FR10C0045I2 - Derive halogene antimitotique d'alcaloide de vinca - Google Patents

Derive halogene antimitotique d'alcaloide de vinca

Info

Publication number
FR10C0045I2
FR10C0045I2 FR10C0045C FR10C0045C FR10C0045I2 FR 10C0045 I2 FR10C0045 I2 FR 10C0045I2 FR 10C0045 C FR10C0045 C FR 10C0045C FR 10C0045 C FR10C0045 C FR 10C0045C FR 10C0045 I2 FR10C0045 I2 FR 10C0045I2
Authority
FR
France
Prior art keywords
antimitotic
vinca alkaloid
halogen
derivative
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR10C0045C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Publication of FR10C0045I1 publication Critical patent/FR10C0045I1/fr
Application granted granted Critical
Publication of FR10C0045I2 publication Critical patent/FR10C0045I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
FR10C0045C 1997-04-10 2010-09-27 Derive halogene antimitotique d'alcaloide de vinca Active FR10C0045I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9704398A FR2761990B1 (fr) 1997-04-10 1997-04-10 Derives halogenes antimitotiques d'alcaloides de vinca
EP98920607A EP0975640B1 (fr) 1997-04-10 1998-04-10 Derives halogenes antimitotiques d'alcaloides de vinca
EP20030017052 EP1357125A3 (fr) 1997-04-10 1998-04-10 Procédé de préparation de dérivés halogénés d'alcaloides de vinca

Publications (2)

Publication Number Publication Date
FR10C0045I1 FR10C0045I1 (fr) 2010-10-29
FR10C0045I2 true FR10C0045I2 (fr) 2011-04-29

Family

ID=9505731

Family Applications (2)

Application Number Title Priority Date Filing Date
FR9704398A Expired - Lifetime FR2761990B1 (fr) 1997-04-10 1997-04-10 Derives halogenes antimitotiques d'alcaloides de vinca
FR10C0045C Active FR10C0045I2 (fr) 1997-04-10 2010-09-27 Derive halogene antimitotique d'alcaloide de vinca

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR9704398A Expired - Lifetime FR2761990B1 (fr) 1997-04-10 1997-04-10 Derives halogenes antimitotiques d'alcaloides de vinca

Country Status (15)

Country Link
US (1) US6127377A (fr)
EP (3) EP0975640B1 (fr)
JP (3) JP4401440B2 (fr)
AT (2) ATE270297T1 (fr)
AU (1) AU737549C (fr)
BR (2) BR9816177B1 (fr)
CA (3) CA2455416C (fr)
CY (2) CY1111476T1 (fr)
DE (3) DE69824840T2 (fr)
DK (2) DK1764368T3 (fr)
ES (2) ES2222588T3 (fr)
FR (2) FR2761990B1 (fr)
LU (1) LU91769I2 (fr)
PT (2) PT1764368E (fr)
WO (1) WO1998045301A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca
US6890558B2 (en) * 2002-05-31 2005-05-10 R.P. Scherer Technologies, Inc. Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
EP1694330A4 (fr) * 2003-12-04 2009-06-24 Amr Technology Inc Derives de la vinorelbine
NZ547370A (en) * 2003-12-04 2010-09-30 Amr Technology Inc Vinca derivatives
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
FR2894966B1 (fr) * 2005-12-20 2008-03-14 Pierre Fabre Medicament Sa Nouvelle forme cristalline de la vinflunine
CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
WO2008033935A2 (fr) * 2006-09-12 2008-03-20 Amr Technology, Inc. Dérivés de la vinorelbine
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives
FR2905949B1 (fr) 2006-09-20 2008-11-21 Pierre Fabre Medicament Sa Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca
FR2910812B1 (fr) * 2006-12-29 2009-03-20 Pierre Fabre Medicament Sa Compositions pharmaceutiques injectables lyophilisees de derives hemi-synthetiques d'alcaloide de vinca stables a temperature ambiante
FR2912406B1 (fr) 2007-02-13 2009-05-08 Pierre Fabre Medicament Sa Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
FR2918566B1 (fr) * 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
US20090076055A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched vinflunine
DE102010020994B4 (de) * 2010-01-27 2022-01-27 Interpane Entwicklungs-Und Beratungsgesellschaft Mbh Verfahren zur Herstellung eines beschichteten Gegenstands mit Texturätzen
US9284350B2 (en) 2010-02-12 2016-03-15 Pharmascience Inc. IAP BIR domain binding compounds
US8940754B2 (en) 2010-02-22 2015-01-27 The Scripps Research Institute 10′-fluorinated Vinca alkaloids provide enhanced biological activity against MDR cancer cells
WO2026064520A1 (fr) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Conjugués médicamenteux à induction covalente ciblant kras et comprenant une charge utile inhibitrice de tubuline
WO2026064527A1 (fr) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Conjugués médicamenteux à induction covalente ciblant kras comprenant une charge utile d'inhibiteur de tubuline

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707988B1 (fr) * 1993-07-21 1995-10-13 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca

Also Published As

Publication number Publication date
US6127377A (en) 2000-10-03
BR9807944A (pt) 2000-03-08
CY1111476T1 (el) 2012-01-25
AU737549B2 (en) 2001-08-23
JP4401440B2 (ja) 2010-01-20
BR9816177B1 (pt) 2010-08-24
JP2004277418A (ja) 2004-10-07
CA2665949A1 (fr) 1998-10-15
JP2009167196A (ja) 2009-07-30
CA2286560A1 (fr) 1998-10-15
FR2761990B1 (fr) 1999-06-25
JP4307292B2 (ja) 2009-08-05
CY2010019I2 (el) 2012-01-25
EP0975640B1 (fr) 2004-06-30
PT1764368E (pt) 2010-09-16
DE69824840D1 (de) 2004-08-05
EP1764368A1 (fr) 2007-03-21
DE69824840T2 (de) 2005-07-21
EP0975640A1 (fr) 2000-02-02
CA2665949C (fr) 2013-06-11
AU7340898A (en) 1998-10-30
PT975640E (pt) 2004-11-30
ES2347878T3 (es) 2010-11-22
JP2001518892A (ja) 2001-10-16
DE122010000054I1 (de) 2011-05-05
CA2455416C (fr) 2010-11-02
LU91769I2 (fr) 2011-02-22
DE69841766D1 (de) 2010-08-26
WO1998045301A1 (fr) 1998-10-15
BR9807944B1 (pt) 2011-02-08
FR10C0045I1 (fr) 2010-10-29
EP1357125A2 (fr) 2003-10-29
AU737549C (en) 2002-03-28
CA2455416A1 (fr) 1998-10-15
ATE270297T1 (de) 2004-07-15
CY2010019I1 (el) 2012-01-25
DK1764368T3 (da) 2010-10-18
DK0975640T3 (da) 2004-11-01
FR2761990A1 (fr) 1998-10-16
CA2286560C (fr) 2009-09-08
ATE473987T1 (de) 2010-07-15
EP1764368B1 (fr) 2010-07-14
EP1357125A3 (fr) 2003-11-26
ES2222588T3 (es) 2005-02-01

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