GR3019512T3 - Immunoassay reagents and method for determining cyclosporine - Google Patents

Immunoassay reagents and method for determining cyclosporine

Info

Publication number: GR3019512T3
Authority: GR; Greece
Prior art keywords: cyclosporine; amino acid; immunoassay; disclosed; immunoassay reagents
Prior art date: 1990-08-15

Application number

GR960400900T

Other languages

English (en)

Inventor

Marjorie A Morrison

Victoria P Meucci

Steven E Lunetta

Mariola B Zajac

Elizabeth A Simpson

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-15

Filing date

1996-04-02

Publication date

1996-07-31

1996-04-02 Application filed by Abbott Lab filed Critical Abbott Lab

1996-07-31 Publication of GR3019512T3 publication Critical patent/GR3019512T3/el

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 12
108010036949 Cyclosporine Proteins 0.000 title abstract 9
229960001265 ciclosporin Drugs 0.000 title abstract 9
229930182912 cyclosporin Natural products 0.000 title abstract 9
238000003018 immunoassay Methods 0.000 title abstract 5
239000003153 chemical reaction reagent Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
150000001413 amino acids Chemical class 0.000 abstract 2
230000010287 polarization Effects 0.000 abstract 2
XJODGRWDFZVTKW-LURJTMIESA-N (2s)-4-methyl-2-(methylamino)pentanoic acid Chemical compound CN[C@H](C(O)=O)CC(C)C XJODGRWDFZVTKW-LURJTMIESA-N 0.000 abstract 1
AHQFCPOIMVMDEZ-UNISNWAASA-N (e,2s,3r,4r)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoic acid Chemical compound CN[C@H](C(O)=O)[C@H](O)[C@H](C)C\C=C\C AHQFCPOIMVMDEZ-UNISNWAASA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000700 radioactive tracer Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

GR960400900T 1990-08-15 1996-04-02 Immunoassay reagents and method for determining cyclosporine GR3019512T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US56784290A	1990-08-15	1990-08-15

Publications (1)

Publication Number	Publication Date
GR3019512T3 true GR3019512T3 (en)	1996-07-31

Family

ID=24268868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR960400900T GR3019512T3 (en)	1990-08-15	1996-04-02	Immunoassay reagents and method for determining cyclosporine

Country Status (10)

Country	Link
US (2)	US5489668A (el)
EP (1)	EP0473961B1 (el)
JP (1)	JP3171460B2 (el)
AT (1)	ATE132504T1 (el)
AU (1)	AU642035B2 (el)
CA (1)	CA2049089C (el)
DE (1)	DE69116034T2 (el)
DK (1)	DK0473961T3 (el)
ES (1)	ES2084069T3 (el)
GR (1)	GR3019512T3 (el)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69121844T2 (de) *	1990-11-20	1997-01-23	Behringwerke Ag	Immunotest für Cyclosporin
ES2148225T3 (es) *	1992-03-30	2000-10-16	Abbott Lab	Reactivos y procedimientos que permiten la deteccion y la cuantificacion de la tiroxina en muestras de fluido.
US5352803A (en) *	1992-03-30	1994-10-04	Abbott Laboratories	5(6)-methyl substituted fluorescein derivatives
GB9307491D0 (en) *	1993-04-08	1993-06-02	Sandoz Ltd	Organic compounds
USRE40596E1 (en) *	1993-04-08	2008-12-02	Novartis Ag	Rapamycin assay
US7279561B1 (en)	1993-04-23	2007-10-09	Wyeth	Anti-rapamycin monoclonal antibodies
US5504091A (en) *	1993-04-23	1996-04-02	American Home Products Corporation	Biotin esters of rapamycin
DE69435044T2 (de)	1993-04-23	2008-09-18	Wyeth	Rapamycin - Konjugate und Antikörper
US5393891A (en) *	1993-06-08	1995-02-28	The Du Pont Merck Pharmaceutical Company	Immunoassay reagents and methods for detecting brequinar and analogs
US5650288A (en) *	1995-07-14	1997-07-22	Macfarlane; Gordon D.	Immunophilin-bound immunosuppressant assay
EP0991660B8 (en)	1997-10-08	2006-04-05	Isotechnika,Inc.	DEUTERATED and undeuterated CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS
US20030220234A1 (en) *	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
US5990274A (en)	1997-11-25	1999-11-23	Dade Behring Inc.	Cyclosporine derivatives and uses thereof
US8569516B2 (en)	2001-09-07	2013-10-29	Elitech Holding B.V.	Compounds and methods for fluorescent labeling
US6972339B2 (en)	2001-09-07	2005-12-06	Epoch Biosciences, Inc.	Compounds and methods for fluorescent labeling
US7141648B2 (en)	2001-10-19	2006-11-28	Isotechnika Inc.	Synthesis of cyclosporin analogs
KR100444698B1 (ko) *	2001-11-08	2004-08-21	한국과학기술연구원	면역복합체 단일검출시약, 그의 제조방법 및 그를 이용한농약의 검출방법
EP1603512A2 (en)	2003-03-17	2005-12-14	Albany Molecular Research, Inc.	Novel cyclosporins
US7378391B2 (en)	2004-09-29	2008-05-27	Amr Technology, Inc.	Cyclosporin alkyne analogues and their pharmaceutical uses
WO2006039164A2 (en)	2004-09-29	2006-04-13	Amr Technology, Inc.	Novel cyclosporin analogues and their pharmaceutical uses
WO2006041631A2 (en)	2004-10-06	2006-04-20	Amr Technology, Inc.	Novel cyclosporin alkynes and their utility as pharmaceutical agents
US8022188B2 (en) *	2006-04-24	2011-09-20	Abbott Laboratories	Immunosuppressant binding antibodies and methods of obtaining and using same
US7883855B2 (en) *	2006-07-21	2011-02-08	Abbott Laboratories	Immunosuppressant drug extraction reagent for immunoassays
WO2008069917A2 (en)	2006-11-20	2008-06-12	Scynexis, Inc.	Novel cyclic peptides
US7914999B2 (en) *	2006-12-29	2011-03-29	Abbott Laboratories	Non-denaturing lysis reagent
WO2008082979A2 (en) *	2006-12-29	2008-07-10	Abbott Laboratories	Diagnostic test for the detection of a molecule or drug in whole blood
CA2673314C (en) *	2006-12-29	2014-03-11	Abbott Laboratories	Non-denaturing lysis reagent for use with capture-in-solution immunoassay
CA2673296C (en) *	2006-12-29	2012-10-16	Abbott Laboratories	Improved assay for immunosuppressant drugs
US8288111B2 (en)	2007-05-24	2012-10-16	Abbott Laboratories	Immunoassays exhibiting reduced cross-reactivity with hydrophobic drug analyte metabolites
BRPI0722361B8 (pt) *	2007-12-19	2021-07-27	Abbott Lab	métodos para avaliar a concentração de um fármaco imunossupressor em uma amostra de sangue humano, composição de reagente de extração e kit de teste
US20090170218A1 (en) *	2008-01-02	2009-07-02	Dade Behring Inc.	Methods for detection of cyclosporin a
CN110320364B (zh) *	2018-03-30	2023-03-31	洛阳普泰生物技术有限公司	一种双抗夹心胶体金检测试剂盒、及其制备方法与应用
US12345641B2 (en)	2020-04-17	2025-07-01	IDEZZ Laboratories, Inc.	Fluorescence quenching immunoassay
JP7755932B2 (ja) *	2021-01-08	2025-10-17	ＴｉａｎｍａＪａｐａｎ株式会社	蛍光偏光免疫分析用支持体、蛍光偏光免疫分析用キットおよび蛍光偏光免疫分析法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1023287A (en) *	1972-12-08	1977-12-27	Boehringer Mannheim G.M.B.H.	Process for the preparation of carrier-bound proteins
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
ATE92501T1 (de) *	1984-10-04	1993-08-15	Sandoz Ag	Monoklonale antikoerper gegen zyklosporine.
US5169773A (en) *	1984-10-04	1992-12-08	Sandoz Ltd.	Monoclonal antibodies to cyclosporins
US4727035A (en) *	1984-11-14	1988-02-23	Mahoney Walter C	Immunoassay for cyclosporin
US5124457A (en) *	1986-05-21	1992-06-23	Abbott Laboratories	Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies
US4939264A (en) *	1986-07-14	1990-07-03	Abbott Laboratories	Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies
US5427960A (en) *	1987-03-27	1995-06-27	Abbott Laboratories	Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies
US5239057A (en) *	1987-03-27	1993-08-24	Abbott Laboratories	Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
EP0283801A3 (en) *	1987-03-27	1990-05-30	Abbott Laboratories	Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
EP0329184A3 (en) *	1988-02-19	1990-05-23	Neorx Corporation	Antimers and antimeric conjugation

1991
- 1991-08-08 EP EP91113328A patent/EP0473961B1/en not_active Expired - Lifetime
- 1991-08-08 ES ES91113328T patent/ES2084069T3/es not_active Expired - Lifetime
- 1991-08-08 DK DK91113328.8T patent/DK0473961T3/da active
- 1991-08-08 DE DE69116034T patent/DE69116034T2/de not_active Expired - Fee Related
- 1991-08-08 AT AT91113328T patent/ATE132504T1/de not_active IP Right Cessation
- 1991-08-13 CA CA002049089A patent/CA2049089C/en not_active Expired - Fee Related
- 1991-08-14 AU AU82471/91A patent/AU642035B2/en not_active Ceased
- 1991-08-15 JP JP20523391A patent/JP3171460B2/ja not_active Expired - Fee Related
1993
- 1993-11-04 US US08/148,164 patent/US5489668A/en not_active Expired - Lifetime
1995
- 1995-05-04 US US08/433,104 patent/US5750413A/en not_active Expired - Lifetime
1996
- 1996-04-02 GR GR960400900T patent/GR3019512T3/el unknown

Also Published As

Publication number	Publication date
AU8247191A (en)	1992-02-20
EP0473961B1 (en)	1996-01-03
EP0473961A2 (en)	1992-03-11
ATE132504T1 (de)	1996-01-15
AU642035B2 (en)	1993-10-07
DE69116034D1 (de)	1996-02-15
DE69116034T2 (de)	1996-06-20
DK0473961T3 (da)	1996-07-01
EP0473961A3 (en)	1993-04-14
CA2049089C (en)	2002-09-03
CA2049089A1 (en)	1992-02-16
JPH04253999A (ja)	1992-09-09
US5750413A (en)	1998-05-12
JP3171460B2 (ja)	2001-05-28
ES2084069T3 (es)	1996-05-01
US5489668A (en)	1996-02-06

Publication	Publication Date	Title
GR3019512T3 (en)	1996-07-31	Immunoassay reagents and method for determining cyclosporine
DK261386A (da)	1986-06-03	Monoklonale antistoffer
ES2181734T3 (es)	2003-03-01	Ensayo inmunologico de ciclosporina.
CA2191950A1 (en)	1995-12-14	Technetium-99m labeled peptides for imaging
CA2140794A1 (en)	1995-08-08	Assay for the determination of protein in a biological sample
EP0363110A3 (en)	1991-07-17	High ph extraction composition and its use to determine a chlamydial, gonococcal or herpes antigen
EP0869177A3 (en)	1999-10-20	Human a- and b- platelet-derived growth factor receptor proteins and uses therefor.
CA2001206A1 (en)	1990-05-18	Substrate composition for alkaline phosphatase and method for assay using same
CA2106563A1 (en)	1993-06-17	Cocaine derivatives and protein and polypeptide cocaine derivative conjugates and labels
CA2100586A1 (en)	1992-08-09	Htlv-i and htlv-ii peptide antigens and methods
CS34889A2 (en)	1990-08-14	Method of affinitive-enzymatic compounds preparation for cholesterol's visul indication
FI912054A0 (fi)	1991-04-29	Entsymaattinen menetelmä -laktaamiantibioottien määrittämiseksi
CA2247009A1 (en)	1997-09-25	Cryptic peptides and method for their identification
CA2223090A1 (en)	1996-12-19	Improved hapten-peptide conjugates to detect anti-hiv-1 or anti-hiv-2 antibodies
WO1997024621A3 (en)	1997-08-14	Reagents for measuring lead levels via the quantification of porphobilinogen
EP0642023A4 (en)	1997-05-14	REAGENTS AND METHOD FOR TESTING FOR HEPATITIS C.
NO924226L (no)	1992-12-08	Proteinnukleinsyreprober og immunoanalyser som anvender disse
EP0379347A3 (en)	1992-04-08	Enzyme-labeled receptor composition, diagnostic kit and use in method to determine a ligand