GR3036132T3 - 17-side chain alkynyl-and 20-oxopregna-derivatives of vitamin d, methods for their production and pharmaceutical compositions thereof - Google Patents

17-side chain alkynyl-and 20-oxopregna-derivatives of vitamin d, methods for their production and pharmaceutical compositions thereof

Info

Publication number: GR3036132T3
Authority: GR; Greece
Prior art keywords: derivatives; oxopregna; vitamin; production; methods
Prior art date: 1995-12-21

Application number

GR20010400985T

Other languages

English (en)

Inventor

Robert Henry Hesse

Maurice Pechet

Sundara Setty

Original Assignee

Res Inst Medicine Chem

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-21

Filing date

2001-06-27

Publication date

2001-09-28

2001-06-27 Application filed by Res Inst Medicine Chem filed Critical Res Inst Medicine Chem

2001-09-28 Publication of GR3036132T3 publication Critical patent/GR3036132T3/el

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
229940046008 vitamin d Drugs 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
XMDLIEZJERQGEY-ZHFUSYIKSA-N (1r,3s,5z)-5-[(2e)-2-[(1s,3as,7ar)-1-ethyl-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)CC)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C XMDLIEZJERQGEY-ZHFUSYIKSA-N 0.000 abstract 1
230000003509 anti-fertility effect Effects 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
230000000118 anti-neoplastic effect Effects 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
239000003418 antiprogestin Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
229940125721 immunosuppressive agent Drugs 0.000 abstract 1
239000003018 immunosuppressive agent Substances 0.000 abstract 1
230000003623 progesteronic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

GR20010400985T 1995-12-21 2001-06-27 17-side chain alkynyl-and 20-oxopregna-derivatives of vitamin d, methods for their production and pharmaceutical compositions thereof GR3036132T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9526208.5A GB9526208D0 (en)	1995-12-21	1995-12-21	Chemical compounds
PCT/GB1996/003218 WO1997023453A1 (en)	1995-12-21	1996-12-23	17-side chain alkynyl-and 20-oxopregna-derivatives of vitamin d, methods for their production and pharmaceutical compositions thereof

Publications (1)

Publication Number	Publication Date
GR3036132T3 true GR3036132T3 (en)	2001-09-28

Family

ID=10785847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR20010400985T GR3036132T3 (en)	1995-12-21	2001-06-27	17-side chain alkynyl-and 20-oxopregna-derivatives of vitamin d, methods for their production and pharmaceutical compositions thereof

Country Status (21)

Country	Link
US (2)	US6372926B2 (el)
EP (1)	EP0874815B1 (el)
JP (1)	JP2000503636A (el)
KR (1)	KR19990076664A (el)
CN (1)	CN1086694C (el)
AT (1)	ATE200663T1 (el)
AU (1)	AU710680B2 (el)
CA (1)	CA2241011A1 (el)
CZ (1)	CZ290930B6 (el)
DE (1)	DE69612568T2 (el)
DK (1)	DK0874815T3 (el)
ES (1)	ES2155948T3 (el)
GB (1)	GB9526208D0 (el)
GR (1)	GR3036132T3 (el)
HU (1)	HUP9903786A3 (el)
IL (1)	IL125027A0 (el)
NO (1)	NO982816L (el)
NZ (1)	NZ324775A (el)
PT (1)	PT874815E (el)
WO (1)	WO1997023453A1 (el)
ZA (1)	ZA9610874B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003087048A2 (en) *	2002-04-11	2003-10-23	Instytut Farmaceutyczny	Preparation of 24 alkyl analogs of cholecalciferol and non-racemic compounds
US7253293B2 (en) *	2004-01-06	2007-08-07	Andrzej Slominski	Enzymatic method to produce 7-dehydropregnenolone, vitamin D3-like compounds and derivatives thereof
WO2006115509A2 (en)	2004-06-24	2006-11-02	Novartis Vaccines And Diagnostics Inc.	Small molecule immunopotentiators and assays for their detection
CA2601545A1 (en) *	2005-03-23	2006-09-28	Bioxell S.P.A.	Use of vitamin d compounds to treat endometriosis
TW200714580A (en) *	2005-10-14	2007-04-16	Formosa Lab Inc	Process for preparing vitamin D analogs
AU2010208323B2 (en)	2009-01-27	2016-03-10	Berg Llc	Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (en)	2009-08-14	2019-05-22	Berg LLC	Vitamin d3 and analogs thereof for treating alopecia
JP5563324B2 (ja) *	2010-02-03	2014-07-30	フォーモサ・ラボラトリーズ・インコーポレーテッド	マキサカルシトール中間体およびその製造方法
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6034543B2 (ja)	1977-07-01	1985-08-09	中外製薬株式会社	ビタミンｄ誘導体
GB9214202D0 (en) *	1992-07-03	1992-08-12	Leo Pharm Prod Ltd	Chemical compounds
GB9220439D0 (en) *	1992-09-28	1992-11-11	Leo Pharm Prod Ltd	Chemical compounds
US5397776A (en)	1993-08-20	1995-03-14	Wisconsin Alumni Research Foundation	Vitamin D compounds with anti-progesterone activity

1995
- 1995-12-21 GB GBGB9526208.5A patent/GB9526208D0/en active Pending
1996
- 1996-12-23 DK DK96943236T patent/DK0874815T3/da active
- 1996-12-23 IL IL12502796A patent/IL125027A0/xx not_active IP Right Cessation
- 1996-12-23 PT PT96943236T patent/PT874815E/pt unknown
- 1996-12-23 KR KR1019980704776A patent/KR19990076664A/ko not_active Ceased
- 1996-12-23 DE DE69612568T patent/DE69612568T2/de not_active Expired - Fee Related
- 1996-12-23 EP EP96943236A patent/EP0874815B1/en not_active Expired - Lifetime
- 1996-12-23 US US09/051,483 patent/US6372926B2/en not_active Expired - Fee Related
- 1996-12-23 WO PCT/GB1996/003218 patent/WO1997023453A1/en not_active Ceased
- 1996-12-23 AU AU12025/97A patent/AU710680B2/en not_active Ceased
- 1996-12-23 CA CA002241011A patent/CA2241011A1/en not_active Abandoned
- 1996-12-23 CZ CZ19981947A patent/CZ290930B6/cs not_active IP Right Cessation
- 1996-12-23 NZ NZ324775A patent/NZ324775A/xx unknown
- 1996-12-23 CN CN96180032A patent/CN1086694C/zh not_active Expired - Fee Related
- 1996-12-23 ZA ZA9610874A patent/ZA9610874B/xx unknown
- 1996-12-23 JP JP9523433A patent/JP2000503636A/ja not_active Ceased
- 1996-12-23 ES ES96943236T patent/ES2155948T3/es not_active Expired - Lifetime
- 1996-12-23 HU HU9903786A patent/HUP9903786A3/hu unknown
- 1996-12-23 AT AT96943236T patent/ATE200663T1/de not_active IP Right Cessation
1998
- 1998-06-18 NO NO982816A patent/NO982816L/no not_active Application Discontinuation
2001
- 2001-06-27 GR GR20010400985T patent/GR3036132T3/el not_active IP Right Cessation
2002
- 2002-03-07 US US10/091,594 patent/US20020188142A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20020188142A1 (en)	2002-12-12
ES2155948T3 (es)	2001-06-01
DE69612568T2 (de)	2001-09-06
CN1086694C (zh)	2002-06-26
DE69612568D1 (de)	2001-05-23
CZ194798A3 (cs)	1998-11-11
NZ324775A (en)	1999-02-25
WO1997023453A1 (en)	1997-07-03
GB9526208D0 (en)	1996-02-21
EP0874815B1 (en)	2001-04-18
NO982816D0 (no)	1998-06-18
IL125027A0 (en)	1999-01-26
HUP9903786A2 (hu)	2000-03-28
ATE200663T1 (de)	2001-05-15
DK0874815T3 (da)	2002-03-04
AU710680B2 (en)	1999-09-30
JP2000503636A (ja)	2000-03-28
US20020010163A1 (en)	2002-01-24
CN1209120A (zh)	1999-02-24
HUP9903786A3 (en)	2000-09-28
ZA9610874B (en)	1997-06-18
NO982816L (no)	1998-08-21
CA2241011A1 (en)	1997-07-03
US6372926B2 (en)	2002-04-16
EP0874815A1 (en)	1998-11-04
CZ290930B6 (cs)	2002-11-13
AU1202597A (en)	1997-07-17
PT874815E (pt)	2001-07-31
KR19990076664A (ko)	1999-10-15

Legal Events

Date	Code	Title	Description
2005-07-04	ML	Lapse due to non-payment of fees

Publication	Publication Date	Title
AU1497997A (en)	1997-09-04	Use of estrogen antagonists and estrogen agonists in inhibiting pathological conditions
DK0982032T3 (da)	2003-11-03	Anvendelse af en sulfamatesterholdig sterolforbindelse til fremstilling af et lægemiddel til kontrol af østrogenproduktion
CA2223513A1 (en)	1996-12-12	Betulinic acid derivatives and uses therefor
NZ331941A (en)	2000-04-28	Pentafluorobenzenesulfonamides and analogs and use in regulation of LDL receptor synthesis
NZ324775A (en)	1999-02-25	17-side chain alkynyl-and 20-oxopregna-derivatives of vitamin d, methods for their production and pharmaceutical compositions thereof
IT1271325B (it)	1997-05-27	Composti diastereomericamente puri derivati da 3-oxo e 3-tioxo-4-azaandrostani e loro uso come antiandrogeni
KR910015590A (ko)	1991-09-30	11베타 위치에 아미드 또는 카르바메이트 관능기 함유 탄화 수소 사슬을 가지는 신규한 19-노르 스테로이드, 그의 제조방법 및 중간체, 약물 용도 및 이들을 함유하는 제약 조성물
ES2138212T3 (es)	2000-01-01	Derivado de la vitamina d3 y procedimiento para producirlo.
HUP9901883A2 (hu)	1999-11-29	Fertőtlenítő készítmény és eljárás felületek fertőtlenítésére
DE69518410D1 (de)	2000-09-21	22-thiavitamin-d3-derivate
FI890302A0 (fi)	1989-01-20	Parannus androsta-1,4-dieeni-3,17-dionin 6-metyleenijohdannaisten synteesissä
DE69939106D1 (de)	2008-08-28	Verfahren zur Herstellung von ED-71
EP0605728A4 (en)	1995-05-03	Chromone derivative and aldose reductase inhibitor containing the same as active ingredient.
AU1382202A (en)	2002-04-08	17alpha fluoroalkyl steroids, method for producing the same and pharmaceutical compositions containing said compounds
IT1269584B (it)	1997-04-08	Procedimento per la preparazione di derivati di 5,6-diidrossi- 2-ammino-1,2,3,4- tetraidronaftalene
MX9604735A (es)	1998-01-31	Derivados de la 22-tiavitamina d3.
IL150082A0 (en)	2002-12-01	Unsaturated 14, 15-cyclopropane-andostranes, a method for their production and pharmaceutical compositions containing these compounds
AU2148899A (en)	1999-06-16	15-methyl-cyclopropanosteroids and method for the production thereof
HU9400795D0 (en)	1994-06-28	Benzene derivatives and pharmaceutical compositions containing them as active components
ECSP961710A (es)	1997-09-22	Nuevos derivados de la etanolamina