FR2400501A1 - Procede adiabatique continu de mononitration du benzene - Google Patents

Procede adiabatique continu de mononitration du benzene

Info

Publication number
FR2400501A1
FR2400501A1 FR7815318A FR7815318A FR2400501A1 FR 2400501 A1 FR2400501 A1 FR 2400501A1 FR 7815318 A FR7815318 A FR 7815318A FR 7815318 A FR7815318 A FR 7815318A FR 2400501 A1 FR2400501 A1 FR 2400501A1
Authority
FR
France
Prior art keywords
benzene
mononitration
mononitrobenzene
continuous adiabatic
adiabatic process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7815318A
Other languages
English (en)
Other versions
FR2400501B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FR2400501A1 publication Critical patent/FR2400501A1/fr
Application granted granted Critical
Publication of FR2400501B1 publication Critical patent/FR2400501B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Pour effectuer la mononitration du benzène selon l'invention, on met en contact un excès de benzène et un mélange d'acide nitrique, d'acide sulfurique et d'eau de composition déterminée entre environ 80 et 120 degrés C sous pression et en agitant énergiquement pendant une durée suffisante pour transformer pratiquement tout l'acide nitrique en mononitrobenzène. L'invention permet en particulier d'obtenir par réaction adiabatique continue du mononitrobenzène très pur avec une vitesse de réaction accrue et un rendement très élevé.
FR7815318A 1977-08-19 1978-05-23 Procede adiabatique continu de mononitration du benzene Granted FR2400501A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/826,208 US4091042A (en) 1977-08-19 1977-08-19 Continuous adiabatic process for the mononitration of benzene

Publications (2)

Publication Number Publication Date
FR2400501A1 true FR2400501A1 (fr) 1979-03-16
FR2400501B1 FR2400501B1 (fr) 1984-01-27

Family

ID=25245976

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7815318A Granted FR2400501A1 (fr) 1977-08-19 1978-05-23 Procede adiabatique continu de mononitration du benzene

Country Status (21)

Country Link
US (1) US4091042A (fr)
JP (1) JPS5432424A (fr)
AT (1) AT357140B (fr)
AU (1) AU518647B2 (fr)
BE (1) BE867355A (fr)
BR (1) BR7803249A (fr)
CA (1) CA1083608A (fr)
CH (1) CH639936A5 (fr)
CS (1) CS207645B2 (fr)
DD (1) DD136960A5 (fr)
DE (1) DE2821571A1 (fr)
EG (1) EG13569A (fr)
FR (1) FR2400501A1 (fr)
GB (1) GB1597433A (fr)
IN (1) IN147796B (fr)
IT (1) IT1103488B (fr)
MX (1) MX148692A (fr)
NL (1) NL189757C (fr)
PL (1) PL113312B1 (fr)
PT (1) PT68105A (fr)
TR (1) TR19875A (fr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4241229A (en) * 1979-08-08 1980-12-23 American Cyanamid Company Recovery of nitrated aromatic compounds from nitration wash liquors
JPS5785332A (en) * 1980-11-17 1982-05-28 Mitsui Toatsu Chem Inc Ortho-alkylation of phenolic compound
DE3409717C2 (de) * 1984-03-16 1994-03-31 Bayer Ag Verfahren zur Herstellung von Nitrobenzol
DE3409719A1 (de) * 1984-03-16 1985-09-19 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von dinitrotoluol
US4973770A (en) * 1988-12-15 1990-11-27 C-I-L, Inc. Manufacture of organic nitro compounds
US5313009A (en) * 1990-01-04 1994-05-17 Nrm International Technologies C.V. Nitration process
TW236610B (en) * 1992-11-13 1994-12-21 Bayer Ag Preparation of dinitrotoluene
DE4309140C2 (de) * 1993-03-22 2001-09-20 Bayer Ag Verfahren zur Herstellung von Dinitrotoluol
DE4410417A1 (de) * 1994-02-14 1995-08-17 Bayer Ag Verfahren zur adiabatischen Herstellung von Mononitrotoluolen
DE4411064A1 (de) * 1994-03-30 1995-10-05 Bayer Ag Verfahren zur adiabatischen Herstellung von Mononitrohalogenbenzolen
DE4428462A1 (de) * 1994-08-11 1996-02-15 Bayer Ag Verfahren zur Herstellung von Dinitrotoluol
DE4428459A1 (de) * 1994-08-11 1996-02-15 Bayer Ag Verfahren zur Herstellung von Dinitrotoluol
DE4437047A1 (de) 1994-10-17 1996-04-18 Bayer Ag Verfahren zur Dinitrierung von aromatischen Verbindungen
US5763687A (en) 1995-12-15 1998-06-09 Mitsui Chemicals, Inc. Preparation process for aromatic mononitro compounds
PT1272268E (pt) 2000-03-02 2012-07-24 Dow Global Technologies Llc Reator tubular, processo de realização de reações multifásicas líquido/ líquido num reator tubular, e um processo de nitração cíclica de compostos aromáticos num reator tubular
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
DE102005057555B3 (de) * 2005-11-21 2007-05-16 Meissner Gmbh & Co Kg Josef Verfahren zur Herstellung von Salpetersäureestern einwertiger Alkohole
WO2007081385A2 (fr) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Dispositifs microfluidiques et leurs procédés d'utilisation dans la formation et le contrôle de nanoréacteurs
DE102006021857A1 (de) 2006-05-09 2007-11-15 Otto Bock Healthcare Ip Gmbh & Co. Kg Verfahren zum Gießen eines Prothesenschaftes
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2007133710A2 (fr) 2006-05-11 2007-11-22 Raindance Technologies, Inc. Dispositifs microfluidiques et leurs procédés d'utilisation
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
WO2008097559A2 (fr) 2007-02-06 2008-08-14 Brandeis University Manipulation de fluides et de réactions dans des systèmes microfluidiques
WO2008130623A1 (fr) 2007-04-19 2008-10-30 Brandeis University Manipulation de fluides, composants fluidiques et réactions dans des systèmes microfluidiques
DE102007059513A1 (de) 2007-12-11 2009-06-18 Bayer Materialscience Ag Verfahren zur Herstellung von Nitrobenzol durch adiabate Nitrierung
EP4047367A1 (fr) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Procedé de détection d'analytes cibles au moyens des bibliothèques de gouttelettes
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
DE102008048713A1 (de) * 2008-09-24 2010-03-25 Bayer Materialscience Ag Verfahren zur kontinuierlichen Herstellung von Nitrobenzol
PT2352717T (pt) 2008-11-10 2017-10-31 Noram International Ltd Resumo
EP2352718B1 (fr) * 2008-11-14 2016-04-13 Noram International Limited Méthode de réduction de la formation de sous-produit dinitrobenzène dans la production de mononitrobenzène
CN101759568A (zh) * 2008-12-25 2010-06-30 南化集团研究院 硝基苯的绝热生产方法
DE102009005324B4 (de) 2009-01-16 2014-04-03 Plinke Gmbh Verfahren zur adiabatischen Nitrierung von Benzol
JP2012518674A (ja) * 2009-02-26 2012-08-16 ビーエーエスエフ ソシエタス・ヨーロピア ニトロ化芳香族化合物及びそれらの混合物の製造方法
WO2010111231A1 (fr) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation de gouttelettes microfluidiques
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (fr) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Procédés pour réduire l'échange de molécules entre des gouttelettes
DE102010006984A1 (de) * 2010-02-05 2011-08-11 Bayer MaterialScience AG, 51373 Verfahren zur kontinuierlichen Herstellung von Nitrobenzol
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP4435111A1 (fr) 2010-02-12 2024-09-25 Bio-Rad Laboratories, Inc. Analyse numérique d'analyte
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
DE102010038519A1 (de) 2010-07-28 2012-02-02 Bayer Materialscience Ag Verfahren zur Herstellung von Nitrobenzol durch adiabate Nitrierung
WO2012045012A2 (fr) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Dosages sandwich dans des gouttelettes
EP3859011A1 (fr) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Procédés permettant de former des gouttelettes mélangées
WO2012112804A1 (fr) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions et méthodes de marquage moléculaire
JP5818287B2 (ja) 2011-05-19 2015-11-18 ヨーゼフ マイスナー ゲーエムベーハー ウント コー カーゲー ニトロ化生成物を精製する方法及び装置
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP2714970B1 (fr) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Quantification d'enzyme
CN102311347B (zh) * 2011-06-28 2013-08-14 江苏科圣化工装备工程有限公司 由焦化苯连续生产混二硝基苯的装置及方法
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013054181A1 (fr) 2011-10-14 2013-04-18 Council Of Scientific & Industrial Research Synthèse en flux continu à deux étapes de m-aminoacétophénone
CN102516082B (zh) * 2011-11-28 2013-11-06 万华化学集团股份有限公司 由苯与混酸反应制备硝基苯以及洗涤粗硝基苯产物的方法
KR20140117474A (ko) * 2012-01-31 2014-10-07 바이엘 인텔렉쳐 프로퍼티 게엠베하 니트로벤젠을 제조하기 위한 방법 및 시스템
US8907144B2 (en) 2012-03-22 2014-12-09 Noram International Limited Process for adiabatic production of mononitrotoluene
KR102067307B1 (ko) 2012-07-27 2020-01-16 코베스트로 도이칠란드 아게 단열 니트로화에 의한 니트로벤젠의 제조방법
KR102066764B1 (ko) * 2012-07-27 2020-01-15 코베스트로 도이칠란드 아게 단열 니트로화에 의한 니트로벤젠의 제조방법
EP2877442B1 (fr) 2012-07-27 2016-11-16 Covestro Deutschland AG Procédé de preparation de nitrobenzène par nitrification adiabatique
EP2991966B1 (fr) * 2013-04-29 2017-07-12 Covestro Deutschland AG Procede destine à la fabrication de benzol nitrique par nitrification d'adiabate
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (fr) 2013-12-31 2015-07-09 Raindance Technologies, Inc. Système et procédé de détection d'une espèce d'arn
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
DE102017110084C5 (de) 2017-02-03 2026-02-26 Josef Meissner Gmbh & Co. Kg Verwendungen von Nitroaromaten in der adiabatischen Nitrierung von Aromaten
PT3592727T (pt) * 2017-03-07 2024-06-26 Covestro Deutschland Ag Método para fabrico de nitrobenzeno
WO2020011817A1 (fr) 2018-07-12 2020-01-16 Covestro Deutschland Ag Procédé de production de nitrobenzène par nitrification adiabatique de benzène
DE102018217955B4 (de) * 2018-10-19 2020-06-04 Plinke Gmbh Verfahren zur Aufarbeitung von Mischsäure und Abwasser aus der Nitrierung von Aromaten sowie Vorrichtung zur Durchführung des Verfahrens
CN111393299A (zh) * 2020-05-06 2020-07-10 沈阳感光化工研究院有限公司 一种使用微通道连续流反应器对硝基苯进行硝化的方法
KR20250026349A (ko) 2022-06-28 2025-02-25 바스프 에스이 니트로벤젠의 제조 방법
EP4766477A1 (fr) 2023-08-25 2026-07-01 Covestro Deutschland AG Réacteur servant à la nitration de composés aromatiques, installation de production comprenant ledit réacteur et procédé de nitration utilisant ledit réacteur
CN118221528A (zh) * 2024-02-04 2024-06-21 清华大学 采用硝硫混酸制备单硝基芳烃的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021498A (en) * 1975-12-09 1977-05-03 American Cyanamid Company Adiabatic process for nitration of nitratable aromatic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3087971A (en) * 1953-12-07 1963-04-30 Samuelsen Eirik Method for trinitrotoluene manufacture
GB1081091A (en) * 1964-01-08 1967-08-31 Ici Ltd Improvements in or relating to the preparation of dinitrotoluenes
US3928475A (en) * 1974-08-09 1975-12-23 Du Pont Azeotropic nitration of benzene

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021498A (en) * 1975-12-09 1977-05-03 American Cyanamid Company Adiabatic process for nitration of nitratable aromatic compounds

Also Published As

Publication number Publication date
TR19875A (tr) 1980-04-03
NL7805409A (nl) 1979-02-21
IN147796B (fr) 1980-06-28
AU3529978A (en) 1979-10-25
AT357140B (de) 1980-06-25
BE867355A (fr) 1978-11-23
IT1103488B (it) 1985-10-14
PL113312B1 (en) 1980-12-31
PL207037A1 (pl) 1979-05-07
MX148692A (es) 1983-06-02
JPS5432424A (en) 1979-03-09
NL189757B (nl) 1993-02-16
US4091042A (en) 1978-05-23
EG13569A (en) 1981-12-31
AU518647B2 (en) 1981-10-15
DD136960A5 (de) 1979-08-08
IT7849331A0 (it) 1978-05-12
CS207645B2 (en) 1981-08-31
FR2400501B1 (fr) 1984-01-27
PT68105A (en) 1978-06-01
ATA369978A (de) 1979-11-15
GB1597433A (en) 1981-09-09
BR7803249A (pt) 1979-03-27
CH639936A5 (de) 1983-12-15
CA1083608A (fr) 1980-08-12
DE2821571A1 (de) 1979-03-01
NL189757C (nl) 1993-07-16

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