FR2299862A1 - Nouveaux N-(1-benzylpyrrolidinyl 2-alkyl) benzamides substitués, leurs dérivés, leur procédé de préparation. - Google Patents

Nouveaux N-(1-benzylpyrrolidinyl 2-alkyl) benzamides substitués, leurs dérivés, leur procédé de préparation.

Info

Publication number: FR2299862A1
Authority: FR; France
Prior art keywords: alkyl; alkoxy; substd; antiemetics; benzylpyrrolidinyl
Prior art date: 1975-02-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

FR7503799A

Other languages

English (en)

Other versions

FR2299862B1 (en

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SOC ET SCIENT ET IND

Original Assignee

SOC ET SCIENT ET IND

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-02-07

Filing date

1975-02-07

Publication date

1976-09-03

1974-03-05 Priority to CH279775A priority Critical patent/CH605793A5/fr

1975-02-07 Application filed by SOC ET SCIENT ET IND filed Critical SOC ET SCIENT ET IND

1975-02-07 Priority to FR7503799A priority patent/FR2299862B1/fr

1975-02-24 Priority to IL46695A priority patent/IL46695A/en

1975-02-25 Priority to DE2508045A priority patent/DE2508045C2/de

1975-02-26 Priority to GB809475A priority patent/GB1466646A/en

1975-02-28 Priority to AU78688/75A priority patent/AU483186B2/en

1975-03-03 Priority to SE7502341A priority patent/SE411753B/sv

1975-03-03 Priority to AT160675A priority patent/AT350546B/de

1975-03-03 Priority to EG108/75A priority patent/EG11971A/ar

1975-03-03 Priority to LU71948A priority patent/LU71948A1/fr

1975-03-04 Priority to DK86875A priority patent/DK145376C/da

1975-03-04 Priority to CS751444A priority patent/CS189691B2/cs

1975-03-04 Priority to FI750619A priority patent/FI58494C/fi

1975-03-04 Priority to NO750714A priority patent/NO144740C/no

1975-03-04 Priority to ES435273A priority patent/ES435273A1/es

1975-03-04 Priority to YU516/75A priority patent/YU40629B/xx

1975-03-04 Priority to SU752109846A priority patent/SU602116A3/ru

1975-03-04 Priority to YU00517/75A priority patent/YU51775A/en

1975-03-04 Priority to BG029147A priority patent/BG25072A3/bg

1975-03-04 Priority to IE456/75A priority patent/IE40860B1/en

1975-03-04 Priority to CA221,237A priority patent/CA1060029A/fr

1975-03-04 Priority to OA55431A priority patent/OA04967A/fr

1975-03-05 Priority to NLAANVRAGE7502607,A priority patent/NL184617C/nl

1975-03-05 Priority to US05/555,376 priority patent/US4029673A/en

1975-03-05 Priority to HU75SO00001139A priority patent/HU172091B/hu

1975-03-05 Priority to JP50027572A priority patent/JPS6058750B2/ja

1975-03-05 Priority to PL1975178532A priority patent/PL96942B1/pl

1975-03-05 Priority to RO7581557A priority patent/RO73247A/fr

1975-03-05 Priority to DD184578A priority patent/DD117451A5/de

1975-03-14 Priority to ZM32/75A priority patent/ZM3275A1/xx

1975-04-04 Priority to AR257836A priority patent/AR212960A1/es

1976-09-03 Publication of FR2299862A1 publication Critical patent/FR2299862A1/fr

1978-01-05 Priority to PH20622A priority patent/PH14207A/en

1978-03-16 Priority to HK139/78A priority patent/HK13978A/en

1978-07-21 Application granted granted Critical

1978-07-21 Publication of FR2299862B1 publication Critical patent/FR2299862B1/fr

Status Expired legal-status Critical Current

Links

230000003474 anti-emetic effect Effects 0.000 title abstract 2
229940125683 antiemetic agent Drugs 0.000 title abstract 2
239000002111 antiemetic agent Substances 0.000 title abstract 2
239000003699 antiulcer agent Substances 0.000 title abstract 2
229940054066 benzamide antipsychotics Drugs 0.000 title 1
150000003936 benzamides Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 3
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 1
-1 Z = H Chemical group 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
150000003863 ammonium salts Chemical class 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
231100000053 low toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)

FR7503799A 1974-03-05 1975-02-07 Substd. N-(1-benzylpyrrolidinyl-2-alkyl)benzamides - used as antiemetics, anti-ulcer agents and CNS active Expired FR2299862B1 (en)

Priority Applications (33)

Application Number	Priority Date	Filing Date	Title
CH279775A CH605793A5 (fr)	1974-03-05	1974-03-05	Procédé de préparation de nouveaux N-(1benzylpyrrollidinil 2-alkyl) benzamides substitués
FR7503799A FR2299862B1 (en)	1975-02-07	1975-02-07	Substd. N-(1-benzylpyrrolidinyl-2-alkyl)benzamides - used as antiemetics, anti-ulcer agents and CNS active
IL46695A IL46695A (en)	1974-03-05	1975-02-24	Substituted n-(1-benzylpyrrolidinyl-2-alkyl)-benzamides, their preparation and pharmaceutical compositions containing them
DE2508045A DE2508045C2 (de)	1974-03-05	1975-02-25	Substituierte n-(1-benzylpyrrolidinyl-2-alkyl)-benzamide, verfahren zu deren herstellung und diese enthaltende arzneimittel
GB809475A GB1466646A (en)	1974-03-05	1975-02-26	Substituted benzamides
AU78688/75A AU483186B2 (en)	1974-03-05	1975-02-28	New n-(1-benzylpyrrolidinyl 2 alkyl substituted benzamides, theer derivatives and its process of preparation
AT160675A AT350546B (de)	1974-03-05	1975-03-03	Verfahren zur herstellung neuer n-(1- benzylpyrrolidinyl-2-alkyl)-benzamide, ihrer saeureadditionssalze, quartaeren ammoniumsalze und der optischen isomeren
EG108/75A EG11971A (en)	1974-03-05	1975-03-03	New n-(1-benzylpyrrolidinyl 2-alkyl)substituted benzamides,their derivatives and its process of preparation
LU71948A LU71948A1 (fr)	1974-03-05	1975-03-03
SE7502341A SE411753B (sv)	1974-03-05	1975-03-03	Forfarande for framstellning av terapeutiskt aktiva nya derivat av n-(1-bensylpyrrolidinyl-2-alkyl)-bensamid
YU00517/75A YU51775A (en)	1974-03-05	1975-03-04	Process for obtaining new n-(1-benzylpyrrolidinyl-2-alkyl)benzamide substituted compounds
FI750619A FI58494C (fi)	1974-03-05	1975-03-04	Menetelmä uusien terapeuttisesti käyttökelpoisten N-(1'-bentsyylipyrrolidin-2'-yylimetyyli) bentsamidien valmistamiseksi
NO750714A NO144740C (no)	1974-03-05	1975-03-04	Analogifremgangsmaate ved fremstilling av nye, terapeutisk virksomme, substituerte n-(1-benzyl-pyrrolidinyl-2-alkyl)-benzamider
ES435273A ES435273A1 (es)	1974-03-05	1975-03-04	Un procedimiento de preparacion de n-(1-bencil-pirrolidi- nil-2-alcohil) -benzamidas sustituidas.
YU516/75A YU40629B (en)	1974-03-05	1975-03-04	Process for obtaining n-(2-pyrrolidinyl-methyl)-2-methoxy-subst benzamides
SU752109846A SU602116A3 (ru)	1974-03-05	1975-03-04	Способ получени замещенных (1-бензилпирролидинил-2-алкил)бензамидов или их кислых или аммонийных солей или их правовращающих или левовращающих изомеров
DK86875A DK145376C (da)	1974-03-05	1975-03-04	Analogifremgangsmaade til fremstilling af n-(1'-benzyl-2'-pyrrolidinylmethyl)-benzamider eller syreadditionssalte,kvaternaere ammoniumsalte eller optisk aktive isomere deraf
BG029147A BG25072A3 (bg)	1974-03-05	1975-03-04	Метод за получаване на n-(1-бензилпиролидинил-2-алкил) субституирани бензамиди
IE456/75A IE40860B1 (en)	1974-03-05	1975-03-04	Substituted benzamides
CA221,237A CA1060029A (fr)	1974-03-05	1975-03-04	Benzamides de type n-(1-benzylpyrrolldinyl 2-alkyl) substituees et leurs derives
OA55431A OA04967A (fr)	1974-03-05	1975-03-04	Nouveaux N-(l-benzylpyrrolidinyl 2-alkyl) benzamides substitués, leurs dérivés, leur procédé de préparation.
CS751444A CS189691B2 (en)	1974-03-05	1975-03-04	Method of producing novel substituted derivatives of n-1-benzylpyrrolidinyl-2-alkyl/benzamide,salts and isomers thereof
US05/555,376 US4029673A (en)	1974-03-05	1975-03-05	N-(1-benzyl pyrrolidinyl 2-alkyl) substituted benzamides and derivatives thereof
HU75SO00001139A HU172091B (hu)	1974-03-05	1975-03-05	Sposob poluchenija proizvodnykh n-skobka-1-benzil-pirrolidinil-2-alkil-skobka zakryta-benzamida
JP50027572A JPS6058750B2 (ja)	1974-03-05	1975-03-05	Ｎ−（１−ベンジルピロリジニル−２−メチル）置換ベンズアミド誘導体またはその塩類の製造法
PL1975178532A PL96942B1 (pl)	1974-03-05	1975-03-05	Sposob wytwarzania nowych podstawionych n-/1-benzylopirodidynylo-2-alkilo/benzoamidow
RO7581557A RO73247A (fr)	1974-03-05	1975-03-05	Procede de preparation des benzamides substitus
DD184578A DD117451A5 (fr)	1974-03-05	1975-03-05
NLAANVRAGE7502607,A NL184617C (nl)	1974-03-05	1975-03-05	Werkwijze voor de bereiding van een preparaat met farmacologische werking op basis van benzamidomethylpyrrolidine-derivaten, alsmede werkwijze voor de bereiding van de hierbij toe te passen benzamidomethylpyrrolidine-derivaten.
ZM32/75A ZM3275A1 (en)	1975-02-07	1975-03-14	New n-(1-benzylpyrrolidinyl 2-alkyl) substituted benzamides, their derivatives and its process of preparation
AR257836A AR212960A1 (es)	1974-03-05	1975-04-04	Procedimiento para preparar n-(1-bencilpirrolidinil-2-alquil)benzaminas sustituidas
PH20622A PH14207A (en)	1974-03-05	1978-01-05	N-(1-benzylpyrrolidinyl 2-alkyl)substituted benzamides
HK139/78A HK13978A (en)	1974-03-05	1978-03-16	Substituted benzamides

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR7503799A FR2299862B1 (en)	1975-02-07	1975-02-07	Substd. N-(1-benzylpyrrolidinyl-2-alkyl)benzamides - used as antiemetics, anti-ulcer agents and CNS active

Publications (2)

Publication Number	Publication Date
FR2299862A1 true FR2299862A1 (fr)	1976-09-03
FR2299862B1 FR2299862B1 (en)	1978-07-21

Family

ID=9150890

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR7503799A Expired FR2299862B1 (en)	1974-03-05	1975-02-07	Substd. N-(1-benzylpyrrolidinyl-2-alkyl)benzamides - used as antiemetics, anti-ulcer agents and CNS active

Country Status (2)

Country	Link
FR (1)	FR2299862B1 (fr)
ZM (1)	ZM3275A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2415099A1 (fr) *	1978-01-20	1979-08-17	Ile De France	Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes
FR2421892A1 (fr) *	1977-10-17	1979-11-02	Fabre Sa Pierre	Procede de synthese industrielle du n(n' ethyl pyrrolidino-2 methyl) aadiphenylahydroxy acetamide
FR2460930A2 (fr) *	1979-07-06	1981-01-30	Ile De France	Nouveau procede de preparation de derives de 4-amino 5-alkylsulfonyl ortho-anisamides et nouveaux derives de 4-nitro 5-alkylsulfonyl ortho-anisamides utiles comme intermediaires de synthese

1975
- 1975-02-07 FR FR7503799A patent/FR2299862B1/fr not_active Expired
- 1975-03-14 ZM ZM32/75A patent/ZM3275A1/xx unknown

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2421892A1 (fr) *	1977-10-17	1979-11-02	Fabre Sa Pierre	Procede de synthese industrielle du n(n' ethyl pyrrolidino-2 methyl) aadiphenylahydroxy acetamide
FR2415099A1 (fr) *	1978-01-20	1979-08-17	Ile De France	Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes
FR2460930A2 (fr) *	1979-07-06	1981-01-30	Ile De France	Nouveau procede de preparation de derives de 4-amino 5-alkylsulfonyl ortho-anisamides et nouveaux derives de 4-nitro 5-alkylsulfonyl ortho-anisamides utiles comme intermediaires de synthese

Also Published As

Publication number	Publication date
FR2299862B1 (en)	1978-07-21
ZM3275A1 (en)	1976-03-22

Legal Events

Date	Code	Title	Description
1993-12-31	ST	Notification of lapse

Publication	Publication Date	Title
GB1302410A (fr)	1973-01-10
EG12320A (en)	1978-12-31	Herbicidal agents of n-(3,4-dichlorophenyl)-n',n',-dimethylthioures
FR2299862A1 (fr)	1976-09-03	Nouveaux N-(1-benzylpyrrolidinyl 2-alkyl) benzamides substitués, leurs dérivés, leur procédé de préparation.
YU215190A (sh)	1993-10-20	Imidazolovi fungicidi
GB1494436A (en)	1977-12-07	O-aminosulphonyl-glycolic anilides
ES8306752A1 (es)	1983-06-01	Un procedimiento para la preparacion de nuevos derivados de benzamina.
DK0934278T3 (da)	2003-01-06	Bis(acridincarboxamid) og bis(phenazincarboxamid) som antitumormidler
EP0666855A1 (fr)	1995-08-16	Derives de la 4-quinoleinyle a activite anti-helicobacter.
GB1154869A (en)	1969-06-11	Fungitoxic Agents
GB1044964A (en)	1966-10-05	New aminoketones
GB1254572A (en)	1971-11-24	Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
GB1355926A (en)	1974-06-12	Herbiciedes herbicidal compositions and benzophenon derivatives
MY102083A (en)	1992-03-31	Phenylbenzoylureas
GB1294009A (en)	1972-10-25	Substituted phenylureas, their preparation and use as pesticides
ES8403447A1 (es)	1984-03-16	Procedimiento para preparar un nuevo derivado de la benzhidrilsulfiniletilamina.
FR2299863A1 (fr)	1976-09-03	Nouveaux N-(Z-pyrrolidiny alkyl) benzamides substitués, leurs dérivés et leur procédé de préparation
GB1255751A (en)	1971-12-01	Herbicidal agents
ID23783A (id)	2000-05-11	Anti fungi 2.4.4.-trisubstitusi-1,3-dioksolan
BG36625A3 (en)	1984-12-16	Herbecide antidote means and method for protection fpom unwanted growth
ES8505367A1 (es)	1985-06-01	Procedimiento para la preparacion de derivados de acridanona
ES412101A1 (es)	1976-06-16	Procedimiento para preparar derivados de n,n'-difenil-n- (n'-alquicarbamoil) formamidina.
GB1305725A (fr)	1973-02-07
FR2190809A1 (en)	1974-02-01	Chloronitrobenzenesulphonamides prodn - from corresp sulphonylchlorides and secondary amines at low temps
ES429127A1 (es)	1976-09-01	Procedimiento para la produccion de ureas aciladas, de efecto insecticida.
FR2331351A1 (fr)	1977-06-10	Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent

FR2299862A1 - Nouveaux N-(1-benzylpyrrolidinyl 2-alkyl) benzamides substitués, leurs dérivés, leur procédé de préparation. - Google Patents

Info

Links

Classifications

Landscapes

Priority Applications (33)

Applications Claiming Priority (1)

Publications (2)

Family

ID=9150890

Family Applications (1)

Country Status (2)

Cited By (3)

Cited By (3)

Also Published As

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