FR2460676A1 - Vaccin contre la rhinotracheite bovine infectieuse - Google Patents
Vaccin contre la rhinotracheite bovine infectieuse Download PDFInfo
- Publication number
- FR2460676A1 FR2460676A1 FR8014845A FR8014845A FR2460676A1 FR 2460676 A1 FR2460676 A1 FR 2460676A1 FR 8014845 A FR8014845 A FR 8014845A FR 8014845 A FR8014845 A FR 8014845A FR 2460676 A1 FR2460676 A1 FR 2460676A1
- Authority
- FR
- France
- Prior art keywords
- virus
- ibr
- protein
- vaccine
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 90
- 208000005562 infectious bovine rhinotracheitis Diseases 0.000 title abstract description 46
- 241000700605 Viruses Species 0.000 claims abstract description 60
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 28
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 28
- 239000002671 adjuvant Substances 0.000 claims abstract description 23
- 239000003599 detergent Substances 0.000 claims abstract description 18
- 108010003533 Viral Envelope Proteins Proteins 0.000 claims abstract description 13
- 210000004779 membrane envelope Anatomy 0.000 claims abstract description 7
- 230000003053 immunization Effects 0.000 claims abstract description 5
- 238000002649 immunization Methods 0.000 claims abstract description 4
- 210000004027 cell Anatomy 0.000 claims description 35
- 241000283690 Bos taurus Species 0.000 claims description 22
- 208000015181 infectious disease Diseases 0.000 claims description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
- 201000010099 disease Diseases 0.000 claims description 14
- 239000007864 aqueous solution Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- 230000003612 virological effect Effects 0.000 claims description 7
- 230000002265 prevention Effects 0.000 claims description 6
- 238000012546 transfer Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 210000000170 cell membrane Anatomy 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 2
- 230000001902 propagating effect Effects 0.000 claims description 2
- 230000002458 infectious effect Effects 0.000 claims 3
- 102000002067 Protein Subunits Human genes 0.000 claims 1
- 108010001267 Protein Subunits Proteins 0.000 claims 1
- 206010051497 Rhinotracheitis Diseases 0.000 claims 1
- 230000009851 immunogenic response Effects 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 abstract description 12
- 238000000605 extraction Methods 0.000 abstract description 6
- 238000002255 vaccination Methods 0.000 description 30
- 244000309466 calf Species 0.000 description 22
- 239000002609 medium Substances 0.000 description 20
- 241000701083 Bovine alphaherpesvirus 1 Species 0.000 description 16
- 229920004890 Triton X-100 Polymers 0.000 description 15
- 239000013504 Triton X-100 Substances 0.000 description 15
- 210000002966 serum Anatomy 0.000 description 14
- 239000002054 inoculum Substances 0.000 description 12
- BHNQPLPANNDEGL-UHFFFAOYSA-N 2-(4-octylphenoxy)ethanol Chemical compound CCCCCCCCC1=CC=C(OCCO)C=C1 BHNQPLPANNDEGL-UHFFFAOYSA-N 0.000 description 11
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 10
- 239000000284 extract Substances 0.000 description 10
- 238000006386 neutralization reaction Methods 0.000 description 10
- 239000012894 fetal calf serum Substances 0.000 description 9
- 230000028327 secretion Effects 0.000 description 9
- 239000000243 solution Substances 0.000 description 8
- 238000011081 inoculation Methods 0.000 description 7
- 238000007918 intramuscular administration Methods 0.000 description 7
- 230000000890 antigenic effect Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 229920001817 Agar Polymers 0.000 description 5
- 239000008272 agar Substances 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 239000010410 layer Substances 0.000 description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 206010000210 abortion Diseases 0.000 description 4
- 231100000176 abortion Toxicity 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 244000144972 livestock Species 0.000 description 3
- 210000005265 lung cell Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000012770 revaccination Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 239000010414 supernatant solution Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- WEEMDRWIKYCTQM-UHFFFAOYSA-N 2,6-dimethoxybenzenecarbothioamide Chemical compound COC1=CC=CC(OC)=C1C(N)=S WEEMDRWIKYCTQM-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 208000032420 Latent Infection Diseases 0.000 description 2
- 241000609499 Palicourea Species 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000000120 cytopathologic effect Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- OOYGSFOGFJDDHP-KMCOLRRFSA-N kanamycin A sulfate Chemical compound OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N OOYGSFOGFJDDHP-KMCOLRRFSA-N 0.000 description 2
- 229960002064 kanamycin sulfate Drugs 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 229960002385 streptomycin sulfate Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- WFCSWCVEJLETKA-UHFFFAOYSA-N 2-piperazin-1-ylethanol Chemical compound OCCN1CCNCC1 WFCSWCVEJLETKA-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010004078 Balanoposthitis Diseases 0.000 description 1
- 241000030939 Bubalus bubalis Species 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical class C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 239000007640 basal medium Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 208000037771 disease arising from reactivation of latent virus Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 201000011475 meningoencephalitis Diseases 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- UYDLBVPAAFVANX-UHFFFAOYSA-N octylphenoxy polyethoxyethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCO)C=C1 UYDLBVPAAFVANX-UHFFFAOYSA-N 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000011886 postmortem examination Methods 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 229960003127 rabies vaccine Drugs 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000009589 serological test Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000014599 transmission of virus Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 208000010484 vulvovaginitis Diseases 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
- A61K39/265—Infectious rhinotracheitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5582179A | 1979-07-09 | 1979-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2460676A1 true FR2460676A1 (fr) | 1981-01-30 |
Family
ID=22000364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8014845A Withdrawn FR2460676A1 (fr) | 1979-07-09 | 1980-07-03 | Vaccin contre la rhinotracheite bovine infectieuse |
Country Status (6)
| Country | Link |
|---|---|
| CA (1) | CA1163556A (da) |
| DE (1) | DE3026044A1 (da) |
| DK (1) | DK276380A (da) |
| FR (1) | FR2460676A1 (da) |
| GB (1) | GB2052983B (da) |
| NL (1) | NL8003889A (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2221040C1 (ru) * | 2002-06-28 | 2004-01-10 | Федеральное государственное учреждение Всероссийский научно-исследовательский институт защиты животных | Штамм "вниизж" вируса инфекционного ринотрахеита крупного рогатого скота для изготовления вакцинных и диагностических препаратов |
| JP7432506B2 (ja) | 2017-10-30 | 2024-02-16 | 武田薬品工業株式会社 | 脂質エンベロープウイルスを不活化するための環境適合性の界面活性剤 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2248054A1 (da) * | 1973-10-18 | 1975-05-16 | Flockhart & Co |
-
1980
- 1980-06-26 DK DK276380A patent/DK276380A/da not_active Application Discontinuation
- 1980-06-30 GB GB8021393A patent/GB2052983B/en not_active Expired
- 1980-07-03 FR FR8014845A patent/FR2460676A1/fr not_active Withdrawn
- 1980-07-04 NL NL8003889A patent/NL8003889A/nl not_active Application Discontinuation
- 1980-07-08 CA CA000355701A patent/CA1163556A/en not_active Expired
- 1980-07-09 DE DE19803026044 patent/DE3026044A1/de not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2248054A1 (da) * | 1973-10-18 | 1975-05-16 | Flockhart & Co |
Non-Patent Citations (1)
| Title |
|---|
| CHEMICAL ABSTRACTS, vol. 92, no. 25, 23 juin 1980, page 463, résumé no. 213436h COLUMBUS OHIO (US) * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2052983A (en) | 1981-02-04 |
| GB2052983B (en) | 1983-09-21 |
| DE3026044A1 (de) | 1981-02-05 |
| CA1163556A (en) | 1984-03-13 |
| DK276380A (da) | 1981-01-10 |
| NL8003889A (nl) | 1981-01-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1268393C (zh) | 经改良修饰的brsv或疫苗 | |
| Jiao et al. | Comparative study of the effects of aluminum adjuvants and Freund's incomplete adjuvant on the immune response to an Edwardsiella tarda major antigen | |
| FR2709966A1 (fr) | Vaccin pour la prévention du syndrome respiratoire et de la reproduction du porc. | |
| MX2010014026A (es) | Composiciones adyuvantes novedosas. | |
| FR2686097A1 (fr) | Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie. | |
| JP2005515236A (ja) | ウエストナイルワクチン | |
| CA2699218C (en) | Mycoplasma bovis vaccine | |
| RU2420310C2 (ru) | ВАКЦИНА НА ОСНОВЕ Lawsonia И СПОСОБЫ ЕЕ ПРИМЕНЕНИЯ | |
| Neer et al. | Efficacy of enrofloxacin for the treatment of experimentally induced Ehrlichia canis infection | |
| JP2020518663A (ja) | 豚サーコウイルス3型免疫原性組成物、その調製方法及び用途 | |
| CA3033730A1 (en) | Porcine epidemic diarrhea preventive or therapeutic method, vaccine, and vaccine kit | |
| US4291019A (en) | Vaccine for infectious bovine rhinotracheitis | |
| Kornuta et al. | TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1 | |
| WO2011117506A2 (fr) | Diluants adjuvants de vaccins vivants pour maladies porcines | |
| CN100518739C (zh) | 逆转录病毒免疫疗法 | |
| AU769390B2 (en) | Vaccine composition | |
| Li et al. | Co-administration of attenuated Mycoplasma hyopneumoniae 168 strain with bacterial DNA enhances the local and systemic immune response after intranasal vaccination in pigs | |
| FR2499410A1 (fr) | Vaccin contre l'avortement enzootique chez les brebis et son procede de preparation | |
| US3000788A (en) | Propagation of modified infectious canine hepatitis virus in tissue cultures of pig kidney and the preparation of a vaccine therefrom | |
| CH382917A (fr) | Procédé pour la production d'un virus-vaccin contre la maladie des chiens | |
| JP2025516762A (ja) | Moritella viscosaに対するワクチン | |
| CA1163556A (en) | Vaccine for infectious bovine rhinotracheitis | |
| Tan et al. | Further studies on feline respiratory virus diseases: 1. Vaccination experiments | |
| FR2796282A1 (fr) | Vaccin inactive contre la calicivirose feline | |
| JPS6244528B2 (da) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |