FR19C1042I2 - Derive de morphinane substitue par un carbamoyle en position 7 et ayant une insauration en position 6,7 - Google Patents

Derive de morphinane substitue par un carbamoyle en position 7 et ayant une insauration en position 6,7

Info

Publication number
FR19C1042I2
FR19C1042I2 FR19C1042C FR19C1042C FR19C1042I2 FR 19C1042 I2 FR19C1042 I2 FR 19C1042I2 FR 19C1042 C FR19C1042 C FR 19C1042C FR 19C1042 C FR19C1042 C FR 19C1042C FR 19C1042 I2 FR19C1042 I2 FR 19C1042I2
Authority
FR
France
Prior art keywords
insauration
carbamoyl
derivative substituted
morphinane derivative
morphinane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR19C1042C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of FR19C1042I1 publication Critical patent/FR19C1042I1/fr
Application granted granted Critical
Publication of FR19C1042I2 publication Critical patent/FR19C1042I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR19C1042C 2005-05-25 2019-06-20 Derive de morphinane substitue par un carbamoyle en position 7 et ayant une insauration en position 6,7 Active FR19C1042I2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005151864 2005-05-25
JP2006065762 2006-03-10
PCT/JP2006/310231 WO2006126529A1 (fr) 2005-05-25 2006-05-23 Derive de morphinane substitue en position 7 par un carbamoyle et insature en positions 6 et 7
PCT/JP2006/310454 WO2006126637A1 (fr) 2005-05-25 2006-05-25 Dérivé de morphinane substitué par un carbamoyle en position 7 et ayant une insauration en position 6,7

Publications (2)

Publication Number Publication Date
FR19C1042I1 FR19C1042I1 (fr) 2019-08-09
FR19C1042I2 true FR19C1042I2 (fr) 2020-06-19

Family

ID=37451954

Family Applications (1)

Application Number Title Priority Date Filing Date
FR19C1042C Active FR19C1042I2 (fr) 2005-05-25 2019-06-20 Derive de morphinane substitue par un carbamoyle en position 7 et ayant une insauration en position 6,7

Country Status (20)

Country Link
US (4) USRE46365E1 (fr)
EP (1) EP1889848B8 (fr)
JP (1) JP4323547B2 (fr)
KR (1) KR100912782B1 (fr)
CN (1) CN101228172B (fr)
AU (1) AU2006250390B2 (fr)
BE (1) BE2019C533I2 (fr)
BR (1) BRPI0610343B8 (fr)
CA (1) CA2609733C (fr)
DK (1) DK1889848T3 (fr)
ES (1) ES2525215T3 (fr)
FR (1) FR19C1042I2 (fr)
HU (1) HUS1900034I1 (fr)
MX (1) MX2007014588A (fr)
NL (1) NL300996I2 (fr)
PL (1) PL1889848T3 (fr)
PT (1) PT1889848E (fr)
RU (1) RU2403255C2 (fr)
TW (1) TWI311056B (fr)
WO (2) WO2006126529A1 (fr)

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WO2006126529A1 (fr) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. Derive de morphinane substitue en position 7 par un carbamoyle et insature en positions 6 et 7
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
JP5714910B2 (ja) * 2008-01-09 2015-05-07 チャールストン ラボラトリーズ，インコーポレイテッド 薬学的組成物
JP5252391B2 (ja) * 2008-02-21 2013-07-31 学校法人北里研究所 オキサビシクロ［２．２．２］オクタンを有するモルヒナン誘導体およびその医薬用途
CA2734333A1 (fr) * 2008-09-16 2010-03-25 Nektar Therapeutics Opioides pegyles dont le potentiel d'usage abusif est faible
JP5797655B2 (ja) * 2009-09-18 2015-10-21 アドラー・コーポレーション 消化管障害のためのオピオイド受容体アンタゴニストの使用
CN102906099A (zh) * 2010-05-13 2013-01-30 株式会社绿十字 作为神经保护剂的基于(+)-3-羟基吗啡喃的多环衍生物
RU2643807C1 (ru) * 2010-11-12 2018-02-06 Сионоги Энд Ко., Лтд. Кристаллы производных 6,7-ненасыщенного-7-карбамоилморфинана и способ их получения
CA2873961C (fr) 2012-05-14 2017-09-26 Shionogi & Co., Ltd. Preparation contenant un derive de 7-carbamoylmorphinane 6,7-insature
CN110325178B (zh) * 2016-12-26 2022-05-13 盐野义制药株式会社 改善含量均一性的制剂的制造方法
CN112312910A (zh) 2018-04-12 2021-02-02 莫菲克医疗股份有限公司 人整合素α4β7拮抗剂
KR102201609B1 (ko) 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
AU2020366435A1 (en) 2019-10-16 2022-04-21 Morphic Therapeutic, Inc. Inhibiting human integrin α4β7
JP7582961B2 (ja) 2019-11-20 2024-11-13 塩野義製薬株式会社 ６，７－不飽和－７－カルバモイルモルヒナン誘導体含有固形製剤
CN111905111B (zh) * 2020-09-16 2023-03-31 地奥集团成都药业股份有限公司 一种评价复方谷氨酰胺组方对腹泻型肠易激综合征疗效的方法
IT202300009864A1 (it) 2023-05-16 2024-11-16 Procos Spa Processo per la preparazione di naldemedina
CN121534059A (zh) * 2024-08-09 2026-02-17 盐野义有限公司 一种治疗帕金森综合征或帕金森病的方法和药物组合物

Family Cites Families (30)

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Publication number Priority date Publication date Assignee Title
US4272541A (en) 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4275205A (en) 1980-05-05 1981-06-23 Miles Laboratories, Inc. 7,7-Ditosyloxymethyl-4,5α-epoxy-morphinan-6-ols
US4347361A (en) 1980-12-10 1982-08-31 Sisa, Incorporated 4,5α-Epoxy-3-hydroxy or methoxy-7-(1-hydroxy-alkyl or 1-oxoalkyl)morphinan-6-one compounds
US4370333A (en) 1981-06-29 1983-01-25 Sisa, Incorporated 17-Cyclopropylmethyl-3-hydroxy-14-methoxy 7α-methyl-morphinan-6-one and therapeutic method of treating pain with it
US4443605A (en) 1982-07-30 1984-04-17 Miles Laboratories, Inc. 7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans
US4440932A (en) 1982-09-09 1984-04-03 Miles Laboratories, Inc. 7β-Arylalkyl-7α-methyl-6-oxo or 6α-hydroxy-3-methoxy or 3-hydroxy-4,5α-epoxy-17-methyl or 17-cycloalkyl-methylmorphinans
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
EP0663401B1 (fr) 1993-07-23 2000-06-07 Toray Industries, Inc. Derive de morphinane et application medicale
US5464841A (en) 1993-11-08 1995-11-07 Univ Minnesota Use of delta opioid receptor antagonists to treat immunoregulatory disorders
ES2188888T3 (es) 1996-01-10 2003-07-01 Glaxosmithkline Spa Derivados morfinoides 8ii) con condensados con heterociclos.
WO2001002375A1 (fr) 1999-07-01 2001-01-11 Chemrx Advanced Technologies, Inc. Synthese d'oxadiazoles
US6451806B2 (en) * 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
MXPA02005335A (es) 1999-11-29 2003-01-28 Adolor Corp Metodos y composiciones novedosos que incluyen opioides y antagonistas de los mismos.
JP2004501094A (ja) * 2000-05-05 2004-01-15 ペイン・セラピューティクス・インコーポレイテッド オピオイドアゴニストの効力を増強するか、またはオピオイドアゴニストの有害な副作用を減弱するための新規な組成物および方法
US20040024004A1 (en) 2001-05-04 2004-02-05 Sherman Barry M. Novel compositions and methods for enhancing potency or reducing adverse side effects of opioid agonists
CA2408106A1 (fr) 2000-05-05 2001-11-15 Pain Therapeutics, Inc. Compositions d'antagoniste opioide et formes de dosage
EP1359146B1 (fr) * 2000-10-31 2008-04-09 Rensselaer Polytechnic Institute 4-ARYL PIPERIDINES avec activité sur le récepteur d'opioides
ATE402179T1 (de) 2000-11-22 2008-08-15 Toray Industries Indolderivate und deren verwendung in medikamenten
ATE466016T1 (de) * 2001-08-23 2010-05-15 Organon Nv Verfahren for zur herstellung eines 14- hydroxynormorphinon-derivats
DE10161963A1 (de) 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
EP1522542A1 (fr) 2002-07-11 2005-04-13 Toray Industries, Inc. Agent therapeutique ou preventif pour la nausee/le vomissement
WO2004026819A2 (fr) 2002-09-18 2004-04-01 The Curators Of The University Of Missouri Analogues d'opiaces selectifs a l'egard du recepteur opioide delta
US20040157784A1 (en) 2003-02-10 2004-08-12 Jame Fine Chemicals, Inc. Opiod tannate compositions
WO2005105093A2 (fr) 2003-08-26 2005-11-10 Duke University METHODE PERMETTANT D'ARRETER LES EFFETS SECONDAIRES DES AGONISTES DES RECEPTEURS µ-OPIOIDES PENDANT LEUR ADMINISTRATION
US8481501B2 (en) 2004-05-28 2013-07-09 Human Biomolecular Research Institute Synthesis of metabolically stable analgesics, pain medications and other agents
US20060063792A1 (en) 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
US7142420B2 (en) 2004-09-20 2006-11-28 Qualcomm, Incorporated Devices and methods for controlling relative movement between layers of an electronic device
WO2006126529A1 (fr) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. Derive de morphinane substitue en position 7 par un carbamoyle et insature en positions 6 et 7
RU2643807C1 (ru) 2010-11-12 2018-02-06 Сионоги Энд Ко., Лтд. Кристаллы производных 6,7-ненасыщенного-7-карбамоилморфинана и способ их получения

Also Published As

Publication number Publication date
NL300996I1 (nl) 2019-07-03
JP4323547B2 (ja) 2009-09-02
US8084460B2 (en) 2011-12-27
RU2007148412A (ru) 2009-06-27
TW200726470A (en) 2007-07-16
EP1889848A4 (fr) 2011-08-10
WO2006126529A1 (fr) 2006-11-30
ES2525215T3 (es) 2014-12-19
RU2403255C2 (ru) 2010-11-10
CA2609733A1 (fr) 2006-11-30
EP1889848A1 (fr) 2008-02-20
CN101228172A (zh) 2008-07-23
US20090203723A1 (en) 2009-08-13
PL1889848T3 (pl) 2015-04-30
AU2006250390B2 (en) 2010-07-08
TWI311056B (en) 2009-06-21
KR100912782B1 (ko) 2009-08-18
KR20080014791A (ko) 2008-02-14
WO2006126637A1 (fr) 2006-11-30
AU2006250390A1 (en) 2006-11-30
BRPI0610343A2 (pt) 2010-06-15
USRE46365E1 (en) 2017-04-11
BE2019C533I2 (fr) 2025-12-10
CA2609733C (fr) 2011-07-19
FR19C1042I1 (fr) 2019-08-09
BRPI0610343B1 (pt) 2020-03-10
US20120135978A1 (en) 2012-05-31
EP1889848B8 (fr) 2014-12-17
DK1889848T3 (en) 2014-12-01
PT1889848E (pt) 2014-12-09
NL300996I2 (nl) 2019-07-30
HUS1900034I1 (hu) 2019-07-29
EP1889848B1 (fr) 2014-10-15
MX2007014588A (es) 2008-01-24
US8536192B2 (en) 2013-09-17
JPWO2006126637A1 (ja) 2008-12-25
CN101228172B (zh) 2013-04-03
BRPI0610343B8 (pt) 2021-05-25
USRE46375E1 (en) 2017-04-25

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