GR1000850B - Διαλυτα ανθρωπινα τεμαχια cd4 και οι χρησεις τους. - Google Patents

Διαλυτα ανθρωπινα τεμαχια cd4 και οι χρησεις τους.

Info

Publication number
GR1000850B
GR1000850B GR880100675A GR880100675A GR1000850B GR 1000850 B GR1000850 B GR 1000850B GR 880100675 A GR880100675 A GR 880100675A GR 880100675 A GR880100675 A GR 880100675A GR 1000850 B GR1000850 B GR 1000850B
Authority
GR
Greece
Prior art keywords
fragments
soluble human
uses therefor
hiv
grp120
Prior art date
Application number
GR880100675A
Other languages
Greek (el)
English (en)
Inventor
Linda K Clayton
Rebecca Hussey
Ellis Reinberz
Neil Richardson
Joseph Sodroski
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/217,475 external-priority patent/US5109123A/en
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of GR1000850B publication Critical patent/GR1000850B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
GR880100675A 1987-10-08 1988-10-07 Διαλυτα ανθρωπινα τεμαχια cd4 και οι χρησεις τους. GR1000850B (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10618587A 1987-10-08 1987-10-08
US14431388A 1988-01-14 1988-01-14
US20658588A 1988-06-14 1988-06-14
US07/217,475 US5109123A (en) 1988-06-14 1988-07-11 Alteration of ability of soluble CD4 fragments to bind HIV

Publications (1)

Publication Number Publication Date
GR1000850B true GR1000850B (el) 1993-02-17

Family

ID=27493499

Family Applications (1)

Application Number Title Priority Date Filing Date
GR880100675A GR1000850B (el) 1987-10-08 1988-10-07 Διαλυτα ανθρωπινα τεμαχια cd4 και οι χρησεις τους.

Country Status (9)

Country Link
EP (1) EP0400010A1 (da)
JP (1) JPH03504234A (da)
AU (1) AU2614888A (da)
DK (1) DK87490A (da)
ES (1) ES2012129A6 (da)
GR (1) GR1000850B (da)
IL (1) IL87902A0 (da)
NZ (1) NZ226475A (da)
WO (1) WO1989003222A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637677A (en) 1987-07-16 1997-06-10 The Trustees Of The University Of Pennsylvania Biologically active compounds and methods of constructing and using the same
ZA887365B (en) * 1987-10-02 1990-05-30 Genentech Inc Adheson variants
AU623924B2 (en) * 1988-07-22 1992-05-28 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Cytotoxic agent against specific virus infection
US5206353A (en) * 1988-07-23 1993-04-27 The United States Of America As Represented By The Department Of Health And Human Services CD-4/cytotoxic gene fusions
EP0408372A1 (en) * 1989-07-13 1991-01-16 Smithkline Beecham Corporation Anti-viral therapy
KR927003613A (ko) * 1989-08-23 1992-12-18 더 제너랄 호스피탈 코오퍼레이숀 비-인체 영장동물의 cd4폴리텝타이드, 글리코실화할 수 있는 인체 cd4분자, 그것의 단편, 그것의 융합 단백질, 유전자 서열 및 그것의 용도
US5614612A (en) * 1990-03-09 1997-03-25 Haigwood; Nancy L. Purified gp120 compositions retaining natural conformation
JPH0725794B2 (ja) * 1990-03-23 1995-03-22 呉羽化学工業株式会社 新規なペプチド
WO1992004914A1 (en) * 1990-09-14 1992-04-02 The Trustees Of The University Of Pennsylvania Design of bioactive peptides based on immunoglobulin structure
JP3670276B2 (ja) 1991-02-08 2005-07-13 プロゲニクス・ファーマスーティカルズ、インコーポレイテッド ＣＤ４― ガンマ・２キメラ及びＣＤ４ ― ＩｇＧ２・キメラ
US7070991B2 (en) 1991-02-08 2006-07-04 Progenics Pharmaceuticals, Inc. Cells expressing a CD4-IgG2 chimeric heterotetramer
AU1438592A (en) * 1991-02-08 1992-09-07 Progenics Pharmaceuticals, Inc. Cd4-gamma1 and cd4-igg1 chimeras
US5234905A (en) * 1991-02-22 1993-08-10 University Of Colorado Foundation, Inc. Soluble CD4 molecules modified to prolong circulating half-life
EP0510483A1 (en) * 1991-04-22 1992-10-28 Boehringer Ingelheim Pharmaceuticals Inc. Method for the detection of viruses
JP4776075B2 (ja) 1998-12-31 2011-09-21 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 改変ｈｉｖｅｎｖポリペプチド
AU2221600A (en) 1998-12-31 2000-07-31 Chiron Corporation Improved expression of hiv polypeptides and production of virus-like particles
AU2487300A (en) 1998-12-31 2000-07-31 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
US7935805B1 (en) 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
EP1411770A4 (en) 2001-07-05 2006-05-10 Chiron Corp POLYNUCLEOTIDES CODING FOR ANTIGENIC C-TYPE HIV POLYPEPTIDES, POLYPEPTIDES AND THEIR USE
US20030170614A1 (en) 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
CA2458995C (en) 2001-08-31 2013-04-30 Chiron Corporation Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof
EP2968453B1 (en) 2013-03-15 2019-12-04 The U.S.A. as represented by the Secretary, Department of Health and Human Services Stabilized single human cd4 domains and fusion proteins
WO2017055522A1 (en) 2015-09-29 2017-04-06 Academisch Medisch Centrum Stabilized env proteins of hiv

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988001304A1 (en) * 1986-08-21 1988-02-25 The Trustees Of Columbia University In The City Of Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids
EP0314317A1 (en) * 1987-10-02 1989-05-03 Genentech, Inc. Adheson variants, nucleic acid encoding them and compositions comprising them

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988001304A1 (en) * 1986-08-21 1988-02-25 The Trustees Of Columbia University In The City Of Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids
EP0314317A1 (en) * 1987-10-02 1989-05-03 Genentech, Inc. Adheson variants, nucleic acid encoding them and compositions comprising them

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CELL, vol. 42, no. 1, August 1985, pages 93-104, MIT; P.J. MADDON et al.: "The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family" *
CLAIMS SEARCHED: ALL *
NATIRE, vol. 331, no. 6151, 7th January 1988, pages 76-78, London, GB; R.A. FISHER et al.: "HIV infection is blocked in vitro by recombinant soluble CD4" *
NATURE, vol. 331, no. 6151, 7th January 1988, pages 78-81, London, GB; R.E. HUSSEY et al.: "A soluble CD4 protein selectively inhibits HIV replication and cyncytium formation" *

Also Published As

Publication number Publication date
AU2614888A (en) 1989-05-02
NZ226475A (en) 1991-03-26
EP0400010A1 (en) 1990-12-05
IL87902A0 (en) 1989-03-31
DK87490D0 (da) 1990-04-06
ES2012129A6 (es) 1990-03-01
JPH03504234A (ja) 1991-09-19
DK87490A (da) 1990-06-08
WO1989003222A1 (en) 1989-04-20

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