Application Discontinuation
- 1977-06-02 GB GB23486/77A patent/GB1539162A/en not_active Expired
- 1977-06-03 JP JP6568177A patent/JPS52148630A/ja active Pending
- 1977-06-03 LU LU77480A patent/LU77480A1/xx unknown
- 1977-06-03 BE BE178155A patent/BE855349A/xx unknown
- 1977-06-03 AT AT393877A patent/AT353406B/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI771660A7 (cs)	1977-12-04
HU174584B (hu)	1980-02-28
DE2722486A1 (de)	1977-12-22
ATA393877A (de)	1979-04-15
FR2353296A1 (fr)	1977-12-30
DD131345A5 (de)	1978-06-21
SE405445B (sv)	1978-12-11
SE7606256L (sv)	1977-12-04
NZ184237A (en)	1979-10-25
AU2561277A (en)	1978-12-07
DK234077A (da)	1977-12-04
AT353406B (de)	1979-11-12
IE45208L (en)	1977-12-03
NO771899L (no)	1977-12-06
AU514929B2 (en)	1981-03-05
NL7706085A (nl)	1977-12-06
IE45208B1 (en)	1982-07-14
FR2353296B1 (cs)	1981-01-16
CS207459B2 (en)	1981-07-31
ZA772913B (en)	1978-04-26
SU812156A3 (ru)	1981-03-07
BE855349A (fr)	1977-12-05
FI59023B (fi)	1981-02-27
GB1539162A (en)	1979-01-31
JPS52148630A (en)	1977-12-10
LU77480A1 (cs)	1978-01-26
CA1087094A (en)	1980-10-07

Legal Events

Date	Code	Title	Description
2004-08-31	MM	Patent lapsed	Owner name: AB HAESSLE

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