ATE109481T1 - Diazinderivate als angiotensin ii rezeptor antagonisten. - Google Patents

Diazinderivate als angiotensin ii rezeptor antagonisten.

Info

Publication number
ATE109481T1
ATE109481T1 AT91900302T AT91900302T ATE109481T1 AT E109481 T1 ATE109481 T1 AT E109481T1 AT 91900302 T AT91900302 T AT 91900302T AT 91900302 T AT91900302 T AT 91900302T AT E109481 T1 ATE109481 T1 AT E109481T1
Authority
AT
Austria
Prior art keywords
angiotensin
receptor antagonists
novel compounds
diazine derivatives
compounds
Prior art date
Application number
AT91900302T
Other languages
English (en)
Inventor
David Anthony Hardknot Roberts
Robert James Fulshaw Av Pearce
Robert Hugh Mainwarin Bradbury
Richard William Arthur Pi Luke
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898926211A external-priority patent/GB8926211D0/en
Priority claimed from GB909011348A external-priority patent/GB9011348D0/en
Application filed by Ici Plc filed Critical Ici Plc
Application granted granted Critical
Publication of ATE109481T1 publication Critical patent/ATE109481T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Insulating Materials (AREA)
  • Vibration Prevention Devices (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
AT91900302T 1989-11-20 1990-11-19 Diazinderivate als angiotensin ii rezeptor antagonisten. ATE109481T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898926211A GB8926211D0 (en) 1989-11-20 1989-11-20 Diazine derivatives
GB909011348A GB9011348D0 (en) 1990-05-21 1990-05-21 Nitrogen heterocycles

Publications (1)

Publication Number Publication Date
ATE109481T1 true ATE109481T1 (de) 1994-08-15

Family

ID=26296233

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91900302T ATE109481T1 (de) 1989-11-20 1990-11-19 Diazinderivate als angiotensin ii rezeptor antagonisten.

Country Status (17)

Country Link
US (1) US5126344A (de)
EP (1) EP0454831B1 (de)
JP (1) JPH04505161A (de)
KR (1) KR920701206A (de)
AT (1) ATE109481T1 (de)
AU (1) AU6733690A (de)
BG (1) BG60068B2 (de)
CA (1) CA2030240A1 (de)
DE (1) DE69011318T2 (de)
FI (1) FI913478A0 (de)
GB (1) GB9024730D0 (de)
HU (1) HUT58334A (de)
IE (1) IE903911A1 (de)
IL (1) IL96407A0 (de)
NZ (1) NZ236127A (de)
PT (1) PT95929A (de)
WO (1) WO1991007404A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122010000024I1 (de) * 1990-02-19 2010-07-08 Novartis Ag Acylverbindungen
GB9010394D0 (en) * 1990-05-09 1990-06-27 Ici Plc Heterocyclic compounds
GB9025123D0 (en) * 1990-11-19 1991-01-02 Ici Plc Nitrogen compounds
GB9102804D0 (en) * 1991-02-11 1991-03-27 Ici Plc Heterocyclic derivatives
IL101860A0 (en) * 1991-05-31 1992-12-30 Ici Plc Heterocyclic derivatives
JPH05213884A (ja) * 1991-06-14 1993-08-24 Upjohn Co:The 新規な４−アミノキノリン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
GB9113626D0 (en) * 1991-06-25 1991-08-14 Ici Plc Heterocyclic compounds
GB9113628D0 (en) * 1991-06-25 1991-08-14 Ici Plc Heterocyclic derivatives
US5246944A (en) * 1991-08-13 1993-09-21 Merck & Co., Inc. Quinoline angiotensin ii antagonists incorporating a substituted benzyl element
GB9121727D0 (en) * 1991-10-14 1991-11-27 Ici Plc Heterocyclic compounds
GB9202633D0 (en) * 1992-02-07 1992-03-25 Fujisawa Pharmaceutical Co Heterocyclic derivatives
TW297025B (de) * 1992-02-14 1997-02-01 Squibb & Sons Inc
GB2264710A (en) * 1992-03-04 1993-09-08 Merck & Co Inc Quinoline and azaquinoline angiotensin ii antagonists incorporating a substituted biphenyl element
WO1993017682A1 (en) * 1992-03-04 1993-09-16 Abbott Laboratories Angiotensin ii receptor antagonists
GB9211270D0 (en) * 1992-05-28 1992-07-15 Ici Plc Nitrogen compounds
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
DE60226756D1 (de) * 2001-10-04 2008-07-03 Merck & Co Inc Heteroarylsubstituierte tetrazolmodulatoren des metabotropischen glutamatrezeptors-5
AR037517A1 (es) * 2001-11-05 2004-11-17 Novartis Ag Derivados de naftiridinas, un proceso para su preparacion, composicion farmaceutica y el uso de los mismos para la preparacion de un medicamento para el tratamiento de una enfermedad inflamatoria
MX2009013293A (es) 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2810951B1 (de) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AR089929A1 (es) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd Proceso para manufacturar un derivado de naftiridina
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
ES2879434T3 (es) 2015-07-23 2021-11-22 Inst Curie Uso de una combinación de molécula Dbait e inhibidores de PARP para tratamiento del cáncer
GB201519573D0 (en) 2015-11-05 2015-12-23 King S College London Combination
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
KR20200130856A (ko) 2018-03-13 2020-11-20 옹쎄오 암 치료에서 획득한 내성에 대한 디베이트 분자
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
DK4426434T3 (da) 2021-11-02 2025-11-10 Flare Therapeutics Inc Pparg inverse agonists and uses thereof
CN121398822A (zh) 2023-06-21 2026-01-23 四方生物科学有限公司 用于在治疗hr功能正常的癌症的方法中的用途的包含脱氧胞苷衍生物和parp抑制剂的组合

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
DE3907937A1 (de) * 1989-03-11 1990-09-13 Basf Ag Substituierte 1,8-naphthylridine, verfahren zu ihrer herstellung und ihre verwendung als antidots
AU634561B2 (en) * 1989-07-27 1993-02-25 Eli Lilly And Company Naphthyridine derivatives

Also Published As

Publication number Publication date
BG60068B2 (bg) 1993-09-30
DE69011318D1 (de) 1994-09-08
FI913478A7 (fi) 1991-07-18
GB9024730D0 (en) 1991-01-02
HU912485D0 (en) 1991-12-30
US5126344A (en) 1992-06-30
HUT58334A (en) 1992-02-28
AU6733690A (en) 1991-06-13
PT95929A (pt) 1991-09-13
JPH04505161A (ja) 1992-09-10
DE69011318T2 (de) 1994-12-01
FI913478A0 (fi) 1991-07-18
EP0454831B1 (de) 1994-08-03
IL96407A0 (en) 1991-08-16
EP0454831A1 (de) 1991-11-06
WO1991007404A1 (en) 1991-05-30
IE903911A1 (en) 1991-05-22
KR920701206A (ko) 1992-08-11
NZ236127A (en) 1993-08-26
CA2030240A1 (en) 1991-05-21

Similar Documents

Publication Publication Date Title
DE69011318D1 (de) Diazinderivate als Angiotensin II Rezeptor Antagonisten.
ATE204873T1 (de) Naphthyridinderivate als angiotensin-ii- antagonist-inhibitoren
NO902262L (no) Fremgangsmaate for fremstilling av azainden-derivater.
NO912859L (no) Fremgangsmaate for fremstilling av terapeutisk aktive benzimidazoler.
ATE106404T1 (de) Angiotensin-ii-antagonisten.
FI960155A7 (fi) Terapeuttisia heterosyklisiä yhdisteitä
ATE334973T1 (de) Chinazolinverbindungen
ATE12042T1 (de) Aminosaeurederivate und ihre therapeutische verwendung.
TR199701647A2 (xx) �kame edilmi� purin t�revleri,bunlar�n imalat usul�
ATE119524T1 (de) Substituierte n-(imidazolyl)alkyl-alanin- derivate.
ATE324890T1 (de) Zusammensetzung enthaltend einen angiotensin-ii- rezeptor-antagonist und einen diuretikum und deren verwendung zur behandlung von bluthochdruck
DK0556329T3 (da) Substituerede piperaziner som midler til behandling af centralnervesystemet
EA200500882A1 (ru) N-арилсульфонил-3-аминоалкоксииндолы
ATE269862T1 (de) Substituierte thiazolidinedione und oxazolidinedione mit antidiabetischen, hypolipidämischen und antihypertensiven eigenschaften
JO1697B1 (en) Pyridine derivatives
JO1648B1 (en) Nitrogen compounds

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties