FR2562543B1 - Nouveaux phosphonites cycliques, leur preparation et applications - Google Patents

Nouveaux phosphonites cycliques, leur preparation et applications

Info

Publication number
FR2562543B1
FR2562543B1 FR8405622A FR8405622A FR2562543B1 FR 2562543 B1 FR2562543 B1 FR 2562543B1 FR 8405622 A FR8405622 A FR 8405622A FR 8405622 A FR8405622 A FR 8405622A FR 2562543 B1 FR2562543 B1 FR 2562543B1
Authority
FR
France
Prior art keywords
applications
preparation
novel cyclic
cyclic phosphonites
phosphonites
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8405622A
Other languages
English (en)
Other versions
FR2562543A1 (fr
Inventor
Sylvain Juge
Yvonne Legras
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe National Elf Aquitaine
Original Assignee
Societe National Elf Aquitaine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe National Elf Aquitaine filed Critical Societe National Elf Aquitaine
Priority to FR8405622A priority Critical patent/FR2562543B1/fr
Priority to GB08508730A priority patent/GB2158441B/en
Priority to CH1476/85A priority patent/CH665644A5/fr
Priority to BE0/214797A priority patent/BE902124A/fr
Priority to IT20279/85A priority patent/IT1201414B/it
Priority to CA000478571A priority patent/CA1258266A/fr
Priority to NL8501030A priority patent/NL8501030A/nl
Priority to JP60074524A priority patent/JPH0662649B2/ja
Priority to DE3512781A priority patent/DE3512781C2/de
Publication of FR2562543A1 publication Critical patent/FR2562543A1/fr
Application granted granted Critical
Publication of FR2562543B1 publication Critical patent/FR2562543B1/fr
Priority to US07/407,702 priority patent/US4952740A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/65719—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonous acid derivative
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3264—Esters with hydroxyalkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3276—Esters with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5325—Aromatic phosphine oxides or thioxides (P-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Compounds Of Unknown Constitution (AREA)
FR8405622A 1984-04-10 1984-04-10 Nouveaux phosphonites cycliques, leur preparation et applications Expired FR2562543B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR8405622A FR2562543B1 (fr) 1984-04-10 1984-04-10 Nouveaux phosphonites cycliques, leur preparation et applications
GB08508730A GB2158441B (en) 1984-04-10 1985-04-03 New cyclic phosphonites, their preparation and uses
BE0/214797A BE902124A (fr) 1984-04-10 1985-04-04 Nouveaux phosphonites cycliques, leur preparation et applications.
CH1476/85A CH665644A5 (fr) 1984-04-10 1985-04-04 Phosphonites cycliques, leur preparation et utilisation chimique.
IT20279/85A IT1201414B (it) 1984-04-10 1985-04-09 Fosfoniti cicliche,loro preparazione e applicazioni
CA000478571A CA1258266A (fr) 1984-04-10 1985-04-09 Phosphonites cycliques, leur preparation et applications
NL8501030A NL8501030A (nl) 1984-04-10 1985-04-09 Nieuwe cyklische fosfonieten, bereidingswerkwijze en toepassingen daarvan.
JP60074524A JPH0662649B2 (ja) 1984-04-10 1985-04-10 環状ホスホナイト化合物およびそのオキサイド
DE3512781A DE3512781C2 (de) 1984-04-10 1985-04-10 Cyclische Phosphonite, Verfahren zu deren Herstellung und ihre Verwendung
US07/407,702 US4952740A (en) 1984-04-10 1989-09-12 Cyclic phosphonites

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8405622A FR2562543B1 (fr) 1984-04-10 1984-04-10 Nouveaux phosphonites cycliques, leur preparation et applications

Publications (2)

Publication Number Publication Date
FR2562543A1 FR2562543A1 (fr) 1985-10-11
FR2562543B1 true FR2562543B1 (fr) 1987-09-25

Family

ID=9303009

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8405622A Expired FR2562543B1 (fr) 1984-04-10 1984-04-10 Nouveaux phosphonites cycliques, leur preparation et applications

Country Status (10)

Country Link
US (1) US4952740A (fr)
JP (1) JPH0662649B2 (fr)
BE (1) BE902124A (fr)
CA (1) CA1258266A (fr)
CH (1) CH665644A5 (fr)
DE (1) DE3512781C2 (fr)
FR (1) FR2562543B1 (fr)
GB (1) GB2158441B (fr)
IT (1) IT1201414B (fr)
NL (1) NL8501030A (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2562543B1 (fr) * 1984-04-10 1987-09-25 Elf Aquitaine Nouveaux phosphonites cycliques, leur preparation et applications
FR2603286B1 (fr) * 1986-08-27 1988-12-09 Elf Aquitaine Procede de preparation de derives de l'acide phosphineux et produit intermediaire utilise a cet effet
EP0472564B1 (fr) * 1989-05-20 1994-09-21 Hoechst Aktiengesellschaft Arylesters d'acide phosphoneux, procede pour les preparer et leur utilisation pour stabiliser des matieres synthetiques, en particulier des matieres moulables polyolefiniques
DE3923492A1 (de) * 1989-05-20 1991-02-07 Hoechst Ag Kunststoff-formmasse
FR2649109B1 (fr) * 1989-06-30 1991-09-13 Elf Aquitaine Composes organiques du phosphore complexes par du bore, leur preparation et applications
US5767276A (en) * 1995-10-13 1998-06-16 The Penn State Research Foundation Asymmetric synthesis catalyzed by transition metal complexes with new chiral ligands
DE19608006A1 (de) * 1996-03-04 1997-09-11 Hoechst Ag Salze von phosphonigen Säuren und deren Verwendung als Flammschutzmittel in Kunststoffen
US5962440A (en) * 1996-05-09 1999-10-05 Bristol-Myers Squibb Company Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method
JP2001521001A (ja) * 1997-10-28 2001-11-06 ブリストル−マイヤーズ スクイブ カンパニー ミクロソーム・トリグリセリド転移たんぱくの環式ホスホネートエステル抑制剤および抑制方法
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
MXPA01008937A (es) 1999-03-05 2004-04-05 Metabasis Therapeutics Inc Nuevos profarmacos que contienen fosforo.
AU7361400A (en) 1999-09-08 2001-04-10 Metabasis Therapeutics, Inc. Prodrugs for liver specific drug delivery
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EP1736478B1 (fr) 2000-05-26 2015-07-22 IDENIX Pharmaceuticals, Inc. Procédés et compositions de traitement des flavivirus et des pestivirus
EP1435974A4 (fr) 2001-09-28 2006-09-06 Idenix Cayman Ltd Procedes et compositions pour le traitement du virus de l'hepatite c au moyen de nucleosides modifies en 4'
EP2223927B1 (fr) * 2002-05-13 2014-10-15 Metabasis Therapeutics, Inc. Sels d' un Pro-médicament de PMEA à base d'acide phosphonique
WO2003095665A2 (fr) * 2002-05-13 2003-11-20 Metabasis Therapeutics, Inc. Procede d'elaboration de promedicaments cycliques de pmea et de pmpa
TW200500375A (en) 2002-06-28 2005-01-01 Idenix Cayman Ltd Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
CN1678326A (zh) 2002-06-28 2005-10-05 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷
BR0315795A (pt) 2002-10-31 2005-09-13 Metabasis Therapeutics Inc Pró-medicamentos de monofosfato de citarabina
LT1576138T (lt) 2002-11-15 2017-06-26 Idenix Pharmaceuticals Llc 2`-šakoti nukleozidai derinyje su interferonu ir flaviviridae mutacija
AU2003300901A1 (en) 2002-12-12 2004-06-30 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
NZ540913A (en) * 2002-12-23 2008-02-29 Idenix Cayman Ltd Process for the production of 3'-nucleoside prodrugs
HUE029877T2 (en) 2003-05-30 2017-04-28 Gilead Pharmasset Llc Modified fluorinated nucleoside analogues
AR046970A1 (es) * 2003-12-23 2006-01-04 Schering Plough Ltd Esteres de fosfato de florfenicol
CA2565966A1 (fr) * 2004-06-08 2005-12-29 Metabasis Therapeutics, Inc. Synthese d'esters cycliques induite par l'acide de lewis
CA2571675A1 (fr) * 2004-06-23 2006-01-05 Idenix (Cayman) Limited Derives de 5-aza-7-deazapurine pour le traitement des infections avec flaviviridae
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
ES2422290T3 (es) 2005-12-23 2013-09-10 Idenix Pharmaceuticals Inc Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados
WO2009129120A2 (fr) 2008-04-15 2009-10-22 Rfs Pharma, Llc Dérivés nucléosidiques destinés au traitement d’infections par un virus de la famille des caliciviridae, y compris d’infections par le norovirus
WO2012079035A1 (fr) 2010-12-10 2012-06-14 Sigmapharm Laboratories, Llc Compositions très stables d'analogues nucléotidiques actifs par voie orale ou de promédicaments sous forme d'analogues nucléotidiques actifs par voie orale
AU2015217221A1 (en) 2014-02-13 2016-08-11 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
CA3087932A1 (fr) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Composes acetal et leurs utilisations therapeutiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3297631A (en) * 1965-10-24 1967-01-10 Exxon Research Engineering Co Novel phenolic phosphorus stabilizers for polyolefins
FR2518100A1 (fr) * 1981-12-11 1983-06-17 Elf Aquitaine Procede de preparation de phosphinamides, applications et nouveaux produits
FR2562543B1 (fr) * 1984-04-10 1987-09-25 Elf Aquitaine Nouveaux phosphonites cycliques, leur preparation et applications

Also Published As

Publication number Publication date
DE3512781A1 (de) 1985-10-17
JPH0662649B2 (ja) 1994-08-17
GB8508730D0 (en) 1985-05-09
CA1258266A (fr) 1989-08-08
BE902124A (fr) 1985-10-04
FR2562543A1 (fr) 1985-10-11
US4952740A (en) 1990-08-28
NL8501030A (nl) 1985-11-01
GB2158441B (en) 1988-08-10
GB2158441A (en) 1985-11-13
IT8520279A0 (it) 1985-04-09
JPS60228492A (ja) 1985-11-13
CH665644A5 (fr) 1988-05-31
DE3512781C2 (de) 1995-07-27
IT1201414B (it) 1989-02-02

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