GR1006875B - Βελτιωμενες φαρμακευτικες συνθεσεις περιεχουσες αναστολεις του μετατρεπτικου ενζυμου αγγειοτενσινης και μεθοδοι παρασκευης αυτων. - Google Patents
Βελτιωμενες φαρμακευτικες συνθεσεις περιεχουσες αναστολεις του μετατρεπτικου ενζυμου αγγειοτενσινης και μεθοδοι παρασκευης αυτων.Info
- Publication number
- GR1006875B GR1006875B GR20050100332A GR20050100332A GR1006875B GR 1006875 B GR1006875 B GR 1006875B GR 20050100332 A GR20050100332 A GR 20050100332A GR 20050100332 A GR20050100332 A GR 20050100332A GR 1006875 B GR1006875 B GR 1006875B
- Authority
- GR
- Greece
- Prior art keywords
- preperation
- improved
- composition containing
- ace inhibitor
- containing ace
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000005541 ACE inhibitor Substances 0.000 title 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 abstract 1
- VXFJYXUZANRPDJ-WTNASJBWSA-N Trandopril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@H]2CCCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 VXFJYXUZANRPDJ-WTNASJBWSA-N 0.000 abstract 1
- 229940008099 dimethicone Drugs 0.000 abstract 1
- 239000004205 dimethyl polysiloxane Substances 0.000 abstract 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 abstract 1
- 238000007907 direct compression Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229960002490 fosinopril Drugs 0.000 abstract 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 239000007909 solid dosage form Substances 0.000 abstract 1
- 229960002051 trandolapril Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/2036—Silicones; Polysiloxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/20—Rubella virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με το σχηματισμό στέρεων δοσολογικών μορφών για από του στόματος ή υπογλώσσια χορήγηση που αποτελούνται από θεραπευτικά αποτελεσματική ποσότητα αναστολέα ΜΕΑ ή φαρμακευτικά αποδεκτού άλατος αυτού και ιδιαιτέρως Fosinopril ή Trandolapril ή αλάτων αυτών σε συνδυασμό με πολυμερές ανόργανου οξειδίου του πυριτίου όπως Διμεθικόνη. Στο παρόν περιγράφεται επίσης, μια διαδικασία για την προετοιμασία αυτών μέσω άμεσης συμπίεσης.
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR20050100332A GR1006875B (el) | 2005-06-30 | 2005-06-30 | Βελτιωμενες φαρμακευτικες συνθεσεις περιεχουσες αναστολεις του μετατρεπτικου ενζυμου αγγειοτενσινης και μεθοδοι παρασκευης αυτων. |
| PL06765392T PL1906931T3 (pl) | 2005-06-30 | 2006-06-29 | Ulepszona kompozycja farmaceutyczna zawierająca inhibitor ACE i sposób jej wytwarzania |
| DE602006004057T DE602006004057D1 (de) | 2005-06-30 | 2006-06-29 | Nem ace-hemmer und herstellungsverfahren dafür |
| ES06765392T ES2318772T3 (es) | 2005-06-30 | 2006-06-29 | Composicion farmaceutica mejorada que contiene un inhibidor de la ace, y metodo para la preparacion de la misma. |
| PCT/GR2006/000033 WO2007003972A1 (en) | 2005-06-30 | 2006-06-29 | Improved pharmaceutical composition containing ace inhibitor and method for the preparation thereof |
| HR20090102T HRP20090102T3 (hr) | 2005-06-30 | 2006-06-29 | Poboljšana farmaceutska smjesa koja sadrži ace inhibitor i postupak za njeno pripravljanje |
| PT06765392T PT1906931E (pt) | 2005-06-30 | 2006-06-29 | Composição farmacêutica melhorada contendo um inibidor da ace e método para a sua preparação |
| EP06765392A EP1906931B1 (en) | 2005-06-30 | 2006-06-29 | Improved pharmaceutical composition containing ace inhibitor and method for the preparation thereof |
| AT06765392T ATE415951T1 (de) | 2005-06-30 | 2006-06-29 | Verbesserte pharmazeutische zusammensetzung mit einem ace-hemmer und herstellungsverfahren dafür |
| CA2612742A CA2612742C (en) | 2005-06-30 | 2006-06-29 | Improved pharmaceutical composition containing ace inhibitor and method for the preparation thereof |
| DK06765392T DK1906931T3 (da) | 2005-06-30 | 2006-06-29 | Forberedt farmaceutisk præparat, de indeholder ACE-inhibitor og fremgangsmåde til fremstilling deraf |
| CY20091100245T CY1108846T1 (el) | 2005-06-30 | 2009-03-03 | Βελτιωμενη φαρμακευτικη συνθεση που περιεχει αναστολεα ace και μεθοδος για την παρασκευη της |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR20050100332A GR1006875B (el) | 2005-06-30 | 2005-06-30 | Βελτιωμενες φαρμακευτικες συνθεσεις περιεχουσες αναστολεις του μετατρεπτικου ενζυμου αγγειοτενσινης και μεθοδοι παρασκευης αυτων. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GR20050100332A GR20050100332A (el) | 2007-01-19 |
| GR1006875B true GR1006875B (el) | 2010-07-12 |
Family
ID=38043070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20050100332A GR1006875B (el) | 2005-06-30 | 2005-06-30 | Βελτιωμενες φαρμακευτικες συνθεσεις περιεχουσες αναστολεις του μετατρεπτικου ενζυμου αγγειοτενσινης και μεθοδοι παρασκευης αυτων. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1906931B1 (el) |
| AT (1) | ATE415951T1 (el) |
| CA (1) | CA2612742C (el) |
| CY (1) | CY1108846T1 (el) |
| DE (1) | DE602006004057D1 (el) |
| DK (1) | DK1906931T3 (el) |
| ES (1) | ES2318772T3 (el) |
| GR (1) | GR1006875B (el) |
| HR (1) | HRP20090102T3 (el) |
| PL (1) | PL1906931T3 (el) |
| PT (1) | PT1906931E (el) |
| WO (1) | WO2007003972A1 (el) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2364011B1 (es) | 2009-11-20 | 2013-01-24 | Gp Pharm, S.A. | Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares. |
| CN114886866A (zh) * | 2022-04-08 | 2022-08-12 | 苏州中化药品工业有限公司 | 一种格列齐特片(ⅱ)药物组合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4793998A (en) * | 1986-10-20 | 1988-12-27 | Warner-Lambert Company | Stabilized drug compositions |
| US4743450A (en) * | 1987-02-24 | 1988-05-10 | Warner-Lambert Company | Stabilized compositions |
| CA2019324C (en) * | 1989-07-10 | 1996-08-20 | Robert L. Jerzewski | Fosinopril tablet formulations |
| JP2002535353A (ja) * | 1999-01-29 | 2002-10-22 | ロザン ファルマ ゲゼルシャフトミットベシュレンクテルハフツンク | 医薬品組成物 |
-
2005
- 2005-06-30 GR GR20050100332A patent/GR1006875B/el not_active IP Right Cessation
-
2006
- 2006-06-29 DK DK06765392T patent/DK1906931T3/da active
- 2006-06-29 AT AT06765392T patent/ATE415951T1/de not_active IP Right Cessation
- 2006-06-29 PT PT06765392T patent/PT1906931E/pt unknown
- 2006-06-29 HR HR20090102T patent/HRP20090102T3/xx unknown
- 2006-06-29 DE DE602006004057T patent/DE602006004057D1/de not_active Expired - Lifetime
- 2006-06-29 ES ES06765392T patent/ES2318772T3/es not_active Expired - Lifetime
- 2006-06-29 WO PCT/GR2006/000033 patent/WO2007003972A1/en not_active Ceased
- 2006-06-29 CA CA2612742A patent/CA2612742C/en not_active Expired - Fee Related
- 2006-06-29 EP EP06765392A patent/EP1906931B1/en not_active Expired - Lifetime
- 2006-06-29 PL PL06765392T patent/PL1906931T3/pl unknown
-
2009
- 2009-03-03 CY CY20091100245T patent/CY1108846T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20090102T3 (hr) | 2009-03-31 |
| DK1906931T3 (da) | 2009-03-09 |
| CA2612742A1 (en) | 2007-01-11 |
| EP1906931B1 (en) | 2008-12-03 |
| CA2612742C (en) | 2010-08-03 |
| WO2007003972A1 (en) | 2007-01-11 |
| PT1906931E (pt) | 2009-02-12 |
| EP1906931A1 (en) | 2008-04-09 |
| CY1108846T1 (el) | 2014-07-02 |
| PL1906931T3 (pl) | 2009-05-29 |
| GR20050100332A (el) | 2007-01-19 |
| DE602006004057D1 (de) | 2009-01-15 |
| ATE415951T1 (de) | 2008-12-15 |
| ES2318772T3 (es) | 2009-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PG | Patent granted | ||
| ML | Lapse due to non-payment of fees |
Effective date: 20130104 |