GR1000618B - Method for the hiv suppression by using nucleosidic associations derivatives - Google Patents

Method for the hiv suppression by using nucleosidic associations derivatives

Info

Publication number
GR1000618B
GR1000618B GR900100189A GR900100189A GR1000618B GR 1000618 B GR1000618 B GR 1000618B GR 900100189 A GR900100189 A GR 900100189A GR 900100189 A GR900100189 A GR 900100189A GR 1000618 B GR1000618 B GR 1000618B
Authority
GR
Greece
Prior art keywords
derivatives
nucleosidic
associations
hiv
hiv suppression
Prior art date
Application number
GR900100189A
Other languages
Greek (el)
Other versions
GR900100189A (en
Inventor
Vera Brankovan
J Richard White
Original Assignee
Oncogen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen filed Critical Oncogen
Publication of GR900100189A publication Critical patent/GR900100189A/en
Publication of GR1000618B publication Critical patent/GR1000618B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται στη χρήση συνεργητικών συνδυασμών παραγώγων νουκλεοζίτη προς αναστολή της αντιγραφής ιού ανοσοανεπάρκειας ανθρώπου (HIV) περιορίζοντας κατά τον τρόπο αυτό τη μόλυνση HIV. Σε μια συγκεκριμένη πρακτική εφαρμογή το ανάλογο νουκλεοζίτη οπουρίνης, διδεοξυινοζίνη, συνδυασμένο με το ανάλογο νουκλεοζίτη πυριμιδίνης, 2,3- διδεοξυ-2,3-διδεϋδροθυμιδίνη 1 (d4T), παρουσιάζουν ισχυρή συνεργητική ενεργότητα και μειωμένη κυτταροτοξική ενεργότητα έναντι κυττάρων θηλαστικών. ωThe present invention relates to the use of synergistic combinations of nucleoside derivatives to inhibit human immunodeficiency virus (HIV) replication thereby limiting HIV infection. In a particular practical embodiment, the opurine nucleoside analog, dideoxyinosine, in combination with the pyrimidine nucleoside analog, 2,3-dideoxy-2,3-dihydrothymidine 1 (d4T), exhibits potent synergistic activity and reduced cytotoxic activity. ω

GR900100189A 1989-03-17 1990-03-14 Method for the hiv suppression by using nucleosidic associations derivatives GR1000618B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32493489A 1989-03-17 1989-03-17
US40190889A 1989-09-01 1989-09-01

Publications (2)

Publication Number Publication Date
GR900100189A GR900100189A (en) 1990-07-31
GR1000618B true GR1000618B (en) 1992-08-31

Family

ID=26984692

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100189A GR1000618B (en) 1989-03-17 1990-03-14 Method for the hiv suppression by using nucleosidic associations derivatives

Country Status (19)

Country Link
EP (1) EP0464137A4 (en)
JP (1) JPH04504850A (en)
KR (1) KR920700653A (en)
CN (1) CN1045791A (en)
AU (1) AU5351490A (en)
CA (1) CA2050473A1 (en)
DD (1) DD301787A9 (en)
FI (1) FI914367A0 (en)
GR (1) GR1000618B (en)
HU (1) HU208254B (en)
IL (1) IL93783A0 (en)
NO (1) NO913659L (en)
NZ (1) NZ232912A (en)
OA (1) OA09555A (en)
PL (1) PL284343A1 (en)
PT (1) PT93449A (en)
WO (1) WO1990011081A1 (en)
YU (1) YU53790A (en)
ZW (1) ZW3290A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69206876T3 (en) * 1991-05-16 2004-08-12 Glaxo Group Ltd., Greenford Antivirus preparations containing nucleoside analogs
BR9911457A (en) * 1998-06-24 2001-12-11 Univ Emory Use of 3'-azide-2 ', 3'-dideoxyuridine in combination with additional anti-HIV drugs for the manufacture of a drug for the treatment of HIV
AU2002255707A1 (en) 2001-03-15 2002-10-03 Trustees Of Boston College, The Selective anti-viral nucleoside chain terminators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001284A1 (en) * 1985-08-26 1987-03-12 United States Of America, Represented By The Unite Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine
GB8712115D0 (en) * 1987-05-22 1987-06-24 Hoffmann La Roche Pyrimidine derivatives
US4837311A (en) * 1987-06-22 1989-06-06 Hoffman-La Roche Inc. Anti-retroviral compounds
NZ226672A (en) * 1987-10-30 1991-07-26 Hoffmann La Roche 6-amino-9-(2,3-dideoxy-2-fluoro-b-d-threopentofuranosyl)-9h-purine derivatives and pharmaceutical compositions
US4908440A (en) * 1987-11-12 1990-03-13 Bristol Myers Company 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides

Also Published As

Publication number Publication date
CN1045791A (en) 1990-10-03
NO913659D0 (en) 1991-09-17
NZ232912A (en) 1992-06-25
CA2050473A1 (en) 1990-09-18
YU53790A (en) 1993-05-28
WO1990011081A1 (en) 1990-10-04
KR920700653A (en) 1992-08-10
EP0464137A4 (en) 1992-01-15
PL284343A1 (en) 1991-06-03
HU902898D0 (en) 1991-12-30
JPH04504850A (en) 1992-08-27
NO913659L (en) 1991-10-18
AU5351490A (en) 1990-10-22
DD301787A9 (en) 1994-01-13
OA09555A (en) 1993-01-31
FI914367A7 (en) 1991-09-17
EP0464137A1 (en) 1992-01-08
GR900100189A (en) 1990-07-31
HU208254B (en) 1993-09-28
IL93783A0 (en) 1990-12-23
ZW3290A1 (en) 1990-11-07
FI914367A0 (en) 1991-09-17
HUT57988A (en) 1992-01-28
PT93449A (en) 1990-11-07

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