GR1000618B - Μεθοδος αναστολης hiv χρησιμοποιωντας συνεργιστικους συνδυασμους νουκλεοσιδικων παραγωγων. - Google Patents

Μεθοδος αναστολης hiv χρησιμοποιωντας συνεργιστικους συνδυασμους νουκλεοσιδικων παραγωγων.

Info

Publication number
GR1000618B
GR1000618B GR900100189A GR900100189A GR1000618B GR 1000618 B GR1000618 B GR 1000618B GR 900100189 A GR900100189 A GR 900100189A GR 900100189 A GR900100189 A GR 900100189A GR 1000618 B GR1000618 B GR 1000618B
Authority
GR
Greece
Prior art keywords
derivatives
nucleosidic
associations
hiv
hiv suppression
Prior art date
Application number
GR900100189A
Other languages
English (en)
Other versions
GR900100189A (en
Inventor
Vera Brankovan
J Richard White
Original Assignee
Oncogen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen filed Critical Oncogen
Publication of GR900100189A publication Critical patent/GR900100189A/el
Publication of GR1000618B publication Critical patent/GR1000618B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται στη χρήση συνεργητικών συνδυασμών παραγώγων νουκλεοζίτη προς αναστολή της αντιγραφής ιού ανοσοανεπάρκειας ανθρώπου (HIV) περιορίζοντας κατά τον τρόπο αυτό τη μόλυνση HIV. Σε μια συγκεκριμένη πρακτική εφαρμογή το ανάλογο νουκλεοζίτη οπουρίνης, διδεοξυινοζίνη, συνδυασμένο με το ανάλογο νουκλεοζίτη πυριμιδίνης, 2,3- διδεοξυ-2,3-διδεϋδροθυμιδίνη 1 (d4T), παρουσιάζουν ισχυρή συνεργητική ενεργότητα και μειωμένη κυτταροτοξική ενεργότητα έναντι κυττάρων θηλαστικών. ω
GR900100189A 1989-03-17 1990-03-14 Μεθοδος αναστολης hiv χρησιμοποιωντας συνεργιστικους συνδυασμους νουκλεοσιδικων παραγωγων. GR1000618B (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32493489A 1989-03-17 1989-03-17
US40190889A 1989-09-01 1989-09-01

Publications (2)

Publication Number Publication Date
GR900100189A GR900100189A (en) 1990-07-31
GR1000618B true GR1000618B (el) 1992-08-31

Family

ID=26984692

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100189A GR1000618B (el) 1989-03-17 1990-03-14 Μεθοδος αναστολης hiv χρησιμοποιωντας συνεργιστικους συνδυασμους νουκλεοσιδικων παραγωγων.

Country Status (19)

Country Link
EP (1) EP0464137A4 (el)
JP (1) JPH04504850A (el)
KR (1) KR920700653A (el)
CN (1) CN1045791A (el)
AU (1) AU5351490A (el)
CA (1) CA2050473A1 (el)
DD (1) DD301787A9 (el)
FI (1) FI914367A0 (el)
GR (1) GR1000618B (el)
HU (1) HU208254B (el)
IL (1) IL93783A0 (el)
NO (1) NO913659L (el)
NZ (1) NZ232912A (el)
OA (1) OA09555A (el)
PL (1) PL284343A1 (el)
PT (1) PT93449A (el)
WO (1) WO1990011081A1 (el)
YU (1) YU53790A (el)
ZW (1) ZW3290A1 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992020344A1 (en) * 1991-05-16 1992-11-26 Glaxo Group Limited Antiviral combinations containing nucleoside analogs
CA2335617C (en) * 1998-06-24 2009-12-15 Novirio Pharmaceuticals Limited Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
AU2002255707A1 (en) 2001-03-15 2002-10-03 Trustees Of Boston College, The Selective anti-viral nucleoside chain terminators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU570853B2 (en) * 1985-08-26 1988-03-24 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Inhibition of infectivity and cytopathic effect of htlv-111/ lav by purine bases
GB8712115D0 (en) * 1987-05-22 1987-06-24 Hoffmann La Roche Pyrimidine derivatives
US4837311A (en) * 1987-06-22 1989-06-06 Hoffman-La Roche Inc. Anti-retroviral compounds
EP0314011A3 (de) * 1987-10-30 1990-04-11 F. Hoffmann-La Roche Ag Purinderivate
US4908440A (en) * 1987-11-12 1990-03-13 Bristol Myers Company 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides

Also Published As

Publication number Publication date
GR900100189A (en) 1990-07-31
EP0464137A1 (en) 1992-01-08
HU902898D0 (en) 1991-12-30
DD301787A9 (de) 1994-01-13
YU53790A (sh) 1993-05-28
NO913659L (no) 1991-10-18
HU208254B (en) 1993-09-28
EP0464137A4 (en) 1992-01-15
PT93449A (pt) 1990-11-07
JPH04504850A (ja) 1992-08-27
FI914367A7 (fi) 1991-09-17
KR920700653A (ko) 1992-08-10
CA2050473A1 (en) 1990-09-18
IL93783A0 (en) 1990-12-23
AU5351490A (en) 1990-10-22
CN1045791A (zh) 1990-10-03
WO1990011081A1 (en) 1990-10-04
NO913659D0 (no) 1991-09-17
OA09555A (en) 1993-01-31
NZ232912A (en) 1992-06-25
HUT57988A (en) 1992-01-28
ZW3290A1 (en) 1990-11-07
PL284343A1 (en) 1991-06-03
FI914367A0 (fi) 1991-09-17

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