FR2380277A1 - L'antibiotique desacetyl, dihydro 890 a9 - Google Patents

L'antibiotique desacetyl, dihydro 890 a9

Info

Publication number
FR2380277A1
FR2380277A1 FR7803667A FR7803667A FR2380277A1 FR 2380277 A1 FR2380277 A1 FR 2380277A1 FR 7803667 A FR7803667 A FR 7803667A FR 7803667 A FR7803667 A FR 7803667A FR 2380277 A1 FR2380277 A1 FR 2380277A1
Authority
FR
France
Prior art keywords
hydro
desacetyl
prepd
acetylation
enzymatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7803667A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2380277A1 publication Critical patent/FR2380277A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne un composé chimique nouveau. Il s'agit du composé désacétyl, dihydro 890 A9 de structure :
FR7803667A 1977-02-11 1978-02-09 L'antibiotique desacetyl, dihydro 890 a9 Withdrawn FR2380277A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76792077A 1977-02-11 1977-02-11

Publications (1)

Publication Number Publication Date
FR2380277A1 true FR2380277A1 (fr) 1978-09-08

Family

ID=25080969

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7803667A Withdrawn FR2380277A1 (fr) 1977-02-11 1978-02-09 L'antibiotique desacetyl, dihydro 890 a9

Country Status (8)

Country Link
JP (1) JPS53103494A (fr)
DE (1) DE2805724A1 (fr)
DK (1) DK40678A (fr)
ES (1) ES466645A1 (fr)
FR (1) FR2380277A1 (fr)
IT (1) IT1105282B (fr)
NL (1) NL7800958A (fr)
SE (1) SE7800979L (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2380280A1 (fr) * 1977-02-11 1978-09-08 Merck & Co Inc Desacetyl 890 a10 antibiotique
EP0010573A1 (fr) 1978-07-24 1980-05-14 Merck & Co. Inc. Acides Z-2-acylamino-propéniques monosubstitués en position 3 et leurs esters et sels et procédés pour leur préparation

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162193A (en) * 1977-08-19 1979-07-24 Merck & Co., Inc. Enzymatic cleavage of N-acyl-thienamycins
US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351979A1 (fr) * 1975-11-24 1977-12-16 Merck & Co Inc Nouvel antibiotique de type thienamycine utile comme medicament
FR2380280A1 (fr) * 1977-02-11 1978-09-08 Merck & Co Inc Desacetyl 890 a10 antibiotique

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351979A1 (fr) * 1975-11-24 1977-12-16 Merck & Co Inc Nouvel antibiotique de type thienamycine utile comme medicament
FR2380280A1 (fr) * 1977-02-11 1978-09-08 Merck & Co Inc Desacetyl 890 a10 antibiotique

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2380280A1 (fr) * 1977-02-11 1978-09-08 Merck & Co Inc Desacetyl 890 a10 antibiotique
EP0010573A1 (fr) 1978-07-24 1980-05-14 Merck & Co. Inc. Acides Z-2-acylamino-propéniques monosubstitués en position 3 et leurs esters et sels et procédés pour leur préparation

Also Published As

Publication number Publication date
DK40678A (da) 1978-08-12
JPS53103494A (en) 1978-09-08
NL7800958A (nl) 1978-08-15
IT1105282B (it) 1985-10-28
IT7847913A0 (it) 1978-02-03
ES466645A1 (es) 1980-12-16
DE2805724A1 (de) 1978-08-17
SE7800979L (sv) 1978-08-12

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Legal Events

Date Code Title Description
ST Notification of lapse