FR2411202A1 - Procede d'extraction et de purification de la globuline transporteur d'hormones thyroidiennes tbg - Google Patents
Procede d'extraction et de purification de la globuline transporteur d'hormones thyroidiennes tbgInfo
- Publication number
- FR2411202A1 FR2411202A1 FR7736668A FR7736668A FR2411202A1 FR 2411202 A1 FR2411202 A1 FR 2411202A1 FR 7736668 A FR7736668 A FR 7736668A FR 7736668 A FR7736668 A FR 7736668A FR 2411202 A1 FR2411202 A1 FR 2411202A1
- Authority
- FR
- France
- Prior art keywords
- tbg
- chromatography
- eluting
- human plasma
- eluted fractions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000002248 Thyroxine-Binding Globulin Human genes 0.000 title abstract 6
- 108010000259 Thyroxine-Binding Globulin Proteins 0.000 title abstract 6
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 title abstract 6
- 238000004587 chromatography analysis Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 abstract 2
- 229920005654 Sephadex Polymers 0.000 abstract 2
- 239000012507 Sephadex™ Substances 0.000 abstract 2
- 238000010828 elution Methods 0.000 abstract 2
- 239000011780 sodium chloride Substances 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 229920002684 Sepharose Polymers 0.000 abstract 1
- 239000007983 Tris buffer Substances 0.000 abstract 1
- 238000001042 affinity chromatography Methods 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 239000008363 phosphate buffer Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4717—Plasma globulins, lactoglobulin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDE D'EXTRACTION ET DE PURIFICATION DE LA GLOBULINE TRANSPORTEUR D'HORMONES THYROIDIENNES TBG CONTENUE DANS UNE FRACTION DE PROTEINES OBTENUE A PARTIR D'UN MELANGE DE PLASMAS HUMAINS ET TRAITEE PAR LA METHODE 6 DE COHN. IL COMPREND SUCCESSIVEMENT: UNE PREMIERE ETAPE SELON LAQUELLE ON SOUMET LADITE FRACTION 6 DE COHN A UNE CHROMATOGRAPHIE PAR ECHANGE D'IONS; UNE DEUXIEME ETAPE SELON LAQUELLE ON SOUMET LES FRACTIONS ELUEES AINSI OBTENUES A UNE CHROMATOGRAPHIE D'AFFINITE; UNE TROISIEME ETAPE SELON LAQUELLE ON SOUMET LES FRACTIONS ELUEES AINSI OBTENUES A UNE DEUXIEME CHROMATOGRAPHIE PAR ECHANGE D'IONS; UNE DERNIERE ETAPE DE PURIFICATION FINALE DES FRACTIONS ELUEES AINSI OBTENUES. APPLICATION A LA REALISATION D'UN SERUM ANTI-TBG.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7736668A FR2411202A1 (fr) | 1977-12-06 | 1977-12-06 | Procede d'extraction et de purification de la globuline transporteur d'hormones thyroidiennes tbg |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7736668A FR2411202A1 (fr) | 1977-12-06 | 1977-12-06 | Procede d'extraction et de purification de la globuline transporteur d'hormones thyroidiennes tbg |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2411202A1 true FR2411202A1 (fr) | 1979-07-06 |
| FR2411202B1 FR2411202B1 (fr) | 1981-06-26 |
Family
ID=9198494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7736668A Granted FR2411202A1 (fr) | 1977-12-06 | 1977-12-06 | Procede d'extraction et de purification de la globuline transporteur d'hormones thyroidiennes tbg |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2411202A1 (fr) |
-
1977
- 1977-12-06 FR FR7736668A patent/FR2411202A1/fr active Granted
Non-Patent Citations (4)
| Title |
|---|
| CA1970 * |
| CA1972 * |
| CA1975 * |
| CA1978 * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2411202B1 (fr) | 1981-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| TP | Transmission of property | ||
| ST | Notification of lapse |