FI970148L - Heterosyklisten yhdisteiden käyttö dopamiini-D3-ligandeina - Google Patents

Heterosyklisten yhdisteiden käyttö dopamiini-D3-ligandeina Download PDF

Info

Publication number
FI970148L
FI970148L FI970148A FI970148A FI970148L FI 970148 L FI970148 L FI 970148L FI 970148 A FI970148 A FI 970148A FI 970148 A FI970148 A FI 970148A FI 970148 L FI970148 L FI 970148L
Authority
FI
Finland
Prior art keywords
dopamine
ligands
heterocyclic compounds
heterocyclic
compounds
Prior art date
Application number
FI970148A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI970148A0 (fi
FI970148A7 (fi
Inventor
Beate Hellendahl
Annegret Lansky
Beatrice Rendenbach-Mueller
Alfred Bach
Liliane Unger
Hans-Juergen Teschendorf
Karsten Wicke
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of FI970148A0 publication Critical patent/FI970148A0/fi
Publication of FI970148A7 publication Critical patent/FI970148A7/fi
Publication of FI970148L publication Critical patent/FI970148L/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
FI970148A 1994-07-15 1995-07-14 Heterosyklisten yhdisteiden käyttö dopamiini-D3-ligandeina FI970148L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4425146A DE4425146A1 (de) 1994-07-15 1994-07-15 Verwendung heterocyclischer Verbindungen
PCT/EP1995/002782 WO1996002246A1 (de) 1994-07-15 1995-07-14 Verwendung heterocyclischer verbindungen als dopamin-d3 liganden

Publications (3)

Publication Number Publication Date
FI970148A0 FI970148A0 (fi) 1997-01-14
FI970148A7 FI970148A7 (fi) 1997-01-14
FI970148L true FI970148L (fi) 1997-01-14

Family

ID=6523325

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970148A FI970148L (fi) 1994-07-15 1995-07-14 Heterosyklisten yhdisteiden käyttö dopamiini-D3-ligandeina

Country Status (22)

Country Link
US (1) US6090807A (cs)
EP (1) EP0771197B1 (cs)
JP (1) JPH10502658A (cs)
KR (2) KR100443850B1 (cs)
CN (2) CN1152870A (cs)
AT (1) ATE236629T1 (cs)
AU (1) AU704839B2 (cs)
BG (1) BG63487B1 (cs)
BR (1) BR9508296A (cs)
CA (1) CA2195242A1 (cs)
CZ (1) CZ293126B6 (cs)
DE (2) DE4425146A1 (cs)
DK (1) DK0771197T3 (cs)
ES (1) ES2196072T3 (cs)
FI (1) FI970148L (cs)
HU (1) HUT77608A (cs)
MX (1) MX9700430A (cs)
NO (1) NO311683B1 (cs)
NZ (1) NZ290388A (cs)
PT (1) PT771197E (cs)
SI (1) SI9520084B (cs)
WO (1) WO1996002246A1 (cs)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114334A (en) * 1995-07-13 2000-09-05 Knoll Aktiengesellschaft Piperazine derivatives as therapeutic agents
DE19600934A1 (de) 1996-01-12 1997-07-17 Basf Ag Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
WO1997043262A1 (en) * 1996-05-11 1997-11-20 Smithkline Beecham P.L.C. Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors
CA2263284A1 (en) * 1996-08-14 1998-02-19 Smithkline Beecham P.L.C. Tetrahydroisoquinoline derivatives and their pharmaceutical use
GB9708694D0 (en) * 1997-04-30 1997-06-18 Smithkline Beecham Plc Compounds
GB9708805D0 (en) * 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9709303D0 (en) * 1997-05-09 1997-06-25 Smithkline Beecham Plc Compounds
DE19728996A1 (de) 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
TW530054B (en) 1997-09-24 2003-05-01 Duphar Int Res New piperazine and piperidine compounds
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
US6218396B1 (en) * 1998-02-20 2001-04-17 Orth-Mcneil Pharmaceutical, Inc. Substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
WO2000021951A1 (en) 1998-10-08 2000-04-20 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
ATE400251T1 (de) 1999-02-09 2008-07-15 Pfizer Prod Inc Zusammensetzungen basischer arzneistoffe mit verbesserter bioverfügbarkeit
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
GB9923748D0 (en) * 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
US6365591B1 (en) 1999-10-18 2002-04-02 Recordati, S.A., Chemical And Pharmacueticals Company Isoxazolecarboxamide derivatives
IT1314191B1 (it) * 1999-10-18 2002-12-06 Recordati Chem Pharm Derivati isossazolcarbossamidici
ATE402704T1 (de) * 2000-03-27 2008-08-15 Abbott Gmbh & Co Kg Dopamin-d3-rezeptor-liganden zur behandlung von sucht
GB0025354D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
GB0117577D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
GB0108594D0 (en) * 2001-04-05 2001-05-23 Glaxo Group Ltd Chemical compounds
HUP0103987A3 (en) * 2001-09-28 2004-11-29 Richter Gedeon Vegyeszet Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates
WO2003066589A1 (en) * 2002-02-08 2003-08-14 Glaxo Group Limited Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases
GB0203020D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
GB0203022D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
KR20050075281A (ko) * 2002-07-04 2005-07-20 쉬바르츠파르마에이지 씨엔에스 질병의 치료를 위한 도파민-디3 리간드로서헤테로아렌 카복스아미드의 용도
DE10232020A1 (de) * 2002-07-04 2004-02-26 Friedrich-Alexander-Universität Erlangen-Nürnberg Neurorezeptoraktive Heteroarencarboxamide
TW200507841A (en) * 2003-03-27 2005-03-01 Glaxo Group Ltd Antibacterial agents
DE10315569A1 (de) * 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazolverbindungen
US7320979B2 (en) * 2003-04-14 2008-01-22 Abbott Gmbh & Co. Kg. N-[(piperazinyl)hetaryl]arylsulfonamide compounds
US20040204422A1 (en) 2003-04-14 2004-10-14 Abbott Gmbh & Co. Kg. N-[(Piperazinyl)hetaryl]arylsulfonamide compounds
DE10358004A1 (de) 2003-12-11 2005-07-14 Abbott Gmbh & Co. Kg Ketolactam-Verbindungen und ihre Verwendung
MXPA06006858A (es) 2003-12-18 2006-09-04 Abbott Gmbh & Co Kg Tetrahidrobenzacepinas y su uso en la modulacion del receptor d3 de la dopamina.
US20050137186A1 (en) 2003-12-18 2005-06-23 Abbott Gmbh & Co. Kg. Tetrahydrobenzazepines and their use
DE102004027358A1 (de) 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidinverbindungen und ihre Verwendung
DE102004027359A1 (de) 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyridin-2-onverbindungen und deren Verwendung
ES2340941T3 (es) 2004-08-09 2010-06-11 ABBOTT GMBH & CO. KG Compuestos de 4-piperazinil-pirimidina adecuados para tretar trastornos que responden a modulacion del receptor d 3 de dopamina.
WO2006072608A2 (en) * 2005-01-03 2006-07-13 Universitá Degli Studi Di Siena Aryl piperazine derivatives for the treatment of neuropsychiatric disorders
US7511035B2 (en) * 2005-01-25 2009-03-31 Glaxo Group Limited Antibacterial agents
PA8802101A1 (es) 2007-11-02 2009-08-26 Abbott Gmbh & Co Kg Compuestos de 1,2,4-3,5-diona adecuados para el tratamiento de trastornos que responden a la modulación del receptor de dopamina d3
WO2009095438A1 (en) * 2008-02-01 2009-08-06 Neurosearch A/S Novel aryl piperazine derivatives useful as modulators of dopamine and serotonin receptors
CN102264733B (zh) * 2008-10-10 2014-07-30 中国人民解放军军事医学科学院毒物药物研究所 新型多巴胺d3受体配体，其制备方法及其医药用途
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
AU2010270797B2 (en) 2009-07-08 2015-03-19 Dermira (Canada), Inc. TOFA analogs useful in treating dermatological disorders or conditions
US8609672B2 (en) 2010-08-27 2013-12-17 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
US20130289047A1 (en) * 2010-10-14 2013-10-31 Epiomed Therapeutics, Inc. Heteroarylthio derivatives and analogues
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
CN102408397B (zh) 2011-10-19 2014-08-20 上海贝美医药科技有限公司 紫杉烷类衍生物及其制备方法
EP4469453A1 (en) 2022-01-29 2024-12-04 Suven Life Sciences Limited Benzoisothiazole and benzoisoxazole compounds for the treatment of mental disorders

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
DE1620016C3 (de) * 1966-07-02 1979-08-30 Merck Patent Gmbh, 6100 Darmstadt 3-{Piperazinoalkyl)-pyrazole und Verfahren zu ihrer Herstellung
DE2060816C3 (de) * 1970-12-10 1980-09-04 Merck Patent Gmbh, 6100 Darmstadt 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen
DE2110568A1 (de) * 1971-03-05 1972-09-07 Merck Patent Gmbh Neue N-Acyl-(piperazinoalkyl)-pyrazole
DE2213808A1 (de) * 1972-03-22 1973-09-27 Merck Patent Gmbh Verfahren zur herstellung von 3-(piperazinoalkyl)-pyrazolen
DE2258033A1 (de) * 1972-11-27 1974-05-30 Merck Patent Gmbh Verfahren zur herstellung von pyrazolderivaten
DE2513940A1 (de) * 1975-03-29 1976-10-14 Merck Patent Gmbh Pharmazeutische zubereitung
US4123529A (en) * 1976-04-23 1978-10-31 Lilly Industries Limited Phenylpiperazine derivatives
US4404382A (en) * 1980-09-17 1983-09-13 The Upjohn Company Piperazinyl-substituted imidazoles
US5254552A (en) * 1988-05-24 1993-10-19 American Home Products Corporation Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity
MX9201991A (es) * 1991-05-02 1992-11-01 Jonh Wyeth & Brother Limited Derivados de piperazina y procedimiento para su preparacion.
FR2682953B1 (fr) * 1991-10-23 1995-04-21 Inst Nat Sante Rech Med Nouveaux derives de naphtamides, leur procede de preparation et leur application dans le domaine therapeutique.
HRP930210A2 (en) * 1992-02-25 1995-06-30 Recordati Chem Pharm Heterobicyclic compounds and pharmaceutical preparations containing them
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
US5395835A (en) * 1994-03-24 1995-03-07 Warner-Lambert Company Naphthalamides as central nervous system agents

Also Published As

Publication number Publication date
HUT77608A (hu) 1998-06-29
DK0771197T3 (da) 2003-06-23
FI970148A0 (fi) 1997-01-14
BG63487B1 (bg) 2002-03-29
AU704839B2 (en) 1999-05-06
NZ290388A (en) 2001-04-27
CZ293126B6 (cs) 2004-02-18
FI970148A7 (fi) 1997-01-14
ATE236629T1 (de) 2003-04-15
MX9700430A (es) 1998-05-31
CN1152870A (zh) 1997-06-25
KR20040000412A (ko) 2004-01-03
DE4425146A1 (de) 1996-01-18
BG101112A (bg) 1998-04-30
NO970163L (no) 1997-03-14
US6090807A (en) 2000-07-18
DE59510635D1 (de) 2003-05-15
CZ9697A3 (en) 1997-08-13
BR9508296A (pt) 1998-05-19
PT771197E (pt) 2003-08-29
CA2195242A1 (en) 1996-02-01
NO311683B1 (no) 2002-01-07
WO1996002246A1 (de) 1996-02-01
JPH10502658A (ja) 1998-03-10
EP0771197B1 (de) 2003-04-09
SI9520084B (sl) 2005-02-28
KR970704435A (ko) 1997-09-06
KR100443850B1 (ko) 2004-08-11
NO970163D0 (no) 1997-01-14
CN1534023A (zh) 2004-10-06
HU9700111D0 (en) 1997-02-28
AU3111495A (en) 1996-02-16
ES2196072T3 (es) 2003-12-16
EP0771197A1 (de) 1997-05-07
SI9520084A (en) 1997-08-31

Similar Documents

Publication Publication Date Title
FI970148L (fi) Heterosyklisten yhdisteiden käyttö dopamiini-D3-ligandeina
FI962749L (fi) Uusia heterosyklisiä yhdisteitä
FI970147A7 (fi) Triatsoliyhdisteitä ja niiden käyttö dopamiini-D3-ligandeina
IS2027B (is) Ný spíróasabísýklísk heterósýklísk efnasambönd
FI956232A7 (fi) Heterosyklisiä karbeeneja sisältäviä metallikompleksiyhdisteitä
FI962800L (fi) Fenyyliheterosyklisiä yhdisteitä COX-2 inhibiittoreina
FI950800L (fi) Menetelmä heterosyklisten yhdisteiden sulfinyloimiseksi
DK154192D0 (da) Heterocycliske forbindelser
ID24372A (id) SENYAWA-SENYAWA 4-AMINO-TIAZOL-2-IL SEBAGAI PENGHAMBAT-PENGHAMBAT CDKs
FI20001406A7 (fi) Terapeuttisia heterosyklisiä yhdisteitä
FI913048A7 (fi) Bisykliset heterosykliset yhdisteet
FI970149A7 (fi) Tiatsoli- ja tiadiatsoliyhdisteiden käyttö D3-reseptoriligandeina
DK0820451T3 (da) Hidtil ukendte heterocykliske forbindelser
FI973207A7 (fi) Heterosyklisiä yhdisteitä
FI914910A7 (fi) Heterosyklisiä yhdisteitä
DE69531522D1 (de) Heterozyklische Verbindungen
FI924071A7 (fi) Heterocykliska foereningar
FI931204A7 (fi) Uusia aminobentsosultaamijohdannaisia lipo-oksigenaasin estäjinä
FI970110A7 (fi) Helico-bakteerin vastaisia heterosyklisiä atsolonijohdannaisia
FI963531A7 (fi) Kinoliini-3-karboksamidiyhdisteiden uusi käyttö
EE9600160A (et) Kinoliin-3-karboksamiidi ühendite kasutamine uuel otstarbel
FI955818A0 (fi) Uudet heterosykliset amidit
FI955933A7 (fi) Abeo-ergoliinijohdannaiset 5HT1A-ligandeina
NO995430D0 (no) Nye heterosykliske forbindelser
SE9402122D0 (sv) Heterocyclic compounds

Legal Events

Date Code Title Description
MA Patent expired