GR3018510T3 - Phenylalkan(en)oic acids. - Google Patents

Phenylalkan(en)oic acids.

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Publication number
GR3018510T3
GR3018510T3 GR950403640T GR950403640T GR3018510T3 GR 3018510 T3 GR3018510 T3 GR 3018510T3 GR 950403640 T GR950403640 T GR 950403640T GR 950403640 T GR950403640 T GR 950403640T GR 3018510 T3 GR3018510 T3 GR 3018510T3
Authority
GR
Greece
Prior art keywords
phenylalkan
oic acids
leukotriene
oic
acids
Prior art date
Application number
GR950403640T
Other languages
English (en)
Inventor
Mitoshi Konno
Takahiko Nakae
Nobuyuki Hamanaka
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of GR3018510T3 publication Critical patent/GR3018510T3/el

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    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
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    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyrrole Compounds (AREA)
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  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
GR950403640T 1989-06-27 1995-12-21 Phenylalkan(en)oic acids. GR3018510T3 (en)

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GR970400301T GR3022801T3 (en) 1989-06-27 1997-03-13 Phenylalkan(en)oic acids with leukotriene B4 antagonistic activity.
GR980400536T GR3026351T3 (en) 1989-06-27 1998-03-13 Phenylalkan(en)oic acids with leukotriene B4 antagonistic activity.

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GR980400536T GR3026351T3 (en) 1989-06-27 1998-03-13 Phenylalkan(en)oic acids with leukotriene B4 antagonistic activity.

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AT (3) ATE131154T1 (el)
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DE (3) DE69031959T2 (el)
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US5273999A (en) * 1991-09-10 1993-12-28 Hoffmann-La Roche Inc. Carboxylic acid leukotriene B4 antagonists
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
DE4224402A1 (de) * 1992-07-21 1994-01-27 Schering Ag Neue Pyridin-Derivate mit Leukotrien-B¶4¶-antagonistischer Wirkung
KR100232340B1 (ko) * 1994-10-13 1999-12-01 디. 제이. 우드, 스피겔 알렌 제이 류코트리엔 b4(ltb4) 길항물질로서의 벤조피란 및 벤조-축합된 화합물
CN1160399A (zh) * 1994-10-13 1997-09-24 美国辉瑞有限公司 苯并吡喃和苯并稠合化合物、其制备方法和它们作为白三烯b4(ltb4)拮抗剂的用途
US5559150A (en) * 1995-06-06 1996-09-24 3-Dimensional Pharmaceuticals, Inc. N,N-disulfonylated aminobenzene carboxlic acids and the use thereof as thrombin inhibitors
RU2171250C2 (ru) * 1996-08-05 2001-07-27 Пролинкс, Инк. Производные 2,6-дигидрокси-4-аминометилбензоата
JP2001501202A (ja) 1996-09-26 2001-01-30 ノバルティス アクチエンゲゼルシャフト ロイコトリエンｂ４（ｌｔｂ―４）レセプターアンタゴニスト活性によるアリル置換アクリルアミド
EP0891772A3 (en) * 1997-06-18 1999-05-19 Santen Pharmaceutical Co., Ltd. Therapeutic agent for rheumatic disease comprising nonsteroidal anti-inflamatory drug and phenylpropionic acid derivative
US7507531B2 (en) 2002-10-17 2009-03-24 Decode Genetics Chf. Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction
US7851486B2 (en) 2002-10-17 2010-12-14 Decode Genetics Ehf. Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
JP4720502B2 (ja) * 2003-09-01 2011-07-13 小野薬品工業株式会社 縮環化合物およびその用途
EP1670445A2 (en) * 2003-09-17 2006-06-21 Decode Genetics EHF. Methods of preventing or treating recurrence of myocardial infarction
US8158362B2 (en) 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
WO2007097279A1 (ja) * 2006-02-21 2007-08-30 Toyama Chemical Co., Ltd. ３－｛５－［４－（シクロペンチルオキシ）－２－ヒドロキシベンゾイル］－２－［（３－オキソ－２－置換－２，３－ジヒドロ－１，２－ベンズイソオキサゾール－６－イル）メトキシ］フェニル｝プロピオン酸エステルの製造法およびその中間体
TWI469965B (zh) 2008-12-22 2015-01-21 Ono Pharmaceutical Co 乙炔基吲哚化合物
ES2572804T3 (es) 2010-06-21 2016-06-02 Ono Pharmaceutical Co., Ltd. Nuevas formas cristalinas de ácido 4,4'-[4-fluoro-7-({4-[4-(3-fluoro-2-metilfenil)butoxi]fenil}etinil)2-metil-1H-indol-1,3-diil]butanoico
WO2016149126A1 (en) 2015-03-13 2016-09-22 The Board Of Trustees Of The Leland Stanford Junior University Ltb4 inhibition to prevent and treat human lymphedema

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GB8311678D0 (en) * 1983-04-28 1983-06-02 Ici Plc Phenol derivatives
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
CA1315279C (en) * 1987-01-12 1993-03-30 Nancy Grace Bollinger Anti-inflammatory agents

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CA2019335C (en) 2000-08-01
JPH0739369B2 (ja) 1995-05-01
JPH0672947A (ja) 1994-03-15
KR0148213B1 (en) 1998-08-17
ATE162181T1 (de) 1998-01-15
GR3022801T3 (en) 1997-06-30
KR0148212B1 (en) 1998-08-17
GR3026351T3 (en) 1998-06-30
KR0143404B1 (ko) 1998-07-15
EP0405116B1 (en) 1995-12-06
ES2114117T3 (es) 1998-05-16
JPH03261752A (ja) 1991-11-21
US5155104A (en) 1992-10-13
DE69031959T2 (de) 1998-06-04
DE69031959D1 (de) 1998-02-19
EP0405116A2 (en) 1991-01-02
CA2019335A1 (en) 1990-12-27
EP0405116A3 (en) 1992-04-15
KR910000622A (ko) 1991-01-29
EP0619296A1 (en) 1994-10-12
ATE131154T1 (de) 1995-12-15
DK0619296T3 (da) 1997-05-05
DE69023960D1 (de) 1996-01-18
JPH0819040B2 (ja) 1996-02-28
EP0652208A1 (en) 1995-05-10
ATE150006T1 (de) 1997-03-15
DK0405116T5 (da) 1996-04-29
DE69023960T2 (de) 1996-10-17
DK0652208T3 (da) 1998-09-14
ES2083396T3 (es) 1996-04-16
ES2102097T3 (es) 1997-07-16
DE69030202T2 (de) 1997-07-10
US5086065A (en) 1992-02-04
EP0619296B1 (en) 1997-03-12
DE69030202D1 (de) 1997-04-17
EP0652208B1 (en) 1998-01-14

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