FI954852L - 1,5-bentsodiatsepiinijohdannaisia, joilla on CCK- ja/tai gastriiniantagonistinen aktiivisuus - Google Patents

1,5-bentsodiatsepiinijohdannaisia, joilla on CCK- ja/tai gastriiniantagonistinen aktiivisuus Download PDF

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Publication number
FI954852L
FI954852L FI954852A FI954852A FI954852L FI 954852 L FI954852 L FI 954852L FI 954852 A FI954852 A FI 954852A FI 954852 A FI954852 A FI 954852A FI 954852 L FI954852 L FI 954852L
Authority
FI
Finland
Prior art keywords
cck
antagonistic activity
benzodiazepine derivatives
gastrin
gastrin antagonistic
Prior art date
Application number
FI954852A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI954852A0 (fi
FI954852A7 (fi
Inventor
Harry Finch
Pritom Shah
Robin Arthur Ellis Carr
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939307833A external-priority patent/GB9307833D0/en
Priority claimed from GB9406037A external-priority patent/GB9406037D0/en
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Publication of FI954852A0 publication Critical patent/FI954852A0/fi
Publication of FI954852A7 publication Critical patent/FI954852A7/fi
Publication of FI954852L publication Critical patent/FI954852L/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI954852A 1993-04-15 1994-04-13 1,5-bentsodiatsepiinijohdannaisia, joilla on CCK- ja/tai gastriiniantagonistinen aktiivisuus FI954852L (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939307833A GB9307833D0 (en) 1993-04-15 1993-04-15 Modulators of cholecystokinin and gastrin
GB9406037A GB9406037D0 (en) 1994-03-29 1994-03-29 1,5 Benzodiazepine derivatives
PCT/EP1994/001130 WO1994024151A1 (en) 1993-04-15 1994-04-13 1,5 benzodiazepine derivatives having cck and/or gastrin antagonistic activity

Publications (3)

Publication Number Publication Date
FI954852A0 FI954852A0 (fi) 1995-10-12
FI954852A7 FI954852A7 (fi) 1995-10-12
FI954852L true FI954852L (fi) 1995-10-12

Family

ID=26302765

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954852A FI954852L (fi) 1993-04-15 1994-04-13 1,5-bentsodiatsepiinijohdannaisia, joilla on CCK- ja/tai gastriiniantagonistinen aktiivisuus

Country Status (14)

Country Link
EP (1) EP0694040A1 (ja)
JP (1) JPH08508743A (ja)
CN (1) CN1120845A (ja)
AU (1) AU688316B2 (ja)
CA (1) CA2158972A1 (ja)
CZ (1) CZ267695A3 (ja)
FI (1) FI954852L (ja)
HU (1) HUT74091A (ja)
NO (1) NO954091L (ja)
NZ (1) NZ265271A (ja)
OA (1) OA10236A (ja)
PL (1) PL311083A1 (ja)
SK (1) SK125495A3 (ja)
WO (1) WO1994024151A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776929A (en) * 1993-12-28 1998-07-07 Shionogi & Co., Ltd. Benzodiazepine derivative
JP3999819B2 (ja) * 1996-12-10 2007-10-31 ゼリア新薬工業株式会社 １，５―ベンゾジアセピン誘導体
US6444849B1 (en) 1997-06-25 2002-09-03 Mitsubishi Chemical Corporation Amide derivatives
JP2000026434A (ja) 1998-06-05 2000-01-25 Zeria Pharmaceut Co Ltd 新規１，５−ベンゾジアゼピン誘導体
WO2000037434A1 (en) * 1998-12-22 2000-06-29 Mitsubishi Chemical Corporation Amide derivatives
GB201414116D0 (en) 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives
GB201513979D0 (en) 2015-08-07 2015-09-23 Trio Medicines Ltd Synthesis of benzodiazepine derivatives
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
IL295825A (en) 2020-02-28 2022-10-01 Kallyope Inc gpr40 agonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
GB9201180D0 (en) * 1992-01-21 1992-03-11 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
FI954852A0 (fi) 1995-10-12
WO1994024151A1 (en) 1994-10-27
HUT74091A (en) 1996-11-28
CN1120845A (zh) 1996-04-17
HU9502977D0 (en) 1995-12-28
AU688316B2 (en) 1998-03-12
NZ265271A (en) 1997-06-24
FI954852A7 (fi) 1995-10-12
EP0694040A1 (en) 1996-01-31
CA2158972A1 (en) 1994-10-27
PL311083A1 (en) 1996-02-05
AU6567594A (en) 1994-11-08
NO954091D0 (no) 1995-10-13
JPH08508743A (ja) 1996-09-17
CZ267695A3 (en) 1996-04-17
SK125495A3 (en) 1996-06-05
NO954091L (no) 1995-12-13
OA10236A (en) 1997-10-07

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