FI60218C - Foerfarande foer framstaellning av terapeutiskt anvaendbara dubbelsalter av s-adenosyl-l-metionin - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara dubbelsalter av s-adenosyl-l-metionin Download PDF

Info

Publication number
FI60218C
FI60218C FI1954/74A FI195474A FI60218C FI 60218 C FI60218 C FI 60218C FI 1954/74 A FI1954/74 A FI 1954/74A FI 195474 A FI195474 A FI 195474A FI 60218 C FI60218 C FI 60218C
Authority
FI
Finland
Prior art keywords
sam
solution
salt
acid
methanol
Prior art date
Application number
FI1954/74A
Other languages
English (en)
Finnish (fi)
Other versions
FI60218B (fi
FI195474A7 (2
Inventor
Alberto Fiecchi
Original Assignee
Bioresearch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT2314874A external-priority patent/IT1022036B/it
Application filed by Bioresearch filed Critical Bioresearch
Publication of FI195474A7 publication Critical patent/FI195474A7/fi
Application granted granted Critical
Publication of FI60218B publication Critical patent/FI60218B/fi
Publication of FI60218C publication Critical patent/FI60218C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI1954/74A 1973-06-27 1974-06-26 Foerfarande foer framstaellning av terapeutiskt anvaendbara dubbelsalter av s-adenosyl-l-metionin FI60218C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IT2589573 1973-06-27
IT2589573 1973-06-27
IT2314874A IT1022036B (it) 1974-05-24 1974-05-24 Processo per la preparazione di sali enzimatici
IT2314874 1974-05-24
LU79038A LU79038A1 (fr) 1973-06-27 1978-02-09 Procede de preparation de sels enzymatiques
LU79038 1978-02-09

Publications (3)

Publication Number Publication Date
FI195474A7 FI195474A7 (2) 1974-12-28
FI60218B FI60218B (fi) 1981-08-31
FI60218C true FI60218C (fi) 1981-12-10

Family

ID=27273344

Family Applications (1)

Application Number Title Priority Date Filing Date
FI1954/74A FI60218C (fi) 1973-06-27 1974-06-26 Foerfarande foer framstaellning av terapeutiskt anvaendbara dubbelsalter av s-adenosyl-l-metionin

Country Status (19)

Country Link
US (1) US3954726A (2)
JP (1) JPS5235727B2 (2)
AR (1) AR202219A1 (2)
AT (1) AT347604B (2)
BE (1) BE816915A (2)
CA (1) CA1024088A (2)
CH (1) CH592686A5 (2)
DD (1) DD112451A5 (2)
DE (1) DE2430999C2 (2)
DK (1) DK137279B (2)
FI (1) FI60218C (2)
FR (1) FR2234891B1 (2)
GB (1) GB1443587A (2)
HK (1) HK31680A (2)
IE (1) IE39517B1 (2)
LU (1) LU79038A1 (2)
NL (1) NL176276C (2)
RO (1) RO64135A (2)
SE (1) SE408712B (2)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR221676A1 (es) * 1974-07-12 1981-03-13 Bioresearch Sas Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico
US4109079A (en) * 1975-10-16 1978-08-22 Yamasa Shoyu Kabushiki Kaisha Stabilized s-adenosyl-l-methionine preparations
JPS5428808A (en) * 1977-08-03 1979-03-03 Yamasa Shoyu Co Ltd Composition containing s-adenoyl-l-methionine and its preparation
GB2001976B (en) * 1977-08-03 1982-03-10 Yamasa Shoyu Kk S-adenosyl-l-methionine compositions and production thereof
GB2064523B (en) * 1979-12-04 1983-06-29 Kanegafuchi Chemical Ind Stable composition of s-adenosyl-l-methionine
IT1137640B (it) 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
US4376116A (en) * 1981-09-01 1983-03-08 Research Corporation Polyamine biosynthesis inhibitors
IT1139974B (it) * 1981-09-11 1986-09-24 Bioresearch Srl Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo
JPS59196408U (ja) * 1983-06-16 1984-12-27 株式会社 永幸 筒形容器
IT1169773B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
IT1173992B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale
US4794174A (en) * 1987-02-10 1988-12-27 Southern Research Institute 5'deoxy-5'-substituted adenosines
WO1989003389A1 (en) * 1987-10-09 1989-04-20 Vincenzo Zappia Lipophilic salts of s-adenosyl-l-methionine (sam) with acylated taurine derivatives
JPH02290896A (ja) * 1989-04-28 1990-11-30 Fuji Kagaku Kogyo Kk 新規なs―アデノシルメチオニン誘導体
JPH0576192U (ja) * 1991-08-27 1993-10-15 株式会社河合楽器製作所 小型電子機器におけるマイクロフオンの保持機構
JP3491938B2 (ja) * 1993-12-13 2004-02-03 キヤノン株式会社 Dnaの回収方法
IT1318535B1 (it) * 2000-05-25 2003-08-27 Chementecno Srl Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina.
US6759395B2 (en) * 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
US6649753B2 (en) 2001-06-07 2003-11-18 Orchid Chemicals & Pharmaceuticals Ltd. Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation
WO2002102823A1 (en) * 2001-06-14 2002-12-27 Orchid Chemicals & Pharmaceuticals Limited Stable salts of s-adenosyl-l-methionine (same) and the process for their preparation
US20050272687A1 (en) * 2004-06-08 2005-12-08 Hebert Rolland F Stable S-adenosyl-l-methionine
FR2884421B1 (fr) 2005-04-15 2007-08-10 Virbac Sa Nouveaux moyens de regulation des troubles du comportement chez les animaux de compagnie
CA2605393A1 (en) * 2005-04-20 2006-10-26 Basf Plant Science Gmbh Expression cassettes for seed-preferential expression in plants
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
ITRM20050344A1 (it) * 2005-06-30 2007-01-01 Luca Maria De Sali o complessi di sostanze metil-donatrici con acido fitico o suoi derivati e relativo metodo di sintesi.
WO2007083631A1 (ja) * 2006-01-17 2007-07-26 Mitsubishi Gas Chemical Company, Inc. S-アデノシル-l-メチオニンの安定化法及び安定化された組成物
ITMI20060629A1 (it) 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
US20090088404A1 (en) * 2007-01-31 2009-04-02 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
US20090197824A1 (en) * 2008-01-31 2009-08-06 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
US20080206333A1 (en) * 2007-01-31 2008-08-28 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
ITMI20071374A1 (it) * 2007-07-10 2009-01-11 Gnosis Spa Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
EP2189154A1 (en) 2008-11-25 2010-05-26 Gnosis S.p.A. Effervescent tablets and mouth-soluble granulates of S-adenosyl methionine and process for the preparation thereof
IT1393331B1 (it) * 2009-02-09 2012-04-20 Graal S R L Composizioni orosolubili e/o effervescenti contenenti almeno un sale di s-adenosilmetionina (same)
US20110027342A1 (en) 2009-07-28 2011-02-03 Msi Methylation Sciences, Inc. S-adenosylmethionine formulations with enhanced bioavailability
US8329208B2 (en) * 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
EP2949331A1 (en) 2012-10-17 2015-12-02 Methylation Sciences International SRL Compositions comprising s-adenosylmethionine and a gallic acid ester
EP2945959B1 (en) 2013-01-16 2020-05-13 Hebert Sam-E LLC Stable indole-3-propionate salts of s-adenosyl-l-methionine
KR102245628B1 (ko) * 2013-04-05 2021-04-28 라이온 가부시키가이샤 내복 조성물
CA3146202A1 (en) * 2019-07-12 2021-01-21 Unilever Global Ip Limited Topical compositions and methods of using same against mitochondrial fragmentation
EP4712796A2 (en) 2023-05-15 2026-03-25 Bonafide Health, LLC Sleep-improving compositions and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642772A (en) * 1968-09-04 1972-02-15 Boehringer Mannheim Gmbh Process for preparing s-adenosyl homocysteine
DE1803978C2 (de) * 1968-10-18 1985-05-02 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Gewinnung von S-Adenosyl-l-methionin und S-Adenosyl-l-ethionin
IE37913B1 (en) * 1972-08-02 1977-11-09 Bioresearch Sas Salt of s-adenosyl-l-methionine

Also Published As

Publication number Publication date
NL176276B (nl) 1984-10-16
DE2430999A1 (de) 1975-01-16
JPS5235727B2 (2) 1977-09-10
CA1024088A (en) 1978-01-10
DK137279B (da) 1978-02-13
HK31680A (en) 1980-06-20
NL176276C (nl) 1985-03-18
IE39517B1 (en) 1978-10-25
NL7408688A (2) 1974-12-31
SE408712B (sv) 1979-07-02
BE816915A (fr) 1974-10-16
AR202219A1 (es) 1975-05-23
CH592686A5 (2) 1977-11-15
AU7068974A (en) 1976-01-08
SE7408388L (2) 1974-12-30
FI60218B (fi) 1981-08-31
AT347604B (de) 1979-01-10
ATA532574A (de) 1978-05-15
FR2234891A1 (2) 1975-01-24
JPS5076215A (2) 1975-06-21
FI195474A7 (2) 1974-12-28
LU79038A1 (fr) 1978-06-26
GB1443587A (en) 1976-07-21
DE2430999C2 (de) 1982-06-09
US3954726A (en) 1976-05-04
DD112451A5 (2) 1975-04-12
RO64135A (fr) 1978-11-15
DK137279C (2) 1978-07-17
DK342974A (2) 1975-03-17
FR2234891B1 (2) 1977-03-11
IE39517L (en) 1974-12-27

Similar Documents

Publication Publication Date Title
FI60218B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara dubbelsalter av s-adenosyl-l-metionin
FI63037C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara stbila sulfonater av s-adenosyl-l-metionin
US3893999A (en) Salt of S-adenosil-L-methionine and process of preparation
US4465672A (en) Stable S-adenosylmethionine salts, the process for their preparation, and therapeutic compositions which contain them as active principle
Allen Role of amantadine in the management of neuroleptic-induced extrapyramidal syndromes: overview and pharmacology
Cox et al. Biosynthesis of carnitine and 4-N-trimethylaminobutyrate from lysine
Vieira-Coelho et al. Effects of tolcapone upon soluble and membrane-bound brain and liver catechol-O-methyltransferase
US4028183A (en) Process of preparing double salts of S-adenosyl-L-methionine
JPH101436A (ja) ウリジンまたはシチジンのアシル誘導体を含有する医薬組成物
FI72525C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara stabila s-adenocylmetioninsalter.
JPH0149276B2 (2)
JPH06509350A (ja) 新規なガングリオシド誘導体
Chandra et al. Effect of manganese on synthesis of brain catecholamines in growing rats
US20050272687A1 (en) Stable S-adenosyl-l-methionine
US20120040923A1 (en) Stable s-adenosyl-l-methionine
US20030144244A1 (en) Stable compositions of S-adenosyl-l-methionine with dextran
JPH05506842A (ja) 神経変性状態の処置方法
CN104974213A (zh) 五环三萜化合物结构衍生物的制备方法及应用
Porcelli et al. Biosynthesis and metabolism of 9-[5′-deoxy-5′-(methylthio)-β-d-xylofuranosyl] adenine, a novel natural analogue of methylthioadenosine
NO139523B (no) Fremgangsmaate for fremstilling av doble salter av s-adenosil-l-methionin
PL95666B1 (pl) Sposob wytwarzania nowych podwojnych soli s-adenozylo-alfa-metioniny
Snyder et al. Amines in schizophrenia
WAGNER et al. Vitamin B12
US20060035972A1 (en) Therapeutic compositions and uses
Weir et al. Urinary excretion of phenothiazine tranquillisers by the horse