FR3048614B1 - Cellules souches stromales derivees du tissu adipeux pour une utilisation dans le traitement des fistules peri-anales complexes refractaires dans la maladie de crohn - Google Patents

Cellules souches stromales derivees du tissu adipeux pour une utilisation dans le traitement des fistules peri-anales complexes refractaires dans la maladie de crohn Download PDF

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FR3048614B1
FR3048614B1 FR1752073A FR1752073A FR3048614B1 FR 3048614 B1 FR3048614 B1 FR 3048614B1 FR 1752073 A FR1752073 A FR 1752073A FR 1752073 A FR1752073 A FR 1752073A FR 3048614 B1 FR3048614 B1 FR 3048614B1
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crohn
disease
treatment
stem cells
fistulas
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FR3048614A1 (fr
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Eduardo BRAVO
Maria PASCUAL
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Takeda Pharmaceutical Co Ltd
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Tigenix SA
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Genetics & Genomics (AREA)
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  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Il est fourni ici des cellules souches stromales dérivées du tissu adipeux allogéniques, expansées pour une utilisation dans le traitement de fistules péri-anales complexes dans la maladie de Crohn.
FR1752073A 2016-03-14 2017-03-14 Cellules souches stromales derivees du tissu adipeux pour une utilisation dans le traitement des fistules peri-anales complexes refractaires dans la maladie de crohn Active FR3048614B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB16043044 2016-03-14
GBGB1604304.4A GB201604304D0 (en) 2016-03-14 2016-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

Publications (2)

Publication Number Publication Date
FR3048614A1 FR3048614A1 (fr) 2017-09-15
FR3048614B1 true FR3048614B1 (fr) 2020-02-21

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FR1752073A Active FR3048614B1 (fr) 2016-03-14 2017-03-14 Cellules souches stromales derivees du tissu adipeux pour une utilisation dans le traitement des fistules peri-anales complexes refractaires dans la maladie de crohn

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US (3) US10357518B2 (fr)
EP (2) EP4074322A1 (fr)
JP (2) JP6931656B2 (fr)
KR (1) KR102277789B1 (fr)
CN (2) CN115569151A (fr)
AU (1) AU2017232718B2 (fr)
BE (1) BE1024781B1 (fr)
CA (1) CA3017694C (fr)
CY (1) CY1125513T1 (fr)
DE (1) DE102017002458B4 (fr)
DK (1) DK3219321T3 (fr)
ES (2) ES2681774B1 (fr)
FR (1) FR3048614B1 (fr)
GB (2) GB201604304D0 (fr)
HR (1) HRP20220539T1 (fr)
HU (1) HUE058739T2 (fr)
IL (2) IL298107B2 (fr)
LT (1) LT3219321T (fr)
MX (1) MX2018010699A (fr)
NL (1) NL2018512B1 (fr)
NO (1) NO345415B1 (fr)
PL (1) PL3219321T3 (fr)
RS (1) RS63163B1 (fr)
RU (1) RU2742308C2 (fr)
SG (2) SG10202008992YA (fr)
SI (1) SI3219321T1 (fr)
WO (1) WO2017158509A1 (fr)

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WO2018183941A2 (fr) 2017-03-30 2018-10-04 Progenity Inc. Traitement d'une maladie du tractus gastro-intestinal avec un agent biothérapeutique vivant
JP7628499B2 (ja) * 2019-02-27 2025-02-10 武田薬品工業株式会社 同種異系療法のための改良された幹細胞集団
WO2021180851A1 (fr) * 2020-03-11 2021-09-16 Mesoblast International Sàrl Procédé de traitement d'une maladie intestinale inflammatoire ii
WO2021180850A1 (fr) * 2020-03-11 2021-09-16 Mesoblast International Sàrl Procédé de traitement d'une maladie intestinale inflammatoire i
CN111481573A (zh) * 2020-03-26 2020-08-04 卡替（上海）生物技术股份有限公司 牙髓间充质干细胞在制备克罗恩病治疗药物中的用途
AU2021388154A1 (en) * 2020-11-25 2023-06-22 Flagship Pioneering Innovations Vi, Llc Adipogenic cell compositions and methods
WO2023230524A1 (fr) * 2022-05-25 2023-11-30 Flagship Pioneering Innovations Vi, Llc Compositions de cellules sécrétoires et/ou catalytiques et procédés les utilisant

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Publication number Publication date
CN108883135B (zh) 2022-11-04
FR3048614A1 (fr) 2017-09-15
ES2681774B1 (es) 2019-12-26
RS63163B1 (sr) 2022-05-31
SI3219321T1 (sl) 2022-05-31
IL298107B1 (en) 2023-10-01
AU2017232718A1 (en) 2018-10-04
GB2548490A (en) 2017-09-20
RU2742308C2 (ru) 2021-02-04
PL3219321T3 (pl) 2022-05-30
DE102017002458B4 (de) 2019-04-25
HRP20220539T1 (hr) 2022-06-10
NL2018512A (en) 2017-03-30
WO2017158509A1 (fr) 2017-09-21
BE1024781A1 (de) 2018-06-27
ES2911718T3 (es) 2022-05-20
DE102017002458A1 (de) 2017-09-14
IL298107B2 (en) 2024-02-01
US10357518B2 (en) 2019-07-23
IL261730B1 (en) 2024-01-01
GB201604304D0 (en) 2016-04-27
JP2019508455A (ja) 2019-03-28
BR112018068493A8 (pt) 2022-06-28
IL261730B2 (en) 2024-05-01
EP4074322A1 (fr) 2022-10-19
JP2021119789A (ja) 2021-08-19
US20190381106A1 (en) 2019-12-19
CN108883135A (zh) 2018-11-23
HUE058739T2 (hu) 2022-09-28
GB2548490B (en) 2020-09-02
MX2018010699A (es) 2019-01-14
CA3017694C (fr) 2024-02-27
BR112018068493A2 (pt) 2019-01-22
EP3219321B1 (fr) 2022-03-30
ES2681774A1 (es) 2018-09-14
GB201704065D0 (en) 2017-04-26
SG11201807404XA (en) 2018-09-27
CA3017694A1 (fr) 2017-09-21
KR102277789B1 (ko) 2021-07-15
NL2018512B1 (en) 2017-09-07
DK3219321T3 (da) 2022-04-25
LT3219321T (lt) 2022-05-10
RU2018131519A (ru) 2020-04-15
CY1125513T1 (el) 2024-12-13
NO20170376A1 (en) 2017-09-15
CN115569151A (zh) 2023-01-06
JP6931656B2 (ja) 2021-09-08
NO345415B1 (en) 2021-01-18
US20170258851A1 (en) 2017-09-14
IL261730A (en) 2018-10-31
AU2017232718B2 (en) 2024-01-18
EP3219321A1 (fr) 2017-09-20
RU2018131519A3 (fr) 2020-07-10
SG10202008992YA (en) 2020-10-29
US20220249574A1 (en) 2022-08-11
US11273182B2 (en) 2022-03-15
US12213998B2 (en) 2025-02-04
KR20180120261A (ko) 2018-11-05
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