FR2376847A1 - Procede ameliore de transposition de morphines en apomorphines - Google Patents
Procede ameliore de transposition de morphines en apomorphinesInfo
- Publication number
- FR2376847A1 FR2376847A1 FR7739473A FR7739473A FR2376847A1 FR 2376847 A1 FR2376847 A1 FR 2376847A1 FR 7739473 A FR7739473 A FR 7739473A FR 7739473 A FR7739473 A FR 7739473A FR 2376847 A1 FR2376847 A1 FR 2376847A1
- Authority
- FR
- France
- Prior art keywords
- transposition
- apomorphins
- morphines
- improved process
- degrees
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000017105 transposition Effects 0.000 title abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical class C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 abstract 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052753 mercury Inorganic materials 0.000 abstract 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
L'invention concerne la préparation de dérivés d'apomorphine avec un rendement amélioré, par transposition du dérivé de morphine correspondant en présence d'acide phosphorique anhydre sous un vide partiel, genéralement compris entre 9 et 20 mm de mercure et à une température comprise entre 125 degrés C et 140 degrés C.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75788877A | 1977-01-10 | 1977-01-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2376847A1 true FR2376847A1 (fr) | 1978-08-04 |
| FR2376847B1 FR2376847B1 (fr) | 1980-08-22 |
Family
ID=25049636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7739473A Granted FR2376847A1 (fr) | 1977-01-10 | 1977-12-28 | Procede ameliore de transposition de morphines en apomorphines |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5387359A (fr) |
| AU (1) | AU510976B2 (fr) |
| BE (1) | BE862389A (fr) |
| CA (1) | CA1092122A (fr) |
| CH (1) | CH624674A5 (fr) |
| DE (1) | DE2758954A1 (fr) |
| DK (1) | DK584077A (fr) |
| FR (1) | FR2376847A1 (fr) |
| GB (1) | GB1566049A (fr) |
| IE (1) | IE45922B1 (fr) |
| LU (1) | LU78790A1 (fr) |
| NL (1) | NL7714227A (fr) |
| NZ (1) | NZ185799A (fr) |
| SE (1) | SE7713456L (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3171561D1 (en) * | 1980-05-08 | 1985-09-05 | Univ Northeastern | N-substituted aporphines, a method of inducing emesis and a method of controlling psychosis utilising the same |
| WO1990012574A1 (fr) * | 1989-04-25 | 1990-11-01 | Northeastern University | Composes agonistes de la dopamine |
| GB201915911D0 (en) * | 2019-11-01 | 2019-12-18 | Johnson Matthey Plc | Process |
-
1977
- 1977-11-22 CA CA291,508A patent/CA1092122A/fr not_active Expired
- 1977-11-22 GB GB4862177A patent/GB1566049A/en not_active Expired
- 1977-11-23 IE IE237377A patent/IE45922B1/en unknown
- 1977-11-28 AU AU31013/77A patent/AU510976B2/en not_active Expired
- 1977-11-28 NZ NZ18579977A patent/NZ185799A/xx unknown
- 1977-11-28 SE SE7713456A patent/SE7713456L/xx not_active Application Discontinuation
- 1977-12-21 NL NL7714227A patent/NL7714227A/xx not_active Application Discontinuation
- 1977-12-28 FR FR7739473A patent/FR2376847A1/fr active Granted
- 1977-12-28 BE BE1008611A patent/BE862389A/fr unknown
- 1977-12-29 CH CH1622177A patent/CH624674A5/fr not_active IP Right Cessation
- 1977-12-29 JP JP15869177A patent/JPS5387359A/ja active Pending
- 1977-12-29 LU LU78790A patent/LU78790A1/xx unknown
- 1977-12-29 DK DK584077A patent/DK584077A/da unknown
- 1977-12-30 DE DE19772758954 patent/DE2758954A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU510976B2 (en) | 1980-07-24 |
| JPS5387359A (en) | 1978-08-01 |
| IE45922B1 (en) | 1982-12-29 |
| FR2376847B1 (fr) | 1980-08-22 |
| DK584077A (da) | 1978-07-11 |
| BE862389A (fr) | 1978-06-28 |
| NZ185799A (en) | 1979-12-11 |
| AU3101377A (en) | 1979-06-07 |
| LU78790A1 (fr) | 1978-07-11 |
| CH624674A5 (en) | 1981-08-14 |
| DE2758954A1 (de) | 1978-07-13 |
| CA1092122A (fr) | 1980-12-23 |
| GB1566049A (en) | 1980-04-30 |
| SE7713456L (sv) | 1978-07-11 |
| IE45922L (en) | 1978-07-10 |
| NL7714227A (nl) | 1978-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |