GR3033594T3 - Hypoglycemic dihydrochalcone derivatives. - Google Patents

Hypoglycemic dihydrochalcone derivatives.

Info

Publication number: GR3033594T3
Authority: GR; Greece
Prior art keywords: group; hydrogen atom; hypoglycemic; formula; acyl group
Prior art date: 1992-11-12

Application number

GR20000401152T

Other languages

English (en)

Inventor

Kenji Tsujihara

Mitsuya Hongu

Nobuyuki Funami

Masanori Inamasu

Kenji Arakawa

Original Assignee

Tanabe Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-12

Filing date

2000-06-15

Publication date

2000-09-29

2000-06-15 Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co

2000-09-29 Publication of GR3033594T3 publication Critical patent/GR3033594T3/el

Links

QGGZBXOADPVUPN-UHFFFAOYSA-N dihydrochalcone Chemical class C=1C=CC=CC=1C(=O)CCC1=CC=CC=C1 QGGZBXOADPVUPN-UHFFFAOYSA-N 0.000 title abstract 2
230000002218 hypoglycaemic effect Effects 0.000 title 1
125000002252 acyl group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
239000004480 active ingredient Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
-1 alpha -D-glucopyranosyl group Chemical group 0.000 abstract 1
239000003472 antidiabetic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229940126904 hypoglycaemic agent Drugs 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

GR20000401152T 1992-11-12 2000-06-15 Hypoglycemic dihydrochalcone derivatives. GR3033594T3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP30148592		1992-11-12
JP2877093		1993-02-18
JP3598893		1993-02-25

Publications (1)

Publication Number	Publication Date
GR3033594T3 true GR3033594T3 (en)	2000-09-29

Family

ID=27286314

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR20000401152T GR3033594T3 (en)	1992-11-12	2000-06-15	Hypoglycemic dihydrochalcone derivatives.

Country Status (12)

Country	Link
US (1)	US5424406A (el)
EP (1)	EP0598359B1 (el)
KR (1)	KR100211438B1 (el)
AT (1)	ATE193828T1 (el)
CA (1)	CA2102591C (el)
DE (1)	DE69328856T2 (el)
DK (1)	DK0598359T3 (el)
ES (1)	ES2149186T3 (el)
GR (1)	GR3033594T3 (el)
PT (1)	PT598359E (el)
SG (1)	SG54120A1 (el)
TW (1)	TW283643B (el)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1020944C (zh)	1990-01-30	1993-05-26	阿图尔-费希尔股份公司费希尔厂	紧固件
US5731292A (en) *	1992-11-12	1998-03-24	Tanabe Seiyaku Co., Ltd.	Dihydrochalcone derivatives which are hypoglycemic agents
US5555329A (en)	1993-11-05	1996-09-10	Alliesignal Inc.	Light directing optical structure
US5830873A (en) *	1994-05-11	1998-11-03	Tanabe Seiyaku Co., Ltd.	Propiophenone derivative and a process for preparing the same
JP3059088B2 (ja) *	1995-11-07	2000-07-04	田辺製薬株式会社	プロピオフェノン誘導体およびその製法
PT850948E (pt) *	1996-12-26	2002-08-30	Tanabe Seiyaku Co	Derivados propiofenona e processo para a preparacao dos mesmos
FR2765801B1 (fr) *	1997-07-08	2003-04-11	Oreal	Utilisation de monoesters d'arbutine comme agent depigmentant
AU5755200A (en)	1999-08-27	2001-03-26	Joel R.L. Ehrenkranz	Method of using dihydrochalcone derivatives to block glucose transfer
PH12000002657B1 (en) *	1999-10-12	2006-02-21	Bristol Myers Squibb Co	C-aryl glucoside SGLT2 inhibitors
US6515117B2 (en)	1999-10-12	2003-02-04	Bristol-Myers Squibb Company	C-aryl glucoside SGLT2 inhibitors and method
US6683056B2 (en) *	2000-03-30	2004-01-27	Bristol-Myers Squibb Company	O-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en)	2000-03-30	2003-04-29	Bristol-Myers Squibb Company	O-glucosylated benzamide SGLT2 inhibitors and method
SK287811B6 (sk) *	2000-09-29	2011-10-04	Kissei Pharmaceutical Co., Ltd	Glukopyranozyloxybenzylbenzénový derivát, farmaceutická kompozícia a ľudský SGLT2-inhibítor tento derivát obsahujúci a použitie tohto derivátu
EP1344780A4 (en) *	2000-11-30	2004-01-28	Kissei Pharmaceutical	GLUCOPYRANOSYLOXYBENZYLBENZOLE DERIVATIVES, MEDICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION
ATE431830T1 (de) *	2000-12-28	2009-06-15	Kissei Pharmaceutical	Glucopyranosylpyrazolderivate und deren verwendung in arzneimitteln
TWI255817B (en) *	2001-02-14	2006-06-01	Kissei Pharmaceutical	Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof
US7087579B2 (en) *	2001-02-26	2006-08-08	Kissei Pharmaceutical Co., Ltd.	Glucopyranosyloxypyrazole derivatives and medicinal use thereof
JP4147111B2 (ja) *	2001-02-27	2008-09-10	キッセイ薬品工業株式会社	グルコピラノシルオキシピラゾール誘導体およびその医薬用途
US6936590B2 (en)	2001-03-13	2005-08-30	Bristol Myers Squibb Company	C-aryl glucoside SGLT2 inhibitors and method
CN100577175C (zh) *	2001-04-04	2010-01-06	奥索-麦克尼尔药品公司	包括葡萄糖重吸收抑制剂和ppar调节剂的联合疗法
WO2002080935A1 (en) *	2001-04-04	2002-10-17	Ortho Mcneil Pharmaceutical, Inc.	Combination therapy comprising glucose reabsorption inhibitors and retinoid-x receptor modulators
DE10258007B4 (de) *	2002-12-12	2006-02-09	Sanofi-Aventis Deutschland Gmbh	Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
TW200504021A (en)	2003-01-24	2005-02-01	Bristol Myers Squibb Co	Substituted anilide ligands for the thyroid receptor
ES2531660T3 (es) *	2003-08-01	2015-03-18	Mitsubishi Tanabe Pharma Corporation	Compuestos novedosos que tienen actividad inhibidora frente a transportador de glucosa dependiente de sodio
US8785403B2 (en)	2003-08-01	2014-07-22	Mitsubishi Tanabe Pharma Corporation	Glucopyranoside compound
TW200526678A (en) *	2003-08-01	2005-08-16	Janssen Pharmaceutica Nv	Substituted indole-O-glucosides
WO2005011592A2 (en) *	2003-08-01	2005-02-10	Janssen Pharmaceutica N.V.	Substituted indazole-o-glucosides
WO2005012242A2 (en) *	2003-08-01	2005-02-10	Janssen Pharmaceutica Nv	Substituted benzimidazole-, benztriazole-, and benzimidazolone-o-glucosides
EP1679965A4 (en) *	2003-08-01	2009-05-27	Janssen Pharmaceutica Nv	SUBSTITUTED ANELLIERED HETEROCYCLIC C-GLYCOSIDES
TW200606129A (en)	2004-07-26	2006-02-16	Chugai Pharmaceutical Co Ltd	Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
TW200637869A (en) *	2005-01-28	2006-11-01	Chugai Pharmaceutical Co Ltd	The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
TWI365186B (en) *	2005-01-31	2012-06-01	Mitsubishi Tanabe Pharma Corp	Indole derivatives
AR053329A1 (es) *	2005-01-31	2007-05-02	Tanabe Seiyaku Co	Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt)
TWI418556B (zh) *	2006-07-27	2013-12-11	Mitsubishi Tanabe Pharma Corp	吲哚衍生物
UY30730A1 (es) *	2006-12-04	2008-07-03	Mitsubishi Tanabe Pharma Corp	Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno
NZ577391A (en) *	2006-12-04	2011-11-25	Janssen Pharmaceutica Nv	Thienyl-containing glycopyranosyl derivatives as antidiabetics
RS56990B1 (sr)	2007-09-10	2018-05-31	Janssen Pharmaceutica Nv	Postupak za dobijanje jedinjenja koja su korisna kao inhibitori sglt
CL2008003653A1 (es)	2008-01-17	2010-03-05	Mitsubishi Tanabe Pharma Corp	Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
US8791077B2 (en)	2008-05-22	2014-07-29	Astrazeneca Ab	Method for treating hyperuricemia employing an SGLT2 inhibitor and composition containing same
US9056850B2 (en) *	2008-10-17	2015-06-16	Janssen Pharmaceutica N.V.	Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en)	2009-07-08	2011-01-13	Yin Liang	Combination therapy for the treatment of diabetes
EP2451797B1 (en)	2009-07-10	2013-04-03	Janssen Pharmaceutica, N.V.	CRYSTALLISATION PROCESS FOR 1-(ß-D-GLUCOPYRANOSYL)-4-METHYL-3-[5-(4-FLUOROPHENYL)-2-THIENYLMETHYL]BENZENE
HUE031375T2 (en) *	2009-10-14	2017-07-28	Janssen Pharmaceutica Nv	Process for the preparation of compounds useful as inhibitors of sglt2
SG10201506114UA (en)	2010-05-11	2015-09-29	Janssen Pharmaceutica Nv	Pharmaceutical formulations comprising 1 - (beta-d-glucopyranosyl) - 2 -thienylmethylbenzene derivatives as inhibitors of sglt
EP2697218B1 (en)	2011-04-13	2016-05-25	Janssen Pharmaceutica NV	Process for the preparation of compounds useful as inhibitors of sglt2
TWI542596B (zh)	2011-05-09	2016-07-21	健生藥品公司	（２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
US9545610B2 (en)	2013-03-04	2017-01-17	Nova Chemicals (International) S.A.	Complex comprising oxidative dehydrogenation unit
US20160033480A1 (en) *	2013-12-16	2016-02-04	Amy Huimeei Lo	Immunovir and Components, Immunovir A, B, C, D Utility and Useful Processes
CN104193786A (zh) *	2014-08-05	2014-12-10	张家港威胜生物医药有限公司	一种新橙皮苷二氢查尔酮的合成方法
CN104447905A (zh) *	2015-01-14	2015-03-25	佛山市赛维斯医药科技有限公司	一种含硝基苯和双o-葡萄糖苷衍生物、其制备方法和用途
CN104447907A (zh) *	2015-01-14	2015-03-25	佛山市赛维斯医药科技有限公司	含硝基联苯双葡萄糖苷结构化合物、其制备方法和用途
CN104478969A (zh) *	2015-01-14	2015-04-01	佛山市赛维斯医药科技有限公司	含烷氧苯基噻唑基的o-半乳糖苷衍生物、其制备方法和用途
CN104478962A (zh) *	2015-01-15	2015-04-01	佛山市赛维斯医药科技有限公司	一类卤代苯基s-葡萄糖苷衍生物、其制备方法和用途
US20170071970A1 (en)	2015-09-15	2017-03-16	Janssen Pharmaceutica Nv	Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
KR101998087B1 (ko) *	2018-02-19	2019-07-09	충북대학교 산학협력단	토종다래 유래 신규 화합물 및 이의 용도
MA53175A (fr)	2018-07-19	2021-05-26	Astrazeneca Ab	Méthodes de traitement de hfpef au moyen de dapagliflozine et compositions comprenant celle-ci
CN110078774A (zh) *	2019-04-25	2019-08-02	北京理工亘舒科技有限公司	一种非葡萄糖碳苷二氢查尔酮及其制备方法
CN116392472B (zh)	2020-07-27	2025-06-20	阿斯利康(瑞典)有限公司	用达格列净治疗慢性肾脏病的方法
US12409186B2 (en)	2020-07-27	2025-09-09	Astrazeneca Ab	Methods of treating chronic kidney disease with dapagliflozin
EP4315350A1 (en)	2021-04-01	2024-02-07	AstraZeneca UK Limited	Systems and methods for managing prediabetes with a gliflozin sodium-glucose cotransport 2 inhibitor pharmaceutical composition
US20250108065A1 (en)	2022-01-26	2025-04-03	Astrazeneca Ab	Methods of treating prediabetes or reducing the risk of developing type 2 diabetes with dapagliflozin
TW202525278A (zh)	2023-12-15	2025-07-01	愛爾蘭商阿斯特捷利康愛爾蘭有限公司	治療慢性腎病及高血壓之方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3984394A (en) *	1971-05-14	1976-10-05	Nutrilite Products, Inc.	Salts of dihydrochalcone derivatives and their use as sweeteners
US4031260A (en) *	1971-05-14	1977-06-21	Nutrilite Products, Inc.	Salts of dihydrochalcone derivatives and their use as sweeteners
US4684627A (en)	1981-09-08	1987-08-04	Leveen Harry H	Treatment of cancer with phlorizin and its derivatives
CA1289077C (en) *	1984-08-13	1991-09-17	Harry H. Leveen	Treatment of cancer with phlorizin and its derivatives
US5110801A (en) *	1984-08-13	1992-05-05	Leveen Harry H	Treatment of acne
US4760135A (en) *	1984-09-06	1988-07-26	University Of Kentucky Research Foundation	Phloretin and phlorizin derivative containing compounds
US4665058A (en) *	1985-03-16	1987-05-12	The University Of Kentucky Research Foundation	Compositions and method of treatment for sickle cell anemia

1993
- 1993-11-05 CA CA002102591A patent/CA2102591C/en not_active Expired - Lifetime
- 1993-11-10 TW TW082109418A patent/TW283643B/zh not_active IP Right Cessation
- 1993-11-10 US US08/149,912 patent/US5424406A/en not_active Expired - Lifetime
- 1993-11-12 SG SG1996000975A patent/SG54120A1/en unknown
- 1993-11-12 AT AT93118365T patent/ATE193828T1/de active
- 1993-11-12 PT PT93118365T patent/PT598359E/pt unknown
- 1993-11-12 DE DE69328856T patent/DE69328856T2/de not_active Expired - Lifetime
- 1993-11-12 EP EP93118365A patent/EP0598359B1/en not_active Expired - Lifetime
- 1993-11-12 ES ES93118365T patent/ES2149186T3/es not_active Expired - Lifetime
- 1993-11-12 DK DK93118365T patent/DK0598359T3/da active
- 1993-11-12 KR KR1019930024082A patent/KR100211438B1/ko not_active Expired - Lifetime
2000
- 2000-06-15 GR GR20000401152T patent/GR3033594T3/el unknown

Also Published As

Publication number	Publication date
DE69328856D1 (de)	2000-07-20
SG54120A1 (en)	1998-11-16
US5424406A (en)	1995-06-13
KR100211438B1 (ko)	1999-08-02
ATE193828T1 (de)	2000-06-15
EP0598359A1 (en)	1994-05-25
DK0598359T3 (da)	2000-07-31
PT598359E (pt)	2000-09-29
TW283643B (el)	1996-08-21
KR940010997A (ko)	1994-06-20
ES2149186T3 (es)	2000-11-01
EP0598359B1 (en)	2000-06-14
CA2102591C (en)	2000-12-26
DE69328856T2 (de)	2000-12-07
CA2102591A1 (en)	1994-05-13

Publication	Publication Date	Title
TW283643B (el)	1996-08-21
ZA95631B (en)	1995-10-05	Prolineamide derivatives
AU689304B2 (en)	1998-03-26	Quinazoline derivative
MX9800577A (es)	1998-04-30	Derivados de 4,5-diaril oxazol.
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CA2103590A1 (en)	1992-08-16	Benzamide derivative
AU1171897A (en)	1997-07-17	1-methylcarbapenem derivatives
EP0408044A3 (en)	1991-07-17	Anti-inflammatory and/or anti-allergic composition comprising glutathione derivatives
EP1034783A4 (en)	2001-03-28	AMIDE DERIVATIVES
EP0546177A4 (en)	1993-04-16	BENZOPYRANE DERIVATIVE, PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME.
ES2092470T3 (es)	1996-12-01	Derivados de pirrolidina.
EP0420086A3 (en)	1991-11-06	Pyrimidoindole derivatives and processes for preparation thereof
EP0919233B8 (en)	2003-08-13	Therapeutic agent for kidney diseases
AU7506591A (en)	1991-10-24	A therapeutic agent for dysuria comprising alpha-phenyl-alpha-pyridylalkanoic acid derivatives
EP0782857A4 (en)	2000-07-26	MEDICINAL PRODUCTS AND PREVENTIVE FOR THE TREATMENT OF NERVOUS SYSTEM DISEASES
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