FR15C0049I2 - Dérivés de 4-phenylpyridine et leur utilisation comme antagonistes du recepteur NK-1 - Google Patents

Dérivés de 4-phenylpyridine et leur utilisation comme antagonistes du recepteur NK-1

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Publication number
FR15C0049I2
FR15C0049I2 FR15C0049C FR15C0049C FR15C0049I2 FR 15C0049 I2 FR15C0049 I2 FR 15C0049I2 FR 15C0049 C FR15C0049 C FR 15C0049C FR 15C0049 C FR15C0049 C FR 15C0049C FR 15C0049 I2 FR15C0049 I2 FR 15C0049I2
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Prior art keywords
receptor antagonists
phenylpyridine derivatives
phenylpyridine
derivatives
antagonists
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FR15C0049C
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English (en)
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of FR15C0049I1 publication Critical patent/FR15C0049I1/fr
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    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR15C0049C 1999-02-24 2015-07-08 Dérivés de 4-phenylpyridine et leur utilisation comme antagonistes du recepteur NK-1 Active FR15C0049I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99103504 1999-02-24
EP99123689 1999-11-29
EP00102260A EP1035115B1 (fr) 1999-02-24 2000-02-15 Dérivés de 4-phenylpyridine et leur utilisation comme antagonistes du recepteur NK-1

Publications (2)

Publication Number Publication Date
FR15C0049I1 FR15C0049I1 (fr) 2015-08-28
FR15C0049I2 true FR15C0049I2 (fr) 2016-02-12

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FR0002170A Expired - Fee Related FR2790473B1 (fr) 1999-02-24 2000-02-22 Nouveaux composes et medicaments les contenant
FR15C0049C Active FR15C0049I2 (fr) 1999-02-24 2015-07-08 Dérivés de 4-phenylpyridine et leur utilisation comme antagonistes du recepteur NK-1

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Application Number Title Priority Date Filing Date
FR0002170A Expired - Fee Related FR2790473B1 (fr) 1999-02-24 2000-02-22 Nouveaux composes et medicaments les contenant

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US (2) US6297375B1 (fr)
EP (2) EP1035115B1 (fr)
JP (1) JP3399900B2 (fr)
KR (1) KR100384904B1 (fr)
CN (1) CN1142144C (fr)
AR (2) AR029614A1 (fr)
AT (2) ATE496032T1 (fr)
AU (1) AU767048B2 (fr)
BE (1) BE2015C057I2 (fr)
BG (1) BG64554B1 (fr)
BR (1) BRPI0000908B8 (fr)
CA (1) CA2299139C (fr)
CY (3) CY1111317T1 (fr)
CZ (1) CZ300596B6 (fr)
DE (3) DE60014216T2 (fr)
DK (2) DK1394150T3 (fr)
EA (1) EA003673B1 (fr)
EG (1) EG23817A (fr)
ES (3) ES2226622T3 (fr)
FR (2) FR2790473B1 (fr)
GB (1) GB2347422A (fr)
GE (1) GEP20022676B (fr)
GT (1) GT200000017A (fr)
HR (2) HRP20000097B1 (fr)
HU (1) HU227629B1 (fr)
IL (1) IL134654A (fr)
IS (1) IS2116B (fr)
IT (1) IT1320763B1 (fr)
JO (1) JO2294B1 (fr)
LT (1) LTC1035115I2 (fr)
LU (1) LU92745I2 (fr)
MA (1) MA26722A1 (fr)
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MY (2) MY123648A (fr)
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UA (1) UA71547C2 (fr)
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US6291465B1 (en) * 1999-03-09 2001-09-18 Hoffmann-La Roche Inc. Biphenyl derivatives
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JP3938651B2 (ja) * 2000-04-13 2007-06-27 セントラル硝子株式会社 光学活性α−メチル−ビス−3、5−(トリフルオロメチル)ベンジルアミンの製造方法
CN1178917C (zh) * 2000-07-14 2004-12-08 弗·哈夫曼-拉罗切有限公司 作为nk1受体拮抗剂前药的4-苯基-吡啶衍生物的n-氧化物
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
AU2002216085B8 (en) * 2000-12-14 2006-03-02 F. Hoffmann-La Roche Ag Self Emulsifying Lipid Matrix (SELM)
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MXPA03009720A (es) * 2001-04-23 2004-01-29 Hoffmann La Roche USO DE ANTAGONISTAS DEL RECEPTOR DE NK-1 PARA TRATAMIENTO O PREVENCIoN DE HIPERPLASIA PROSTATICA BENIGNA.
ES2357808T3 (es) * 2001-06-07 2011-04-29 Christine Dr. Sang Tratamiento del dolor neuropático con antagonistas del receptor de n-metil-d-aspartato (nmda).
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
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PT1427397E (pt) * 2001-09-10 2008-03-24 Hoffmann La Roche Formulações tixotrópicas oleosas
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
JP2006508061A (ja) 2002-09-20 2006-03-09 ファイザー・プロダクツ・インク エストロゲン受容体に対するアミドおよびスルホンアミドリガンド
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SI1035115T1 (en) 2005-02-28
SK287911B6 (sk) 2012-03-02
CA2299139A1 (fr) 2000-08-24
NO315554B1 (no) 2003-09-22
JP2000247957A (ja) 2000-09-12
HRP20000097A2 (en) 2001-10-31
HU227629B1 (en) 2011-10-28
EA003673B1 (ru) 2003-08-28
TR200000520A3 (tr) 2001-06-21
TNSN00032A1 (fr) 2005-11-10
NZ502948A (en) 2001-09-28
YU9500A (sh) 2002-11-15
IS2116B (is) 2006-06-15
MY123648A (en) 2006-05-31
GEP20022676B (en) 2002-04-25
IS5381A (is) 2000-08-25
HUP0000748A2 (en) 2001-03-28
CZ2000609A3 (cs) 2001-01-17
NO20000885L (no) 2000-08-25
EP1035115B1 (fr) 2004-09-29
BR0000908B1 (pt) 2013-09-24
FR2790473A1 (fr) 2000-09-08
EG23817A (en) 2007-09-19
CA2299139C (fr) 2011-03-29
BG104187A (en) 2000-11-30
NO20000885D0 (no) 2000-02-23

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