NO954091L - 1,5-Benzodinazepinderivater med CCK- og/eller gastrinantagonistisk aktivitet - Google Patents

1,5-Benzodinazepinderivater med CCK- og/eller gastrinantagonistisk aktivitet

Info

Publication number
NO954091L
NO954091L NO954091A NO954091A NO954091L NO 954091 L NO954091 L NO 954091L NO 954091 A NO954091 A NO 954091A NO 954091 A NO954091 A NO 954091A NO 954091 L NO954091 L NO 954091L
Authority
NO
Norway
Prior art keywords
hydrogen
cck
calkyl
alkyl
benzodinazine
Prior art date
Application number
NO954091A
Other languages
English (en)
Other versions
NO954091D0 (no
Inventor
Harry Finch
Pritom Shah
Robin Arthur Ellis Carr
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939307833A external-priority patent/GB9307833D0/en
Priority claimed from GB9406037A external-priority patent/GB9406037D0/en
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Publication of NO954091D0 publication Critical patent/NO954091D0/no
Publication of NO954091L publication Critical patent/NO954091L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Forbindelser med den generelle formel (I) og deres fysio-logisk akseptable salter hvor gruppen NRRer en 5 til 7-leddet mettet heterocyklisk ring som kan være substituert med én eller to metylgrupper; Rer Calkyl, C.cykloalkyl eller : fenyl, eventuelt substituert med 1 eller 2 halogenatomer; R» er fenyl eller fenyl substituert med én eller to grupper valgt fra halogen, Calkyl, trifluormetyl, trifluormetoksy eller (CH)Rhvor n er null eller 1, og Rer Calkoksy, hydroksy, nitro, cyano, C0R, S(0)pCH, NRR, CONRR, S0NRCO(C.alkyl), tetrazolyl, karboksamidotetrazolyl, eller 3-trifluormetyl-. ! 1,2,4-triazolyl; Rer hydrogen, C.alkyl eller benzyl; Rer j hydrogen eller Calkyl, Rer hydrogen, Calkyl, S0CHeller S0CF, X er hydrogen, C-alkyl eller halogen; m er null, 1 \ eller, og p er null, 1 eller 2; fremgangsmåter for deres i fremstilling og deres medisinske anvendelse som antagonister ! for gastrin og CCK.
NO954091A 1993-04-15 1995-10-13 1,5-Benzodinazepinderivater med CCK- og/eller gastrinantagonistisk aktivitet NO954091L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939307833A GB9307833D0 (en) 1993-04-15 1993-04-15 Modulators of cholecystokinin and gastrin
GB9406037A GB9406037D0 (en) 1994-03-29 1994-03-29 1,5 Benzodiazepine derivatives
PCT/EP1994/001130 WO1994024151A1 (en) 1993-04-15 1994-04-13 1,5 benzodiazepine derivatives having cck and/or gastrin antagonistic activity

Publications (2)

Publication Number Publication Date
NO954091D0 NO954091D0 (no) 1995-10-13
NO954091L true NO954091L (no) 1995-12-13

Family

ID=26302765

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954091A NO954091L (no) 1993-04-15 1995-10-13 1,5-Benzodinazepinderivater med CCK- og/eller gastrinantagonistisk aktivitet

Country Status (14)

Country Link
EP (1) EP0694040A1 (no)
JP (1) JPH08508743A (no)
CN (1) CN1120845A (no)
AU (1) AU688316B2 (no)
CA (1) CA2158972A1 (no)
CZ (1) CZ267695A3 (no)
FI (1) FI954852A0 (no)
HU (1) HUT74091A (no)
NO (1) NO954091L (no)
NZ (1) NZ265271A (no)
OA (1) OA10236A (no)
PL (1) PL311083A1 (no)
SK (1) SK125495A3 (no)
WO (1) WO1994024151A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1073089C (zh) * 1993-12-28 2001-10-17 盐野义制药株式会社 苯并二氮杂噁衍生物、其组合物及其在药物制备中的用途
PT945445E (pt) * 1996-12-10 2004-01-30 Zeria Pharm Co Ltd Derivados de 1,5-benzodiazepina
US6444849B1 (en) 1997-06-25 2002-09-03 Mitsubishi Chemical Corporation Amide derivatives
JP2000026434A (ja) 1998-06-05 2000-01-25 Zeria Pharmaceut Co Ltd 新規１，５−ベンゾジアゼピン誘導体
WO2000037434A1 (en) * 1998-12-22 2000-06-29 Mitsubishi Chemical Corporation Amide derivatives
GB201414116D0 (en) 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives
GB201513979D0 (en) 2015-08-07 2015-09-23 Trio Medicines Ltd Synthesis of benzodiazepine derivatives
KR20220150270A (ko) 2019-10-07 2022-11-10 칼리오페, 인크. Gpr119 효능제
TW202140440A (zh) 2020-02-28 2021-11-01 美商克力歐普股份有限公司 Gpr40激動劑

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
GB9201180D0 (en) * 1992-01-21 1992-03-11 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
HU9502977D0 (en) 1995-12-28
EP0694040A1 (en) 1996-01-31
PL311083A1 (en) 1996-02-05
OA10236A (en) 1997-10-07
AU6567594A (en) 1994-11-08
CN1120845A (zh) 1996-04-17
HUT74091A (en) 1996-11-28
AU688316B2 (en) 1998-03-12
FI954852L (fi) 1995-10-12
FI954852A7 (fi) 1995-10-12
NZ265271A (en) 1997-06-24
FI954852A0 (fi) 1995-10-12
CZ267695A3 (en) 1996-04-17
NO954091D0 (no) 1995-10-13
JPH08508743A (ja) 1996-09-17
CA2158972A1 (en) 1994-10-27
SK125495A3 (en) 1996-06-05
WO1994024151A1 (en) 1994-10-27

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