GR3023932T3 - Pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them - Google Patents

Pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them

Info

Publication number: GR3023932T3
Authority: GR; Greece
Prior art keywords: group; optionally substituted; thromboxane; pharmaceuticals; saturated
Prior art date: 1992-02-12

Application number

GR970401580T

Other languages

English (en)

Inventor

Gilbert Lavielle

Thierry Dubuffet

Olivier Muller

Michel Laubie

Tony Verbeuren

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-12

Filing date

1997-06-30

Publication date

1997-09-30

1997-06-30 Application filed by Adir filed Critical Adir

1997-09-30 Publication of GR3023932T3 publication Critical patent/GR3023932T3/el

Links

239000003814 drug Substances 0.000 title abstract 2
125000005313 fatty acid group Chemical group 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
125000000719 pyrrolidinyl group Chemical group 0.000 title 1
229920006395 saturated elastomer Polymers 0.000 title 1
DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
-1 phenylsulphonyl group Chemical group 0.000 abstract 2
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000005400 pyridylcarbonyl group Chemical group N1=C(C=CC=C1)C(=O)* 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)

GR970401580T 1992-02-12 1997-06-30 Pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them GR3023932T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9201523A FR2687146B1 (fr)	1992-02-12	1992-02-12	Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number	Publication Date
GR3023932T3 true GR3023932T3 (en)	1997-09-30

Family

ID=9426530

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR970401580T GR3023932T3 (en)	1992-02-12	1997-06-30	Pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them

Country Status (13)

Country	Link
US (2)	US5387591A (el)
EP (1)	EP0556119B1 (el)
JP (1)	JPH0739385B2 (el)
AT (1)	ATE153016T1 (el)
AU (1)	AU655868B2 (el)
CA (1)	CA2089349C (el)
DE (1)	DE69310567T2 (el)
DK (1)	DK0556119T3 (el)
ES (1)	ES2105145T3 (el)
FR (1)	FR2687146B1 (el)
GR (1)	GR3023932T3 (el)
NZ (1)	NZ245884A (el)
ZA (1)	ZA93996B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2685325B1 (fr) *	1991-12-20	1994-02-04	Adir Cie	Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2722194B1 (fr) *	1994-07-06	1996-08-23	Adir	Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
JP4057088B2 (ja) *	1996-04-22	2008-03-05	株式会社カネカ	ピロリジン誘導体の製造方法
US5891882A (en) *	1996-12-06	1999-04-06	Abbott Laboratories	Benzopyranopyrrole and benzopyranopyridine α-1 adenergic compounds
CA2272330A1 (en) *	1996-12-06	1998-06-11	Irene Drizin	Benzopyranopyrrole and benzopyranopyridine alpha-1 adrenergic compounds
TWI274750B (en)	1999-01-12	2007-03-01	Abbott Gmbh & Co Kg	Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same
GB0002100D0 (en) *	2000-01-28	2000-03-22	Novartis Ag	Organic compounds
TW200302717A (en) *	2002-02-06	2003-08-16	Schering Corp	Novel gamma secretase inhibitors
US7468437B2 (en) *	2003-09-30	2008-12-23	Merck & Co., Inc.	Phenyl pyrrolidine ether tachykinin receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3881755T2 (de) *	1987-05-01	1993-10-21	Fujisawa Pharmaceutical Co	Pyrrolidin-Derivate.
JPH0798795B2 (ja) *	1987-05-08	1995-10-25	塩野義製薬株式会社	スルホンアミド置換不飽和脂肪酸
US5130323A (en) *	1988-10-31	1992-07-14	Fujisawa Pharmaceutical Co., Ltd.	Pyrrolidine derivatives
US5128366A (en) *	1990-07-05	1992-07-07	Shinogi & Co., Ltd.	Pyrrole derivatives
US5157128A (en) *	1990-11-30	1992-10-20	Warner-Lambert Company	Certain optically active substituted α,α-dialkyl-pyrrolidine-3-methamines useful as intermediates
FR2685325B1 (fr) *	1991-12-20	1994-02-04	Adir Cie	Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

1992
- 1992-02-12 FR FR9201523A patent/FR2687146B1/fr not_active Expired - Fee Related
1993
- 1993-02-11 EP EP93400340A patent/EP0556119B1/fr not_active Expired - Lifetime
- 1993-02-11 DE DE69310567T patent/DE69310567T2/de not_active Expired - Fee Related
- 1993-02-11 CA CA002089349A patent/CA2089349C/fr not_active Expired - Fee Related
- 1993-02-11 US US08/016,501 patent/US5387591A/en not_active Expired - Fee Related
- 1993-02-11 AU AU33010/93A patent/AU655868B2/en not_active Ceased
- 1993-02-11 NZ NZ245884A patent/NZ245884A/en unknown
- 1993-02-11 ES ES93400340T patent/ES2105145T3/es not_active Expired - Lifetime
- 1993-02-11 AT AT93400340T patent/ATE153016T1/de not_active IP Right Cessation
- 1993-02-11 DK DK93400340.1T patent/DK0556119T3/da active
- 1993-02-12 ZA ZA93996A patent/ZA93996B/xx unknown
- 1993-02-12 JP JP5024421A patent/JPH0739385B2/ja not_active Expired - Lifetime
1994
- 1994-06-14 US US08/259,697 patent/US5407946A/en not_active Expired - Fee Related
1997
- 1997-06-30 GR GR970401580T patent/GR3023932T3/el unknown

Also Published As

Publication number	Publication date
JPH069552A (ja)	1994-01-18
EP0556119B1 (fr)	1997-05-14
DK0556119T3 (da)	1997-12-15
FR2687146B1 (fr)	1994-04-01
CA2089349A1 (fr)	1993-08-13
JPH0739385B2 (ja)	1995-05-01
FR2687146A1 (fr)	1993-08-13
NZ245884A (en)	1994-11-25
ES2105145T3 (es)	1997-10-16
ATE153016T1 (de)	1997-05-15
DE69310567T2 (de)	1997-12-18
AU655868B2 (en)	1995-01-12
ZA93996B (en)	1993-09-20
AU3301093A (en)	1993-08-19
DE69310567D1 (de)	1997-06-19
CA2089349C (fr)	2001-10-16
US5387591A (en)	1995-02-07
EP0556119A1 (fr)	1993-08-18
US5407946A (en)	1995-04-18

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HUT36840A (en)	1985-10-28	Process for producing 11-beta-estradiene derivatives and pharmaceutical compositions containing them
MY101208A (en)	1991-08-17	Phenyl-piperazine anti-arrhythmia agents.
HU892555D0 (en)	1991-03-28	Process for producing complex compounds of platinum (ii) and pharmaceutical preparatives containing such compounds as active substance
NO892058D0 (no)	1989-05-23	Fremgangsnaate for fremstilling av terapeutisk aktive benzamider.
GR3023932T3 (en)	1997-09-30	Pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them
ES476343A1 (es)	1979-10-16	Procedimiento para la obtencion de ciclopentan-1-aminas
ES467627A1 (es)	1979-09-01	Procedimiento para la preparacion de derivados de acido 3- fenoxi-alfa-fenoxi-alcancarboxilico
ATE59033T1 (de)	1990-12-15	N-enthaltende heterozyklische verbindungen, verfahren zu deren herstellung und diese enthaltende arzneimittel.
IL106997A (en)	1997-06-10	4-hyteroaroylisoxazole derivatives and their use as herbicides
ES8300745A1 (es)	1982-11-01	Un procedimiento para la preparacion de nuevos derivados de la quinoleina.
AU569208B2 (en)	1988-01-21	5-alkyl-piperazinyl-quinoline derivatives
CA2085570A1 (fr)	1993-06-21	Nouveaux derives de pyrrolidine , leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ATE107298T1 (de)	1994-07-15	3-aminochroman-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE112552T1 (de)	1994-10-15	Harnstoffderivate, ihre herstellung und deren enthaltende arzneimittel.
GR3030234T3 (en)	1999-08-31	4-Phenylcarbamoyl-3-isoxazolecarboxylic acid derivatives with antiinflammatory activity
JPS6461466A (en)	1989-03-08	Derivatives of ureylene, 2,4-triminopyrimidine- 3-oxide, preparation and use for cosmetic and pharmacological composition
ES8303397A1 (es)	1983-02-01	Un procedimiento para la preparacion de nuevos derivados de quinoleinetanol o quinoleinpropanol utiles como medicamentos
PL301776A1 (en)	1995-05-02	Method of obtaining sulphuric derivatives of imidazole and novel intermediate products
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