FI955537L - Fibrinolyyttiset ja hyytymistä estävät proteiinit - Google Patents

Fibrinolyyttiset ja hyytymistä estävät proteiinit Download PDF

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Publication number
FI955537L
FI955537L FI955537A FI955537A FI955537L FI 955537 L FI955537 L FI 955537L FI 955537 A FI955537 A FI 955537A FI 955537 A FI955537 A FI 955537A FI 955537 L FI955537 L FI 955537L
Authority
FI
Finland
Prior art keywords
fibrinolytic
anticoagulant proteins
anticoagulant
proteins
Prior art date
Application number
FI955537A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI955537A7 (fi
FI955537A0 (fi
Inventor
Stephan Wnendt
Regina Heinzel-Wieland
Gerd Josef Steffens
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of FI955537A0 publication Critical patent/FI955537A0/fi
Publication of FI955537A7 publication Critical patent/FI955537A7/fi
Publication of FI955537L publication Critical patent/FI955537L/fi

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121Serpins
    • C07K14/8128Antithrombin III
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/815Protease inhibitors from leeches, e.g. hirudin, eglin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • C12N2800/101Plasmid DNA for bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI955537A 1994-11-17 1995-11-16 Fibrinolyyttiset ja hyytymistä estävät proteiinit FI955537L (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4440892A DE4440892A1 (de) 1994-11-17 1994-11-17 Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften

Publications (3)

Publication Number Publication Date
FI955537A0 FI955537A0 (fi) 1995-11-16
FI955537A7 FI955537A7 (fi) 1996-05-18
FI955537L true FI955537L (fi) 1996-05-18

Family

ID=6533447

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955537A FI955537L (fi) 1994-11-17 1995-11-16 Fibrinolyyttiset ja hyytymistä estävät proteiinit

Country Status (10)

Country Link
US (1) US5976841A (fr)
EP (1) EP0712934A3 (fr)
JP (1) JPH08231594A (fr)
KR (1) KR960017687A (fr)
CA (1) CA2162986A1 (fr)
DE (1) DE4440892A1 (fr)
FI (1) FI955537L (fr)
IL (1) IL115999A0 (fr)
MX (1) MX9504686A (fr)
ZA (1) ZA959762B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892014A (en) * 1996-10-30 1999-04-06 The Regents Of The University Of California DNA encoding a protease-activated receptor 3
US5922540A (en) * 1996-12-20 1999-07-13 Eli Lilly And Company Monofunctional glycosyltransferase gene of Staphylococcus aureus
CA2376467A1 (fr) * 1999-06-12 2000-12-21 Merck Patent Gesellschaft Mit Beschraenkter Haftung Hyaluronidase provenant de <i>hirudinaria manillensis</i>, procede d'isolation, de purification et de preparation par recombinaison
DE10033195A1 (de) * 2000-07-07 2002-03-21 Aventis Pharma Gmbh Bifunktionale Fusionsproteine aus Hirudin und TAP
DK1737889T3 (da) 2004-10-19 2011-01-03 Lonza Ag Fremgangsmåde til fastfase-peptidsyntese

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187098A (en) * 1984-03-02 1993-02-16 Board Of Regents Of The University Of Oklahoma DNA encoding hybrid streptokinases with plasminogen fibrin binding domains
US5242919A (en) * 1984-08-31 1993-09-07 Otsuka Pharmaceutical Co., Ltd. 2,3-dihydro-1H-indene derivatives
DE3445517C2 (de) * 1984-12-13 1993-11-18 Ciba Geigy Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US5204255A (en) * 1986-01-31 1993-04-20 Sagami Chemical Research Center Hybrid tissue plasminogen activator/urokinase polypeptides
US5002887A (en) * 1986-01-31 1991-03-26 Genetics Institute, Inc. Truncated thrombolytic proteins
US5194589A (en) * 1986-09-18 1993-03-16 Pennsylvania Hospital Leech protein having anticoagulant and antimetastatic properties
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same
EP0330700B1 (fr) * 1987-08-19 1993-12-22 Sagami Chemical Research Center Polypeptide ressemblant à la prourokinase humaine
DE3804600A1 (de) * 1988-02-13 1989-08-24 Basf Ag Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz
GB8809093D0 (en) * 1988-04-18 1988-05-18 Erba Carlo Spa Low molecular weight derivatives of prourokinase
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
IL86856A0 (en) * 1988-06-24 1988-11-30 Yissum Res Dev Co Bovine xa factor and pharmaceutical compositions containing the same
GB8822147D0 (en) * 1988-09-21 1988-10-26 Ciba Geigy Ag Pharmaceutically active combination
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
IE901849A1 (en) * 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
EP0482069A1 (fr) * 1989-07-20 1992-04-29 Biogen, Inc. Combinaisons et procedes de traitement ou de prevention de maladies thrombotiques
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
US5189019A (en) * 1990-04-23 1993-02-23 Merck & Co., Inc. Antistasin derived anticoagulant protein
US5328898A (en) * 1990-06-22 1994-07-12 Duke University Factor XIIIA fibrin binding fragments
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5688768A (en) * 1991-02-19 1997-11-18 Cor Therapeutics, Inc. Recombinant thrombin receptor and related pharmaceuticals
US5183672A (en) * 1991-04-16 1993-02-02 Gary W. Fetterhoff Apparatus for forming at least one fold line pattern in a rigid plastic material
DE4137996A1 (de) * 1991-11-19 1993-05-27 Behringwerke Ag Verfahren zur herstellung eines virussicheren thrombinkonzentrates
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
DE69429858D1 (de) * 1993-04-09 2002-03-21 Bio Technology General Corp Herstellung eines rekombinanten inhibitors des faktors xa des blutegels hirudo medicinalis
US5571708A (en) * 1993-04-19 1996-11-05 Bristol-Myers Squibb Company Thrombin-activatable plasminogen activator
DE4323754C1 (de) * 1993-07-15 1994-12-01 Gruenenthal Gmbh Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung
DE4442665A1 (de) * 1994-11-30 1996-06-05 Gruenenthal Gmbh Chimäre Proteine mit fibrinolytischen und thrombinhemmenden Eigenschaften

Also Published As

Publication number Publication date
EP0712934A3 (fr) 2000-08-23
EP0712934A2 (fr) 1996-05-22
IL115999A0 (en) 1996-01-31
CA2162986A1 (fr) 1996-05-18
KR960017687A (ko) 1996-06-17
MX9504686A (es) 1997-04-30
JPH08231594A (ja) 1996-09-10
DE4440892A1 (de) 1996-05-23
FI955537A7 (fi) 1996-05-18
ZA959762B (en) 1996-09-30
US5976841A (en) 1999-11-02
FI955537A0 (fi) 1995-11-16

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