FR2424247A2 - Nouveaux derives d'acides arylalcanoiques a action hypolipemiante et leurs procedes d'obtention - Google Patents
Nouveaux derives d'acides arylalcanoiques a action hypolipemiante et leurs procedes d'obtentionInfo
- Publication number
- FR2424247A2 FR2424247A2 FR7812452A FR7812452A FR2424247A2 FR 2424247 A2 FR2424247 A2 FR 2424247A2 FR 7812452 A FR7812452 A FR 7812452A FR 7812452 A FR7812452 A FR 7812452A FR 2424247 A2 FR2424247 A2 FR 2424247A2
- Authority
- FR
- France
- Prior art keywords
- atheroma
- substd
- aryl
- antilipaemic
- alkanoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000031226 Hyperlipidaemia Diseases 0.000 title abstract 3
- 206010003210 Arteriosclerosis Diseases 0.000 title abstract 2
- 208000037260 Atherosclerotic Plaque Diseases 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 230000002402 anti-lipaemic effect Effects 0.000 title abstract 2
- 208000035150 Hypercholesterolemia Diseases 0.000 title 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 125000005041 acyloxyalkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000033 alkoxyamino group Chemical group 0.000 abstract 1
- 125000003418 alkyl amino alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005237 alkyleneamino group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000004984 dialkylaminoalkoxy group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 150000002892 organic cations Chemical class 0.000 abstract 1
- -1 polyhydroxyalkoxy Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000003966 vascular damage Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
Abstract
L'INVENTION SE RAPPORTE A TITRE DE COMPOSES INDUSTRIELS NOUVEAUX, A DES ACIDES ARYLALCOYLALCANOIQUES ET A LEURS DERIVES REPONDANT A LA FORMULE GENERALE I: (CF DESSIN DANS BOPI) DANS LAQUELLE: Z EST DE L'OXYGENE OU DU SOUFRE; R EST UN RADICAL HYDROCARBONE; AR EST UN RADICAL MONO- OU BICYCLIQUE, HOMO OU HETEROCYCLIQUE EVENTUELLEMENT SUBSTITUE; ET X EST UN HYDROXYLE, UN ALCOXY, UN GROUPE OM, UN RADICAL AMINE OU UN RADICAL HYDROXY AMINE. L'INVENTION S'ETEND AUSSI AUX DIASTEREOISOMERES ERYTHRO ET THREO DES COMPOSES CONFORMES A LA PRESENTE ADDITION. LES COMPOSES CONFORMES A LA PRESENTE ADDITION SONT DOUES DE PROPRIETES PHARMACOLOGIQUES INTERESSANTES QUI LES RENDENT APTES A SERVIR DE PRINCIPE ACTIF DANS DES COMPOSITIONS PHARMACEUTIQUES.
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7812452A FR2424247A2 (fr) | 1978-04-27 | 1978-04-27 | Nouveaux derives d'acides arylalcanoiques a action hypolipemiante et leurs procedes d'obtention |
| FI783042A FI783042A7 (fi) | 1977-10-07 | 1978-10-06 | Foerfarande foer framstaellning av nya derivat av arylalkankarboxylsyror |
| SU782672304A SU884568A3 (ru) | 1977-10-07 | 1978-10-06 | Способ получени (арилалкил) алкановых кислот |
| ES474002A ES474002A1 (es) | 1977-10-07 | 1978-10-06 | Procedimiento de preparacion de nuevos derivados de acidos arilalcanoicos y de sus sales con una base mineral u organi-ca |
| GR57395A GR66480B (fr) | 1977-10-07 | 1978-10-06 | |
| DK444278A DK444278A (da) | 1977-10-07 | 1978-10-06 | Arylalkylalkansyrer og fremgangsmaade til fremstilling heraf |
| DE19782843776 DE2843776A1 (de) | 1977-10-07 | 1978-10-06 | (arylalkyl)-alkansaeurederivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
| NL7810163A NL7810163A (nl) | 1977-10-07 | 1978-10-09 | Arylalkylalkaancarbonzuren, geneesmiddel met als werk- zaam bestanddeel alkaancarbonzuur en werkwijze voor de bereiding van de arylalkylalkaancarbonzuren. |
| AT0726178A AT363462B (de) | 1977-10-07 | 1978-10-09 | Verfahren zur herstellung von neuen arylalkansaeurederivaten |
| GB7839761A GB2007649B (en) | 1977-10-07 | 1978-10-09 | Derivatives of arylalcanoic acid and processes for making them |
| AU40552/78A AU4055278A (en) | 1977-10-07 | 1978-10-09 | Novel derivatives of arylalcanoic acids and processes for making them |
| PL1978210157A PL120454B1 (en) | 1977-10-07 | 1978-10-09 | Process for preparing novel derivatives of arylalkanocarboxylic acidsvykh kislot |
| SE7810536A SE7810536L (sv) | 1977-10-07 | 1978-10-09 | Nya arylalkansyraderivat och sett att framstella dessa |
| US05/949,571 US4288453A (en) | 1977-10-07 | 1978-10-10 | Derivatives of arylalkanoic acids, compositions and use |
| PT68652A PT68652A (fr) | 1978-04-27 | 1978-10-13 | Procede d'obtention de nouveaux derives d'acides arylalcanoiques |
| IL7855766A IL55766A0 (en) | 1978-04-27 | 1978-10-19 | Novel arylalkanoic acids and derivatives thereof,their production and pharmaceutical compositions containing them |
| JP13248478A JPS54144328A (en) | 1978-04-27 | 1978-10-27 | Novel derivative of arylalkanoic acid |
| HU78SI1661A HU178741B (en) | 1978-04-27 | 1978-11-08 | Process for producing new arylalkanoic acid derivatives |
| IT52191/78A IT1158156B (it) | 1978-04-27 | 1978-12-05 | Procedimento per la preparazione di derivati di acidi arilalcanoici e relative composizioni farmaceutiche |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7812452A FR2424247A2 (fr) | 1978-04-27 | 1978-04-27 | Nouveaux derives d'acides arylalcanoiques a action hypolipemiante et leurs procedes d'obtention |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2424247A2 true FR2424247A2 (fr) | 1979-11-23 |
| FR2424247B2 FR2424247B2 (fr) | 1980-10-10 |
Family
ID=9207642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7812452A Granted FR2424247A2 (fr) | 1977-10-07 | 1978-04-27 | Nouveaux derives d'acides arylalcanoiques a action hypolipemiante et leurs procedes d'obtention |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS54144328A (fr) |
| FR (1) | FR2424247A2 (fr) |
| HU (1) | HU178741B (fr) |
| IL (1) | IL55766A0 (fr) |
| IT (1) | IT1158156B (fr) |
| PT (1) | PT68652A (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2472560A2 (fr) * | 1979-11-30 | 1981-07-03 | Science Union & Cie | Nouveaux derives d'acides alcanoiques, leur procede d'obtention et leur utilisation therapeutique |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR93175E (fr) * | 1964-03-20 | 1969-02-21 | Merck & Co Inc | Nouveaux acides alkanoiques a substituant aryle et procédés pour leur préparation. |
| FR1573841A (fr) * | 1966-10-03 | 1969-07-11 | ||
| US3742043A (en) * | 1972-04-24 | 1973-06-26 | Dow Chemical Co | 2-(alpha,alpha-bis(trifluoromethyl)benzyloxy) acetic acid and esters thereof |
| FR2296405A1 (fr) * | 1974-12-30 | 1976-07-30 | Synthelabo | Nouveaux derives de l'acide phenyl-acetique, leur preparation et les medicaments qui les renferment |
| FR2325362A2 (fr) * | 1975-09-26 | 1977-04-22 | Synthelabo | Nouveaux derives de l'acide phenyl-acetique, leur preparation et les medicaments qui les renferment |
| FR2351945A1 (fr) * | 1976-05-21 | 1977-12-16 | Ici Ltd | Nouveaux derives aromatiques de l'acide acetique, leur procede de preparation et medicament les contenant |
-
1978
- 1978-04-27 FR FR7812452A patent/FR2424247A2/fr active Granted
- 1978-10-13 PT PT68652A patent/PT68652A/fr unknown
- 1978-10-19 IL IL7855766A patent/IL55766A0/xx unknown
- 1978-10-27 JP JP13248478A patent/JPS54144328A/ja active Pending
- 1978-11-08 HU HU78SI1661A patent/HU178741B/hu unknown
- 1978-12-05 IT IT52191/78A patent/IT1158156B/it active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR93175E (fr) * | 1964-03-20 | 1969-02-21 | Merck & Co Inc | Nouveaux acides alkanoiques a substituant aryle et procédés pour leur préparation. |
| FR1573841A (fr) * | 1966-10-03 | 1969-07-11 | ||
| US3742043A (en) * | 1972-04-24 | 1973-06-26 | Dow Chemical Co | 2-(alpha,alpha-bis(trifluoromethyl)benzyloxy) acetic acid and esters thereof |
| FR2296405A1 (fr) * | 1974-12-30 | 1976-07-30 | Synthelabo | Nouveaux derives de l'acide phenyl-acetique, leur preparation et les medicaments qui les renferment |
| FR2325362A2 (fr) * | 1975-09-26 | 1977-04-22 | Synthelabo | Nouveaux derives de l'acide phenyl-acetique, leur preparation et les medicaments qui les renferment |
| FR2351945A1 (fr) * | 1976-05-21 | 1977-12-16 | Ici Ltd | Nouveaux derives aromatiques de l'acide acetique, leur procede de preparation et medicament les contenant |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2472560A2 (fr) * | 1979-11-30 | 1981-07-03 | Science Union & Cie | Nouveaux derives d'acides alcanoiques, leur procede d'obtention et leur utilisation therapeutique |
Also Published As
| Publication number | Publication date |
|---|---|
| IL55766A0 (en) | 1978-12-17 |
| FR2424247B2 (fr) | 1980-10-10 |
| PT68652A (fr) | 1978-11-01 |
| HU178741B (en) | 1982-06-28 |
| IT7852191A0 (it) | 1978-12-05 |
| JPS54144328A (en) | 1979-11-10 |
| IT1158156B (it) | 1987-02-18 |
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