ES466645A1 - Un procedimiento para la produccion de desacetildihidro 890a9 - Google Patents

Un procedimiento para la produccion de desacetildihidro 890a9

Info

Publication number
ES466645A1
ES466645A1 ES466645A ES466645A ES466645A1 ES 466645 A1 ES466645 A1 ES 466645A1 ES 466645 A ES466645 A ES 466645A ES 466645 A ES466645 A ES 466645A ES 466645 A1 ES466645 A1 ES 466645A1
Authority
ES
Spain
Prior art keywords
dihydro
acetyl
amidohydrolase
microorganisms
cpd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES466645A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES466645A1 publication Critical patent/ES466645A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta invención se refiere al nuevo antibiótico desaceril-dihidro-890A9, activo contra las bacterias Gram-positivas y Gram-negativas, que se obtiene por tratamiento de dihidro 890A9 con una N-acetil-890A9-amidohidrolasa producida por un microorganismo de la tierra aislado por técnicas de enriquecimiento. Esta invención también se refiere al procedimiento mediante el cual enzimáticamente desacetilado el dihidro-890A9
ES466645A 1977-02-11 1978-02-03 Un procedimiento para la produccion de desacetildihidro 890a9 Expired ES466645A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76792077A 1977-02-11 1977-02-11

Publications (1)

Publication Number Publication Date
ES466645A1 true ES466645A1 (es) 1980-12-16

Family

ID=25080969

Family Applications (1)

Application Number Title Priority Date Filing Date
ES466645A Expired ES466645A1 (es) 1977-02-11 1978-02-03 Un procedimiento para la produccion de desacetildihidro 890a9

Country Status (8)

Country Link
JP (1) JPS53103494A (es)
DE (1) DE2805724A1 (es)
DK (1) DK40678A (es)
ES (1) ES466645A1 (es)
FR (1) FR2380277A1 (es)
IT (1) IT1105282B (es)
NL (1) NL7800958A (es)
SE (1) SE7800979L (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7800978L (sv) * 1977-02-11 1978-08-12 Merck & Co Inc Antibiotikum
US4162193A (en) * 1977-08-19 1979-07-24 Merck & Co., Inc. Enzymatic cleavage of N-acyl-thienamycins
PH16708A (en) 1978-07-24 1984-01-20 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates
US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK497476A (da) * 1975-11-24 1977-05-25 Merck & Co Inc Fremgangsmade til fremstilling af et antibiotisk stof
SE7800978L (sv) * 1977-02-11 1978-08-12 Merck & Co Inc Antibiotikum

Also Published As

Publication number Publication date
DK40678A (da) 1978-08-12
SE7800979L (sv) 1978-08-12
IT7847913A0 (it) 1978-02-03
FR2380277A1 (fr) 1978-09-08
JPS53103494A (en) 1978-09-08
DE2805724A1 (de) 1978-08-17
IT1105282B (it) 1985-10-28
NL7800958A (nl) 1978-08-15

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