FI67404C - Foerfarande foer utfoering av mutagenitettest - Google Patents
Foerfarande foer utfoering av mutagenitettest Download PDFInfo
- Publication number
- FI67404C FI67404C FI822473A FI822473A FI67404C FI 67404 C FI67404 C FI 67404C FI 822473 A FI822473 A FI 822473A FI 822473 A FI822473 A FI 822473A FI 67404 C FI67404 C FI 67404C
- Authority
- FI
- Finland
- Prior art keywords
- growth
- test
- sample
- population
- mutagenicity
- Prior art date
Links
- 230000012010 growth Effects 0.000 claims description 24
- 231100000150 mutagenicity / genotoxicity testing Toxicity 0.000 claims description 18
- 239000003102 growth factor Substances 0.000 claims description 15
- 230000003505 mutagenic effect Effects 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 12
- 239000003471 mutagenic agent Substances 0.000 claims description 11
- 231100000707 mutagenic chemical Toxicity 0.000 claims description 11
- 238000002835 absorbance Methods 0.000 claims description 9
- 230000003287 optical effect Effects 0.000 claims description 7
- 231100000219 mutagenic Toxicity 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 4
- 230000035484 reaction time Effects 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 33
- 239000000523 sample Substances 0.000 description 31
- 230000001580 bacterial effect Effects 0.000 description 11
- 238000010953 Ames test Methods 0.000 description 6
- 231100000039 Ames test Toxicity 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 231100000299 mutagenicity Toxicity 0.000 description 5
- 230000007886 mutagenicity Effects 0.000 description 5
- 231100000419 toxicity Toxicity 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 230000035772 mutation Effects 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000002906 microbiologic effect Effects 0.000 description 3
- 231100000243 mutagenic effect Toxicity 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 2
- 231100000357 carcinogen Toxicity 0.000 description 2
- 239000003183 carcinogenic agent Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 238000011481 absorbance measurement Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000036438 mutation frequency Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000007793 ph indicator Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 231100000563 toxic property Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 101150005573 uvrA gene Proteins 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
- G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI822473A FI67404C (fi) | 1982-07-12 | 1982-07-12 | Foerfarande foer utfoering av mutagenitettest |
| IT67732/83A IT1162893B (it) | 1982-07-12 | 1983-07-05 | Procedimento per l'esecuzione di una prova di mutageneita |
| DE8383902261T DE3366962D1 (en) | 1982-07-12 | 1983-07-11 | Method for the performance of a mutagenicity test |
| JP58502397A JPS59501294A (ja) | 1982-07-12 | 1983-07-11 | 突然変異誘発性試験の遂行方法 |
| US06/585,375 US4675288A (en) | 1982-07-12 | 1983-07-11 | Method for the performance of a mutagenicity test |
| AT83902261T ATE22927T1 (de) | 1982-07-12 | 1983-07-11 | Verfahren zur durchfuehrung eines mutagenitaetstests. |
| EP83902261A EP0112888B1 (de) | 1982-07-12 | 1983-07-11 | Verfahren zur durchführung eines mutagenitätstests |
| PCT/FI1983/000053 WO1984000384A1 (en) | 1982-07-12 | 1983-07-11 | Method for the performance of a mutagenicity test |
| DD83252995A DD210076A5 (de) | 1982-07-12 | 1983-07-12 | Verfahren zur durchfuehrung einer mutagenitaetspruefung |
| CA000433828A CA1204373A (en) | 1982-07-12 | 1983-08-03 | Method for the performance of a mutagenicity test |
| AU17618/83A AU566150B2 (en) | 1982-07-12 | 1983-08-05 | Turbidity change mutagenicity test method |
| NO840823A NO840823L (no) | 1982-07-12 | 1984-03-05 | Fremgangsmaate for utfoerelse av en mutagenitetsproeve |
| SU843715344A SU1442090A3 (ru) | 1982-07-12 | 1984-03-11 | Способ определени мутаций в культуре клеток Е. coLI WP2/тRр-/ и S.тUрнIмURIUм(нIS-) |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI822473A FI67404C (fi) | 1982-07-12 | 1982-07-12 | Foerfarande foer utfoering av mutagenitettest |
| FI822473 | 1982-07-12 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI822473A0 FI822473A0 (fi) | 1982-07-12 |
| FI822473L FI822473L (fi) | 1984-01-13 |
| FI67404B FI67404B (fi) | 1984-11-30 |
| FI67404C true FI67404C (fi) | 1986-07-28 |
Family
ID=8515808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI822473A FI67404C (fi) | 1982-07-12 | 1982-07-12 | Foerfarande foer utfoering av mutagenitettest |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4675288A (de) |
| EP (1) | EP0112888B1 (de) |
| JP (1) | JPS59501294A (de) |
| AU (1) | AU566150B2 (de) |
| CA (1) | CA1204373A (de) |
| DD (1) | DD210076A5 (de) |
| DE (1) | DE3366962D1 (de) |
| FI (1) | FI67404C (de) |
| IT (1) | IT1162893B (de) |
| NO (1) | NO840823L (de) |
| SU (1) | SU1442090A3 (de) |
| WO (1) | WO1984000384A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1313613C (en) * | 1986-12-30 | 1993-02-16 | Fateme Sima Sariaslani | Induction of cytochrome p-450 enzymes in streptomyces bacteria |
| US5169755A (en) * | 1986-12-30 | 1992-12-08 | E. I. Du Pont De Nemours And Company | Process for inducing cytochrome P-450 enzymes in streptomyces bacteria and determining the mutagenicity of chemicals |
| US5213971A (en) * | 1986-12-30 | 1993-05-25 | E. I. Du Pont De Nemours And Company | Process for inducing cytochrome P-450 enzymes in Streptomyces bacteria and determining the mutagenicity of chemicals |
| NZ223569A (en) * | 1987-02-24 | 1990-06-26 | Mobil Oil Corp | Assaying polynuclear compounds for mutagenic activity |
| US5246837A (en) * | 1988-10-19 | 1993-09-21 | Spiral System Instruments, Inc. | Processor implemented method for determining the potency of a growth affecting substance interacting with micro-organisms on the surface of microbial culture media |
| US5079145A (en) * | 1988-10-21 | 1992-01-07 | Synergen Associates, Inc. | Process for preparing microorganisms used for making phenyl acetyl carlinol (pac) |
| US4983527A (en) * | 1989-05-26 | 1991-01-08 | Arizona Board Of Regents | Oocyte test for detection of tumor promoting compounds |
| AU2007235445B2 (en) | 2006-04-05 | 2011-04-14 | Intercontinental Great Brands Llc | Calcium phosphate complex in acid containing confectionery |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3255095A (en) * | 1962-10-08 | 1966-06-07 | Martin C Baer | Mutant detection method |
| DE2145787A1 (de) * | 1971-02-04 | 1972-09-28 | VEB Chemiekombinat Bitterfeld, χ 4400 Bitterfeld | Verfahren zur Selektion biochemisch wirksamer Substanzen |
| GB1358760A (en) * | 1971-08-09 | 1974-07-03 | Bitterfeld Chemie | Process for the selection of biochemically-active substances |
| US4072574A (en) * | 1976-07-30 | 1978-02-07 | The Institute For Cancer Research | System for in vitro assay for mutagenicity and/or carcinogenicity of chemicals or other exogenous agents |
| US4299915A (en) * | 1977-10-17 | 1981-11-10 | Massachusetts Institute Of Technology | Assay for mutagenesis in bacterial cells |
| US4256832A (en) * | 1978-12-12 | 1981-03-17 | Bioresearch Inc. | Carcinogen and mutagen screening method and apparatus |
| US4345026A (en) * | 1981-01-12 | 1982-08-17 | The Children's Hospital Medical Center | Mutagenicity assay |
-
1982
- 1982-07-12 FI FI822473A patent/FI67404C/fi not_active IP Right Cessation
-
1983
- 1983-07-05 IT IT67732/83A patent/IT1162893B/it active
- 1983-07-11 WO PCT/FI1983/000053 patent/WO1984000384A1/en not_active Ceased
- 1983-07-11 DE DE8383902261T patent/DE3366962D1/de not_active Expired
- 1983-07-11 EP EP83902261A patent/EP0112888B1/de not_active Expired
- 1983-07-11 US US06/585,375 patent/US4675288A/en not_active Expired - Fee Related
- 1983-07-11 JP JP58502397A patent/JPS59501294A/ja active Pending
- 1983-07-12 DD DD83252995A patent/DD210076A5/de not_active IP Right Cessation
- 1983-08-03 CA CA000433828A patent/CA1204373A/en not_active Expired
- 1983-08-05 AU AU17618/83A patent/AU566150B2/en not_active Ceased
-
1984
- 1984-03-05 NO NO840823A patent/NO840823L/no unknown
- 1984-03-11 SU SU843715344A patent/SU1442090A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| SU1442090A3 (ru) | 1988-11-30 |
| WO1984000384A1 (en) | 1984-02-02 |
| IT8367732A0 (it) | 1983-07-05 |
| JPS59501294A (ja) | 1984-07-26 |
| AU1761883A (en) | 1985-02-07 |
| NO840823L (no) | 1984-03-05 |
| DD210076A5 (de) | 1984-05-30 |
| AU566150B2 (en) | 1987-10-08 |
| FI822473L (fi) | 1984-01-13 |
| DE3366962D1 (en) | 1986-11-20 |
| FI67404B (fi) | 1984-11-30 |
| CA1204373A (en) | 1986-05-13 |
| EP0112888A1 (de) | 1984-07-11 |
| EP0112888B1 (de) | 1986-10-15 |
| FI822473A0 (fi) | 1982-07-12 |
| IT1162893B (it) | 1987-04-01 |
| US4675288A (en) | 1987-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: LABSYSTEMS OY |