FI59813C - Foerfarande foer framstaellning av antibiotikumet ps-5 och salter daerav med en beta-laktamas inhiberande aktivitet - Google Patents

Foerfarande foer framstaellning av antibiotikumet ps-5 och salter daerav med en beta-laktamas inhiberande aktivitet Download PDF

Info

Publication number: FI59813C
Authority: FI; Finland
Prior art keywords: antibiotic; yellow; medium; activity; light
Prior art date: 1977-03-31

Application number

FI780671A

Other languages

English (en)

Finnish (fi)

Other versions

FI59813B (fi

FI780671A7 (fi

Inventor

Kazuhiko Okumura

Shoji Hirata

Yasushi Okumura

Yasuo Fukagawa

Yasutaka Shimauchi

Tomoyuki Ishikura

Kageaki Kouno

Joseph Lein

Original Assignee

Panlabs Inc

Sanraku Ocean Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-31

Filing date

1978-02-28

Publication date

1981-10-12

1977-03-31 Priority claimed from JP52035375A external-priority patent/JPS604719B2/ja

1977-08-09 Priority claimed from JP9465177A external-priority patent/JPS5430195A/ja

1978-02-28 Application filed by Panlabs Inc, Sanraku Ocean Co filed Critical Panlabs Inc

1978-10-01 Publication of FI780671A7 publication Critical patent/FI780671A7/fi

1980-04-28 Priority to FI801352A priority Critical patent/FI801352A7/fi

1981-06-30 Publication of FI59813B publication Critical patent/FI59813B/fi

1981-10-12 Application granted granted Critical

1981-10-12 Publication of FI59813C publication Critical patent/FI59813C/fi

Links

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235000013379 molasses Nutrition 0.000 description 1
ZJQHPWUVQPJPQT-UHFFFAOYSA-N muscimol Chemical compound NCC1=CC(=O)NO1 ZJQHPWUVQPJPQT-UHFFFAOYSA-N 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
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239000000312 peanut oil Substances 0.000 description 1
229950009506 penicillinase Drugs 0.000 description 1
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229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
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229920001282 polysaccharide Polymers 0.000 description 1
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229920001296 polysiloxane Polymers 0.000 description 1
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XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
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159000000001 potassium salts Chemical class 0.000 description 1
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239000002243 precursor Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
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XOVSRHHCHKUFKM-UHFFFAOYSA-N s-methylthiohydroxylamine Chemical compound CSN XOVSRHHCHKUFKM-UHFFFAOYSA-N 0.000 description 1
239000012488 sample solution Substances 0.000 description 1
238000012216 screening Methods 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
238000012206 semi-quantitative assay Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
229940098362 serratia marcescens Drugs 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000009518 sodium iodide Nutrition 0.000 description 1
239000004317 sodium nitrate Substances 0.000 description 1
235000010344 sodium nitrate Nutrition 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
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230000002110 toxicologic effect Effects 0.000 description 1
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SZYJELPVAFJOGJ-UHFFFAOYSA-N trimethylamine hydrochloride Chemical group Cl.CN(C)C SZYJELPVAFJOGJ-UHFFFAOYSA-N 0.000 description 1
239000012137 tryptone Substances 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Cephalosporin Compounds (AREA)

FI780671A 1977-03-31 1978-02-28 Foerfarande foer framstaellning av antibiotikumet ps-5 och salter daerav med en beta-laktamas inhiberande aktivitet FI59813C (fi)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
FI801352A FI801352A7 (fi)	1977-03-31	1980-04-28	Foerfarande foer framstaellning av estrar av antibioten ps-5

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP52035375A JPS604719B2 (ja)	1977-03-31	1977-03-31	β‐ラクタマーゼ阻害活性を有する抗生物質ＰＳ―５の製造方法
JP3537577		1977-03-31
JP9465177A JPS5430195A (en)	1977-08-09	1977-08-09	Antibiotic substance ps-5 having beta-lactamase inhibiting activity, its derivative and their preparation
JP9465177		1977-08-09

Publications (3)

Publication Number	Publication Date
FI780671A7 FI780671A7 (fi)	1978-10-01
FI59813B FI59813B (fi)	1981-06-30
FI59813C true FI59813C (fi)	1981-10-12

Family

ID=26374352

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI780671A FI59813C (fi)	1977-03-31	1978-02-28	Foerfarande foer framstaellning av antibiotikumet ps-5 och salter daerav med en beta-laktamas inhiberande aktivitet

Country Status (21)

Country	Link
US (1)	US4318916A (fr)
AR (1)	AR219738A1 (fr)
AT (1)	AT362059B (fr)
AU (1)	AU518781B2 (fr)
CA (1)	CA1123767A (fr)
CH (1)	CH643262A5 (fr)
DE (1)	DE2813922A1 (fr)
DK (1)	DK144098C (fr)
FI (1)	FI59813C (fr)
FR (1)	FR2408608B1 (fr)
GB (1)	GB1598062A (fr)
GR (1)	GR62185B (fr)
IE (1)	IE46369B1 (fr)
IL (1)	IL54118A (fr)
IT (1)	IT1113066B (fr)
LU (1)	LU79351A1 (fr)
NL (1)	NL7802976A (fr)
NO (1)	NO781076L (fr)
NZ (1)	NZ186830A (fr)
PT (1)	PT67848B (fr)
SE (1)	SE7803623L (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0011173B1 (fr)	1978-11-01	1983-05-11	Sanraku-Ocean Co., Ltd.	Procédé pour la production de composés antibiotiques bêta-lactame
DE3146190A1 (de) *	1981-11-21	1983-06-16	Hoechst Ag, 6230 Frankfurt	Isolierung von chemisch instabilen antibiotika aus fermentationsloesungen
US5650290A (en) *	1994-04-01	1997-07-22	Hach Company	Method & Medium for use in detecting E. coli and total coliforms
US5849515A (en) *	1994-04-01	1998-12-15	Hach Company	Method and medium for use in detecting E. coli and total coliforms
KR100379075B1 (en) *	2002-03-07	2003-04-08	Jinis Biopharmaceuticals Co	Method for producing low cholesterol animal food product and food product therefrom
FI20205368A1 (en) *	2020-04-07	2021-10-08	Aalto Univ Foundation Sr	FORMULATION
CN111826334A (zh) *	2020-07-24	2020-10-27	暨南大学	一种超长大肠杆菌及其制备方法与应用
CN113960188B (zh) *	2021-09-09	2024-01-26	中车青岛四方机车车辆股份有限公司	高效液相色谱-串联质谱法测定样品中的4,4-二(二甲氨基)-4-甲氨基三苯甲醇

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3928569A (en) *	1972-08-09	1975-12-23	Microbial Chem Res Found	Two substances inhibiting beta-lactamase and their production
GB1467413A (en) *	1974-03-28	1977-03-16	Beecham Group Ltd	Antibiotics
US3950357A (en) *	1974-11-25	1976-04-13	Merck & Co., Inc.	Antibiotics
US4162324A (en) *	1975-11-21	1979-07-24	Merck & Co., Inc.	Antibiotics 890A1 and 890A3
US4165379A (en) *	1975-11-21	1979-08-21	Merck & Co., Inc.	N-acetyl thienamycin
NL7704040A (nl) *	1976-04-28	1977-11-01	Merck & Co Inc	Werkwijze voor het bereiden van nieuwe anti- biotica.
NL7802826A (nl) *	1977-04-08	1978-10-10	Merck & Co Inc	Thienamycinederivaat, werkwijze voor het bereiden daarvan, alsmede farmaceutische preparaten.
US4162323A (en) *	1977-04-18	1979-07-24	Merck & Co., Inc.	Antibiotic N-acetyl-dehydro-thienamycin
US4235922A (en) *	1979-06-15	1980-11-25	Merck & Co., Inc.	3-(2-Aminoethylthio)-6-ethyl-7-oxo-1-azabicyclo [3.2.0]hept-2-ene-2-carboxylic acid

1978
- 1978-02-15 GR GR55463A patent/GR62185B/el unknown
- 1978-02-23 IL IL54118A patent/IL54118A/xx unknown
- 1978-02-28 FI FI780671A patent/FI59813C/fi not_active IP Right Cessation
- 1978-03-02 US US05/882,730 patent/US4318916A/en not_active Expired - Lifetime
- 1978-03-09 GB GB9338/78A patent/GB1598062A/en not_active Expired
- 1978-03-20 NL NL7802976A patent/NL7802976A/xx not_active Application Discontinuation
- 1978-03-29 AR AR271592A patent/AR219738A1/es active
- 1978-03-29 NO NO781076A patent/NO781076L/no unknown
- 1978-03-30 IE IE638/78A patent/IE46369B1/en unknown
- 1978-03-30 CH CH340678A patent/CH643262A5/de not_active IP Right Cessation
- 1978-03-30 CA CA300,097A patent/CA1123767A/fr not_active Expired
- 1978-03-30 SE SE7803623A patent/SE7803623L/xx unknown
- 1978-03-30 PT PT67848A patent/PT67848B/pt unknown
- 1978-03-30 IT IT21748/78A patent/IT1113066B/it active
- 1978-03-30 NZ NZ186830A patent/NZ186830A/xx unknown
- 1978-03-30 AT AT224578A patent/AT362059B/de not_active IP Right Cessation
- 1978-03-30 AU AU34592/78A patent/AU518781B2/en not_active Expired
- 1978-03-31 FR FR7809644A patent/FR2408608B1/fr not_active Expired
- 1978-03-31 DE DE19782813922 patent/DE2813922A1/de not_active Withdrawn
- 1978-03-31 DK DK143678A patent/DK144098C/da not_active IP Right Cessation
- 1978-03-31 LU LU79351A patent/LU79351A1/fr unknown

Also Published As

Publication number	Publication date
IE46369B1 (en)	1983-05-18
DE2813922A1 (de)	1978-10-19
AT362059B (de)	1981-04-27
ATA224578A (de)	1980-09-15
CH643262A5 (de)	1984-05-30
PT67848A (en)	1978-04-01
FI59813B (fi)	1981-06-30
AU518781B2 (en)	1981-10-22
FR2408608B1 (fr)	1986-05-16
IE780638L (en)	1978-09-30
LU79351A1 (fr)	1979-03-26
GR62185B (en)	1979-03-02
SE7803623L (sv)	1978-11-17
FI780671A7 (fi)	1978-10-01
IT1113066B (it)	1986-01-20
DK143678A (da)	1978-10-01
GB1598062A (en)	1981-09-16
NO781076L (no)	1978-10-03
CA1123767A (fr)	1982-05-18
DK144098B (da)	1981-12-07
NZ186830A (en)	1981-12-15
FR2408608A1 (fr)	1979-06-08
PT67848B (en)	1979-09-28
AU3459278A (en)	1979-10-04
US4318916A (en)	1982-03-09
IT7821748A0 (it)	1978-03-30
DK144098C (da)	1982-06-01
NL7802976A (nl)	1978-10-03
AR219738A1 (es)	1980-09-15
IL54118A (en)	1981-09-13

Legal Events

Date

Code

Title

Description

2004-08-31

MM

Patent lapsed

Owner name: SANRAKU-OCEAN CO., LTD.

Owner name: PANLABS INC

Publication	Publication Date	Title
Stapley et al.	1972	Cephamycins, a new family of β-lactam antibiotics I. Production by Actinomycetes, including Streptomyces lactamdurans sp. n
EP0376300B1 (fr)	1993-07-28	Substance DC 113 et procédé pour sa production
Okamura et al.	1978	PS-5, a new β-lactam antibiotic from Streptomyces
Ohkuma et al.	1980	BBM-928, a new antitumor antibiotic complex I. Production, isolation, characterization and antitumor activity
CA1242159A (fr)	1988-09-20	Bbm-2478, complexe antibiotique
FI59813C (fi)	1981-10-12	Foerfarande foer framstaellning av antibiotikumet ps-5 och salter daerav med en beta-laktamas inhiberande aktivitet
Okamura et al.	1979	PS-5, A NEW β-LACTAM ANTIBIOTIC. I TAXONOMY OF THE PRODUCING ORGANISM, ISOLATION AND PHYSICO-CHEMICAL PROPERTIES
CA1213542A (fr)	1986-11-04	Antibiotique bbm-2040 antitumoral produit par les streptomyces
EP1211259B1 (fr)	2003-11-19	Caprazamycines antibiotiques et leur procede de production
Okabe et al.	1982	STUDIES ON THE OA-6129 GROUP OF ANTIBIOTICS, NEW CARBAPENEM COMPOUNDS I. TAXONOMY, ISOLATION AND PHYSICAL PROPERTIES
US4368203A (en)	1983-01-11	Antibiotics and derivatives thereof having β-lactamase inhibitory activity and production thereof
SHIBAMAMOTO et al.	1982	PS-8, a minor carbapenem antibiotic
US5114967A (en)	1992-05-19	Antibiotic alisamycin and its use
US4806566A (en)	1989-02-21	Anti-gram positive bacteria tri-yne carbonates
CA1159782A (fr)	1984-01-03	Pa-39504-x inn nn antibiotique et mode de production
US4861796A (en)	1989-08-29	Gentisic acid derivatives having antibiotic activity
US5334613A (en)	1994-08-02	Antibacterial substance BE-24566B
US4427655A (en)	1984-01-24	Antibiotics-875A and production thereof
EP0002058B1 (fr)	1982-06-23	3-(2-Aminoéthylthio-6-éthyl-7-oxo-1-azabicylo-(3.2.0)-hept-2-en-2-acide carboxylique, procédé pour sa préparation et compositions le contenant
US4100273A (en)	1978-07-11	Antibiotic substance from Actinoplanes sarveparensis CBS 305.76 (antibiotic L 13365)
US4468350A (en)	1984-08-28	KA-6643-Series antibiotics, process for producing same and medical composition containing same
JPH04316578A (ja)	1992-11-06	新規抗生物質ｐｆ１０５２物質およびその製造法
IWAMI et al.	1989	NEW ANTITUMOR ANTIBIOTIC, FR-900462 II. PRODUCTION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITY
Bombay et al.	0	EUROPEAN PATENT APPLICATION
JPS6215558B2 (fr)	1987-04-08