GR3000677T3 - Derivatives of aza-z-bicyclooctane-caboxylicacid-3, processes for their preparation and pharmaceutical compositions containing them - Google Patents

Derivatives of aza-z-bicyclooctane-caboxylicacid-3, processes for their preparation and pharmaceutical compositions containing them

Info

Publication number: GR3000677T3
Authority: GR; Greece
Prior art keywords: formula; derivative; see diagramm; iii; compound
Prior art date: 1987-08-28

Application number

GR90400526T

Other languages

English (en)

Inventor

Michel Vincent

Georges Remond

Michel Laubie

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-28

Filing date

1990-07-27

Publication date

1991-09-27

1990-07-27 Application filed by Adir filed Critical Adir

1991-09-27 Publication of GR3000677T3 publication Critical patent/GR3000677T3/el

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 8
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 4
239000002253 acid Substances 0.000 abstract 4
229910052783 alkali metal Inorganic materials 0.000 abstract 4
150000001340 alkali metals Chemical class 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
239000002585 base Substances 0.000 abstract 3
JMTMSDXUXJISAY-UHFFFAOYSA-N 2H-benzotriazol-4-ol Chemical compound OC1=CC=CC2=C1N=NN2 JMTMSDXUXJISAY-UHFFFAOYSA-N 0.000 abstract 2
-1 benzyl ester Chemical class 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
238000004587 chromatography analysis Methods 0.000 abstract 2
239000007822 coupling agent Substances 0.000 abstract 2
238000010511 deprotection reaction Methods 0.000 abstract 2
150000004678 hydrides Chemical class 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 abstract 2
NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 abstract 2
150000002668 lysine derivatives Chemical class 0.000 abstract 2
238000005897 peptide coupling reaction Methods 0.000 abstract 2
238000006268 reductive amination reaction Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
238000000926 separation method Methods 0.000 abstract 2
239000000377 silicon dioxide Substances 0.000 abstract 2
BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 abstract 2
YDIUZWIFYIATRZ-AHXFUIDQSA-N (2s)-3-azoniabicyclo[2.2.2]octane-2-carboxylate Chemical compound C1CC2[C@@H](C(=O)O)NC1CC2 YDIUZWIFYIATRZ-AHXFUIDQSA-N 0.000 abstract 1
PPKAIMDMNWBOKN-UHFFFAOYSA-N 2-Oxo-4-phenylbutyric acid Chemical compound OC(=O)C(=O)CCC1=CC=CC=C1 PPKAIMDMNWBOKN-UHFFFAOYSA-N 0.000 abstract 1
QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
239000004472 Lysine Substances 0.000 abstract 1
238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000002843 carboxylic acid group Chemical group 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
239000003610 charcoal Substances 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
125000001288 lysyl group Chemical group 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Biophysics (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Gastroenterology & Hepatology (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

GR90400526T 1987-08-28 1990-07-27 Derivatives of aza-z-bicyclooctane-caboxylicacid-3, processes for their preparation and pharmaceutical compositions containing them GR3000677T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8712013A FR2619813B1 (fr)	1987-08-28	1987-08-28	Nouveaux derives de l'acide aza - 2 bicyclooctane carboxylique - 3, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
GR3000677T3 true GR3000677T3 (en)	1991-09-27

Family

ID=9354475

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR90400526T GR3000677T3 (en)	1987-08-28	1990-07-27	Derivatives of aza-z-bicyclooctane-caboxylicacid-3, processes for their preparation and pharmaceutical compositions containing them

Country Status (16)

Country	Link
US (1)	US4959372A (el)
EP (1)	EP0305297B1 (el)
JP (1)	JPS6471875A (el)
AT (1)	ATE52789T1 (el)
AU (1)	AU612689B2 (el)
CA (1)	CA1327800C (el)
DE (1)	DE3860148D1 (el)
DK (1)	DK170978B1 (el)
ES (1)	ES2031616T3 (el)
FR (1)	FR2619813B1 (el)
GR (1)	GR3000677T3 (el)
IE (1)	IE60505B1 (el)
NZ (1)	NZ225943A (el)
OA (1)	OA08754A (el)
PT (1)	PT88357B (el)
ZA (1)	ZA886368B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2655989B1 (fr) *	1989-12-20	1992-02-28	Adir	Nouveaux derives d'amino-acides substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5458883A (en) *	1994-01-12	1995-10-17	Duke University	Method of treating disorders of the eye
EP1233811A2 (en) *	1999-11-12	2002-08-28	Leo Rubin	Methods for treating cardiac arrest or pulmonary hypertension and compositions for use therein comprising vasoactive intestinal polypeptide and cardiac device for electrical and chemical regulation and methods of use
JPWO2002076981A1 (ja) *	2001-03-26	2004-10-07	壽製薬株式会社	イソキヌクリジン誘導体及びその製造方法並びにこれを含有する医薬組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL58849A (en) *	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2492381A1 (fr) *	1980-10-21	1982-04-23	Science Union & Cie	Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3227055A1 (de) *	1982-07-20	1984-01-26	Hoechst Ag, 6230 Frankfurt	Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung

1987
- 1987-08-28 FR FR8712013A patent/FR2619813B1/fr not_active Expired - Lifetime
1988
- 1988-08-11 CA CA000574529A patent/CA1327800C/fr not_active Expired - Fee Related
- 1988-08-24 DK DK472788A patent/DK170978B1/da active
- 1988-08-26 ZA ZA886368A patent/ZA886368B/xx unknown
- 1988-08-26 JP JP63212329A patent/JPS6471875A/ja active Pending
- 1988-08-26 US US07/237,497 patent/US4959372A/en not_active Expired - Fee Related
- 1988-08-26 AU AU21594/88A patent/AU612689B2/en not_active Ceased
- 1988-08-26 ES ES198888402165T patent/ES2031616T3/es not_active Expired - Lifetime
- 1988-08-26 DE DE8888402165T patent/DE3860148D1/de not_active Expired - Lifetime
- 1988-08-26 EP EP88402165A patent/EP0305297B1/fr not_active Expired - Lifetime
- 1988-08-26 IE IE259988A patent/IE60505B1/en not_active IP Right Cessation
- 1988-08-26 NZ NZ225943A patent/NZ225943A/xx unknown
- 1988-08-26 OA OA59416A patent/OA08754A/xx unknown
- 1988-08-26 PT PT88357A patent/PT88357B/pt not_active IP Right Cessation
- 1988-08-26 AT AT88402165T patent/ATE52789T1/de not_active IP Right Cessation
1990
- 1990-07-27 GR GR90400526T patent/GR3000677T3/el unknown

Also Published As

Publication number	Publication date
FR2619813A1 (fr)	1989-03-03
ATE52789T1 (de)	1990-06-15
ZA886368B (en)	1989-05-30
DK170978B1 (da)	1996-04-09
DK472788D0 (da)	1988-08-24
FR2619813B1 (fr)	1991-05-03
DE3860148D1 (de)	1990-06-21
CA1327800C (fr)	1994-03-15
NZ225943A (en)	1990-06-26
OA08754A (fr)	1989-03-31
AU612689B2 (en)	1991-07-18
DK472788A (da)	1989-03-01
AU2159488A (en)	1989-03-09
JPS6471875A (en)	1989-03-16
IE60505B1 (en)	1994-07-27
PT88357A (pt)	1989-06-30
EP0305297A1 (fr)	1989-03-01
PT88357B (pt)	1995-03-31
IE882599L (en)	1989-02-28
ES2031616T3 (es)	1992-12-16
US4959372A (en)	1990-09-25
EP0305297B1 (fr)	1990-05-16

Publication	Publication Date	Title
US4035507A (en)	1977-07-12	Novel, transient pro-drug forms of L-DOPA to treat Parkinson's disease
AU582600B2 (en)	1989-04-06	Dipeptide compounds having pharmaceutical activity and compositions containing them
KR960004858B1 (ko)	1996-04-16	프롤리날 유도체, 이의 제조방법 및 이를 함유하는 약제학적 조성물
KR890003603B1 (ko)	1989-09-27	5-아미노-2,5-이치환된-4-하이드록시펜타노산 잔기를 함유하는 레닌 억제물의 제조방법
US3998799A (en)	1976-12-21	Novel, transient pro-drug forms of l-dopa
JPS6120544B2 (el)	1986-05-22
RU96118225A (ru)	1999-01-10	Циклопептиды, способ их получения, содержащая их фармацевтическая композиция, способ ее получения, способ борьбы с заболеваниями, способ получения иммобилизированных лигандов, способ очистки интегринов
US4065566A (en)	1977-12-27	N-Nicotinoyl-3,4-dinicotinoyloxy-L-phenylalanine and derivatives pharmaceutical compositions and methods containing same
WO1988006890A1 (en)	1988-09-22	Synthetic inhibitors of mammalian collagenase
GR3000677T3 (en)	1991-09-27	Derivatives of aza-z-bicyclooctane-caboxylicacid-3, processes for their preparation and pharmaceutical compositions containing them
US4587238A (en)	1986-05-06	Substituted caprylolactam derivatives as anti-hypertensives
HUT50342A (en)	1990-01-29	Process for producing n-/5,6,7,8-tetrahydropyrido(3,3-d) pyrimidin-6-yl-alkanoyl/-glutamic acid derivatives and pharmaceutical compositions comprising same
US4684660A (en)	1987-08-04	Mercaptoacyldepeptides
US4713367A (en)	1987-12-15	Retro-inverso analogs of the bradykinin potentiating peptide BPP5a
GB2050359A (en)	1981-01-07	Derivatives of mercaptoacyl amino acids
AU625406B2 (en)	1992-07-09	New substituted amino acid derivatives, process for preparing these and pharmaceutical compositions containing them
US4920144A (en)	1990-04-24	Derivatives of bicyclic amino acids, agents containing them and their use as hypotensives
JPS63218697A (ja)	1988-09-12	ジフルオルシクロスタチン含有ポリペプチド
Vidal-Cros et al.	1990	Vitamin K-dependent carboxylation. Mechanistic studies with 3-fluoroglutamate-containing substrates
ES8506623A1 (es)	1985-08-01	Procedimiento de obtencion de nuevos derivados isoindolicos dicarboxilicos sustituidos.
Chen et al.	2000	Synthesis of 2 (S)‐benzyl‐3‐[hydroxy (1′(R)‐amino ethyl) phosphinyl] propanoyl‐L‐3‐[125I]‐iodotyrosine: a radiolabelled inhibitor of aminopeptidase N
FI84481B (fi)	1991-08-30	Foerfarande foer framstaellning av nya antihypertensiva 7-amino-1,2,3,4,6,7,8,12b-oktahydro-6-oxopyrido/2,1-a// 2/-bensazepin-4-karboxylsyraderivat.
EP0190597A2 (en)	1986-08-13	Retro-inverso analogs of the bradykinin potentiating peptide bpp 5a
KR910002787A (ko)	1991-02-26	아크릴산 아미드유도체, 이들의 제조방법, 이들을 함유하는 약리학적 조성물 및 이들을 사용하는 약품
CS237326B2 (cs)	1985-07-16	Způsob přípravy karboxyalkyldipeptidů