FI67373C - Foerfarande foer framstaellning av 6,7-bensomorfanderivat vilka aer anvaendbara som analgetiska medel antagonister foer nakotiska medel och inhibitorer foer sekretion av det luten isrande hormonet - Google Patents

Foerfarande foer framstaellning av 6,7-bensomorfanderivat vilka aer anvaendbara som analgetiska medel antagonister foer nakotiska medel och inhibitorer foer sekretion av det luten isrande hormonet Download PDF

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Publication number
FI67373C
FI67373C FI803237A FI803237A FI67373C FI 67373 C FI67373 C FI 67373C FI 803237 A FI803237 A FI 803237A FI 803237 A FI803237 A FI 803237A FI 67373 C FI67373 C FI 67373C
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FI
Finland
Prior art keywords
alkyl
formula
compound
hydrogen
hydroxy
Prior art date
Application number
FI803237A
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English (en)
Finnish (fi)
Other versions
FI803237L (fi
FI67373B (fi
Inventor
Antony Marie Akkerman
Hermanus Carolus Cathari Bakel
Roelof Christiaan Klaas Smit
Hendricus Bernardus Anto Welle
Magda Marko
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Acf Chemiefarma Nv
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Publication date
Application filed by Acf Chemiefarma Nv filed Critical Acf Chemiefarma Nv
Publication of FI803237L publication Critical patent/FI803237L/fi
Priority to FI833267A priority Critical patent/FI68224C/fi
Priority to FI833268A priority patent/FI68225C/fi
Priority to FI833269A priority patent/FI68226C/fi
Application granted granted Critical
Publication of FI67373B publication Critical patent/FI67373B/fi
Publication of FI67373C publication Critical patent/FI67373C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
FI803237A 1979-10-23 1980-10-14 Foerfarande foer framstaellning av 6,7-bensomorfanderivat vilka aer anvaendbara som analgetiska medel antagonister foer nakotiska medel och inhibitorer foer sekretion av det luten isrande hormonet FI67373C (fi)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FI833267A FI68224C (fi) 1979-10-23 1983-09-13 Foerfarande foer framstaellning av 6,7-benzomorfanderivat vilka aer anvaendbara som analgetiska aemnen antagonister foer narkotiska medel och inhibitorer foer sekretion av luteiniseringshormon
FI833268A FI68225C (fi) 1979-10-23 1983-09-13 Foerfarande foer framstaellning av 6,7-benzomorfanderivat vilka aer anvaendbara som analgetiska medel antagonister foer nakotiska medel och inhibitorer foer sekretion av luteinise rigshormon
FI833269A FI68226C (fi) 1979-10-23 1983-09-13 Foerfarande foer framstaellning av 6,7-benzomorfanderivat vilka aer anvaendbara som analgetiska aemnen antagonister foer narkotiska medel och inhibitorer foer sekretion av luteiniseringshormon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL7907800 1979-10-23
NL7907800A NL7907800A (nl) 1979-10-23 1979-10-23 Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.

Publications (3)

Publication Number Publication Date
FI803237L FI803237L (fi) 1981-04-24
FI67373B FI67373B (fi) 1984-11-30
FI67373C true FI67373C (fi) 1985-03-11

Family

ID=19834064

Family Applications (1)

Application Number Title Priority Date Filing Date
FI803237A FI67373C (fi) 1979-10-23 1980-10-14 Foerfarande foer framstaellning av 6,7-bensomorfanderivat vilka aer anvaendbara som analgetiska medel antagonister foer nakotiska medel och inhibitorer foer sekretion av det luten isrande hormonet

Country Status (17)

Country Link
US (2) US4406904A (de)
EP (1) EP0028717B1 (de)
JP (1) JPS5686164A (de)
AT (1) ATE8990T1 (de)
AU (1) AU539310B2 (de)
CA (1) CA1155840A (de)
DE (1) DE3068961D1 (de)
DK (1) DK435380A (de)
ES (1) ES8106894A1 (de)
FI (1) FI67373C (de)
IE (1) IE50667B1 (de)
IL (1) IL61324A (de)
MY (1) MY8700184A (de)
NL (1) NL7907800A (de)
NZ (1) NZ195329A (de)
PT (1) PT71949B (de)
ZA (1) ZA806528B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4579950A (en) * 1982-08-20 1986-04-01 Hoechst-Roussel Pharmaceuticals Inc. Intermediates for spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine] compounds
JPH01102077A (ja) * 1987-09-24 1989-04-19 Hoechst Roussel Pharmaceut Inc ２，６‐メタノピロロ‐３‐ベンズアゾジン類
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
EP1028690A2 (de) * 1997-10-20 2000-08-23 Novo Nordisk A/S Luteinisierender hormonantagonist zur behandlung von östrogenmangel oder als kontrazeptivum
US6136980A (en) * 1998-05-01 2000-10-24 Boehringer Ingelheim Kg Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
AU7604400A (en) 1999-09-21 2001-04-24 Emory University Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
US6495694B2 (en) * 2000-06-16 2002-12-17 Boehringer Ingelheim Pharma Kg Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer
US20150210646A1 (en) 2012-05-11 2015-07-30 Purdue Pharma L.P. Benzomorphan compounds as opioid receptors modulators
EP3333156A3 (de) * 2012-11-09 2018-09-26 Purdue Pharma L.P. Benzomorphan-analoge und ihre verwendung
US9056836B2 (en) 2013-01-31 2015-06-16 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
CA2948144A1 (en) 2014-05-06 2015-11-12 Purdue Pharma L.P. Benzomorphan analogs and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1050227A (de) 1963-11-07
US4087532A (en) 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates
DE2716687A1 (de) 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
US4202897A (en) * 1977-07-25 1980-05-13 Sandoz, Inc. Prolactin secretion inhibitors
IT8049377A0 (it) 1979-08-03 1980-07-30 Sandoz Ag Medicamento a base di composti triciclici per inibire la secrezione dell'ormone luteinizzante(caso 1005224)

Also Published As

Publication number Publication date
ES496167A0 (es) 1981-09-16
DE3068961D1 (en) 1984-09-20
IE802188L (en) 1981-04-23
CA1155840A (en) 1983-10-25
EP0028717A1 (de) 1981-05-20
JPS5686164A (en) 1981-07-13
PT71949B (en) 1981-12-17
US4425353A (en) 1984-01-10
IL61324A0 (en) 1980-12-31
IE50667B1 (en) 1986-06-11
ES8106894A1 (es) 1981-09-16
ATE8990T1 (de) 1984-09-15
US4406904A (en) 1983-09-27
EP0028717B1 (de) 1984-08-15
MY8700184A (en) 1987-12-31
PT71949A (en) 1981-08-19
DK435380A (da) 1981-04-24
IL61324A (en) 1985-03-31
AU539310B2 (en) 1984-09-20
FI803237L (fi) 1981-04-24
AU6354080A (en) 1981-04-30
FI67373B (fi) 1984-11-30
NZ195329A (en) 1984-05-31
NL7907800A (nl) 1981-04-27
ZA806528B (en) 1982-06-30

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Owner name: ACF CHEMIEFARMA NV