FI912280L - Kiral syntes av 1-aryl-3-aminopropan-1 -oler. - Google Patents

Kiral syntes av 1-aryl-3-aminopropan-1 -oler. Download PDF

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Publication number
FI912280L
FI912280L FI912280A FI912280A FI912280L FI 912280 L FI912280 L FI 912280L FI 912280 A FI912280 A FI 912280A FI 912280 A FI912280 A FI 912280A FI 912280 L FI912280 L FI 912280L
Authority
FI
Finland
Prior art keywords
oler
synthes
aminopropan
chiral
aryl
Prior art date
Application number
FI912280A
Other languages
English (en)
Finnish (fi)
Other versions
FI912280A0 (fi
FI912280A7 (fi
Inventor
Michael Alexander Staszak
Gilbert Stanley Staten
Leland Otto Weigel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI912280A0 publication Critical patent/FI912280A0/fi
Publication of FI912280A7 publication Critical patent/FI912280A7/fi
Publication of FI912280L publication Critical patent/FI912280L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
FI912280A 1990-05-17 1991-05-10 Kiral syntes av 1-aryl-3-aminopropan-1 -oler. FI912280L (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52451290A 1990-05-17 1990-05-17

Publications (3)

Publication Number Publication Date
FI912280A0 FI912280A0 (fi) 1991-05-10
FI912280A7 FI912280A7 (fi) 1991-11-18
FI912280L true FI912280L (fi) 1991-11-18

Family

ID=24089523

Family Applications (1)

Application Number Title Priority Date Filing Date
FI912280A FI912280L (fi) 1990-05-17 1991-05-10 Kiral syntes av 1-aryl-3-aminopropan-1 -oler.

Country Status (8)

Country Link
EP (1) EP0457559A3 (de)
JP (1) JPH04226948A (de)
KR (1) KR910019960A (de)
CA (1) CA2042346A1 (de)
FI (1) FI912280L (de)
HU (1) HUT57760A (de)
IE (1) IE911677A1 (de)
IL (1) IL98108A0 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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EP0571685A1 (de) * 1992-05-27 1993-12-01 Novo Nordisk A/S Aryloxyheteroarylpropylamine, ihre Herstellung und Verwendung
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
US6090950A (en) * 1996-08-23 2000-07-18 Zeeland Chemicals, Inc. Chiral hydride complexes
US6008412A (en) * 1997-10-14 1999-12-28 Eli Lilly And Company Process to make chiral compounds
TW514634B (en) * 1997-10-14 2002-12-21 Lilly Co Eli Process to make chiral compounds
US5936124A (en) * 1998-06-22 1999-08-10 Sepacor Inc. Fluoxetine process from benzoylpropionic acid
US6025517A (en) * 1998-08-03 2000-02-15 Sepracor Inc. Fluoxetine process from benzoylacetonitrile
DE10207586A1 (de) * 2002-02-22 2003-09-11 Degussa Herstellung von N-Methyl-3-hydroxy-3-(2-thienyl)propanamin über neue carbamatgruppenhaltige Thiophenderivate als Zwischenprodukte
US7659409B2 (en) 2002-03-19 2010-02-09 Mitsubishi Chemical Corporation 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same
EP1486493A4 (de) * 2002-03-19 2007-04-04 Mitsubishi Chem Corp 3-hydroxy-3-(2-thienyl) propionsäureamid verbindung, verfahren zu deren herstellung und verfahren zur herstellung einer 3-amino-1-(2-thienyl)-1-propanolverbindung daraus
WO2003097632A1 (en) * 2002-05-20 2003-11-27 Mitsubishi Rayon Co., Ltd. Propanolamine derivatives, process for preparation of 3-n-methylamino-1-(2-thienyl)-1-propanols and process for preparation of propanolamine derivatives
DK1539673T3 (da) * 2002-07-09 2008-01-21 Lonza Ag Fremgangsmåde til fremstilling af N-monosubstituerede beta-aminoalkoholer
EP1852415B1 (de) * 2002-07-09 2009-10-07 Lonza Ag Verfahren zur Herstellung von N-Monoalkyl-Beta-Aminoalkoholen
DE10235206A1 (de) 2002-08-01 2004-02-19 Basf Ag Verfahren zur Herstellung von (S)-3-Methylmino-1-(thien-2-yl)propan-1-ol
MXPA05002114A (es) * 2002-08-27 2005-05-23 Merck Patent Gmbh Procedimientos para la hidrogenacion enantioselectiva de aminoalcoholes.
GB0221438D0 (en) * 2002-09-16 2002-10-23 Avecia Ltd Processes and compounds
US6846957B2 (en) 2002-11-22 2005-01-25 Board Of Regents, The University Of Texas System Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor
GB0229583D0 (en) * 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
DE10302595A1 (de) * 2003-01-22 2004-07-29 Basf Ag 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung
DE10345772A1 (de) 2003-10-01 2005-04-21 Basf Ag Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol
DE102004004719A1 (de) 2004-01-29 2005-08-18 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen
EP1566383A1 (de) * 2004-02-19 2005-08-24 Lonza AG Verfahren zur Herstellung von enantiomerenreinen 1-substituierten 3-Aminoalkoholen
CA2556891C (en) 2004-02-19 2012-12-18 Lonza Ag Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
CN1300137C (zh) * 2004-03-31 2007-02-14 上海医药工业研究院 (s)－(+)－n,n－二甲基－3－(1－萘氧基)－3－(2－噻吩基)丙胺的制备方法
DE102004022686A1 (de) 2004-05-05 2005-11-24 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
TWI306858B (en) * 2004-12-23 2009-03-01 Teva Pharma Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
EA200701613A1 (ru) 2005-02-21 2008-02-28 Лонца Аг Способ получения энантиомерно чистых 1-замещенных 3-аминоспиртов
WO2006096809A1 (en) 2005-03-08 2006-09-14 Teva Pharmaceutical Industries Ltd. Crystal forms of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine oxalate and the preparation thereof
TW200639162A (en) 2005-03-14 2006-11-16 Teva Pharma Pure duloxetine hydrochloride
WO2007038253A2 (en) * 2005-09-22 2007-04-05 Teva Pharmaceutical Industries Ltd. Dnt-maleate and methods of preparation thereof
EP1863782A1 (de) 2005-12-05 2007-12-12 Teva Pharmaceutical Industries Ltd. 2-(n-methyl-propanamin)-3-(2-naphthol) thiophen, eine verunreinigung von duloxetin hydrochlorid
DE102005062662A1 (de) 2005-12-23 2007-06-28 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
DE102005062661A1 (de) 2005-12-23 2007-08-16 Basf Ag Verfahren zur Herstellung von optisch aktivem (1S)-3-Chlor-(-thien-2-yl)-propan-1-ol
EP1976844A4 (de) 2006-01-06 2010-11-03 Msn Lab Ltd Verbessertes verfahren für reines duloxetin-hydrochlorid
WO2007084193A1 (en) * 2006-01-23 2007-07-26 Teva Pharmaceutical Industries Ltd. Dnt-succinate and methods of preparation thereof
WO2007086948A1 (en) * 2006-01-23 2007-08-02 Teva Pharmaceutical Industries Ltd. Dnt-fumarate and methods of preparation thereof
US20070173540A1 (en) * 2006-01-23 2007-07-26 Santiago Ini DNT-benzenesulfonate and methods of preparation thereof
CA2640212A1 (en) * 2006-02-13 2007-08-23 Teva Pharmaceutical Industries Ltd. A process for the preparation of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a duloxetine intermediate
EP1888554A2 (de) 2006-02-21 2008-02-20 Teva Pharmaceutical Industries Ltd Verfahren zur herstellung von (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamin, einem duloxetin-zwischenprodukt
HU228458B1 (en) * 2006-03-13 2013-03-28 Egis Gyogyszergyar Nyrt Duloxetine salts for producing pharmaceutical compositions
EP2044049A2 (de) 2006-07-03 2009-04-08 Ranbaxy Laboratories Limited Verfahren zur herstellung von enantiomerenreinen salzen von n-methyl-3 -( 1-naph-thaleneoxy)- 3 - (-2-thienyl)-propanamin
CN101657438A (zh) 2006-12-22 2010-02-24 斯索恩有限公司 制备度洛西汀和相关化合物的方法
EP2291181B9 (de) 2008-04-18 2013-09-11 University College Dublin National University Of Ireland, Dublin Captodiamine zur Behandlung von depressionartigen Symptomen
HU230480B1 (hu) * 2008-07-25 2016-07-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Eljárás N-metil-ariloxi-propánamin származékok előállítására
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329013B1 (de) 2008-08-27 2015-10-28 Codexis, Inc. Ketoreduktasepolypeptide zur herstellung von einem 3-aryl-3-hydroxypropanamin aus einem 3-aryl-3-ketopropanamin
CA2758736A1 (en) * 2009-01-06 2010-07-15 Alembic Pharmaceuticals Limited An improved process for the reparation of duloxetine and salts thereof
CN102822161A (zh) 2010-03-24 2012-12-12 住友精化株式会社 制造光学活性n-单烷基-3-羟基-3-芳基丙胺化合物的方法
CN116640115A (zh) * 2023-05-16 2023-08-25 浙江工业大学 一种3-甲氨基-1-(2-噻吩基)-1-丙酮盐酸盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880007433A (ko) * 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
DK630987D0 (da) * 1987-12-01 1987-12-01 Ferrosan As Aryloxyphenylpropylaminer, deres fremstilling og anvendelse
IL89854A (en) * 1988-04-08 1994-02-27 Lilly Co Eli Phenoxypropanamines, the process for their preparation and medicinal preparations containing them

Also Published As

Publication number Publication date
EP0457559A2 (de) 1991-11-21
HU911648D0 (en) 1991-11-28
KR910019960A (ko) 1991-12-19
CA2042346A1 (en) 1991-11-18
IE911677A1 (en) 1991-11-20
FI912280A0 (fi) 1991-05-10
JPH04226948A (ja) 1992-08-17
IL98108A0 (en) 1992-06-21
FI912280A7 (fi) 1991-11-18
EP0457559A3 (en) 1993-05-12
HUT57760A (en) 1991-12-30

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