FI781966A7 - Foerfarande foer framstaellning av amilorid och andra nya 6-substituerade derivat - Google Patents

Foerfarande foer framstaellning av amilorid och andra nya 6-substituerade derivat Download PDF

Info

Publication number
FI781966A7
FI781966A7 FI781966A FI781966A FI781966A7 FI 781966 A7 FI781966 A7 FI 781966A7 FI 781966 A FI781966 A FI 781966A FI 781966 A FI781966 A FI 781966A FI 781966 A7 FI781966 A7 FI 781966A7
Authority
FI
Finland
Prior art keywords
amilorid
derivats
substituerade
nya
foerfarande foer
Prior art date
Application number
FI781966A
Other languages
English (en)
Finnish (fi)
Inventor
Jr Otto William Woltersdorf
Susan Jane De Solms
Jr Edward Jethro Cragoe
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI781966A7 publication Critical patent/FI781966A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Liquid Crystal Substances (AREA)
FI781966A 1977-06-29 1978-06-20 Foerfarande foer framstaellning av amilorid och andra nya 6-substituerade derivat FI781966A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/811,011 US4196292A (en) 1977-06-29 1977-06-29 6-Substituted amiloride derivatives

Publications (1)

Publication Number Publication Date
FI781966A7 true FI781966A7 (fi) 1978-12-30

Family

ID=25205286

Family Applications (1)

Application Number Title Priority Date Filing Date
FI781966A FI781966A7 (fi) 1977-06-29 1978-06-20 Foerfarande foer framstaellning av amilorid och andra nya 6-substituerade derivat

Country Status (12)

Country Link
US (1) US4196292A (de)
EP (1) EP0000200B1 (de)
JP (1) JPS5412389A (de)
AT (1) AT362795B (de)
DE (1) DE2861684D1 (de)
DK (1) DK290278A (de)
ES (1) ES471244A1 (de)
FI (1) FI781966A7 (de)
HU (1) HU178302B (de)
IT (1) IT1105454B (de)
NO (1) NO782230L (de)
PL (1) PL119097B1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362724A (en) * 1980-05-19 1982-12-07 Merck & Co., Inc. Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic
US4952582A (en) * 1982-01-04 1990-08-28 Beyer Jr Karl H Pyrazinoylguanidine and derivatives thereof having few polar substituents and being useful as hyperuretic agents
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
WO1990009792A1 (en) * 1989-03-03 1990-09-07 The General Hospital Corporation Topical application of amiloride or analogues thereof for treatment of inflammation
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
PE20151054A1 (es) 2012-12-17 2015-08-07 Parion Sciences Inc Derivados de cloro-pirazin carboxamida con actividad bloqueadora sobre los canales de sodio epiteliales
MX2015007797A (es) 2012-12-17 2015-10-05 Parion Sciences Inc Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida.
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB286896A (en) * 1927-03-29 1928-03-15 Arthur William Howarth Improvements in smokers' pipes
US3305552A (en) * 1965-11-22 1967-02-21 Merck & Co Inc 3-aminopyrazinoic acids and process for their preparation
US3507865A (en) * 1967-04-27 1970-04-21 Merck & Co Inc 3-hydroxy- and 3-mercaptopyrazinamidoguanidines the corresponding ethers and thioethers and processes for their preparation
US3573306A (en) * 1969-03-05 1971-03-30 Merck & Co Inc Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides

Also Published As

Publication number Publication date
DK290278A (da) 1978-12-30
DE2861684D1 (en) 1982-04-29
AT362795B (de) 1981-06-10
US4196292A (en) 1980-04-01
JPS5412389A (en) 1979-01-30
PL119097B1 (en) 1981-11-30
IT1105454B (it) 1985-11-04
NO782230L (no) 1979-01-02
IT7849984A0 (it) 1978-06-22
ES471244A1 (es) 1979-10-01
EP0000200A1 (de) 1979-01-10
EP0000200B1 (de) 1982-03-24
HU178302B (en) 1982-04-28
ATA469078A (de) 1980-11-15
PL207947A1 (pl) 1979-10-22

Similar Documents

Publication Publication Date Title
FI782880A7 (fi) Selektiva hydreringsprodukter av c-076-foereningar och av deras derivat
FI783867A7 (fi) Nya 4-hydroxi-2h-1 2-benzotiatsin-3-karboxamid-1 1-dioxider deras framstaellningsfoerfarande deras anvaendning och dessa foereningar innehaollande laekemedel
FI780801A7 (fi) Nya cefem- och cefam-kompositioner och foerfarande foer deras framstaellning
FI782530A7 (fi) Nya nitroimidazoler och foerfarande foer deras framstaellning
FI780589A7 (fi) Nya 4-acylamino-fenyl-etanolaminer
FI783590A7 (fi) Nya prostacyklinderivat och foerfarande foer deras framstaellning
FI782157A7 (fi) Foerfarande foer framstaellning av nya 1-asyl-2-cyanaziridiner
FI782481A7 (fi) Foerfarande foer framstaellning av nya organiska foereningar
FI780437A7 (fi) Foerfarande foer framstaellning av heteromonocykliska och heterobicykliska derivat av omaettad 7-acylamido-3-kefem-karboxyl-syra
FI783327A7 (fi) Foerfarande foer framstaellning av nya kemiska foereningar
FI782369A7 (fi) Selektivt n-skydd av aminoglykosider och nya selektivt skyddade aminoglykosidmellanprodukter
FI780168A7 (fi) Nya organiska foereningar deras framstaellning och anvaendning
FI782138A7 (fi) Nya indolderivat foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska foereningar
FI780029A7 (fi) Nya organiska foereningar deras framstaellning och anvaendning
FI782215A7 (fi) Nya nitrosoureafoereningar och deras framstaellningsfoerfarande
FI781779A7 (fi) Foerfarande foer framstaellning av nya nitroso-urinaemnen
FI780083A7 (fi) Nya ditienylalkylaminer och foerfarande foer deras framstaellning
FI780182A7 (fi) Nya derivat av isokinolin deras framstaellning och preparat innehaollande desamma
FI782294A7 (fi) Nya 7-alfa-metoxikefalosporiner och foerfarande foer deras framstaellning
FI782228A7 (fi) Foerfarande foer framstaellning av nya bensopyranderivat
FI782039A7 (fi) Nya 2-pyridyl- och 2-pyrimidylaminobensoesyror
FI780130A7 (fi) Nya organiska foereningar deras framstaellning och anvaendning
FI781886A7 (fi) Foerfarande foer framstaellning av nya pyridazinylhydrazoner
FI780772A7 (fi) Nya spiro-oxazolinderivat av steroider och foerfarande foer deras framstaellning
FI781520A7 (fi) Nya organiska foereningar deras framstaellning och anvaendning

Legal Events

Date Code Title Description
FD Application lapsed

Owner name: MERCK & CO INC.