FR2362631A2 - Nouveaux 2,2-dimethyl steroides, leur procede de preparation et leur application comme medicament - Google Patents
Nouveaux 2,2-dimethyl steroides, leur procede de preparation et leur application comme medicamentInfo
- Publication number
- FR2362631A2 FR2362631A2 FR7625939A FR7625939A FR2362631A2 FR 2362631 A2 FR2362631 A2 FR 2362631A2 FR 7625939 A FR7625939 A FR 7625939A FR 7625939 A FR7625939 A FR 7625939A FR 2362631 A2 FR2362631 A2 FR 2362631A2
- Authority
- FR
- France
- Prior art keywords
- pregnene
- prepd
- oxo
- hydroxy
- arterial hypertension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 oxy pregnene Chemical compound 0.000 title abstract 3
- 239000005977 Ethylene Substances 0.000 title abstract 2
- 208000037849 arterial hypertension Diseases 0.000 title abstract 2
- CVRYIPLPFAKSEY-SJFWLOONSA-N 2-[(8s,9s,10r,13r,14s,17r)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl]ethanol Chemical compound C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)CCO)[C@@H]4[C@@H]3CCC2=C1 CVRYIPLPFAKSEY-SJFWLOONSA-N 0.000 title 1
- HZNVUJQVZSTENZ-UHFFFAOYSA-N 2,3-dichloro-5,6-dicyano-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(C#N)=C(C#N)C1=O HZNVUJQVZSTENZ-UHFFFAOYSA-N 0.000 abstract 2
- 241000790917 Dioxys <bee> Species 0.000 abstract 1
- 208000004880 Polyuria Diseases 0.000 abstract 1
- MJOQJPYNENPSSS-XQHKEYJVSA-N [(3r,4s,5r,6s)-4,5,6-triacetyloxyoxan-3-yl] acetate Chemical compound CC(=O)O[C@@H]1CO[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O MJOQJPYNENPSSS-XQHKEYJVSA-N 0.000 abstract 1
- URPRZZYALBSQAE-LADKUVSDSA-N [2-oxo-2-[(8S,9S,10R,13S,14S,17S)-2,2,10,13-tetramethyl-3-oxo-6,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]ethyl] propanoate Chemical compound CC1(C(C=C2CC[C@H]3[C@@H]4CC[C@H](C(COC(CC)=O)=O)[C@]4(CC[C@@H]3[C@]2(C1)C)C)=O)C URPRZZYALBSQAE-LADKUVSDSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 238000006137 acetoxylation reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002170 aldosterone antagonist Substances 0.000 abstract 1
- 229940083712 aldosterone antagonist Drugs 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000035619 diuresis Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- DUYAAUVXQSMXQP-UHFFFAOYSA-M thioacetate Chemical compound CC([S-])=O DUYAAUVXQSMXQP-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Les composés répondant à la formule I du brevet principal dont les noms suivent : - le 2,2-diméthyl 3,20-dioxo 7 alpha -acétylthio 21-hydroxy pregn 4-ène; - le 2,2-diméthyl 3,20-dioxo 21-propionyloxy pregn 4-ène. Les composés de l'invention présentent d'intéressantes propriétés pharmacologiques qui justifient leur utilisation comme médicament
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7625939A FR2362631A2 (fr) | 1976-08-27 | 1976-08-27 | Nouveaux 2,2-dimethyl steroides, leur procede de preparation et leur application comme medicament |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7625939A FR2362631A2 (fr) | 1976-08-27 | 1976-08-27 | Nouveaux 2,2-dimethyl steroides, leur procede de preparation et leur application comme medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2362631A2 true FR2362631A2 (fr) | 1978-03-24 |
| FR2362631B2 FR2362631B2 (fr) | 1980-03-21 |
Family
ID=9177186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7625939A Granted FR2362631A2 (fr) | 1976-08-27 | 1976-08-27 | Nouveaux 2,2-dimethyl steroides, leur procede de preparation et leur application comme medicament |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2362631A2 (fr) |
-
1976
- 1976-08-27 FR FR7625939A patent/FR2362631A2/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2362631B2 (fr) | 1980-03-21 |
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