ATE176905T1 - Pyrimidine-cyanoguanidine als kaliumkanalblocker - Google Patents

Pyrimidine-cyanoguanidine als kaliumkanalblocker

Info

Publication number: ATE176905T1
Authority: AT; Austria
Prior art keywords: alkyl; hydrogen; pyrimidine; cyanoguanidine; potassium channel
Prior art date: 1993-06-11

Application number

AT94904387T

Other languages

English (en)

Inventor

Stephen J Humphrey

Kaushik D Meisheri

James R Ludens

Jackson B Hester Jr

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-11

Filing date

1993-11-26

Publication date

1999-03-15

1993-06-11 Priority claimed from PCT/US1993/005458 external-priority patent/WO1994004499A1/en

1993-11-26 Application filed by Upjohn Co filed Critical Upjohn Co

1999-03-15 Application granted granted Critical

1999-03-15 Publication of ATE176905T1 publication Critical patent/ATE176905T1/de

Links

ZMNAWJVCOXWDKO-UHFFFAOYSA-N 2-cyanoguanidine;pyrimidine Chemical compound C1=CN=CN=C1.NC(=N)NC#N ZMNAWJVCOXWDKO-UHFFFAOYSA-N 0.000 title abstract 2
239000003450 potassium channel blocker Substances 0.000 title abstract 2
229940125422 potassium channel blocker Drugs 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
230000001882 diuretic effect Effects 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT94904387T 1993-06-11 1993-11-26 Pyrimidine-cyanoguanidine als kaliumkanalblocker ATE176905T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1993/005458 WO1994004499A1 (en)	1992-08-13	1993-06-11	Cyanoguanidines as potassium channel blockers
PCT/US1993/011332 WO1994029280A1 (en)	1993-06-11	1993-11-26	Pyrimidine cyanoguanidines as k-channel blockers

Publications (1)

Publication Number	Publication Date
ATE176905T1 true ATE176905T1 (de)	1999-03-15

Family

ID=22236674

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94904387T ATE176905T1 (de)	1993-06-11	1993-11-26	Pyrimidine-cyanoguanidine als kaliumkanalblocker

Country Status (11)

Country	Link
EP (1)	EP0703904B1 (de)
JP (1)	JPH08511264A (de)
AT (1)	ATE176905T1 (de)
AU (1)	AU673785B2 (de)
CA (1)	CA2161325A1 (de)
DE (1)	DE69323633T2 (de)
DK (1)	DK0703904T3 (de)
ES (1)	ES2127918T3 (de)
GR (1)	GR3029737T3 (de)
NZ (1)	NZ259600A (de)
WO (1)	WO1994029280A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1917244A2 (de)	2005-08-24	2008-05-07	Abbott GmbH & Co. KG	Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1489879A (en) *	1974-12-20	1977-10-26	Leo Pharm Prod Ltd	N'-cyano-n'-3-pyridylguanidines
US4287346A (en) *	1979-02-16	1981-09-01	Eisai Co., Ltd.	Cyanoguanidine derivatives
NZ229828A (en) *	1988-08-09	1992-03-26	Squibb & Sons Inc	Aryl cyanoguanidine derivatives and pharmaceutical compositions
CA2009074C (en) *	1989-02-03	1999-07-27	David Wayne Robertson	Improvements in and relating to guanidine derivatives
US5006523A (en) *	1989-10-26	1991-04-09	E. R. Squibb & Sons, Inc.	Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers

1993
- 1993-11-26 JP JP7501716A patent/JPH08511264A/ja active Pending
- 1993-11-26 WO PCT/US1993/011332 patent/WO1994029280A1/en not_active Ceased
- 1993-11-26 ES ES94904387T patent/ES2127918T3/es not_active Expired - Lifetime
- 1993-11-26 AU AU10303/95A patent/AU673785B2/en not_active Ceased
- 1993-11-26 CA CA002161325A patent/CA2161325A1/en not_active Abandoned
- 1993-11-26 EP EP94904387A patent/EP0703904B1/de not_active Expired - Lifetime
- 1993-11-26 DE DE69323633T patent/DE69323633T2/de not_active Expired - Fee Related
- 1993-11-26 AT AT94904387T patent/ATE176905T1/de not_active IP Right Cessation
- 1993-11-26 NZ NZ259600A patent/NZ259600A/xx unknown
- 1993-11-26 DK DK94904387T patent/DK0703904T3/da active
1999
- 1999-03-19 GR GR990400822T patent/GR3029737T3/el unknown

Also Published As

Publication number	Publication date
AU673785B2 (en)	1996-11-21
AU1030395A (en)	1995-01-03
DE69323633T2 (de)	1999-07-08
DE69323633D1 (de)	1999-04-01
EP0703904B1 (de)	1999-02-24
NZ259600A (en)	1997-08-22
ES2127918T3 (es)	1999-05-01
EP0703904A1 (de)	1996-04-03
GR3029737T3 (en)	1999-06-30
DK0703904T3 (da)	1999-09-27
JPH08511264A (ja)	1996-11-26
WO1994029280A1 (en)	1994-12-22
CA2161325A1 (en)	1994-12-22

Legal Events

Date	Code	Title	Description
1999-11-15	UEP	Publication of translation of european patent specification
2003-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE158279T1 (de)	1997-10-15	Cyanoguanidine als kaliumkanalblocker
NO20013379D0 (no)	2001-07-06	4-okso-1,4-dihydro-3-kinolinkarboksamider som antivirusmidler
TW370529B (en)	1999-09-21	Pyrazolopyrimidines
DK584886D0 (da)	1986-12-05	Vanduoplaeselige, mono- og disubstituerede derivater af rapamycin og farmaceutisk acceptable salte deraf
CA2044748A1 (en)	1991-12-21	Pyrazolopyrimidinone antianginal agents
EP1288199A4 (de)	2005-10-12	Mnp-12 inhibitoren
CA2055670A1 (en)	1992-05-21	Retroviral protease inhibiting compounds
NO883487L (no)	1989-02-08	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser.
DK1113011T3 (da)	2006-11-27	Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer
ES2191985T3 (es)	2003-09-16	S-oxido de tetrahidrotiopirano feniloxazolidinonas.
DE69925472D1 (de)	2005-06-30	Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel
ATE163288T1 (de)	1998-03-15	2-amino-1,2,3,4-tetrahydronaphthalenderivate mit cardiovaskulärer wirkung
WO2002028844A1 (en)	2002-04-11	Thiazole or oxazole derivatives
NO944069L (no)	1995-05-02	Hemming av uterinfibrose
DE69323633D1 (de)	1999-04-01	Pyrimidine-cyanoguanidine als kaliumkanalblocker
ATE166343T1 (de)	1998-06-15	Cyanoguanidine als k-kanal-blocker
NO20023041L (no)	2002-08-16	Fremgangsmåte for fremstilling av pyrazolopyridazinderivater
MY131544A (en)	2007-08-30	Fluorinated 4-aminoandrostadienone derivatives and process for their preparation
DK0705263T3 (da)	1997-05-05	Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner
MX9305918A (es)	1994-05-31	Derivados de n-(2-amino-2-oxoetil)butanodiamida inhibidores de la renina procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ATE200673T1 (de)	2001-05-15	1,9-diazabicyclo(4.3.0)nona-3,8-dienderivate
SE7713864L (sv)	1978-06-09	Nortropinkarbazatderivat och forfarande for framstellning av dem
IT1271703B (it)	1997-06-04	"derivati 6-o 7-sostituiti del 4-aminoandrostadienone e procedimento per la loro preparazione"
EP0794185A4 (de)	1998-03-25	Bizyklische thiazolverbindung
CO4810228A1 (es)	1999-06-30	Derivados de pirazol piridazina, procesos para su preparacion y composiciones farmaceuticas que los contienen