FR23C1041I2 - Alpha-galactosidase stabilise et ses utilisations - Google Patents

Alpha-galactosidase stabilise et ses utilisations

Info

Publication number
FR23C1041I2
FR23C1041I2 FR23C1041C FR23C1041C FR23C1041I2 FR 23C1041 I2 FR23C1041 I2 FR 23C1041I2 FR 23C1041 C FR23C1041 C FR 23C1041C FR 23C1041 C FR23C1041 C FR 23C1041C FR 23C1041 I2 FR23C1041 I2 FR 23C1041I2
Authority
FR
France
Prior art keywords
galactosidase
stabilized alpha
stabilized
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR23C1041C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Protalix Ltd
Original Assignee
Protalix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IL2010/000956 external-priority patent/WO2011061736A1/fr
Application filed by Protalix Ltd filed Critical Protalix Ltd
Publication of FR23C1041I1 publication Critical patent/FR23C1041I1/fr
Application granted granted Critical
Publication of FR23C1041I2 publication Critical patent/FR23C1041I2/fr
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01022—Alpha-galactosidase (3.2.1.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
FR23C1041C 2010-03-02 2023-11-02 Alpha-galactosidase stabilise et ses utilisations Active FR23C1041I2 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30948710P 2010-03-02 2010-03-02
PCT/IL2010/000956 WO2011061736A1 (fr) 2009-11-17 2010-11-17 Alpha galactosidase alcaline pour le traitement de la maladie de fabry
US201161434499P 2011-01-20 2011-01-20
US201161434503P 2011-01-20 2011-01-20
EP11712340.6A EP2542675B1 (fr) 2010-03-02 2011-03-02 Alpha-galactosidase stabilisée et ses applications

Publications (2)

Publication Number Publication Date
FR23C1041I1 FR23C1041I1 (fr) 2023-12-29
FR23C1041I2 true FR23C1041I2 (fr) 2024-08-02

Family

ID=44121635

Family Applications (1)

Application Number Title Priority Date Filing Date
FR23C1041C Active FR23C1041I2 (fr) 2010-03-02 2023-11-02 Alpha-galactosidase stabilise et ses utilisations

Country Status (23)

Country Link
EP (3) EP2542675B1 (fr)
JP (2) JP5758920B2 (fr)
KR (1) KR101928403B1 (fr)
CN (1) CN102933707B (fr)
AU (1) AU2011222452B2 (fr)
BR (1) BR112012022029B1 (fr)
CA (1) CA2791461C (fr)
DK (1) DK2865751T3 (fr)
ES (2) ES2708843T3 (fr)
FI (1) FIC20230032I1 (fr)
FR (1) FR23C1041I2 (fr)
HR (1) HRP20200428T1 (fr)
HU (2) HUE030959T2 (fr)
IL (2) IL221741A (fr)
IN (1) IN2012MN02262A (fr)
NL (1) NL301249I2 (fr)
NO (1) NO2023041I1 (fr)
NZ (2) NZ623294A (fr)
PL (1) PL2865751T3 (fr)
SG (2) SG183558A1 (fr)
SI (1) SI2865751T1 (fr)
WO (1) WO2011107990A1 (fr)
ZA (1) ZA201206725B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9194011B2 (en) 2009-11-17 2015-11-24 Protalix Ltd. Stabilized alpha-galactosidase and uses thereof
DK2865751T3 (en) * 2010-03-02 2017-01-09 Protalix Ltd Stabilized alpha-galactosidase and uses thereof
RS60129B1 (sr) * 2011-01-20 2020-05-29 Protalix Ltd Kompozicije alfa-galaktozidaze
TWI642782B (zh) * 2013-10-23 2018-12-01 健臻公司 重組醣蛋白及其用途
US20170360900A1 (en) 2014-12-22 2017-12-21 Codexis, Inc. Human alpha-galactosidase variants
WO2016116966A1 (fr) * 2015-01-22 2016-07-28 Jcr Pharmaceuticals Co., Ltd. Procédé de purification d'une alpha-galactosidase a recombinante humaine à partir de matériel contenant des protéines contaminantes des cellules hôtes
CN107429257B (zh) 2015-03-17 2022-02-15 艾丽法有限责任公司 糖基化溶酶体蛋白、生产方法和用途
GB201508025D0 (en) 2015-05-11 2015-06-24 Ucl Business Plc Fabry disease gene therapy
CA3048151A1 (fr) * 2017-01-05 2018-07-12 Protalix Ltd. Regime therapeutique pour le traitement de la maladie de fabry a l'aide d'une alpha-galactosidase stabilisee
CN110651043A (zh) * 2017-06-07 2020-01-03 天野酶制品株式会社 乳糖酶原料粉末和乳糖酶制剂
MX2021007552A (es) 2018-12-20 2021-08-11 Codexis Inc Variantes de alfa-galactosidasa humana.
IL295818A (en) * 2020-02-28 2022-10-01 Codexis Inc Human alpha-galactosidase variants
CN117098559A (zh) 2020-11-03 2023-11-21 波塔力克斯有限公司 修饰的尿酸酶及其用途
CN112176026A (zh) * 2020-11-06 2021-01-05 诺道中科(北京)生物科技有限公司 一种α-半乳糖苷酶活性的检测试剂盒
CN116254287B (zh) * 2022-11-24 2024-06-04 西北农林科技大学 玉米ZmAGA3基因用于提高植物耐旱性的应用
CN118243646B (zh) * 2024-04-24 2025-01-24 武汉简为医疗科技有限公司 一种乳糖不耐受检测试剂盒及其使用方法
JP7745040B1 (ja) 2024-06-21 2025-09-26 デンカ株式会社 目的タンパク質の回収方法及び製造方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766897A (en) 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
US5401650A (en) * 1990-10-24 1995-03-28 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-galactosidase A
CA2052728A1 (fr) 1991-10-03 1993-04-04 Guy Ampleman Polymere de glycidylazide
US6329191B1 (en) * 1993-08-30 2001-12-11 Hawaii Biotechnology Group, Inc. DNA encoding recombinant coffee bean alpha-galactosidase
US6458574B1 (en) * 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
WO1999012959A1 (fr) * 1997-09-05 1999-03-18 Altus Biologics Inc. Cristaux de glycoproteine reticules aux hydrates de carbone
IL125423A (en) 1998-07-20 2004-08-31 Israel State Alkaline alpha-galactosidase having broad substrate specificity
WO2000059926A1 (fr) 1999-04-02 2000-10-12 Ajinomoto Co., Inc. Procede de production de sous-unite de peptide issue d'une proteine de polymere
EP1523548B1 (fr) 2002-05-15 2009-12-30 Agricultural Research Organization Sequences de polynucleotides codant pour des alpha-galactosidases alcalines et methodes d'utilisation
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
WO2006108052A2 (fr) * 2005-04-06 2006-10-12 Genzyme Corporation Ciblage de glycoproteines therapeutiques
US7935336B2 (en) * 2005-11-18 2011-05-03 Tokyo Metropolitan Organization For Medical Research Highly functional enzyme having α-galactosidase activity
US20100144008A1 (en) 2006-12-21 2010-06-10 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Treatment of fabry disease
JP2008169195A (ja) * 2007-01-05 2008-07-24 Hanmi Pharmaceutical Co Ltd キャリア物質を用いたインスリン分泌ペプチド薬物結合体
EP1955712A1 (fr) * 2007-02-09 2008-08-13 Scil proteins GmbH Conjugué multimère
EP2192924B1 (fr) * 2007-08-20 2017-10-11 Protalix Ltd. Conjugués de protéines contenant un saccharide et leurs utilisations
DK2865751T3 (en) * 2010-03-02 2017-01-09 Protalix Ltd Stabilized alpha-galactosidase and uses thereof

Also Published As

Publication number Publication date
SG183558A1 (en) 2012-10-30
ZA201206725B (en) 2013-06-26
BR122014021216A2 (pt) 2021-06-01
EP2865751A1 (fr) 2015-04-29
HK1180720A1 (en) 2013-10-25
NO2023041I1 (no) 2023-11-01
ES2606532T3 (es) 2017-03-24
KR101928403B1 (ko) 2018-12-14
HUS2300038I1 (hu) 2023-11-28
RU2012141651A (ru) 2014-04-10
SG10201502609QA (en) 2015-05-28
IL253249A (en) 2019-08-29
ES2708843T3 (es) 2019-04-11
SI2865751T1 (sl) 2017-01-31
CN102933707A (zh) 2013-02-13
EP2542675B1 (fr) 2014-12-17
AU2011222452A1 (en) 2012-09-27
EP2865751B1 (fr) 2016-09-14
JP2013520986A (ja) 2013-06-10
NL301249I2 (nl) 2023-12-14
NZ623294A (en) 2015-10-30
AU2011222452B2 (en) 2015-09-03
DK2865751T3 (en) 2017-01-09
IL253249B (en) 2020-08-31
FR23C1041I1 (fr) 2023-12-29
CA2791461A1 (fr) 2011-09-09
PL2865751T3 (pl) 2017-03-31
KR20130056216A (ko) 2013-05-29
EP2542675A1 (fr) 2013-01-09
JP5758920B2 (ja) 2015-08-05
EP3088514B1 (fr) 2018-11-28
BR112012022029A2 (pt) 2021-05-18
JP2014237694A (ja) 2014-12-18
RU2604795C2 (ru) 2016-12-10
WO2011107990A1 (fr) 2011-09-09
CN102933707B (zh) 2015-09-30
HRP20200428T1 (hr) 2020-06-12
FIC20230032I1 (fi) 2023-11-02
NL301249I1 (fr) 2023-11-08
HUE030959T2 (en) 2017-06-28
BR112012022029B1 (pt) 2022-10-11
IL221741A (en) 2017-07-31
NZ602317A (en) 2014-04-30
EP3088514A1 (fr) 2016-11-02
IN2012MN02262A (fr) 2015-06-12
JP5871999B2 (ja) 2016-03-01
CA2791461C (fr) 2019-10-22

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