FR2804971B1 - Adn codant une acetohydroxyacide synthase, bacterie le contenant et procede de production de l-valine par culture de cette bacterie - Google Patents

Adn codant une acetohydroxyacide synthase, bacterie le contenant et procede de production de l-valine par culture de cette bacterie

Info

Publication number
FR2804971B1
FR2804971B1 FR0101070A FR0101070A FR2804971B1 FR 2804971 B1 FR2804971 B1 FR 2804971B1 FR 0101070 A FR0101070 A FR 0101070A FR 0101070 A FR0101070 A FR 0101070A FR 2804971 B1 FR2804971 B1 FR 2804971B1
Authority
FR
France
Prior art keywords
same
acetohydroxyacide
synthase
valine
culturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR0101070A
Other languages
English (en)
Other versions
FR2804971A1 (fr
Inventor
Vitaliy Livshits
Vera Dorshenko
Nataliya Gorshkova
Alla Belaryeva
Lirina Ivanovskaya
Evgeni Khourges
Valery Akhverdian
Mikhail Gusyatiner
Uri Kozlov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of FR2804971A1 publication Critical patent/FR2804971A1/fr
Application granted granted Critical
Publication of FR2804971B1 publication Critical patent/FR2804971B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
FR0101070A 2000-01-26 2001-01-26 Adn codant une acetohydroxyacide synthase, bacterie le contenant et procede de production de l-valine par culture de cette bacterie Expired - Lifetime FR2804971B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2000101678/13A RU2209246C2 (ru) 2000-01-26 2000-01-26 Малая субъединица изозима iii и изозим iii синтетазы ацетогидроксикислот из escherichia coli, фрагмент днк (варианты), штамм бактерии escherichia coli - продуцент l-валина (варианты) и способ получения l-валина

Publications (2)

Publication Number Publication Date
FR2804971A1 FR2804971A1 (fr) 2001-08-17
FR2804971B1 true FR2804971B1 (fr) 2004-04-23

Family

ID=20229713

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0101070A Expired - Lifetime FR2804971B1 (fr) 2000-01-26 2001-01-26 Adn codant une acetohydroxyacide synthase, bacterie le contenant et procede de production de l-valine par culture de cette bacterie

Country Status (5)

Country Link
US (1) US6737255B2 (fr)
JP (1) JP2001231584A (fr)
CN (1) CN1182246C (fr)
FR (1) FR2804971B1 (fr)
RU (1) RU2209246C2 (fr)

Families Citing this family (27)

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Publication number Priority date Publication date Assignee Title
US20060040364A1 (en) * 1998-10-13 2006-02-23 Livshits Vitaly A DNA coding for a protein which imparts L-homoserine resistance to Escherichia coli bacterium, and a method for producing L-amino acids
RU2144564C1 (ru) * 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ
RU2175351C2 (ru) 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
RU2212447C2 (ru) * 2000-04-26 2003-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты)
RU2208640C2 (ru) * 2000-07-06 2003-07-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА, ШТАММ Escherichia coli - ПРОДУЦЕНТ L-АРГИНИНА
RU2229513C2 (ru) * 2001-11-23 2004-05-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислот, штамм escherichia coli - продуцент l-аминокислоты (варианты)
EP1491634A1 (fr) * 2003-06-26 2004-12-29 Degussa AG Mutants de synthétase d' acide acétohydroxy résistents au feedback
US7300776B2 (en) * 2004-04-26 2007-11-27 Ajinomoto Co., Inc. L-amino acid-producing bacterium and a method for producing L-amino acid
RU2315807C2 (ru) * 2004-09-10 2008-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ НОРЛЕЙЦИНА И НОРВАЛИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ РОДА Escherichia, В КОТОРОЙ ВСЕ СИНТАЗЫ АЦЕТОГИДРОКСИКИСЛОТ ИНАКТИВИРОВАНЫ
RU2355763C2 (ru) * 2006-09-13 2009-05-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Мутантная ацетолактатсинтаза и способ продукции разветвленных l-аминокислот
KR100832740B1 (ko) 2007-01-17 2008-05-27 한국과학기술원 분지쇄 아미노산 생성능이 개선된 변이 미생물 및 이를이용한 분지쇄 아미노산의 제조방법
CN101962664A (zh) * 2010-11-02 2011-02-02 天津科技大学 一种高效生产l-缬氨酸的发酵工艺
WO2017194696A1 (fr) 2016-05-12 2017-11-16 Danmarks Tekniske Universitet Cellules bactériennes à tolérance améliorée pour l'acide isobutyrique
JP7447810B2 (ja) 2018-05-23 2024-03-12 味の素株式会社 腸内細菌科を用いたトリペプチドγ－ＧＬＵ－ＶＡＬ－ＧＬＹの製造方法
CN113195711B (zh) * 2018-12-12 2024-12-27 株式会社Co2资源化研究所 具有增强的产缬氨酸能力的嗜氢菌属细菌基因重组体
CN113278655B (zh) 2020-05-13 2022-05-17 安徽华恒生物科技股份有限公司 生产l-缬氨酸的重组微生物及构建方法、应用
CN113278568B (zh) 2020-05-27 2022-10-21 安徽华恒生物科技股份有限公司 生产l-缬氨酸的重组大肠杆菌及其应用
CN113278641B (zh) 2020-05-27 2022-06-21 安徽华恒生物科技股份有限公司 生产l-缬氨酸的重组大肠杆菌、其构建方法及其应用
CN116656754B (zh) * 2022-02-21 2026-03-24 廊坊梅花生物技术开发有限公司 一种异亮氨酸生产方法、乙酰羟酸合酶突变体及重组微生物与应用
CN117304283A (zh) 2022-06-22 2023-12-29 安徽华恒生物科技股份有限公司 一种mreC突变体及其在L-缬氨酸发酵生产中的应用
CN118895260B (zh) * 2023-05-04 2025-06-27 安徽华恒生物科技股份有限公司 一种乙酰乳酸合酶突变体及其在制备l-异亮氨酸中的应用
KR20260036560A (ko) * 2023-07-04 2026-03-17 헤이룽지앙 에펜 바이오테크 컴퍼니 리미티드 L-발린의 생산을 위한 조작 세균, 구축 방법, 및 용도
CN116555153B (zh) * 2023-07-04 2023-09-29 黑龙江伊品生物科技有限公司 一种用于生产l-缬氨酸的大肠杆菌的构建方法与应用
CN116555151B (zh) * 2023-07-04 2023-10-17 黑龙江伊品生物科技有限公司 产l-缬氨酸工程菌及构建方法与应用
CN116555152B (zh) * 2023-07-04 2023-10-20 黑龙江伊品生物科技有限公司 大肠杆菌及其构建方法与在生产l-缬氨酸中的应用
WO2025127547A1 (fr) * 2023-12-14 2025-06-19 씨제이제일제당 (주) Micro-organisme ayant une activité améliorée de sous-unité importante d'acétohydroxy acide synthase et ses utilisations
CN120866266B (zh) * 2025-09-28 2026-01-27 江西农业大学 乙酰乳酸合酶突变体及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5188948A (en) * 1987-04-16 1993-02-23 Ajinomoto Co., Inc. Process for producing L-valine by fermentation
JP2748418B2 (ja) 1988-08-03 1998-05-06 味の素株式会社 組換えｄｎａ、該組換えｄｎａを有する微生物
WO1990004636A1 (fr) 1988-10-25 1990-05-03 Vsesojuzny Nauchno-Issledovatelsky Institut Genetiki I Selektsii Promyshlennykh Mikroorganizmov (Vniigenetika) Souche de bacteries escherichia coli, productrices de la threonine l
US5705371A (en) 1990-06-12 1998-01-06 Ajinomoto Co., Inc. Bacterial strain of escherichia coli BKIIM B-3996 as the producer of L-threonine
US5976843A (en) 1992-04-22 1999-11-02 Ajinomoto Co., Inc. Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
DE3942947A1 (de) 1989-12-23 1991-06-27 Forschungszentrum Juelich Gmbh Verfahren zur herstellung von l-isoleucin und dafuer geeignete mikroorganismen und rekombinante dna
DE69116964T2 (de) * 1990-09-18 1996-10-02 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von L-Valin
US5534421A (en) * 1991-05-30 1996-07-09 Ajinomoto Co., Inc. Production of isoleucine by escherichia coli having isoleucine auxotrophy and no negative feedback inhibition of isoleucine production
US6132999A (en) 1992-09-21 2000-10-17 Ajinomoto Co., Inc. L-threonine-producing microbacteria and a method for the production of L-threonine
JP3709564B2 (ja) 1994-08-30 2005-10-26 味の素株式会社 Ｌ−バリン及びｌ−ロイシンの製造法
RU2144564C1 (ru) * 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ

Also Published As

Publication number Publication date
FR2804971A1 (fr) 2001-08-17
US6737255B2 (en) 2004-05-18
CN1310233A (zh) 2001-08-29
CN1182246C (zh) 2004-12-29
JP2001231584A (ja) 2001-08-28
RU2209246C2 (ru) 2003-07-27
US20020037562A1 (en) 2002-03-28

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