FR3146678B1 - Procédé de synthèse du composé 5,7-diiodo-1-oxaspiro[2,5]octa-4,7-dien-6-one - Google Patents

Procédé de synthèse du composé 5,7-diiodo-1-oxaspiro[2,5]octa-4,7-dien-6-one

Info

Publication number
FR3146678B1
FR3146678B1 FR2302388A FR2302388A FR3146678B1 FR 3146678 B1 FR3146678 B1 FR 3146678B1 FR 2302388 A FR2302388 A FR 2302388A FR 2302388 A FR2302388 A FR 2302388A FR 3146678 B1 FR3146678 B1 FR 3146678B1
Authority
FR
France
Prior art keywords
oxaspiro
diiodo
dien
octa
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR2302388A
Other languages
English (en)
Other versions
FR3146678A1 (fr
Inventor
Anthony Garcia
Sylvain Daunay
Irene Erdelmeier
Claire Fave
Bernd Schöllhorn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innoverda
Centre National de la Recherche Scientifique CNRS
Universite Paris Cite
Original Assignee
Innoverda
Centre National de la Recherche Scientifique CNRS
Universite Paris Cite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innoverda, Centre National de la Recherche Scientifique CNRS, Universite Paris Cite filed Critical Innoverda
Priority to FR2302388A priority Critical patent/FR3146678B1/fr
Priority to PCT/EP2024/056787 priority patent/WO2024189137A1/fr
Priority to EP24711542.1A priority patent/EP4680599A1/fr
Publication of FR3146678A1 publication Critical patent/FR3146678A1/fr
Application granted granted Critical
Publication of FR3146678B1 publication Critical patent/FR3146678B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L’invention concerne un procédé de synthèse du composé 5,7-diiodo-1-oxaspiro[2,5]octa-4,7-dien-6-one. Ce procédé de synthèse du composé 5,7-diiodo-1-oxaspiro[2,5]octa-4,7-dien-6-one comprend une réaction d’ oxydation du 4-Hydroxy-3,5-diiodobenzyl alcool avec un oxydant hypochlorite, en particulier choisi parmi le sodium, le calcium et le potassium hypochlorite. Ce procédé permet une amélioration importante du rendement d’une manière simple et peu coûteuse.
FR2302388A 2023-03-15 2023-03-15 Procédé de synthèse du composé 5,7-diiodo-1-oxaspiro[2,5]octa-4,7-dien-6-one Active FR3146678B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR2302388A FR3146678B1 (fr) 2023-03-15 2023-03-15 Procédé de synthèse du composé 5,7-diiodo-1-oxaspiro[2,5]octa-4,7-dien-6-one
PCT/EP2024/056787 WO2024189137A1 (fr) 2023-03-15 2024-03-14 Procédé de synthèse du composé 5,7-diiodo-1-oxaspiro[2,5]octa-4,7-dién-6-one
EP24711542.1A EP4680599A1 (fr) 2023-03-15 2024-03-14 Procédé de synthèse du composé 5,7-diiodo-1-oxaspiro[2,5]octa-4,7-dién-6-one

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR2302388A FR3146678B1 (fr) 2023-03-15 2023-03-15 Procédé de synthèse du composé 5,7-diiodo-1-oxaspiro[2,5]octa-4,7-dien-6-one
FR2302388 2023-03-15

Publications (2)

Publication Number Publication Date
FR3146678A1 FR3146678A1 (fr) 2024-09-20
FR3146678B1 true FR3146678B1 (fr) 2025-09-05

Family

ID=86764940

Family Applications (1)

Application Number Title Priority Date Filing Date
FR2302388A Active FR3146678B1 (fr) 2023-03-15 2023-03-15 Procédé de synthèse du composé 5,7-diiodo-1-oxaspiro[2,5]octa-4,7-dien-6-one

Country Status (3)

Country Link
EP (1) EP4680599A1 (fr)
FR (1) FR3146678B1 (fr)
WO (1) WO2024189137A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130017163A1 (en) 2011-07-14 2013-01-17 Latham Keith R Halogenated phenols for diagnostics, antioxidant protection and drug delivery
FR3113904B1 (fr) 2020-09-08 2022-08-12 Innoverda Procédé de synthèse du 3,5-diiodo-4-hydroxy benzylalcool

Also Published As

Publication number Publication date
FR3146678A1 (fr) 2024-09-20
WO2024189137A1 (fr) 2024-09-19
EP4680599A1 (fr) 2026-01-21

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