FR2076787A5 - Lyophilisation stabiliser - for viruses contg potassium phosphate lactose and albumin - Google Patents

Lyophilisation stabiliser - for viruses contg potassium phosphate lactose and albumin

Info

Publication number
FR2076787A5
FR2076787A5 FR7002975A FR7002975A FR2076787A5 FR 2076787 A5 FR2076787 A5 FR 2076787A5 FR 7002975 A FR7002975 A FR 7002975A FR 7002975 A FR7002975 A FR 7002975A FR 2076787 A5 FR2076787 A5 FR 2076787A5
Authority
FR
France
Prior art keywords
viruses
albumin
contg
potassium phosphate
lyophilisation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7002975A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Merieux SA
Original Assignee
Institut Merieux SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Merieux SA filed Critical Institut Merieux SA
Priority to FR7002975A priority Critical patent/FR2076787A5/en
Application granted granted Critical
Publication of FR2076787A5 publication Critical patent/FR2076787A5/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36211—Rubivirus, e.g. rubella virus
    • C12N2770/36251—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Stabiliser for lyophilisation esp. for viruses such as that of rubella, contains phosphoric anions, potassium cations, lactose and albumin. Storage-stability is improved. Lyophilisation period is reduced from ca.
FR7002975A 1970-01-28 1970-01-28 Lyophilisation stabiliser - for viruses contg potassium phosphate lactose and albumin Expired FR2076787A5 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7002975A FR2076787A5 (en) 1970-01-28 1970-01-28 Lyophilisation stabiliser - for viruses contg potassium phosphate lactose and albumin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7002975A FR2076787A5 (en) 1970-01-28 1970-01-28 Lyophilisation stabiliser - for viruses contg potassium phosphate lactose and albumin

Publications (1)

Publication Number Publication Date
FR2076787A5 true FR2076787A5 (en) 1971-10-15

Family

ID=9049721

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7002975A Expired FR2076787A5 (en) 1970-01-28 1970-01-28 Lyophilisation stabiliser - for viruses contg potassium phosphate lactose and albumin

Country Status (1)

Country Link
FR (1) FR2076787A5 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337242A (en) * 1980-02-05 1982-06-29 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
US4338335A (en) * 1980-02-05 1982-07-06 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
FR2505657A1 (en) * 1981-05-13 1982-11-19 Pasteur Institut IMPROVEMENTS IN LIVE STABILIZING AGENTS FOR THE PREPARATION OF VACCINES, AND STABILIZED VACCINES CONTAINING SAID STABILIZING AGENTS
FR2532548A1 (en) * 1982-09-03 1984-03-09 Pasteur Institut NOVEL PROCESS FOR THE PRODUCTION OF VACCINES HAVING A HIGH TITLE OF VIRUSES AND HIGHLY PURIFIED VACCINES, A HIGH TITLE OF VIRUSES, SO OBTAINED
EP0028563B1 (en) * 1979-10-29 1984-04-04 Merck & Co. Inc. Stabilizer for liquid vaccines and liquid vaccine containing said stabilizer
US4555401A (en) * 1980-07-03 1985-11-26 The Green Cross Corporation Live mumps vaccine and method of stabilizing the same
WO1995010601A1 (en) * 1993-10-12 1995-04-20 Chiron Viagene, Inc. Methods for preserving recombinant viruses
WO2001005941A3 (en) * 1999-07-16 2001-07-19 Health Lab Service Board Storage of microorganisms, cells and tissue
EP0872249A4 (en) * 1995-03-17 2001-10-24 Hisamitsu Pharmaceutical Co Gene transfer preparation
RU2686108C2 (en) * 2012-10-02 2019-04-24 Трансген Са Virrary-dimensioning preparation and use thereof

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL124941C (en) *
NL296078A (en) *
US2912361A (en) * 1956-11-28 1959-11-10 Sterling Drug Inc Canine distemper vaccine and its preparation
US3014843A (en) * 1955-02-07 1961-12-26 Armour & Co Method of producing non-virulent strains of attenuated and stabilized hog cholera virus
FR1299503A (en) * 1960-01-18 1962-07-27 Anchor Serum Company Method of attenuating infectious rhinotracheitis virus in cattle
GB1000907A (en) * 1961-11-08 1965-08-11 Dow Chemical Co Attenuated live measles virus vaccine and method of production
DE1209245B (en) * 1961-11-08 1966-01-20 Dow Chemical Co Process for the manufacture of measles vaccines
GB1049386A (en) * 1962-08-16 1966-11-23 Parke Davis & Co Improvements in or relating to stabilized virus antigens
BE685270A (en) * 1965-08-13 1967-02-09
BE700795A (en) * 1965-07-29 1968-01-02
BE701496A (en) * 1967-05-22 1968-01-18
US3366543A (en) * 1964-08-17 1968-01-30 American Home Prod Process of attenuating infectious bovine rhinotracheitis viruses
BE720444A (en) * 1967-09-05 1969-03-05
GB1152626A (en) * 1967-07-07 1969-05-21 Merck & Co Inc Rubella Vaccine

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL296078A (en) *
NL124941C (en) *
US3014843A (en) * 1955-02-07 1961-12-26 Armour & Co Method of producing non-virulent strains of attenuated and stabilized hog cholera virus
US2912361A (en) * 1956-11-28 1959-11-10 Sterling Drug Inc Canine distemper vaccine and its preparation
FR1299503A (en) * 1960-01-18 1962-07-27 Anchor Serum Company Method of attenuating infectious rhinotracheitis virus in cattle
GB1000907A (en) * 1961-11-08 1965-08-11 Dow Chemical Co Attenuated live measles virus vaccine and method of production
DE1209245B (en) * 1961-11-08 1966-01-20 Dow Chemical Co Process for the manufacture of measles vaccines
GB1049386A (en) * 1962-08-16 1966-11-23 Parke Davis & Co Improvements in or relating to stabilized virus antigens
US3366543A (en) * 1964-08-17 1968-01-30 American Home Prod Process of attenuating infectious bovine rhinotracheitis viruses
BE700795A (en) * 1965-07-29 1968-01-02
BE685270A (en) * 1965-08-13 1967-02-09
BE701496A (en) * 1967-05-22 1968-01-18
GB1152645A (en) * 1967-05-22 1969-05-21 Merck & Co Inc Rubella Vaccine
FR1583642A (en) * 1967-05-22 1969-11-21
GB1152626A (en) * 1967-07-07 1969-05-21 Merck & Co Inc Rubella Vaccine
BE720444A (en) * 1967-09-05 1969-03-05
NL6812467A (en) * 1967-09-05 1969-03-07

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028563B1 (en) * 1979-10-29 1984-04-04 Merck & Co. Inc. Stabilizer for liquid vaccines and liquid vaccine containing said stabilizer
US4338335A (en) * 1980-02-05 1982-07-06 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
US4337242A (en) * 1980-02-05 1982-06-29 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
US4555401A (en) * 1980-07-03 1985-11-26 The Green Cross Corporation Live mumps vaccine and method of stabilizing the same
US4500512A (en) * 1981-05-13 1985-02-19 Institut Pasteur Stabilizing agents for live viruses for preparing vaccines, and stabilized vaccines containing said stabilizing agents
EP0065905A1 (en) * 1981-05-13 1982-12-01 Institut Pasteur Stabilizing agents for live viruses for the preparation of vaccines, and stabilized vaccines containing these stabilizing agents
FR2505657A1 (en) * 1981-05-13 1982-11-19 Pasteur Institut IMPROVEMENTS IN LIVE STABILIZING AGENTS FOR THE PREPARATION OF VACCINES, AND STABILIZED VACCINES CONTAINING SAID STABILIZING AGENTS
FR2532548A1 (en) * 1982-09-03 1984-03-09 Pasteur Institut NOVEL PROCESS FOR THE PRODUCTION OF VACCINES HAVING A HIGH TITLE OF VIRUSES AND HIGHLY PURIFIED VACCINES, A HIGH TITLE OF VIRUSES, SO OBTAINED
WO1995010601A1 (en) * 1993-10-12 1995-04-20 Chiron Viagene, Inc. Methods for preserving recombinant viruses
US5792643A (en) * 1993-10-12 1998-08-11 Herrmann; Steven M. Methods for preserving recombinant retroviruses
EP0872249A4 (en) * 1995-03-17 2001-10-24 Hisamitsu Pharmaceutical Co Gene transfer preparation
WO2001005941A3 (en) * 1999-07-16 2001-07-19 Health Lab Service Board Storage of microorganisms, cells and tissue
RU2686108C2 (en) * 2012-10-02 2019-04-24 Трансген Са Virrary-dimensioning preparation and use thereof

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Legal Events

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