ES2105145T3 - Nuevos derivados de la pirrolidina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de la pirrolidina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2105145T3
ES2105145T3 ES93400340T ES93400340T ES2105145T3 ES 2105145 T3 ES2105145 T3 ES 2105145T3 ES 93400340 T ES93400340 T ES 93400340T ES 93400340 T ES93400340 T ES 93400340T ES 2105145 T3 ES2105145 T3 ES 2105145T3
Authority
ES
Spain
Prior art keywords
group
optionally substituted
pirrolidine
contain
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93400340T
Other languages
English (en)
Inventor
Gilbert Lavielle
Thierry Dubuffet
Olivier Muller
Michel Laubie
Tony Verbeuren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2105145T3 publication Critical patent/ES2105145T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMPUESTOS DE FORMULA (I): EN LA QUE: R1 REPRESENTA: GRUPO ALQUILO EVENTUALMENTE SUSTITUIDO, TUALMENTE SUSTITUIDO, FONIL EVENTUALMENTE SUSTITUIDO, ENZOILO O PIRIDILCARBONIL EVENTUALMENTE SUSTITUDO, UN GRUPO ALQUILAMINOCARBONILO O FENILAMINOCARBONILO, O BENZOILAMINO, R2 REPRESENTA: RUPO FENILO EVENTUALMENTE SUSTITUIDO, O PIRIDIN-2-ILO EVENTUALMENTE SUSTITUIDO, R3 REPRESENTA UNO CUALQUIERA DE LOS SIGUIENTES GRUPOS: EN LOS QUE M ES IGUAL A 2,3 O 4, N ES IGUAL A 4, 5, 6 O 7, Y R REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO. MEDICAMENTOS.
ES93400340T 1992-02-12 1993-02-11 Nuevos derivados de la pirrolidina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2105145T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9201523A FR2687146B1 (fr) 1992-02-12 1992-02-12 Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2105145T3 true ES2105145T3 (es) 1997-10-16

Family

ID=9426530

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93400340T Expired - Lifetime ES2105145T3 (es) 1992-02-12 1993-02-11 Nuevos derivados de la pirrolidina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Country Status (13)

Country Link
US (2) US5387591A (es)
EP (1) EP0556119B1 (es)
JP (1) JPH0739385B2 (es)
AT (1) ATE153016T1 (es)
AU (1) AU655868B2 (es)
CA (1) CA2089349C (es)
DE (1) DE69310567T2 (es)
DK (1) DK0556119T3 (es)
ES (1) ES2105145T3 (es)
FR (1) FR2687146B1 (es)
GR (1) GR3023932T3 (es)
NZ (1) NZ245884A (es)
ZA (1) ZA93996B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2685325B1 (fr) * 1991-12-20 1994-02-04 Adir Cie Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2722194B1 (fr) * 1994-07-06 1996-08-23 Adir Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
JP4057088B2 (ja) * 1996-04-22 2008-03-05 株式会社カネカ ピロリジン誘導体の製造方法
ES2168682T3 (es) * 1996-12-06 2002-06-16 Abbott Lab Compuestos alfa-1 adrenergicos a base de benzopiranopirrol y de benzopiranopiridina.
US5891882A (en) * 1996-12-06 1999-04-06 Abbott Laboratories Benzopyranopyrrole and benzopyranopyridine α-1 adenergic compounds
TWI274750B (en) 1999-01-12 2007-03-01 Abbott Gmbh & Co Kg Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same
GB0002100D0 (en) * 2000-01-28 2000-03-22 Novartis Ag Organic compounds
TW200302717A (en) * 2002-02-06 2003-08-16 Schering Corp Novel gamma secretase inhibitors
US7468437B2 (en) * 2003-09-30 2008-12-23 Merck & Co., Inc. Phenyl pyrrolidine ether tachykinin receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3881755T2 (de) * 1987-05-01 1993-10-21 Fujisawa Pharmaceutical Co Pyrrolidin-Derivate.
JPH0798795B2 (ja) * 1987-05-08 1995-10-25 塩野義製薬株式会社 スルホンアミド置換不飽和脂肪酸
US5130323A (en) * 1988-10-31 1992-07-14 Fujisawa Pharmaceutical Co., Ltd. Pyrrolidine derivatives
US5128366A (en) * 1990-07-05 1992-07-07 Shinogi & Co., Ltd. Pyrrole derivatives
US5157128A (en) * 1990-11-30 1992-10-20 Warner-Lambert Company Certain optically active substituted α,α-dialkyl-pyrrolidine-3-methamines useful as intermediates
FR2685325B1 (fr) * 1991-12-20 1994-02-04 Adir Cie Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
NZ245884A (en) 1994-11-25
AU655868B2 (en) 1995-01-12
DE69310567D1 (de) 1997-06-19
FR2687146A1 (fr) 1993-08-13
US5387591A (en) 1995-02-07
FR2687146B1 (fr) 1994-04-01
DE69310567T2 (de) 1997-12-18
ATE153016T1 (de) 1997-05-15
CA2089349A1 (fr) 1993-08-13
ZA93996B (en) 1993-09-20
EP0556119A1 (fr) 1993-08-18
US5407946A (en) 1995-04-18
EP0556119B1 (fr) 1997-05-14
JPH069552A (ja) 1994-01-18
DK0556119T3 (da) 1997-12-15
GR3023932T3 (en) 1997-09-30
CA2089349C (fr) 2001-10-16
JPH0739385B2 (ja) 1995-05-01
AU3301093A (en) 1993-08-19

Similar Documents

Publication Publication Date Title
ES2080815T3 (es) Derivados de la 1-naftil-piperacina, sus procedimientos de preparacion y composiciones farmaceuticas que los contienen.
SE8406200L (sv) Indolderivat
NO892058D0 (no) Fremgangsnaate for fremstilling av terapeutisk aktive benzamider.
ES530902A0 (es) Procedimiento para preparar derivados de piperazina
DK0463945T3 (da) Chalcon-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende derivaterne
NZ237052A (en) N-phenyl-n-acetamidoglycinamide derivatives and pharmaceutical compositions
DK0379412T3 (da) Derivater af 1,8-benzonaphthyridin, fremstilling af disse forbindelser og midler, som indeholder forbindelserne
TR199801218T2 (xx) Takikinin antagonistleri olarak N-asil-2-ikameli-4-(Benzimidazolil-ya da imidazopiridinil-ikameli art�klar)-piperidinler.
ZA93996B (en) Pyrrolidine compounds, processes for preparing them and pharmaceutical compositions containing them.
ES2057802T3 (es) Nuevos derivados de 3-amino-cromano, procedimiento de preparacion y composiciones farmaceuticas que los contienen.
DE3170937D1 (en) 2-(1,4-benzodioxan-2-ylalkyl) imidazoles, their preparation and pharmaceutical compositions containing them
ES2061236T3 (es) Derivados de la urea, su preparacion y los medicamentos que les contienen.
AU3734785A (en) 5-alkyl-piperazinyl-quinoline derivatives
DE68921719D1 (de) Amphotericin B Derivate.
DE3567201D1 (en) Derivatives of 3-phenyl-2-propenamine, their preparation and medicines containing them
ZA894399B (en) New derivatives of phenothiazine,their preparation and the compositions which contain them
ES2063157T3 (es) Nuevos derivados del indol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2062772T3 (es) N-fenil n-alcoxicarbonilalquilo glicinamidas, su preparacion y los medicamentos que les contienen.
ATE11413T1 (de) Aminoalkylbenzofuran-derivate, ihre herstellung und sie enthaltende zusammensetzungen.
TH14687A (th) กรรมวิธีสำหรับเตรียมอนุพันธ์ต่าง ๆ ของเฮเทอโร?ไซเคิลซับสทิทิวเทด เบนซีนมีเธนแอมีน
FI933205L (fi) Tiatsolietanolijohdannaisia, menetelmä niiden valmistamiseksi ja niiden välituotteet

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 556119

Country of ref document: ES