GR3025926T3 - Condensed pyrimidine derivatives and their use as angiotensine II antagonists - Google Patents

Condensed pyrimidine derivatives and their use as angiotensine II antagonists

Info

Publication number: GR3025926T3
Authority: GR; Greece
Prior art keywords: angiotensine; antagonists; pyrimidine derivatives; condensed pyrimidine; condensed
Prior art date: 1991-10-24

Application number

GR980400096T

Other languages

Greek (el)

English (en)

Inventor

John Watson Ellingboe

Madelene Nikaido

Jehan Franroz Bagli

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-24

Filing date

1998-01-15

Publication date

1998-04-30

1991-10-24 Priority claimed from US07/782,025 external-priority patent/US5149699A/en

1992-04-07 Priority claimed from GB9207560A external-priority patent/GB2265899A/en

1992-06-25 Priority claimed from US07/901,485 external-priority patent/US5256654A/en

1998-01-15 Application filed by American Home Prod filed Critical American Home Prod

1998-04-30 Publication of GR3025926T3 publication Critical patent/GR3025926T3/el

Links

JYPVVOOBQVVUQV-CGHBYZBKSA-N angiotensinamide Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(N)=O)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=C(O)C=C1 JYPVVOOBQVVUQV-CGHBYZBKSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
150000003230 pyrimidines Chemical class 0.000 title 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
238000002399 angioplasty Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

GR980400096T 1991-10-24 1998-01-15 Condensed pyrimidine derivatives and their use as angiotensine II antagonists GR3025926T3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/782,025 US5149699A (en)	1991-10-24	1991-10-24	Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560A GB2265899A (en)	1992-04-07	1992-04-07	Substituted pyrimidines
US07/901,485 US5256654A (en)	1991-10-24	1992-06-25	Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists

Publications (1)

Publication Number	Publication Date
GR3025926T3 true GR3025926T3 (en)	1998-04-30

Family

ID=27266132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR980400096T GR3025926T3 (en)	1991-10-24	1998-01-15	Condensed pyrimidine derivatives and their use as angiotensine II antagonists

Country Status (21)

Country	Link
EP (1)	EP0539086B1 (2)
JP (1)	JP3240192B2 (2)
KR (1)	KR100286624B1 (2)
CN (2)	CN1039324C (2)
AT (1)	ATE161537T1 (2)
AU (1)	AU653635B2 (2)
CA (1)	CA2080705C (2)
DE (1)	DE69223734T2 (2)
DK (1)	DK0539086T3 (2)
ES (1)	ES2111617T3 (2)
FI (1)	FI103971B1 (2)
GR (1)	GR3025926T3 (2)
HK (1)	HK1003031A1 (2)
HU (2)	HU218786B (2)
IL (1)	IL103436A (2)
LV (1)	LV12047B (2)
NO (1)	NO301275B1 (2)
SG (1)	SG47626A1 (2)
SK (1)	SK280292B6 (2)
TW (1)	TW226375B (2)
UA (1)	UA27748C2 (2)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1384717B1 (en) *	1991-11-18	2008-05-14	E.I. Dupont De Nemours And Company	2-(2'-triphenylmethyl-2'H-tetrazol-5'-yl)phenylboronic acid intermediates for the synthesis of A II receptor antagonists
DE69415706T2 (de) *	1993-03-24	1999-05-20	American Home Products Corp., Madison, N.J.	Substituierte Pyridopyrimidine als Antihypertensiva
DE69507887T2 (de) *	1994-09-20	1999-06-17	Wakunaga Seiyaku K.K., Osaka	Verfahren zur herstellung von n-biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
IT1292437B1 (it) *	1997-06-30	1999-02-08	Zambon Spa	Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en)	1998-07-06	2003-10-28	Bristol-Myers Squibb Co.	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
PE20020617A1 (es)	2000-08-22	2002-08-05	Novartis Ag	Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en)	2003-12-01	2003-12-31	Novartis Ag	Organic compounds
GB0402262D0 (en)	2004-02-02	2004-03-10	Novartis Ag	Process for the manufacture of organic compounds
NZ549535A (en)	2004-03-17	2010-11-26	Novartis Ag	Use of aliskiren for treating renal and other disorders
ES2384637T3 (es)	2004-10-08	2012-07-10	Novartis Ag	Uso de inhibidores de la renina para la prevención o el tratamiento de disfunción diastólica o insuficiencia cardiaca diastólica
EP1749828A1 (en)	2005-08-04	2007-02-07	Farmaprojects S.L.	Process for preparing an angiotensin II receptor antagonist
JP5930573B2 (ja)	2007-03-01	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (en)	2007-04-18	2014-12-24	Probiodrug AG	Thiourea derivatives as glutaminyl cyclase inhibitors
MX354786B (es)	2007-06-04	2018-03-21	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
KR101530019B1 (ko) *	2007-06-07	2015-06-18	시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이.	혈관성형술 또는 동맥내막절제술 후 재협착 및 장기 섬유증으로 인한 질환의 치료에 유용한 5베타, 14베타-안드로스테인 유도체
ES2522968T3 (es)	2008-06-04	2014-11-19	Synergy Pharmaceuticals Inc.	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en)	2008-07-16	2015-02-19	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
JP5934645B2 (ja)	2009-09-11	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
NZ602312A (en)	2010-03-10	2014-02-28	Probiodrug Ag	Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
EP2686313B1 (en)	2011-03-16	2016-02-03	Probiodrug AG	Benzimidazole derivatives as inhibitors of glutaminyl cyclase
WO2013090196A1 (en)	2011-12-15	2013-06-20	Takeda Pharmaceuticals U.S.A., Inc.	Combinations of azilsartan and chlorthalidone for treating hypertension black patients
AU2014235215A1 (en)	2013-03-15	2015-10-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
BR112015030326A2 (pt)	2013-06-05	2017-08-29	Synergy Pharmaceuticals Inc	Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0407342A3 (en) *	1989-07-06	1991-07-10	Ciba-Geigy Ag	Pyrimidine derivatives
US5100897A (en) *	1989-08-28	1992-03-31	Merck & Co., Inc.	Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) *	1989-08-30	1991-10-23	Ciba-Geigy Ag	Aza compounds
JPH05504969A (ja) *	1990-02-13	1993-07-29	メルク・エンド・カムパニー・インコーポレーテツド	置換ベンジル要素を含有するアンギオテンシン２アンタゴニスト類
IL100917A0 (en)	1991-02-16	1992-11-15	Fisons Plc	Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
US5149699A (en) *	1991-10-24	1992-09-22	American Home Products Corporation	Substituted pyridopyrimidines useful as antgiotensin II antagonists

1992
- 1992-08-27 TW TW081106755A patent/TW226375B/zh active
- 1992-09-30 FI FI924397A patent/FI103971B1/fi not_active IP Right Cessation
- 1992-10-01 AU AU26079/92A patent/AU653635B2/en not_active Ceased
- 1992-10-06 HU HU9203161A patent/HU218786B/hu not_active IP Right Cessation
- 1992-10-14 SG SG1996003253A patent/SG47626A1/en unknown
- 1992-10-14 ES ES92309333T patent/ES2111617T3/es not_active Expired - Lifetime
- 1992-10-14 DK DK92309333.0T patent/DK0539086T3/da active
- 1992-10-14 AT AT92309333T patent/ATE161537T1/de not_active IP Right Cessation
- 1992-10-14 EP EP92309333A patent/EP0539086B1/en not_active Expired - Lifetime
- 1992-10-14 DE DE69223734T patent/DE69223734T2/de not_active Expired - Fee Related
- 1992-10-15 IL IL10343692A patent/IL103436A/en not_active IP Right Cessation
- 1992-10-16 CA CA002080705A patent/CA2080705C/en not_active Expired - Fee Related
- 1992-10-23 JP JP28588592A patent/JP3240192B2/ja not_active Expired - Fee Related
- 1992-10-23 NO NO924121A patent/NO301275B1/no not_active IP Right Cessation
- 1992-10-23 CN CN92113781A patent/CN1039324C/zh not_active Expired - Fee Related
- 1992-10-23 KR KR1019920019580A patent/KR100286624B1/ko not_active Expired - Fee Related
- 1992-10-26 SK SK3221-92A patent/SK280292B6/sk unknown
1993
- 1993-06-18 UA UA93003129A patent/UA27748C2/uk unknown
1995
- 1995-06-29 HU HU95P/P00549P patent/HU211915A9/hu unknown
1997
- 1997-05-13 CN CN97111592A patent/CN1175414A/zh active Pending
1998
- 1998-01-15 GR GR980400096T patent/GR3025926T3/el unknown
- 1998-03-09 LV LVP-98-45A patent/LV12047B/en unknown
- 1998-03-12 HK HK98102075A patent/HK1003031A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH05222039A (ja)	1993-08-31
FI924397A0 (fi)	1992-09-30
UA27748C2 (uk)	2000-10-16
KR930007949A (ko)	1993-05-20
FI103971B (fi)	1999-10-29
JP3240192B2 (ja)	2001-12-17
EP0539086A2 (en)	1993-04-28
KR100286624B1 (ko)	2001-05-02
LV12047B (en)	1998-08-20
HU211915A9 (en)	1996-01-29
DE69223734D1 (de)	1998-02-05
ES2111617T3 (es)	1998-03-16
FI924397L (fi)	1993-04-25
CN1072682A (zh)	1993-06-02
CA2080705A1 (en)	1993-04-25
ATE161537T1 (de)	1998-01-15
SG47626A1 (en)	1998-04-17
HUT62893A (en)	1993-06-28
AU653635B2 (en)	1994-10-06
SK322192A3 (en)	1999-11-08
NO924121L (no)	1993-04-26
CA2080705C (en)	2002-12-03
IL103436A0 (en)	1993-03-15
AU2607992A (en)	1993-04-29
NO924121D0 (no)	1992-10-23
FI103971B1 (fi)	1999-10-29
HU218786B (hu)	2000-12-28
LV12047A (lv)	1998-05-20
HU9203161D0 (en)	1992-12-28
EP0539086B1 (en)	1997-12-29
NO301275B1 (no)	1997-10-06
CN1175414A (zh)	1998-03-11
SK280292B6 (sk)	1999-11-08
EP0539086A3 (en)	1993-06-16
IL103436A (en)	1996-03-31
HK1003031A1 (en)	1998-09-30
CN1039324C (zh)	1998-07-29
DE69223734T2 (de)	1998-04-16
DK0539086T3 (da)	1998-02-02
TW226375B (2)	1994-07-11

Publication	Publication Date	Title
GR3025926T3 (en)	1998-04-30	Condensed pyrimidine derivatives and their use as angiotensine II antagonists
NZ234327A (en)	1992-12-23	Quinazoline derivatives and pharmaceutical compositions
HUT61748A (en)	1993-03-01	Process for producing angiotensin ii receptor blocking 2,3,6-substituted quinazolinone derivatives and pharmaceutical compositions comprising same
NL300006I1 (nl)	2000-07-03	Imidazolylalkeenzuurderivaten.
TR200201057T2 (tr)	2002-09-23	P38 protein kinazı inhibitörleri olarak heteroalkilamino ikameli bisiklik nitrojen heterosaykılları.
DE60023318D1 (de)	2006-03-02	Heteropolycyclische verbindungen und ihre verwendung als antagonisten von metabotropen glutamatrezeptoren
DE69413274D1 (de)	1998-10-22	Chinoloncarbonsäurederivate, ihre Herstellung und ihre Verwendung als Zelladhäsion Inhibitoren
ATE109481T1 (de)	1994-08-15	Diazinderivate als angiotensin ii rezeptor antagonisten.
GR3019543T3 (en)	1996-07-31	Substituted aminopyrimidines as angiotensine ii antagonists.
DE69200160D1 (de)	1994-07-07	Angiotensin-II-Antagonisten.
ZA903983B (en)	1991-03-27	Diarylstyrylquinoline diacids
LV12261A (lv)	1999-04-20	Aizvietoti piridopirimidini ka antihipertensivi savienojumi
ATE91487T1 (de)	1993-07-15	Dibenzodioxazecin- und dibenzodioxaazacycloundecin-derivate.
JO1697B1 (en)	1992-12-15	Pyridine derivatives