GR3029737T3 - Pyrimidine cyanoguanidines as k-channel blockers - Google Patents

Pyrimidine cyanoguanidines as k-channel blockers

Info

Publication number: GR3029737T3
Authority: GR; Greece
Prior art keywords: alkyl; hydrogen; pyrimidine; channel blockers; cyanoguanidines
Prior art date: 1993-06-11

Application number

GR990400822T

Other languages

Greek (el)

English (en)

Inventor

Stephen J Humphrey

Kaushik D Meisheri

James R Ludens

Jackson B Hester Jr

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-11

Filing date

1999-03-19

Publication date

1999-06-30

1993-06-11 Priority claimed from PCT/US1993/005458 external-priority patent/WO1994004499A1/fr

1999-03-19 Application filed by Upjohn Co filed Critical Upjohn Co

1999-06-30 Publication of GR3029737T3 publication Critical patent/GR3029737T3/el

Links

ZMNAWJVCOXWDKO-UHFFFAOYSA-N 2-cyanoguanidine;pyrimidine Chemical class C1=CN=CN=C1.NC(=N)NC#N ZMNAWJVCOXWDKO-UHFFFAOYSA-N 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
230000001882 diuretic effect Effects 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000003450 potassium channel blocker Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

GR990400822T 1993-06-11 1999-03-19 Pyrimidine cyanoguanidines as k-channel blockers GR3029737T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1993/005458 WO1994004499A1 (fr)	1992-08-13	1993-06-11	Des cyanoguanidines, agents bloquants du canal potassium
PCT/US1993/011332 WO1994029280A1 (fr)	1993-06-11	1993-11-26	Cyanoguanidines au pyrimidine utilisees en tant qu'agents bloquant des vannes a potassium

Publications (1)

Publication Number	Publication Date
GR3029737T3 true GR3029737T3 (en)	1999-06-30

Family

ID=22236674

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR990400822T GR3029737T3 (en)	1993-06-11	1999-03-19	Pyrimidine cyanoguanidines as k-channel blockers

Country Status (11)

Country	Link
EP (1)	EP0703904B1 (fr)
JP (1)	JPH08511264A (fr)
AT (1)	ATE176905T1 (fr)
AU (1)	AU673785B2 (fr)
CA (1)	CA2161325A1 (fr)
DE (1)	DE69323633T2 (fr)
DK (1)	DK0703904T3 (fr)
ES (1)	ES2127918T3 (fr)
GR (1)	GR3029737T3 (fr)
NZ (1)	NZ259600A (fr)
WO (1)	WO1994029280A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1917244A2 (fr)	2005-08-24	2008-05-07	Abbott GmbH & Co. KG	Composes guanidine a substitution hetaryl et utilisation en tant que partenaires de liaison pour des recepteurs de 5-ht5

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1489879A (en) *	1974-12-20	1977-10-26	Leo Pharm Prod Ltd	N'-cyano-n'-3-pyridylguanidines
US4287346A (en) *	1979-02-16	1981-09-01	Eisai Co., Ltd.	Cyanoguanidine derivatives
NZ229828A (en) *	1988-08-09	1992-03-26	Squibb & Sons Inc	Aryl cyanoguanidine derivatives and pharmaceutical compositions
CA2009074C (fr) *	1989-02-03	1999-07-27	David Wayne Robertson	Ameliorations concernant les derives de guanidine
US5006523A (en) *	1989-10-26	1991-04-09	E. R. Squibb & Sons, Inc.	Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers

1993
- 1993-11-26 JP JP7501716A patent/JPH08511264A/ja active Pending
- 1993-11-26 WO PCT/US1993/011332 patent/WO1994029280A1/fr not_active Ceased
- 1993-11-26 ES ES94904387T patent/ES2127918T3/es not_active Expired - Lifetime
- 1993-11-26 AU AU10303/95A patent/AU673785B2/en not_active Ceased
- 1993-11-26 CA CA002161325A patent/CA2161325A1/fr not_active Abandoned
- 1993-11-26 EP EP94904387A patent/EP0703904B1/fr not_active Expired - Lifetime
- 1993-11-26 DE DE69323633T patent/DE69323633T2/de not_active Expired - Fee Related
- 1993-11-26 AT AT94904387T patent/ATE176905T1/de not_active IP Right Cessation
- 1993-11-26 NZ NZ259600A patent/NZ259600A/xx unknown
- 1993-11-26 DK DK94904387T patent/DK0703904T3/da active
1999
- 1999-03-19 GR GR990400822T patent/GR3029737T3/el unknown

Also Published As

Publication number	Publication date
AU673785B2 (en)	1996-11-21
AU1030395A (en)	1995-01-03
DE69323633T2 (de)	1999-07-08
DE69323633D1 (de)	1999-04-01
EP0703904B1 (fr)	1999-02-24
NZ259600A (en)	1997-08-22
ATE176905T1 (de)	1999-03-15
ES2127918T3 (es)	1999-05-01
EP0703904A1 (fr)	1996-04-03
DK0703904T3 (da)	1999-09-27
JPH08511264A (ja)	1996-11-26
WO1994029280A1 (fr)	1994-12-22
CA2161325A1 (fr)	1994-12-22

Publication	Publication Date	Title
ZA935619B (en)	1995-02-03	Cyanoguanidines as k-channel blockers
PT1585739E (pt)	2011-05-13	Arilciclopropilacetamidas substitu?das como activadores da glucocinase
CA2044748A1 (fr)	1991-12-21	Agents antiangineux a base de pyrazolopyrimidinone
PT1485359E (pt)	2008-03-17	Bloqueadores dos canais de sódio
WO2001056989A3 (fr)	2002-02-28	Inhibiteurs du facteur xa contenant du phenylene bivalent
NO20013369L (no)	2001-09-03	Arylpiperazinyl-cykloheksyl-indol-derivater for behandling av depresjon
WO2003084937A3 (fr)	2004-06-03	Nouveaux derives de pyrimidinedione
NO883487D0 (no)	1988-08-05	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser.
CA2203237A1 (fr)	1996-05-23	Derives d'aminotetrazole utiles en tant qu'inhibiteurs de la monoxyde d'azote synthetase
AU7615794A (en)	1995-04-03	Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the cardiovascular system
NO944069L (no)	1995-05-02	Hemming av uterinfibrose
MY130375A (en)	2007-06-29	Non-nucleoside reverse trancriptase inhibitors
WO1992019608A3 (fr)	1993-01-07	Thioethers phenoliques cycliques
AU1556695A (en)	1995-08-15	Cyanoguanidines as k-channel blockers
GR3029737T3 (en)	1999-06-30	Pyrimidine cyanoguanidines as k-channel blockers
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NO20023041L (no)	2002-08-16	Fremgangsmåte for fremstilling av pyrazolopyridazinderivater
MY131544A (en)	2007-08-30	Fluorinated 4-aminoandrostadienone derivatives and process for their preparation
MXPA03008085A (es)	2004-03-10	Derivados de acido fusidico poliaminados novedosos.
ZA924445B (en)	1993-02-24	Orally active antiviral compounds
NO922523D0 (no)	1992-06-26	Aminopyrimidinkarboksamiddrivater med terapeutisk virkning
DK1049670T3 (da)	2002-11-11	Azetidincarboxamidderivater til behandling af CNS-lidelser
SE7713864L (sv)	1978-06-09	Nortropinkarbazatderivat och forfarande for framstellning av dem
EP0794185A4 (fr)	1998-03-25	Compose thiazole bicyclique