MA29852B1 - Synthese d'inhibiteurs de la renine impliquant une reaction de cycloaddition - Google Patents
Synthese d'inhibiteurs de la renine impliquant une reaction de cycloadditionInfo
- Publication number
- MA29852B1 MA29852B1 MA30815A MA30815A MA29852B1 MA 29852 B1 MA29852 B1 MA 29852B1 MA 30815 A MA30815 A MA 30815A MA 30815 A MA30815 A MA 30815A MA 29852 B1 MA29852 B1 MA 29852B1
- Authority
- MA
- Morocco
- Prior art keywords
- synthesis
- cycloaddition reaction
- renine
- formula
- inhibitors involving
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 238000006352 cycloaddition reaction Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- UXOWGYHJODZGMF-QORCZRPOSA-N Aliskiren Chemical compound COCCCOC1=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-QORCZRPOSA-N 0.000 abstract 1
- 229960004601 aliskiren Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002461 renin inhibitor Substances 0.000 abstract 1
- 229940086526 renin-inhibitors Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
L'invention concerne un nouveau procédé, de nouvelles étapes de processus ainsi que de nouveaux intermédiaires utilisés dans la synthèse de composés actif sur le plan pharmaceutique, en particulier des inhibiteurs de la rénine, tels que l'aliskiren. L'invention concerne notamment un procédé de préparation d'un composé représenté par la formule (III), dans laquelle R, R1, et R¿ sont tels que définis dans la description, ou un sel de celui-ci, un composé représenté par la formule (IV), dans laquelle R, R1, R2 et R' sont tels que définis dans la description, ainsi que des procédés de fabrication de ces composés.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0519764.5A GB0519764D0 (en) | 2005-09-28 | 2005-09-28 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA29852B1 true MA29852B1 (fr) | 2008-10-03 |
Family
ID=35394904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA30815A MA29852B1 (fr) | 2005-09-28 | 2008-04-04 | Synthese d'inhibiteurs de la renine impliquant une reaction de cycloaddition |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7973175B2 (fr) |
| EP (2) | EP1931629B1 (fr) |
| JP (1) | JP2009509990A (fr) |
| KR (1) | KR20080048042A (fr) |
| CN (1) | CN101273012A (fr) |
| AR (1) | AR057137A1 (fr) |
| AT (1) | ATE492533T1 (fr) |
| AU (1) | AU2006299097B2 (fr) |
| BR (1) | BRPI0616707A2 (fr) |
| CA (1) | CA2623495A1 (fr) |
| DE (1) | DE602006019114D1 (fr) |
| EC (1) | ECSP088319A (fr) |
| ES (1) | ES2358536T3 (fr) |
| GB (1) | GB0519764D0 (fr) |
| GT (1) | GT200600427A (fr) |
| IL (1) | IL189763A0 (fr) |
| MA (1) | MA29852B1 (fr) |
| MY (1) | MY143251A (fr) |
| NO (1) | NO20082005L (fr) |
| NZ (1) | NZ566429A (fr) |
| PE (1) | PE20070488A1 (fr) |
| PL (1) | PL1931629T3 (fr) |
| PT (1) | PT1931629E (fr) |
| RU (1) | RU2423348C2 (fr) |
| TN (1) | TNSN08142A1 (fr) |
| TW (1) | TW200730480A (fr) |
| WO (1) | WO2007039183A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2062874B1 (fr) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Procédé et intermédiaires pour la préparation d'aliskiren |
| SI2189442T1 (sl) | 2008-11-20 | 2015-03-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek in intermediati za pripravo aliskirena |
| WO2011051853A1 (fr) | 2009-10-29 | 2011-05-05 | CarboDesign LLC | Procédé de production de dérivés d'acides 8-aryloctanoïques énantiomèrement purs tels que l'aliskiren |
| CN101774986B (zh) * | 2010-01-06 | 2012-03-28 | 浙江天宇药业股份有限公司 | 一种制备阿利克伦及其中间体的方法 |
| CN101863796B (zh) * | 2010-05-12 | 2011-08-24 | 海南美兰史克制药有限公司 | 一种阿利克仑化合物及其制法 |
| EP2551260A1 (fr) | 2011-07-28 | 2013-01-30 | Chemo Ibérica, S.A. | Procédé chimique pour l'ouverture de composés cycliques |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3421295A1 (de) | 1984-06-08 | 1985-12-12 | Basf Ag, 6700 Ludwigshafen | Neue pyrrolidincarbonsaeurederivative, verfahren zu ihrer herstellung |
| MY119161A (en) | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| US6730798B2 (en) | 2000-07-05 | 2004-05-04 | Speedel Pharma Ag | Process for the preparation of substituted octanoyl amides |
| DE10116816A1 (de) * | 2001-04-04 | 2002-10-17 | Basf Ag | Verfahren zur Herstellung von N-Benzylaminen |
| GB0419361D0 (en) | 2004-08-31 | 2004-10-06 | Novartis Ag | Organic compounds |
-
2005
- 2005-09-28 GB GBGB0519764.5A patent/GB0519764D0/en not_active Ceased
-
2006
- 2006-09-25 GT GT200600427A patent/GT200600427A/es unknown
- 2006-09-26 WO PCT/EP2006/009323 patent/WO2007039183A1/fr not_active Ceased
- 2006-09-26 PT PT06805861T patent/PT1931629E/pt unknown
- 2006-09-26 AU AU2006299097A patent/AU2006299097B2/en not_active Ceased
- 2006-09-26 ES ES06805861T patent/ES2358536T3/es active Active
- 2006-09-26 RU RU2008116317/04A patent/RU2423348C2/ru not_active IP Right Cessation
- 2006-09-26 AR ARP060104197A patent/AR057137A1/es not_active Application Discontinuation
- 2006-09-26 US US12/067,055 patent/US7973175B2/en not_active Expired - Fee Related
- 2006-09-26 JP JP2008532650A patent/JP2009509990A/ja active Pending
- 2006-09-26 DE DE602006019114T patent/DE602006019114D1/de active Active
- 2006-09-26 PE PE2006001166A patent/PE20070488A1/es not_active Application Discontinuation
- 2006-09-26 PL PL06805861T patent/PL1931629T3/pl unknown
- 2006-09-26 NZ NZ566429A patent/NZ566429A/en not_active IP Right Cessation
- 2006-09-26 EP EP06805861A patent/EP1931629B1/fr not_active Not-in-force
- 2006-09-26 AT AT06805861T patent/ATE492533T1/de active
- 2006-09-26 KR KR1020087007396A patent/KR20080048042A/ko not_active Ceased
- 2006-09-26 MY MYPI20080623A patent/MY143251A/en unknown
- 2006-09-26 EP EP10178025A patent/EP2287153A1/fr not_active Withdrawn
- 2006-09-26 CN CNA2006800353469A patent/CN101273012A/zh active Pending
- 2006-09-26 CA CA002623495A patent/CA2623495A1/fr not_active Abandoned
- 2006-09-26 BR BRPI0616707-1A patent/BRPI0616707A2/pt not_active IP Right Cessation
- 2006-09-27 TW TW095135800A patent/TW200730480A/zh unknown
-
2008
- 2008-02-25 IL IL189763A patent/IL189763A0/en unknown
- 2008-03-27 TN TNP2008000142A patent/TNSN08142A1/en unknown
- 2008-03-27 EC EC2008008319A patent/ECSP088319A/es unknown
- 2008-04-04 MA MA30815A patent/MA29852B1/fr unknown
- 2008-04-28 NO NO20082005A patent/NO20082005L/no not_active Application Discontinuation
-
2011
- 2011-05-26 US US13/116,349 patent/US20110230665A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20082005L (no) | 2008-06-24 |
| PE20070488A1 (es) | 2007-06-13 |
| TNSN08142A1 (en) | 2009-07-14 |
| AR057137A1 (es) | 2007-11-21 |
| EP1931629A1 (fr) | 2008-06-18 |
| JP2009509990A (ja) | 2009-03-12 |
| US7973175B2 (en) | 2011-07-05 |
| RU2008116317A (ru) | 2009-11-10 |
| IL189763A0 (en) | 2008-08-07 |
| AU2006299097B2 (en) | 2010-11-04 |
| ES2358536T3 (es) | 2011-05-11 |
| GB0519764D0 (en) | 2005-11-09 |
| ATE492533T1 (de) | 2011-01-15 |
| WO2007039183A1 (fr) | 2007-04-12 |
| ECSP088319A (es) | 2008-04-28 |
| NZ566429A (en) | 2010-10-29 |
| MY143251A (en) | 2011-04-15 |
| PT1931629E (pt) | 2011-03-09 |
| GT200600427A (es) | 2007-04-30 |
| EP2287153A1 (fr) | 2011-02-23 |
| US20080255369A1 (en) | 2008-10-16 |
| DE602006019114D1 (de) | 2011-02-03 |
| CA2623495A1 (fr) | 2007-04-12 |
| PL1931629T3 (pl) | 2011-05-31 |
| BRPI0616707A2 (pt) | 2011-06-28 |
| US20110230665A1 (en) | 2011-09-22 |
| EP1931629B1 (fr) | 2010-12-22 |
| RU2423348C2 (ru) | 2011-07-10 |
| KR20080048042A (ko) | 2008-05-30 |
| CN101273012A (zh) | 2008-09-24 |
| AU2006299097A1 (en) | 2007-04-12 |
| TW200730480A (en) | 2007-08-16 |
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